Species

KNApSAcK Entry

Organism name Ligustrum obtusifolium
Genus Ligustrum
Family Oleaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ligustrum obtusifolium
Linked NCBI taxonomy ID 178760
Linked level species

Family

Family in NCBI taxonomy Oleaceae
ID 4144

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000659 External link 512 Medioresinol
/ (+)-Medioresinol
CHEMBL376507
CHEMBL513023
2 / 1 / 1 No. 38 No. 21
C00007190 External link 512 (+)-Pinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
C103298
7 / 5 / 6 No. 38 No. 21
C00003093 External link 512 Oleuropein
CHEMBL1911053
C002769
8 / 5 No. 243
C00010785 External link 512 Ligustroside
CHEMBL1086877
1 / 1 / 0 No. 243
C00000682 External link 512 (-)-Olivil
/ Vladinol C
CHEMBL517144
1 / 1 / 1 No. 700 No. 21

Human Protein / Gene in interactions

11 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000659 1 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00007190 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00007190 0 / 3
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00007190 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000682 1 / 1
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00007190 5 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00007190 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000659 0 / 1
P14672 Solute carrier family 2, facilitated glucose transporter member 4 Unclassified protein C00010785 1 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00007190 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00007190 0 / 0

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1588 CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) C00003093
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00003093
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00003093
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00003093
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00003093
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00003093
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00003093
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00003093

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#125853 Diabetes mellitus, noninsulin-dependent; niddm P14672
#608902 Drug metabolism, poor, cyp2d6-related P10635
#137800 Glioma susceptibility 1; glm1 P37231
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#601665 Obesity P37231
#278300 Xanthinuria, type i P47989

KEGG DISEASE (8)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00192 Xanthinuria P47989 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D064420 Drug-Related Side Effects and Adverse Reactions C00003093
D006331 Heart Diseases C00003093
D006937 Hypercholesterolemia C00003093
D006949 Hyperlipidemias C00003093
D015228 Hypertriglyceridemia C00003093