Olea europaea

• Index
• Plant Species
• Metabolite list (41)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Olea europaea
Genus	Olea
Family	Oleaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Olea europaea
Linked NCBI taxonomy ID	4146
Linked level	species

Family

Family in NCBI taxonomy	Oleaceae
ID	4144

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (41)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00002376	Cyanidin 3-rutinoside	CHEMBL505251	C020386	3 / 0 / 1		No. 1	No. 15
C00031198	Rotundic acid	CHEMBL523209 CHEMBL493908 CHEMBL1271052		2 / 0 / 0		No. 13	No. 51
C00029859	Bryonolic acid	CHEMBL482596 CHEMBL1982562	C074984			No. 13	No. 51
C00029451	Glucosol / Corsolic acid / 2alpha-Hydroxyursolic acid	CHEMBL391533 CHEMBL237535 CHEMBL391534 CHEMBL574993	C113861	17 / 7 / 6		No. 13	No. 51
C00029412	19alpha-Hydroxyasiatic acid	CHEMBL515920				No. 13	No. 51
C00030742	Maslinic acid / Crategolic acid / 2alpha,3beta-Dihydroxyolean-12-en-28-oic acid	CHEMBL201515 CHEMBL383749 CHEMBL482673 CHEMBL577380	C412811	8 / 5 / 4		No. 13	No. 51
C00019065	Erythrodiol / 3beta-Erythrodiol	CHEMBL298604 CHEMBL60687 CHEMBL400074	C077953	4 / 0 / 1		No. 13	No. 51
C00019490	Tormentic acid / 2alpha,3beta,19alpha-Trihydroxyurs-12-en-28-oic acid	CHEMBL223484 CHEMBL239077 CHEMBL1270647		2 / 2 / 2		No. 13	No. 51
C00019064	Oleanolic acid / Astrantiagenin C / Virgaureagenin B / 3beta-Hydroxyolean-12-en-28-oic acid	CHEMBL56615 CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454	D009828	30 / 8 / 12	21 / 15	No. 13	No. 51
C00032467	Uvaol / Uvalol / Urs-12-ene-3beta,28-diol / 3beta,28-Dihydroxyurs-12-ene	CHEMBL58872 CHEMBL399873	C013330	5 / 2 / 2		No. 13	No. 51
C00003558	Ursolic acid	CHEMBL297810 CHEMBL56048 CHEMBL300594 CHEMBL169 CHEMBL176234 CHEMBL491715 CHEMBL1316667 CHEMBL1555307 CHEMBL1593360 CHEMBL1979720	C005466	47 / 26 / 33	15 / 12	No. 13	No. 51
C00031074	Pomolic acid	CHEMBL486986 CHEMBL464567		2 / 0 / 0		No. 13	No. 51
C00003741	Betulinic acid	CHEMBL269277 CHEMBL71690 CHEMBL519059 CHEMBL1318530 CHEMBL2005635	C002070	34 / 17 / 14	10 / 2	No. 23	No. 51
C00006861	Peonidin 3-(6''-p-coumarylglucoside)					No. 30	No. 15
C00003093	Oleuropein	CHEMBL1911053	C002769		8 / 5	No. 243
C00010789	Oleuroside					No. 243
C00000682	(-)-Olivil / Vladinol C	CHEMBL517144		1 / 1 / 1		No. 700	No. 21
C00002588	1-Acetoxypinoresinol					No. 700	No. 21
C00007191	(+)-8(1)-Hydroxypinoresinol	CHEMBL471274				No. 700	No. 21
C00049004	Methyl nonanoate					No. 869
C00010784	Oleoside					No. 924
C00010848	Oleuropeic acid	CHEMBL1077602	C417926			No. 983	No. 35
C00002147	Cinchonidine	CHEMBL15134 CHEMBL461234 CHEMBL518804 CHEMBL533841 CHEMBL588619 CHEMBL611480 CHEMBL1414315 CHEMBL1477170 CHEMBL1590546 CHEMBL2079612 CHEMBL2357353	C041622	13 / 10 / 8		No. 1378	No. 7
C00048963	cis-2-Hexen-1-ol					No. 1746
C00000356	cis-3-Hexen-1-ol		C051918		0 / 1	No. 1746
C00035857	Octane / n-Octane	CHEMBL134886	C026728			No. 1749
C00030828	Nonanal / n-Nonanal		C008664		1 / 1	No. 1993
C00000351	trans-2-Hexenal					No. 2883
C00030880	Octanal / n-Octanal	CHEMBL18407	C031639		2 / 0	No. 3593
C00000357	Hexanal	CHEMBL280331	C010463		7 / 0	No. 3593
C00048948	3-Hexenal					No. 4004
C00001308	Ethyl acetate	CHEMBL14152	C007650	4 / 14 / 13	4 / 0	No. 4274
C00048958	Butyl acetate	CHEMBL284391	C006848	1 / 0 / 0		No. 4274
C00048964	cis-3-Hexenyl acetate		C425828			No. 4548
C00049006	n-Hexane	CHEMBL15939	C026385		21 / 1	No. 5177
C00048954	Acetone	CHEMBL14253	D000096	1 / 11 / 10	10 / 8	No. 5308
C00048943	3,4-Dimethyl heptane					No. 6818
C00007392	Acetaldehyde / Acetic aldehyde	CHEMBL170365	D000079	2 / 8 / 5	126 / 15	No. 7289
C00035617	Ethyl propionate	CHEMBL44115	C069373			No. 7748
C00001176	Acetic acid	CHEMBL539	D019342	6 / 0 / 1	5 / 14	No. 8271
C00048949	3-Methyl-butanal	CHEMBL18360	C032251			No. 8581

Human Protein / Gene in interactions

92 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00003558 C00019064 C00019065 C00029451 C00030742 C00031074 C00031198 C00032467	0 / 0
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00003558 C00003741 C00019064 C00019065 C00030742	0 / 0
P15121	Aldose reductase	Enzyme	C00003558 C00003741 C00019064 C00019065 C00030742	0 / 0
P17706	Tyrosine-protein phosphatase non-receptor type 2	Tyr	C00003558 C00019064 C00019065 C00029451 C00030742	0 / 1
P10586	Receptor-type tyrosine-protein phosphatase F	Receptor tyrosine-protein phosphatase	C00003558 C00019064 C00029451 C00030742	0 / 0
P29350	Tyrosine-protein phosphatase non-receptor type 6	Tyr	C00003558 C00019064 C00029451 C00030742	0 / 0
P80365	Corticosteroid 11-beta-dehydrogenase isozyme 2	Enzyme	C00003558 C00019490 C00029451 C00032467	1 / 1
O75496	Geminin	Unclassified protein	C00002147 C00003741 C00019064 C00029451	0 / 0
P06746	DNA polymerase beta	Enzyme	C00003558 C00003741 C00019064 C00029451	0 / 0
P28845	Corticosteroid 11-beta-dehydrogenase isozyme 1	Enzyme	C00003558 C00019490 C00029451 C00032467	1 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00002147 C00003558 C00019064 C00029451	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00003558 C00003741 C00019064 C00032467	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00001308 C00003558 C00003741 C00048954	11 / 10
Q8TDU6	G-protein coupled bile acid receptor 1	Steroid-like ligand receptor	C00003558 C00003741 C00019064 C00032467	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00003558 C00003741 C00019064	0 / 0
P18433	Receptor-type tyrosine-protein phosphatase alpha	Receptor tyrosine-protein phosphatase	C00003558 C00019064 C00029451	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002147 C00003558 C00003741	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002147 C00003558 C00003741	1 / 1
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00001308 C00002147 C00003741	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00003558 C00003741 C00019064	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002147 C00003558 C00003741	0 / 1
P23469	Receptor-type tyrosine-protein phosphatase epsilon	Receptor tyrosine-protein phosphatase	C00003558 C00019064 C00029451	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002147 C00003558 C00003741	1 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002147 C00003558 C00003741	0 / 1
P11217	Glycogen phosphorylase, muscle form	Enzyme	C00029451 C00030742	1 / 1
P15559	NAD(P)H dehydrogenase [quinone] 1	Enzyme	C00003741 C00031198	0 / 0
Q01196	Runt-related transcription factor 1	Unclassified protein	C00003558 C00019064	1 / 4
Q13951	Core-binding factor subunit beta	Unclassified protein	C00003558 C00019064	0 / 1
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00003558 C00019064	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00001308 C00048958	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003558 C00003741	1 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00001176 C00003741	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00003558 C00019064	0 / 3
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00003558 C00019064	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002147 C00029451	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00003558 C00019064	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00002147 C00019064	0 / 0
Q06124	Tyrosine-protein phosphatase non-receptor type 11	Tyr	C00019064 C00030742	4 / 2
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00003558 C00003741	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00019064 C00029451	0 / 0
P24666	Low molecular weight phosphotyrosine protein phosphatase	Tyr	C00003558 C00019064	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00002147 C00007392	3 / 2
P08047	Transcription factor Sp1	Unclassified protein	C00003558 C00031074	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00003558 C00019064	2 / 2
Q04206	Transcription factor p65	Transcription Factor	C00003558 C00003741	0 / 0
O43521	Bcl-2-like protein 11	Unclassified protein	C00002376	0 / 0
Q16611	Bcl-2 homologous antagonist/killer	Unclassified protein	C00002376	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00003741	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00003558	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00003741	1 / 1
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00007392	5 / 3
Q9UGP5	DNA polymerase lambda	Enzyme	C00001176	0 / 0
O15379	Histone deacetylase 3	Hydrolase	C00003558	0 / 0
Q13133	Oxysterols receptor LXR-alpha	NR1H3	C00003741	0 / 0
Q07812	Apoptosis regulator BAX	Unclassified protein	C00002376	0 / 1
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00019064	0 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00000682	1 / 1
P55055	Oxysterols receptor LXR-beta	NR1H3	C00003741	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001308	3 / 3
P10828	Thyroid hormone receptor beta	NR1A2	C00003558	3 / 1
P56524	Histone deacetylase 4	Hydrolase	C00003558	1 / 1
Q02156	Protein kinase C epsilon type	Eta	C00003741	0 / 0
P30305	M-phase inducer phosphatase 2	Ser_Thr_Tyr	C00003558	0 / 0
P05771	Protein kinase C beta type	Alpha	C00003741	0 / 0
P35228	Nitric oxide synthase, inducible	Enzyme	C00019064	1 / 1
Q13547	Histone deacetylase 1	Hydrolase	C00003558	0 / 0
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00019064	0 / 0
O15552	Free fatty acid receptor 2	Free fatty acid receptor	C00001176	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00029451	2 / 0
P42858	Huntingtin	Unclassified protein	C00029451	1 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	C00002147	4 / 3
P08151	Zinc finger protein GLI1	Unclassified protein	C00003741	0 / 0
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00003558	0 / 0
P06239	Tyrosine-protein kinase Lck	Src	C00001176	0 / 1
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00003741	0 / 0
Q9UBN7	Histone deacetylase 6	Hydrolase	C00003558	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00003741	2 / 0
P04054	Phospholipase A2	Enzyme	C00019064	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00029451	1 / 1
O94956	Solute carrier organic anion transporter family member 2B1	Unclassified protein	C00001176	0 / 0
Q9UQL6	Histone deacetylase 5	Hydrolase	C00003558	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00003558	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00001176	0 / 0
Q8IUX4	DNA dC->dU-editing enzyme APOBEC-3F	Enzyme	C00003741	0 / 0
O00255	Menin	Unclassified protein	C00003558	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00003558	1 / 2
P11388	DNA topoisomerase 2-alpha	Isomerase	C00003741	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00003741	0 / 0
Q9UBT2	SUMO-activating enzyme subunit 2	Enzyme	C00003741	0 / 0
Q9UBE0	SUMO-activating enzyme subunit 1	Unclassified protein	C00003741	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00003558	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00002147	1 / 1

185 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
231	AKR1B1, ADR, ALDR1, ALR2, AR	aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)	C00000357 C00030828 C00030880 C00049006
1571	CYP2E1, CPE1, CYP2E, P450-J, P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	C00001176 C00007392 C00048954 C00049006
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00003093 C00007392 C00019064 C00048954
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00003558 C00003741 C00007392 C00019064
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00003741 C00007392 C00019064
581	BAX, BCL2L4	BCL2-associated X protein	C00003558 C00003741 C00007392
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00003741 C00007392 C00019064
847	CAT	catalase (EC:1.11.1.6)	C00007392 C00019064 C00048954
7150	TOP1, TOPI	topoisomerase (DNA) I (EC:5.99.1.2)	C00003558 C00003741 C00019064
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00003558 C00003741 C00019064
221	ALDH3B1, ALDH4, ALDH7	aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5)	C00000357 C00007392 C00030880
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00003093 C00003558 C00019064
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00003093 C00003558 C00007392
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00001308 C00003093 C00007392
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00003093 C00007392
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00003093 C00019064
3565	IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4	interleukin 4	C00007392 C00048954
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00003093 C00019064
218	ALDH3A1, ALDH3, ALDHIII	aldehyde dehydrogenase 3 family, member A1 (EC:1.2.1.5)	C00000357 C00007392
217	ALDH2, ALDH-E2, ALDHI, ALDM	aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)	C00000357 C00007392
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00003558 C00007392
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00003558 C00019064
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00019064 C00048954
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00001308 C00007392
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00003558 C00007392
1437	CSF2, GMCSF	colony stimulating factor 2 (granulocyte-macrophage)	C00001308 C00007392
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00003558 C00007392
5742	PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00007392
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00003558
1557	CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19	cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00003558
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00003558
578	BAK1, BAK, BAK-LIKE, BCL2L7, CDN1	BCL2-antagonist/killer 1	C00003558
9131	AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8	apoptosis-inducing factor, mitochondrion-associated, 1	C00003558
1588	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00003093
501	ALDH7A1, ATQ1, EPD, PDE	aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)	C00000357
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00000357
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00000357
57016	AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI	aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2)	C00049006
1645	AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB	aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112)	C00049006
8644	AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS	aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357)	C00049006
24300			C00049006
1555	CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450	cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1)	C00049006
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00003741
2235	FECH, EPP, FCE	ferrochelatase (EC:4.99.1.1)	C00049006
2512	FTL, NBIA3	ferritin, light polypeptide	C00049006
2539	G6PD, G6PD1	glucose-6-phosphate dehydrogenase (EC:1.1.1.49)	C00049006
2729	GCLC, GCL, GCS, GLCL, GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	C00049006
2730	GCLM, GLCLR	glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2)	C00049006
2936	GSR	glutathione reductase (EC:1.8.1.7)	C00049006
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00049006
4097	MAFG, hMAF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G	C00049006
4199	ME1, HUMNDME, MES	malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40)	C00049006
1728	NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	C00049006
5226	PGD, 6PGD	phosphogluconate dehydrogenase (EC:1.1.1.44)	C00049006
22949	PTGR1, LTB4DH, PGR1, ZADH3	prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74)	C00049006
140809	SRXN1, C20orf139, Npn3, SRX, SRX1	sulfiredoxin 1 (EC:1.8.98.2)	C00049006
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00049006
25	ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl	c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2)	C00007392
43	ACHE, ACEE, ARACHE, N-ACHE, YT	acetylcholinesterase (EC:3.1.1.7)	C00007392
125	ADH1B, ADH2	alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1)	C00007392
126	ADH1C, ADH3	alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1)	C00007392
127	ADH4, ADH-2	alcohol dehydrogenase 4 (class II), pi polypeptide (EC:1.1.1.1)	C00007392
9370	ADIPOQ, ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28	adiponectin, C1Q and collagen domain containing	C00007392
216	ALDH1A1, ALDC, ALDH-E1, ALDH1, ALDH11, PUMB1, RALDH1	aldehyde dehydrogenase 1 family, member A1 (EC:1.2.1.36)	C00007392
219	ALDH1B1, ALDH5, ALDHX	aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)	C00007392
223	ALDH9A1, ALDH4, ALDH7, ALDH9, E3, TMABADH	aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)	C00007392
57679	ALS2, ALS2CR6, ALSJ, IAHSP, PLSJ	amyotrophic lateral sclerosis 2 (juvenile)	C00007392
221079	ARL5B, ARL8	ADP-ribosylation factor-like 5B	C00007392
8553	BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14	basic helix-loop-helix family, member e40	C00007392
283687	C15orf37	chromosome 15 open reading frame 37	C00007392
57035	C1orf63, DJ465N24.2.1, NPD014, RP3-465N24.4	chromosome 1 open reading frame 63	C00007392
840	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	C00003741
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00007392
57018	CCNL1, ANIA6A, PRO1073, ania-6a	cyclin L1	C00007392
729230	CCR2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R	chemokine (C-C motif) receptor 2	C00007392
1081	CGA, CG-ALPHA, FSHA, GPHA1, GPHa, HCG, LHA, TSHA	glycoprotein hormones, alpha polypeptide	C00007392
1268	CNR1, CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR	cannabinoid receptor 1 (brain)	C00007392
728577	CNTNAP3B	contactin associated protein-like 3B	C00007392
1277	COL1A1, OI4	collagen, type I, alpha 1	C00007392
1278	COL1A2, OI4	collagen, type I, alpha 2	C00007392
1282	COL4A1, HANAC, ICH, POREN1, arresten	collagen, type IV, alpha 1	C00007392
64651	CSRNP1, AXUD1, CSRNP-1, FAM130B, TAIP-3, URAX1	cysteine-serine-rich nuclear protein 1	C00007392
1536	CYBB, AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2, p91-PHOX	cytochrome b-245, beta polypeptide	C00007392
1649	DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153	DNA-damage-inducible transcript 3	C00007392
22943	DKK1, DKK-1, SK	dickkopf WNT signaling pathway inhibitor 1	C00007392
1850	DUSP8, C11orf81, HB5, HVH-5, HVH8	dual specificity phosphatase 8 (EC:3.1.3.16 3.1.3.48)	C00007392
1950	EGF, HOMG4, URG	epidermal growth factor	C00007392
1958	EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225	early growth response 1	C00007392
1974	EIF4A2, BM-010, DDX2B, EIF4A, EIF4F, eIF-4A-II, eIF4A-II	eukaryotic translation initiation factor 4A2 (EC:3.6.4.13)	C00007392
1978	EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I	eukaryotic translation initiation factor 4E binding protein 1	C00007392
2177	FANCD2, FA-D2, FA4, FACD, FAD, FAD2, FANCD	Fanconi anemia, complementation group D2	C00007392
2335	FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF	fibronectin 1	C00007392
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00007392
94234	FOXQ1, HFH1	forkhead box Q1	C00007392
2597	GAPDH, G3PD, GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	C00007392
100702724			C00007392
2669	GEM, KIR	GTP binding protein overexpressed in skeletal muscle	C00007392
2741	GLRA1, HKPX1, STHE	glycine receptor, alpha 1	C00007392
57817	HAMP, HEPC, HFE2B, LEAP1, PLTR	hepcidin antimicrobial peptide	C00007392
3280	HES1, HES-1, HHL, HRY, bHLHb39	hes family bHLH transcription factor 1	C00007392
29923	HILPDA, C7orf68, HIG-2, HIG2	hypoxia inducible lipid droplet-associated	C00007392
554219			C00007392
3586	IL10, CSIF, GVHDS, IL-10, IL10A, TGIF	interleukin 10	C00007392
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00007392
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00003741
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00007392
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00007392
3708	ITPR1, INSP3R1, IP3R, IP3R1, SCA15, SCA16, SCA29	inositol 1,4,5-trisphosphate receptor, type 1	C00007392
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00007392
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00007392
5601	MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK	mitogen-activated protein kinase 9 (EC:2.7.11.24)	C00007392
4144	MAT2A, MATA2, MATII, SAMS2	methionine adenosyltransferase II, alpha (EC:2.5.1.6)	C00007392
153364	MBLAC2	metallo-beta-lactamase domain containing 2	C00007392
4170	MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT	myeloid cell leukemia sequence 1 (BCL2-related)	C00007392
84981	MIR22HG, C17orf91	MIR22 host gene (non-protein coding)	C00007392
4312	MMP1, CLG, CLGN	matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)	C00007392
4320	MMP11, SL-3, ST3, STMY3	matrix metallopeptidase 11 (stromelysin 3) (EC:3.4.24.-)	C00007392
4353	MPO	myeloperoxidase (EC:1.11.2.2)	C00007392
2475	MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1	mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)	C00007392
4791	NFKB2, H2TF1, LYT-10, LYT10, NF-kB2, p105, p52	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	C00007392
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00007392
4843	NOS2, HEP-NOS, INOS, NOS, NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	C00007392
3164	NR4A1, GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3	nuclear receptor subfamily 4, group A, member 1	C00007392
4929	NR4A2, HZF-3, NOT, NURR1, RNR1, TINUR	nuclear receptor subfamily 4, group A, member 2	C00007392
424046			C00007392
100506658	OCLN, BLCPMG	occludin (EC:2.1.1.67)	C00007392
4953	ODC1, ODC	ornithine decarboxylase 1 (EC:4.1.1.17)	C00007392
23035	PHLPP2, PHLPPL	PH domain and leucine rich repeat protein phosphatase 2 (EC:3.1.3.16)	C00007392
57157	PHTF2	putative homeodomain transcription factor 2	C00007392
91461	PKDCC, SGK493, Vlk	protein kinase domain containing, cytoplasmic	C00007392
5335	PLCG1, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1	phospholipase C, gamma 1 (EC:3.1.4.11)	C00007392
55629	PNRC2	proline-rich nuclear receptor coactivator 2	C00007392
5465	PPARA, NR1C1, PPAR, PPARalpha, hPPAR	peroxisome proliferator-activated receptor alpha	C00007392
5468	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma	peroxisome proliferator-activated receptor gamma	C00007392
5514	PPP1R10, CAT53, FB19, PNUTS, PP1R10, R111, p99	protein phosphatase 1, regulatory subunit 10	C00007392
5579	PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2	protein kinase C, beta (EC:2.7.11.13)	C00007392
5580	PRKCD, MAY1, PKCD, nPKC-delta	protein kinase C, delta (EC:2.7.10.2 2.7.11.13)	C00007392
5581	PRKCE, PKCE, nPKC-epsilon	protein kinase C, epsilon (EC:2.7.11.13)	C00007392
6352	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP	chemokine (C-C motif) ligand 5	C00001308
51655	RASD1, AGS1, DEXRAS1, MGC:26290	RAS, dexamethasone-induced 1	C00007392
5994	RFXAP	regulatory factor X-associated protein	C00007392
9886	RHOBTB1	Rho-related BTB domain containing 1	C00007392
27289	RND1, ARHS, RHO6, RHOS	Rho family GTPase 1	C00007392
6198	RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1)	C00007392
65117	RSRC2	arginine/serine-rich coiled-coil 2	C00007392
27111	SDCBP2, SITAC, SITAC18, ST-2	syndecan binding protein (syntenin) 2	C00007392
6403	SELP, CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL	selectin P (granule membrane protein 140kDa, antigen CD62)	C00007392
54093	SETD4, C21orf18, C21orf27	SET domain containing 4	C00007392
84826	SFT2D3	SFT2 domain containing 3	C00007392
387640	SKIDA1, C10orf140, DLN-1	SKI/DACH domain containing 1	C00007392
6498	SKIL, SNO, SnoA, SnoI, SnoN	SKI-like oncogene	C00007392
6566	SLC16A1, HHF7, MCT, MCT1	solute carrier family 16 (monocarboxylate transporter), member 1	C00007392
4088	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3	SMAD family member 3	C00007392
4089	SMAD4, DPC4, JIP, MADH4, MYHRS	SMAD family member 4	C00007392
6667	SP1	Sp1 transcription factor	C00007392
6696	SPP1, BNSP, BSPI, ETA-1, OPN	secreted phosphoprotein 1	C00007392
6720	SREBF1, SREBP-1c, SREBP1, bHLHd1	sterol regulatory element binding transcription factor 1	C00007392
56977	STOX2	storkhead box 2	C00007392
7082	TJP1, ZO-1	tight junction protein 1	C00007392
22888	UBOX5, RNF37, UBCE7IP5, UIP5	U-box domain containing 5	C00007392
7498	XDH, XO, XOR	xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2)	C00007392
10138	YAF2	YY1 associated factor 2	C00007392
56829	ZC3HAV1, ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2	zinc finger CCCH-type, antiviral 1	C00007392
7539	ZFP37, ZNF906, zfp-37	ZFP37 zinc finger protein	C00007392
7769	ZNF226	zinc finger protein 226	C00007392
7310			C00007392
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00003741
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00048954
2263	FGFR2, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25	fibroblast growth factor receptor 2 (EC:2.7.10.1)	C00048954
3596	IL13, IL-13, P600	interleukin 13	C00048954
3567	IL5, EDF, IL-5, TRF	interleukin 5 (colony-stimulating factor, eosinophil)	C00048954
3678	ITGA5, CD49e, FNRA, VLA5A	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	C00048954
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00019064
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00019064
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00019064
3065	HDAC1, GON-10, HD1, RPD3, RPD3L1	histone deacetylase 1 (EC:3.5.1.98)	C00019064
3146	HMGB1, HMG1, HMG3, SBP-1	high mobility group box 1	C00019064
4233	MET, AUTS9, HGFR, RCCP2, c-Met	met proto-oncogene (EC:2.7.10.1)	C00019064
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00019064
5052	PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2	peroxiredoxin 1 (EC:1.11.1.15)	C00019064
5728	PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1	phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48)	C00019064
1786	DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT	DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37)	C00001176
2571	GAD1, CPSQ1, GAD, SCP	glutamate decarboxylase 1 (brain, 67kDa) (EC:4.1.1.15)	C00001176
5447	POR, CPR, CYPOR, P450R	P450 (cytochrome) oxidoreductase (EC:1.6.2.4)	C00001176
5649	RELN, LIS2, PRO1598, RL	reelin	C00001176

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