KCF-S cluster No. 7289 (1 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 1 |
| asterids | 1 |
Cumulative family count
| class name | count |
|---|---|
| Enterobacteriaceae | 1 |
| Brassicaceae | 1 |
| Oleaceae | 1 |
KEGG BRITE br08003
Categories (0)
| br08003 Category | # of metabolite |
|---|
metabolites link (0)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00007392
|
Acetaldehyde
/ Acetic aldehyde |
CHEMBL170365
|
D000079
|
2 / 8 / 5 | 126 / 15 |
|
Human Protein / Gene in interactions
2 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00007392 | 3 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00007392 | 5 / 3 |
126 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 25 | ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl | c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) |
C00007392
|
| 43 | ACHE, ACEE, ARACHE, N-ACHE, YT | acetylcholinesterase (EC:3.1.1.7) |
C00007392
|
| 125 | ADH1B, ADH2 | alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) |
C00007392
|
| 126 | ADH1C, ADH3 | alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1) |
C00007392
|
| 127 | ADH4, ADH-2 | alcohol dehydrogenase 4 (class II), pi polypeptide (EC:1.1.1.1) |
C00007392
|
| 9370 | ADIPOQ, ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28 | adiponectin, C1Q and collagen domain containing |
C00007392
|
| 216 | ALDH1A1, ALDC, ALDH-E1, ALDH1, ALDH11, PUMB1, RALDH1 | aldehyde dehydrogenase 1 family, member A1 (EC:1.2.1.36) |
C00007392
|
| 219 | ALDH1B1, ALDH5, ALDHX | aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3) |
C00007392
|
| 217 | ALDH2, ALDH-E2, ALDHI, ALDM | aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) |
C00007392
|
| 218 | ALDH3A1, ALDH3, ALDHIII | aldehyde dehydrogenase 3 family, member A1 (EC:1.2.1.5) |
C00007392
|
| 221 | ALDH3B1, ALDH4, ALDH7 | aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5) |
C00007392
|
| 223 | ALDH9A1, ALDH4, ALDH7, ALDH9, E3, TMABADH | aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47) |
C00007392
|
| 57679 | ALS2, ALS2CR6, ALSJ, IAHSP, PLSJ | amyotrophic lateral sclerosis 2 (juvenile) |
C00007392
|
| 221079 | ARL5B, ARL8 | ADP-ribosylation factor-like 5B |
C00007392
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00007392
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00007392
|
| 8553 | BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14 | basic helix-loop-helix family, member e40 |
C00007392
|
| 283687 | C15orf37 | chromosome 15 open reading frame 37 |
C00007392
|
| 57035 | C1orf63, DJ465N24.2.1, NPD014, RP3-465N24.4 | chromosome 1 open reading frame 63 |
C00007392
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00007392
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00007392
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00007392
|
| 57018 | CCNL1, ANIA6A, PRO1073, ania-6a | cyclin L1 |
C00007392
|
| 729230 | CCR2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R | chemokine (C-C motif) receptor 2 |
C00007392
|
| 1081 | CGA, CG-ALPHA, FSHA, GPHA1, GPHa, HCG, LHA, TSHA | glycoprotein hormones, alpha polypeptide |
C00007392
|
| 1268 | CNR1, CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR | cannabinoid receptor 1 (brain) |
C00007392
|
| 728577 | CNTNAP3B | contactin associated protein-like 3B |
C00007392
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00007392
|
| 1278 | COL1A2, OI4 | collagen, type I, alpha 2 |
C00007392
|
| 1282 | COL4A1, HANAC, ICH, POREN1, arresten | collagen, type IV, alpha 1 |
C00007392
|
| 1437 | CSF2, GMCSF | colony stimulating factor 2 (granulocyte-macrophage) |
C00007392
|
| 64651 | CSRNP1, AXUD1, CSRNP-1, FAM130B, TAIP-3, URAX1 | cysteine-serine-rich nuclear protein 1 |
C00007392
|
| 1536 | CYBB, AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2, p91-PHOX | cytochrome b-245, beta polypeptide |
C00007392
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00007392
|
| 1649 | DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 | DNA-damage-inducible transcript 3 |
C00007392
|
| 22943 | DKK1, DKK-1, SK | dickkopf WNT signaling pathway inhibitor 1 |
C00007392
|
| 1850 | DUSP8, C11orf81, HB5, HVH-5, HVH8 | dual specificity phosphatase 8 (EC:3.1.3.16 3.1.3.48) |
C00007392
|
| 1950 | EGF, HOMG4, URG | epidermal growth factor |
C00007392
|
| 1958 | EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 | early growth response 1 |
C00007392
|
| 1974 | EIF4A2, BM-010, DDX2B, EIF4A, EIF4F, eIF-4A-II, eIF4A-II | eukaryotic translation initiation factor 4A2 (EC:3.6.4.13) |
C00007392
|
| 1978 | EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I | eukaryotic translation initiation factor 4E binding protein 1 |
C00007392
|
| 2177 | FANCD2, FA-D2, FA4, FACD, FAD, FAD2, FANCD | Fanconi anemia, complementation group D2 |
C00007392
|
| 2335 | FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF | fibronectin 1 |
C00007392
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00007392
|
| 94234 | FOXQ1, HFH1 | forkhead box Q1 |
C00007392
|
| 2597 | GAPDH, G3PD, GAPD | glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12) |
C00007392
|
| 100702724 |
C00007392
|
||
| 2669 | GEM, KIR | GTP binding protein overexpressed in skeletal muscle |
C00007392
|
| 2741 | GLRA1, HKPX1, STHE | glycine receptor, alpha 1 |
C00007392
|
| 57817 | HAMP, HEPC, HFE2B, LEAP1, PLTR | hepcidin antimicrobial peptide |
C00007392
|
| 3280 | HES1, HES-1, HHL, HRY, bHLHb39 | hes family bHLH transcription factor 1 |
C00007392
|
| 29923 | HILPDA, C7orf68, HIG-2, HIG2 | hypoxia inducible lipid droplet-associated |
C00007392
|
| 554219 |
C00007392
|
||
| 3586 | IL10, CSIF, GVHDS, IL-10, IL10A, TGIF | interleukin 10 |
C00007392
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00007392
|
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 |
C00007392
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00007392
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00007392
|
| 3708 | ITPR1, INSP3R1, IP3R, IP3R1, SCA15, SCA16, SCA29 | inositol 1,4,5-trisphosphate receptor, type 1 |
C00007392
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00007392
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00007392
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00007392
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00007392
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00007392
|
| 4144 | MAT2A, MATA2, MATII, SAMS2 | methionine adenosyltransferase II, alpha (EC:2.5.1.6) |
C00007392
|
| 153364 | MBLAC2 | metallo-beta-lactamase domain containing 2 |
C00007392
|
| 4170 | MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT | myeloid cell leukemia sequence 1 (BCL2-related) |
C00007392
|
| 84981 | MIR22HG, C17orf91 | MIR22 host gene (non-protein coding) |
C00007392
|
| 4312 | MMP1, CLG, CLGN | matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) |
C00007392
|
| 4320 | MMP11, SL-3, ST3, STMY3 | matrix metallopeptidase 11 (stromelysin 3) (EC:3.4.24.-) |
C00007392
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00007392
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00007392
|
| 4353 | MPO | myeloperoxidase (EC:1.11.2.2) |
C00007392
|
| 2475 | MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1 | mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) |
C00007392
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00007392
|
| 4791 | NFKB2, H2TF1, LYT-10, LYT10, NF-kB2, p105, p52 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
C00007392
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00007392
|
| 4843 | NOS2, HEP-NOS, INOS, NOS, NOS2A | nitric oxide synthase 2, inducible (EC:1.14.13.39) |
C00007392
|
| 3164 | NR4A1, GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3 | nuclear receptor subfamily 4, group A, member 1 |
C00007392
|
| 4929 | NR4A2, HZF-3, NOT, NURR1, RNR1, TINUR | nuclear receptor subfamily 4, group A, member 2 |
C00007392
|
| 424046 |
C00007392
|
||
| 100506658 | OCLN, BLCPMG | occludin (EC:2.1.1.67) |
C00007392
|
| 4953 | ODC1, ODC | ornithine decarboxylase 1 (EC:4.1.1.17) |
C00007392
|
| 23035 | PHLPP2, PHLPPL | PH domain and leucine rich repeat protein phosphatase 2 (EC:3.1.3.16) |
C00007392
|
| 57157 | PHTF2 | putative homeodomain transcription factor 2 |
C00007392
|
| 91461 | PKDCC, SGK493, Vlk | protein kinase domain containing, cytoplasmic |
C00007392
|
| 5335 | PLCG1, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1 | phospholipase C, gamma 1 (EC:3.1.4.11) |
C00007392
|
| 55629 | PNRC2 | proline-rich nuclear receptor coactivator 2 |
C00007392
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00007392
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00007392
|
| 5514 | PPP1R10, CAT53, FB19, PNUTS, PP1R10, R111, p99 | protein phosphatase 1, regulatory subunit 10 |
C00007392
|
| 5579 | PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2 | protein kinase C, beta (EC:2.7.11.13) |
C00007392
|
| 5580 | PRKCD, MAY1, PKCD, nPKC-delta | protein kinase C, delta (EC:2.7.10.2 2.7.11.13) |
C00007392
|
| 5581 | PRKCE, PKCE, nPKC-epsilon | protein kinase C, epsilon (EC:2.7.11.13) |
C00007392
|
| 5742 | PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00007392
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00007392
|
| 51655 | RASD1, AGS1, DEXRAS1, MGC:26290 | RAS, dexamethasone-induced 1 |
C00007392
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00007392
|
| 5994 | RFXAP | regulatory factor X-associated protein |
C00007392
|
| 9886 | RHOBTB1 | Rho-related BTB domain containing 1 |
C00007392
|
| 27289 | RND1, ARHS, RHO6, RHOS | Rho family GTPase 1 |
C00007392
|
| 6198 | RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha | ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) |
C00007392
|
| 65117 | RSRC2 | arginine/serine-rich coiled-coil 2 |
C00007392
|
| 27111 | SDCBP2, SITAC, SITAC18, ST-2 | syndecan binding protein (syntenin) 2 |
C00007392
|
| 6403 | SELP, CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL | selectin P (granule membrane protein 140kDa, antigen CD62) |
C00007392
|
| 54093 | SETD4, C21orf18, C21orf27 | SET domain containing 4 |
C00007392
|
| 84826 | SFT2D3 | SFT2 domain containing 3 |
C00007392
|
| 387640 | SKIDA1, C10orf140, DLN-1 | SKI/DACH domain containing 1 |
C00007392
|
| 6498 | SKIL, SNO, SnoA, SnoI, SnoN | SKI-like oncogene |
C00007392
|
| 6566 | SLC16A1, HHF7, MCT, MCT1 | solute carrier family 16 (monocarboxylate transporter), member 1 |
C00007392
|
| 4088 | SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 | SMAD family member 3 |
C00007392
|
| 4089 | SMAD4, DPC4, JIP, MADH4, MYHRS | SMAD family member 4 |
C00007392
|
| 6667 | SP1 | Sp1 transcription factor |
C00007392
|
| 6696 | SPP1, BNSP, BSPI, ETA-1, OPN | secreted phosphoprotein 1 |
C00007392
|
| 6720 | SREBF1, SREBP-1c, SREBP1, bHLHd1 | sterol regulatory element binding transcription factor 1 |
C00007392
|
| 56977 | STOX2 | storkhead box 2 |
C00007392
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00007392
|
| 7082 | TJP1, ZO-1 | tight junction protein 1 |
C00007392
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00007392
|
| 22888 | UBOX5, RNF37, UBCE7IP5, UIP5 | U-box domain containing 5 |
C00007392
|
| 7498 | XDH, XO, XOR | xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) |
C00007392
|
| 10138 | YAF2 | YY1 associated factor 2 |
C00007392
|
| 56829 | ZC3HAV1, ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2 | zinc finger CCCH-type, antiviral 1 |
C00007392
|
| 7539 | ZFP37, ZNF906, zfp-37 | ZFP37 zinc finger protein |
C00007392
|
| 7769 | ZNF226 | zinc finger protein 226 |
C00007392
|
| 7310 |
C00007392
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (8)
| OMIM | preferred title | UniProt |
|---|---|---|
| %606641 | Body mass index; bmi |
P37231
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #601665 | Obesity |
P37231
|
KEGG DISEASE (5)
| KEGG | name | UniProt |
|---|---|---|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
Diseases related to CTD interactions
15 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001249 | Asthma |
C00007392
|
| D002277 | Carcinoma |
C00007392
|
| D002310 | Cardiomyopathy, Alcoholic |
C00007392
|
| D005235 | Fatty Liver, Alcoholic |
C00007392
|
| D006331 | Heart Diseases |
C00007392
|
| D007022 | Hypotension |
C00007392
|
| D007414 | Intestinal Neoplasms |
C00007392
|
| D008175 | Lung Neoplasms |
C00007392
|
| D015674 | Mammary Neoplasms, Animal |
C00007392
|
| D009336 | Necrosis |
C00007392
|
| D009421 | Nervous System Malformations |
C00007392
|
| D011041 | Poisoning |
C00007392
|
| D012220 | Rhinitis |
C00007392
|
| D013274 | Stomach Neoplasms |
C00007392
|
| D013610 | Tachycardia |
C00007392
|