PCIDB

KNApSAcK Metabolite C00007392

Metabolite

KNApSAcK Entry

id C00007392
Name Acetaldehyde / Acetic aldehyde
CAS RN 75-07-0
Standard InChI InChI=1S/C2H4O/c1-2-3/h2H,1H3
Standard InChI (Main Layer) InChI=1S/C2H4O/c1-2-3/h2H,1H3

Cluster

Phytochemical cluster
KCF-S cluster No. 7289

Link

ChEMBL

By standard InChI CHEMBL170365
By standard InChI Main Layer CHEMBL170365

KEGG

By LinkDB C00084

CTD

By CAS RN D000079

Human Protein / Gene in interaction

2 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL170365 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL170365 CHEMBL1794510 (1)
5 / 3

CTD interaction (258)

compound gene gene name gene description interaction interaction type form reference
pmid
D000079 25 ABL1
ABL
JTK7
bcr/abl
c-ABL
p150
v-abl
c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) ABL1 protein promotes the reaction [Acetaldehyde results in increased phosphorylation of and results in decreased activity of PPARG protein] decreases activity
/ increases phosphorylation
/ increases reaction
protein 17030193
D000079 25 ABL1
ABL
JTK7
bcr/abl
c-ABL
p150
v-abl
c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) Acetaldehyde results in increased activity of ABL1 protein increases activity
protein 17030193
D000079 25 ABL1
ABL
JTK7
bcr/abl
c-ABL
p150
v-abl
c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) imatinib inhibits the reaction [Acetaldehyde results in increased activity of ABL1 protein] decreases reaction
/ increases activity
protein 17030193
D000079 43 ACHE
ACEE
ARACHE
N-ACHE
YT
acetylcholinesterase (EC:3.1.1.7) Acetaldehyde results in decreased activity of ACHE protein decreases activity
protein 8292740
D000079 125 ADH1B
ADH2
alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) [ADH1B protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde increases chemical synthesis
/ increases metabolic processing
protein 15499379
D000079 126 ADH1C
ADH3
alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1) [ADH1C protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde increases chemical synthesis
/ increases metabolic processing
protein 15138216
D000079 127 ADH4
ADH-2
alcohol dehydrogenase 4 (class II), pi polypeptide (EC:1.1.1.1) ADH4 promoter polymorphism affects the abundance of Acetaldehyde affects abundance
promoter 19182438
D000079 127 ADH4
ADH-2
alcohol dehydrogenase 4 (class II), pi polypeptide (EC:1.1.1.1) ADH4 protein results in increased abundance of Acetaldehyde increases abundance
protein 19182438
D000079 9370 ADIPOQ
ACDC
ACRP30
ADIPQTL1
ADPN
APM-1
APM1
GBP28
adiponectin, C1Q and collagen domain containing ADIPOQ protein inhibits the reaction [Acetaldehyde results in decreased expression of BCL2 mRNA] decreases expression
/ decreases reaction
protein 16814256
D000079 9370 ADIPOQ
ACDC
ACRP30
ADIPQTL1
ADPN
APM-1
APM1
GBP28
adiponectin, C1Q and collagen domain containing ADIPOQ protein inhibits the reaction [Acetaldehyde results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 16814256
D000079 9370 ADIPOQ
ACDC
ACRP30
ADIPQTL1
ADPN
APM-1
APM1
GBP28
adiponectin, C1Q and collagen domain containing ADIPOQ protein inhibits the reaction [Acetaldehyde results in increased expression of BAX mRNA] decreases reaction
/ increases expression
protein 16814256
D000079 216 ALDH1A1
ALDC
ALDH-E1
ALDH1
ALDH11
PUMB1
RALDH1
aldehyde dehydrogenase 1 family, member A1 (EC:1.2.1.36) ALDH1A1 protein results in increased oxidation of Acetaldehyde increases oxidation
protein 18940187
D000079 219 ALDH1B1
ALDH5
ALDHX
aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3) [ALDH1B1 protein co-treated with NAD] results in increased metabolism of Acetaldehyde affects cotreatment
/ increases metabolic processing
protein 7779080
D000079 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 gene polymorphism affects the oxidation of Acetaldehyde affects oxidation
gene 19393179
D000079 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 gene polymorphism affects the susceptibility to Acetaldehyde affects response to substance
gene 15840430
D000079 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 gene polymorphism results in decreased metabolism of Acetaldehyde decreases metabolic processing
gene 8512495
D000079 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein polymorphism affects the metabolism of Acetaldehyde affects metabolic processing
protein 11744614
D000079 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein polymorphism results in decreased metabolism of Acetaldehyde decreases metabolic processing
protein 15380331
D000079 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein results in decreased susceptibility to Acetaldehyde decreases response to substance
protein 14722101
D000079 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein results in increased chemical synthesis of Acetaldehyde increases chemical synthesis
protein 10940605
D000079 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein results in increased metabolism of Acetaldehyde increases metabolic processing
protein 8850269
9273829
10780266
10826103
15380331
D000079 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein results in increased oxidation of Acetaldehyde increases oxidation
protein 18940187
19393179
D000079 217 ALDH2
ALDH-E2
ALDHI
ALDM
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) ALDH2 protein results in increased susceptibility to Acetaldehyde increases response to substance
protein 15840430
D000079 218 ALDH3A1
ALDH3
ALDHIII
aldehyde dehydrogenase 3 family, member A1 (EC:1.2.1.5) ALDH3A1 protein results in increased oxidation of Acetaldehyde increases oxidation
protein 18940187
D000079 221 ALDH3B1
ALDH4
ALDH7
aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5) Acetaldehyde binds to ALDH3B1 protein affects binding
protein 20699116
D000079 223 ALDH9A1
ALDH4
ALDH7
ALDH9
E3
TMABADH
aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47) ALDH9A1 protein results in increased oxidation of Acetaldehyde increases oxidation
protein 18940187
D000079 57679 ALS2
ALS2CR6
ALSJ
IAHSP
PLSJ
amyotrophic lateral sclerosis 2 (juvenile) Acetaldehyde results in increased expression of ALS2 mRNA increases expression
mRNA 23416264
D000079 221079 ARL5B
ARL8
ADP-ribosylation factor-like 5B Acetaldehyde results in increased expression of ARL5B mRNA increases expression
mRNA 23416264
D000079 581 BAX
BCL2L4
BCL2-associated X protein Acetaldehyde results in increased expression of BAX mRNA increases expression
mRNA 16814256
D000079 581 BAX
BCL2L4
BCL2-associated X protein ADIPOQ protein inhibits the reaction [Acetaldehyde results in increased expression of BAX mRNA] decreases reaction
/ increases expression
mRNA 16814256
D000079 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Acetaldehyde results in decreased expression of BCL2 mRNA decreases expression
mRNA 16814256
D000079 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 ADIPOQ protein inhibits the reaction [Acetaldehyde results in decreased expression of BCL2 mRNA] decreases expression
/ decreases reaction
mRNA 16814256
D000079 8553 BHLHE40
BHLHB2
DEC1
HLHB2
SHARP-2
STRA13
Stra14
basic helix-loop-helix family, member e40 Acetaldehyde results in increased expression of BHLHE40 mRNA increases expression
mRNA 23416264
D000079 283687 C15orf37
chromosome 15 open reading frame 37 Acetaldehyde results in decreased expression of C15ORF37 mRNA decreases expression
mRNA 23416264
D000079 57035 C1orf63
DJ465N24.2.1
NPD014
RP3-465N24.4
chromosome 1 open reading frame 63 Acetaldehyde results in increased expression of C1ORF63 mRNA increases expression
mRNA 23416264
D000079 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Acetaldehyde results in increased activity of CASP3 protein increases activity
protein 14722101
16814256
D000079 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) ADIPOQ protein inhibits the reaction [Acetaldehyde results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 16814256
D000079 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) alpha-Tocopherol inhibits the reaction [Acetaldehyde results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 14722101
D000079 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) SB 203580 inhibits the reaction [Acetaldehyde results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 14722101
D000079 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) U 0126 inhibits the reaction [Acetaldehyde results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 14722101
D000079 847 CAT
catalase (EC:1.11.1.6) Acetaldehyde results in decreased activity of CAT protein decreases activity
protein 11344824
D000079 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Acetaldehyde results in increased expression of CCL2 mRNA increases expression
mRNA 17050345
D000079 57018 CCNL1
ANIA6A
PRO1073
ania-6a
cyclin L1 Acetaldehyde results in increased expression of CCNL1 mRNA increases expression
mRNA 23416264
D000079 729230 CCR2
CC-CKR-2
CCR-2
CCR2A
CCR2B
CD192
CKR2
CKR2A
CKR2B
CMKBR2
MCP-1-R
chemokine (C-C motif) receptor 2 Acetaldehyde results in increased expression of CCR2 protein increases expression
protein 19036374
D000079 1081 CGA
CG-ALPHA
FSHA
GPHA1
GPHa
HCG
LHA
TSHA
glycoprotein hormones, alpha polypeptide CGA protein results in increased abundance of Acetaldehyde increases abundance
protein 22285649
D000079 1268 CNR1
CANN6
CB-R
CB1
CB1A
CB1K5
CB1R
CNR
cannabinoid receptor 1 (brain) Acetaldehyde results in increased expression of CNR1 mRNA increases expression
mRNA 21863215
D000079 728577 CNTNAP3B
contactin associated protein-like 3B Acetaldehyde results in increased expression of CNTNAP3B mRNA increases expression
mRNA 23416264
D000079 1277 COL1A1
OI4
collagen, type I, alpha 1 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 protein] decreases reaction
/ increases expression
protein 17030193
D000079 1277 COL1A1
OI4
collagen, type I, alpha 1 Acetaldehyde results in increased expression of COL1A1 protein increases expression
protein 17030193
D000079 1277 COL1A1
OI4
collagen, type I, alpha 1 [Acetaldehyde results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein decreases activity
/ increases expression
/ increases phosphorylation
protein 17030193
D000079 1277 COL1A1
OI4
collagen, type I, alpha 1 imatinib inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA] decreases reaction
/ increases expression
mRNA 17030193
D000079 1277 COL1A1
OI4
collagen, type I, alpha 1 imatinib inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 protein] decreases reaction
/ increases expression
protein 17030193
D000079 1277 COL1A1
OI4
collagen, type I, alpha 1 MAPK1 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A1 protein] increases expression
/ increases reaction
protein 17030193
D000079 1277 COL1A1
OI4
collagen, type I, alpha 1 MAPK3 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A1 protein] increases expression
/ increases reaction
protein 17030193
D000079 1277 COL1A1
OI4
collagen, type I, alpha 1 PPARG protein promotes the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA] increases expression
/ increases reaction
mRNA 17030193
D000079 1277 COL1A1
OI4
collagen, type I, alpha 1 PPARG protein promotes the reaction [Acetaldehyde results in increased expression of COL1A1 protein] increases expression
/ increases reaction
protein 17030193
D000079 1277 COL1A1
OI4
collagen, type I, alpha 1 PRKCD protein promotes the reaction [Acetaldehyde results in increased expression of COL1A1 protein] increases expression
/ increases reaction
protein 17030193
D000079 1277 COL1A1
OI4
collagen, type I, alpha 1 rottlerin inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA] decreases reaction
/ increases expression
mRNA 17030193
D000079 1277 COL1A1
OI4
collagen, type I, alpha 1 rottlerin inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 protein] decreases reaction
/ increases expression
protein 17030193
D000079 1278 COL1A2
OI4
collagen, type I, alpha 2 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] decreases reaction
/ increases expression
mRNA 11343241
D000079 1278 COL1A2
OI4
collagen, type I, alpha 2 4-hydroxymercuribenzoate inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] decreases reaction
/ increases expression
mRNA 11343241
D000079 1278 COL1A2
OI4
collagen, type I, alpha 2 Acetaldehyde results in increased expression of COL1A2 mRNA increases expression
mRNA 11343241
16025520
D000079 1278 COL1A2
OI4
collagen, type I, alpha 2 calphostin C inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] decreases reaction
/ increases expression
mRNA 11343241
D000079 1278 COL1A2
OI4
collagen, type I, alpha 2 Sirolimus inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] decreases reaction
/ increases expression
mRNA 11343241
D000079 1278 COL1A2
OI4
collagen, type I, alpha 2 SMAD3 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] increases expression
/ increases reaction
mRNA 16025520
D000079 1278 COL1A2
OI4
collagen, type I, alpha 2 SMAD4 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] increases expression
/ increases reaction
mRNA 16025520
D000079 1278 COL1A2
OI4
collagen, type I, alpha 2 SP1 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] increases expression
/ increases reaction
mRNA 16025520
D000079 1278 COL1A2
OI4
collagen, type I, alpha 2 wortmannin inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] decreases reaction
/ increases expression
mRNA 11343241
D000079 1282 COL4A1
HANAC
ICH
POREN1
arresten
collagen, type IV, alpha 1 Acetaldehyde results in decreased expression of COL4A1 mRNA decreases expression
mRNA 8135774
D000079 1282 COL4A1
HANAC
ICH
POREN1
arresten
collagen, type IV, alpha 1 Acetaldehyde results in decreased expression of COL4A1 protein decreases expression
protein 8135774
D000079 1282 COL4A1
HANAC
ICH
POREN1
arresten
collagen, type IV, alpha 1 TGFB1 protein inhibits the reaction [Acetaldehyde results in decreased expression of COL4A1 protein] decreases expression
/ decreases reaction
protein 8135774
D000079 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) Acetaldehyde results in increased secretion of CSF2 protein increases secretion
protein 14619338
D000079 64651 CSRNP1
AXUD1
CSRNP-1
FAM130B
TAIP-3
URAX1
cysteine-serine-rich nuclear protein 1 Acetaldehyde results in increased expression of CSRNP1 mRNA increases expression
mRNA 23416264
D000079 1536 CYBB
AMCBX2
CGD
GP91-1
GP91-PHOX
GP91PHOX
NOX2
p91-PHOX
cytochrome b-245, beta polypeptide Acetaldehyde results in increased expression of CYBB mRNA increases expression
mRNA 18845238
D000079 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) CYP2E1 protein results in increased metabolism of Acetaldehyde increases metabolic processing
protein 10826103
D000079 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) [CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Acetaldehyde increases abundance
/ increases metabolic processing
protein 18845238
D000079 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 Acetaldehyde results in increased expression of DDIT3 protein increases expression
protein 12612910
D000079 22943 DKK1
DKK-1
SK
dickkopf WNT signaling pathway inhibitor 1 Acetaldehyde results in decreased expression of DKK1 mRNA decreases expression
mRNA 23416264
D000079 1850 DUSP8
C11orf81
HB5
HVH-5
HVH8
dual specificity phosphatase 8 (EC:3.1.3.16 3.1.3.48) Acetaldehyde results in increased expression of DUSP8 mRNA increases expression
mRNA 23416264
D000079 1950 EGF
HOMG4
URG
epidermal growth factor chelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]] affects localization
/ decreases reaction
protein 17991733
D000079 1950 EGF
HOMG4
URG
epidermal growth factor chelerythrine inhibits the reaction [EGF protein results in decreased susceptibility to Acetaldehyde] decreases reaction
/ decreases response to substance
protein 17991733
D000079 1950 EGF
HOMG4
URG
epidermal growth factor EGF protein inhibits the reaction [Acetaldehyde affects the localization of OCLN protein] affects localization
/ decreases reaction
protein 17991733
D000079 1950 EGF
HOMG4
URG
epidermal growth factor EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein] affects localization
/ decreases reaction
protein 17991733
D000079 1950 EGF
HOMG4
URG
epidermal growth factor EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin] decreases reaction
/ increases transport
protein 17991733
D000079 1950 EGF
HOMG4
URG
epidermal growth factor EGF protein results in decreased susceptibility to Acetaldehyde decreases response to substance
protein 17991733
D000079 1950 EGF
HOMG4
URG
epidermal growth factor PLCG1 protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of OCLN protein]] affects localization
/ affects reaction
/ decreases reaction
protein 17991733
D000079 1950 EGF
HOMG4
URG
epidermal growth factor PLCG1 protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]] affects localization
/ affects reaction
/ decreases reaction
protein 17991733
D000079 1950 EGF
HOMG4
URG
epidermal growth factor PRKCB protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]] affects reaction
/ decreases reaction
/ increases transport
protein 17991733
D000079 1950 EGF
HOMG4
URG
epidermal growth factor PRKCB protein affects the reaction [EGF protein results in decreased susceptibility to Acetaldehyde] affects reaction
/ decreases response to substance
protein 17991733
D000079 1950 EGF
HOMG4
URG
epidermal growth factor PRKCE protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]] affects reaction
/ decreases reaction
/ increases transport
protein 17991733
D000079 1950 EGF
HOMG4
URG
epidermal growth factor PRKCE protein affects the reaction [EGF protein results in decreased susceptibility to Acetaldehyde] affects reaction
/ decreases response to substance
protein 17991733
D000079 1950 EGF
HOMG4
URG
epidermal growth factor Ro 32-0432 inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]] affects localization
/ decreases reaction
protein 17991733
D000079 1950 EGF
HOMG4
URG
epidermal growth factor Ro 32-0432 inhibits the reaction [EGF protein results in decreased susceptibility to Acetaldehyde] decreases reaction
/ decreases response to substance
protein 17991733
D000079 1958 EGR1
AT225
G0S30
KROX-24
NGFI-A
TIS8
ZIF-268
ZNF225
early growth response 1 Acetaldehyde results in increased expression of EGR1 mRNA increases expression
mRNA 23416264
D000079 1974 EIF4A2
BM-010
DDX2B
EIF4A
EIF4F
eIF-4A-II
eIF4A-II
eukaryotic translation initiation factor 4A2 (EC:3.6.4.13) Acetaldehyde results in increased expression of EIF4A2 mRNA increases expression
mRNA 23416264
D000079 1978 EIF4EBP1
4E-BP1
4EBP1
BP-1
PHAS-I
eukaryotic translation initiation factor 4E binding protein 1 Acetaldehyde results in decreased phosphorylation of EIF4EBP1 protein decreases phosphorylation
protein 16962100
D000079 1978 EIF4EBP1
4E-BP1
4EBP1
BP-1
PHAS-I
eukaryotic translation initiation factor 4E binding protein 1 Sirolimus promotes the reaction [Acetaldehyde results in decreased phosphorylation of EIF4EBP1 protein] decreases phosphorylation
/ increases reaction
protein 16962100
D000079 2177 FANCD2
FA-D2
FA4
FACD
FAD
FAD2
FANCD
Fanconi anemia, complementation group D2 Acetaldehyde results in increased expression of FANCD2 protein increases expression
protein 18482162
D000079 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 4-hydroxymercuribenzoate inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] decreases reaction
/ increases expression
mRNA 11343241
D000079 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 Acetaldehyde results in increased expression of FN1 mRNA increases expression
mRNA 8135774
11343241
D000079 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 Acetaldehyde results in increased expression of FN1 protein increases expression
protein 8135774
D000079 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 calphostin C inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] decreases reaction
/ increases expression
mRNA 11343241
D000079 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 TGFB1 protein promotes the reaction [Acetaldehyde results in increased expression of FN1 protein] increases expression
/ increases reaction
protein 8135774
D000079 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Acetaldehyde results in increased expression of FOS mRNA increases expression
mRNA 23416264
D000079 94234 FOXQ1
HFH1
forkhead box Q1 Acetaldehyde results in decreased expression of FOXQ1 mRNA decreases expression
mRNA 23416264
D000079 2597 GAPDH
G3PD
GAPD
glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12) [MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein affects binding
/ affects cotreatment
/ affects metabolic processing
protein 23009681
D000079 100702724 Acetaldehyde results in increased expression of GCFC1 mRNA increases expression
mRNA 23416264
D000079 2669 GEM
KIR
GTP binding protein overexpressed in skeletal muscle Acetaldehyde results in increased expression of GEM mRNA increases expression
mRNA 23416264
D000079 2741 GLRA1
HKPX1
STHE
glycine receptor, alpha 1 Acetaldehyde results in increased activity of GLRA1 protein increases activity
protein 11707631
D000079 57817 HAMP
HEPC
HFE2B
LEAP1
PLTR
hepcidin antimicrobial peptide Acetaldehyde inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA] decreases expression
/ decreases reaction
mRNA 16737972
D000079 57817 HAMP
HEPC
HFE2B
LEAP1
PLTR
hepcidin antimicrobial peptide Acetaldehyde results in decreased expression of HAMP mRNA decreases expression
mRNA 16737972
D000079 3280 HES1
HES-1
HHL
HRY
bHLHb39
hes family bHLH transcription factor 1 Acetaldehyde results in increased expression of HES1 mRNA increases expression
mRNA 23416264
D000079 29923 HILPDA
C7orf68
HIG-2
HIG2
hypoxia inducible lipid droplet-associated Acetaldehyde results in decreased expression of HILPDA mRNA decreases expression
mRNA 23416264
D000079 554219 Acetaldehyde results in increased expression of IFNB protein increases expression
protein 15885616
D000079 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 IL10 protein promotes the reaction [Acetaldehyde results in increased secretion of IL8 protein] increases reaction
/ increases secretion
protein 15698409
D000079 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Acetaldehyde results in increased expression of IL1B mRNA increases expression
mRNA 17050345
D000079 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Acetaldehyde results in increased expression of IL1B protein increases expression
protein 11344824
17050345
D000079 3565 IL4
BCGF-1
BCGF1
BSF-1
BSF1
IL-4
interleukin 4 IL4 protein inhibits the reaction [Acetaldehyde results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
protein 15698409
D000079 3565 IL4
BCGF-1
BCGF1
BSF-1
BSF1
IL-4
interleukin 4 IL4 protein inhibits the reaction [Acetaldehyde results in increased expression of and results in increased secretion of IL8 protein] decreases reaction
/ increases expression
/ increases secretion
protein 15698409
D000079 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Acetaldehyde results in increased expression of IL6 mRNA increases expression
mRNA 17050345
D000079 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Acetaldehyde results in increased expression of and results in increased secretion of IL8 protein increases expression
/ increases secretion
protein 15698409
D000079 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Acetaldehyde results in increased expression of IL8 mRNA increases expression
mRNA 11344824
23416264
D000079 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Acetaldehyde results in increased expression of IL8 protein increases expression
protein 11344824
D000079 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 IL10 protein promotes the reaction [Acetaldehyde results in increased secretion of IL8 protein] increases reaction
/ increases secretion
protein 15698409
D000079 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 IL4 protein inhibits the reaction [Acetaldehyde results in increased expression of and results in increased secretion of IL8 protein] decreases reaction
/ increases expression
/ increases secretion
protein 15698409
D000079 3708 ITPR1
INSP3R1
IP3R
IP3R1
SCA15
SCA16
SCA29
inositol 1,4,5-trisphosphate receptor, type 1 Acetaldehyde results in increased expression of and affects the localization of ITPR1 protein affects localization
/ increases expression
protein 17241155
D000079 3708 ITPR1
INSP3R1
IP3R
IP3R1
SCA15
SCA16
SCA29
inositol 1,4,5-trisphosphate receptor, type 1 ITPR1 protein promotes the reaction [Acetaldehyde metabolite results in increased abundance of Calcium] increases abundance
/ increases reaction
protein 17241155
D000079 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Acetaldehyde results in increased activity of JUN protein increases activity
protein 10799556
D000079 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Acetaldehyde results in increased expression of JUN mRNA increases expression
mRNA 11978551
D000079 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Acetaldehyde results in increased expression of JUN protein increases expression
protein 11978551
D000079 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene JUN protein promotes the reaction [Acetaldehyde results in increased expression of MMP11 mRNA] increases expression
/ increases reaction
protein 11978551
D000079 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 17030193
D000079 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 11343241
D000079 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 4-hydroxymercuribenzoate inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 11343241
D000079 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein increases activity
/ increases phosphorylation
protein 14722101
17030193
D000079 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Acetaldehyde results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 11343241
D000079 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) calphostin C inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 11343241
D000079 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) imatinib inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 17030193
D000079 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) MAPK1 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A1 protein] increases expression
/ increases reaction
protein 17030193
D000079 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) rottlerin inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 17030193
D000079 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 17030193
D000079 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 11343241
D000079 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 4-hydroxymercuribenzoate inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 11343241
D000079 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein increases activity
/ increases phosphorylation
protein 14722101
17030193
D000079 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Acetaldehyde results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 11343241
D000079 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) calphostin C inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 11343241
D000079 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) imatinib inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 17030193
D000079 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) MAPK3 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A1 protein] increases expression
/ increases reaction
protein 17030193
D000079 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) rottlerin inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 17030193
D000079 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Acetaldehyde results in increased phosphorylation of MAPK8 protein increases phosphorylation
protein 19110045
D000079 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK8 protein] decreases reaction
/ increases phosphorylation
protein 19110045
D000079 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) Acetaldehyde results in increased phosphorylation of MAPK9 protein increases phosphorylation
protein 19110045
D000079 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK9 protein] decreases reaction
/ increases phosphorylation
protein 19110045
D000079 4144 MAT2A
MATA2
MATII
SAMS2
methionine adenosyltransferase II, alpha (EC:2.5.1.6) Acetaldehyde results in decreased expression of MAT2A mRNA decreases expression
mRNA 23416264
D000079 153364 MBLAC2
metallo-beta-lactamase domain containing 2 Acetaldehyde results in decreased expression of MBLAC2 mRNA decreases expression
mRNA 23416264
D000079 4170 MCL1
BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
myeloid cell leukemia sequence 1 (BCL2-related) Acetaldehyde results in increased expression of MCL1 mRNA increases expression
mRNA 23416264
D000079 84981 MIR22HG
C17orf91
MIR22 host gene (non-protein coding) Acetaldehyde results in decreased expression of MIR22HG mRNA decreases expression
mRNA 23416264
D000079 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Acetaldehyde results in decreased expression of MMP1 mRNA decreases expression
mRNA 7934638
D000079 4320 MMP11
SL-3
ST3
STMY3
matrix metallopeptidase 11 (stromelysin 3) (EC:3.4.24.-) Acetaldehyde results in increased expression of MMP11 mRNA increases expression
mRNA 11978551
D000079 4320 MMP11
SL-3
ST3
STMY3
matrix metallopeptidase 11 (stromelysin 3) (EC:3.4.24.-) JUN protein promotes the reaction [Acetaldehyde results in increased expression of MMP11 mRNA] increases expression
/ increases reaction
mRNA 11978551
D000079 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Acetaldehyde results in increased expression of MMP2 mRNA increases expression
mRNA 7934638
D000079 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Acetaldehyde results in increased expression of and results in increased activity of MMP9 protein increases activity
/ increases expression
protein 19110045
D000079 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Acetaldehyde results in increased expression of MMP9 mRNA increases expression
mRNA 19110045
D000079 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of and results in increased activity of MMP9 protein] decreases reaction
/ increases activity
/ increases expression
protein 19110045
D000079 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of MMP9 mRNA] decreases reaction
/ increases expression
mRNA 19110045
D000079 4353 MPO
myeloperoxidase (EC:1.11.2.2) [MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein affects binding
/ affects cotreatment
/ affects metabolic processing
protein 23009681
D000079 4353 MPO
myeloperoxidase (EC:1.11.2.2) [MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine] affects binding
/ affects cotreatment
/ increases reaction
protein 23009681
D000079 2475 MTOR
FRAP
FRAP1
FRAP2
RAFT1
RAPT1
mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) Acetaldehyde results in decreased phosphorylation of MTOR protein decreases phosphorylation
protein 16962100
D000079 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Acetaldehyde results in increased activity of [RELA protein binds to NFKB1 protein] affects binding
/ increases activity
protein 10799556
D000079 4791 NFKB2
H2TF1
LYT-10
LYT10
NF-kB2
p105
p52
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) Acetaldehyde results in increased activity of [NFKBIA protein binds to NFKB2 protein] affects binding
/ increases activity
protein 10799556
D000079 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Acetaldehyde results in increased activity of [NFKBIA protein binds to NFKB2 protein] affects binding
/ increases activity
protein 10799556
D000079 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Acetaldehyde results in increased degradation of NFKBIA protein increases degradation
protein 10799556
15698409
D000079 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Acetaldehyde results in increased expression of NFKBIA mRNA increases expression
mRNA 23416264
D000079 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Acetaldehyde results in increased phosphorylation of and results in increased degradation of NFKBIA protein increases degradation
/ increases phosphorylation
protein 19110045
D000079 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha IL4 protein inhibits the reaction [Acetaldehyde results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
protein 15698409
D000079 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) Acetaldehyde results in increased expression of NOS2 protein increases expression
protein 18845238
D000079 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) [Acetaldehyde results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide increases abundance
/ increases expression
protein 18845238
D000079 3164 NR4A1
GFRP1
HMR
N10
NAK-1
NGFIB
NP10
NUR77
TR3
nuclear receptor subfamily 4, group A, member 1 Acetaldehyde results in increased expression of NR4A1 mRNA increases expression
mRNA 23416264
D000079 4929 NR4A2
HZF-3
NOT
NURR1
RNR1
TINUR
nuclear receptor subfamily 4, group A, member 2 Acetaldehyde results in increased expression of NR4A2 mRNA increases expression
mRNA 23416264
D000079 424046 Acetaldehyde results in decreased expression of OBFC2A mRNA decreases expression
mRNA 23416264
D000079 100506658 OCLN
BLCPMG
occludin (EC:2.1.1.67) Acetaldehyde affects the localization of OCLN protein affects localization
protein 22563376
D000079 100506658 OCLN
BLCPMG
occludin (EC:2.1.1.67) EGF protein inhibits the reaction [Acetaldehyde affects the localization of OCLN protein] affects localization
/ decreases reaction
protein 17991733
D000079 100506658 OCLN
BLCPMG
occludin (EC:2.1.1.67) PLCG1 protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of OCLN protein]] affects localization
/ affects reaction
/ decreases reaction
protein 17991733
D000079 4953 ODC1
ODC
ornithine decarboxylase 1 (EC:4.1.1.17) Acetaldehyde results in decreased activity of ODC1 protein decreases activity
protein 3986791
D000079 23035 PHLPP2
PHLPPL
PH domain and leucine rich repeat protein phosphatase 2 (EC:3.1.3.16) Acetaldehyde results in decreased expression of PHLPP2 mRNA decreases expression
mRNA 23416264
D000079 57157 PHTF2
putative homeodomain transcription factor 2 Acetaldehyde results in increased expression of PHTF2 mRNA increases expression
mRNA 23416264
D000079 91461 PKDCC
SGK493
Vlk
protein kinase domain containing, cytoplasmic Acetaldehyde results in decreased expression of PKDCC mRNA decreases expression
mRNA 23416264
D000079 5335 PLCG1
NCKAP3
PLC-II
PLC1
PLC148
PLCgamma1
phospholipase C, gamma 1 (EC:3.1.4.11) PLCG1 protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of OCLN protein]] affects localization
/ affects reaction
/ decreases reaction
protein 17991733
D000079 5335 PLCG1
NCKAP3
PLC-II
PLC1
PLC148
PLCgamma1
phospholipase C, gamma 1 (EC:3.1.4.11) PLCG1 protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]] affects localization
/ affects reaction
/ decreases reaction
protein 17991733
D000079 55629 PNRC2
proline-rich nuclear receptor coactivator 2 Acetaldehyde results in decreased expression of PNRC2 mRNA decreases expression
mRNA 23416264
D000079 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Acetaldehyde inhibits the reaction [GW 7647 results in increased activity of PPARA protein] decreases reaction
/ increases activity
protein 18003597
D000079 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetaldehyde inhibits the reaction [rosiglitazone results in increased activity of PPARG protein]] decreases reaction
/ increases activity
protein 17030193
D000079 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in decreased activity of PPARG protein] decreases activity
/ decreases reaction
/ increases phosphorylation
protein 17030193
D000079 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma ABL1 protein promotes the reaction [Acetaldehyde results in increased phosphorylation of and results in decreased activity of PPARG protein] decreases activity
/ increases phosphorylation
/ increases reaction
protein 17030193
D000079 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Acetaldehyde inhibits the reaction [rosiglitazone results in increased activity of PPARG protein] decreases reaction
/ increases activity
protein 17030193
D000079 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Acetaldehyde results in increased phosphorylation of and results in decreased activity of PPARG protein decreases activity
/ increases phosphorylation
protein 17030193
D000079 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma [Acetaldehyde results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein decreases activity
/ increases expression
/ increases phosphorylation
protein 17030193
D000079 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma imatinib inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in decreased activity of PPARG protein] decreases activity
/ decreases reaction
/ increases phosphorylation
protein 17030193
D000079 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma PPARG protein promotes the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA] increases expression
/ increases reaction
protein 17030193
D000079 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma PPARG protein promotes the reaction [Acetaldehyde results in increased expression of COL1A1 protein] increases expression
/ increases reaction
protein 17030193
D000079 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma U 0126 inhibits the reaction [Acetaldehyde inhibits the reaction [rosiglitazone results in increased activity of PPARG protein]] decreases reaction
/ increases activity
protein 17030193
D000079 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma U 0126 inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in decreased activity of PPARG protein] decreases activity
/ decreases reaction
/ increases phosphorylation
protein 17030193
D000079 5514 PPP1R10
CAT53
FB19
PNUTS
PP1R10
R111
p99
protein phosphatase 1, regulatory subunit 10 Acetaldehyde results in decreased expression of PPP1R10 mRNA decreases expression
mRNA 23416264
D000079 5579 PRKCB
PKC-beta
PKCB
PRKCB1
PRKCB2
protein kinase C, beta (EC:2.7.11.13) PRKCB protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]] affects reaction
/ decreases reaction
/ increases transport
protein 17991733
D000079 5579 PRKCB
PKC-beta
PKCB
PRKCB1
PRKCB2
protein kinase C, beta (EC:2.7.11.13) PRKCB protein affects the reaction [EGF protein results in decreased susceptibility to Acetaldehyde] affects reaction
/ decreases response to substance
protein 17991733
D000079 5580 PRKCD
MAY1
PKCD
nPKC-delta
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) Acetaldehyde results in increased phosphorylation of and results in increased activity of PRKCD protein increases activity
/ increases phosphorylation
protein 17030193
D000079 5580 PRKCD
MAY1
PKCD
nPKC-delta
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) imatinib inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of PRKCD protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 17030193
D000079 5580 PRKCD
MAY1
PKCD
nPKC-delta
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) PRKCD protein promotes the reaction [Acetaldehyde results in increased expression of COL1A1 protein] increases expression
/ increases reaction
protein 17030193
D000079 5581 PRKCE
PKCE
nPKC-epsilon
protein kinase C, epsilon (EC:2.7.11.13) PRKCE protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]] affects reaction
/ decreases reaction
/ increases transport
protein 17991733
D000079 5581 PRKCE
PKCE
nPKC-epsilon
protein kinase C, epsilon (EC:2.7.11.13) PRKCE protein affects the reaction [EGF protein results in decreased susceptibility to Acetaldehyde] affects reaction
/ decreases response to substance
protein 17991733
D000079 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Acetaldehyde results in increased expression of PTGS1 mRNA increases expression
mRNA 17050345
D000079 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Acetaldehyde results in increased expression of PTGS2 mRNA increases expression
mRNA 17050345
19110045
23416264
D000079 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
mRNA 19110045
D000079 51655 RASD1
AGS1
DEXRAS1
MGC:26290
RAS, dexamethasone-induced 1 Acetaldehyde results in increased expression of RASD1 mRNA increases expression
mRNA 23416264
D000079 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Acetaldehyde affects the localization of RELA protein affects localization
protein 14619338
D000079 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Acetaldehyde results in increased activity of [RELA protein binds to NFKB1 protein] affects binding
/ increases activity
protein 10799556
D000079 5994 RFXAP
regulatory factor X-associated protein Acetaldehyde results in decreased expression of RFXAP mRNA decreases expression
mRNA 23416264
D000079 9886 RHOBTB1
Rho-related BTB domain containing 1 Acetaldehyde results in decreased expression of RHOBTB1 mRNA decreases expression
mRNA 23416264
D000079 27289 RND1
ARHS
RHO6
RHOS
Rho family GTPase 1 Acetaldehyde results in increased expression of RND1 mRNA increases expression
mRNA 23416264
D000079 6198 RPS6KB1
PS6K
S6K
S6K-beta-1
S6K1
STK14A
p70_S6KA
p70(S6K)-alpha
p70-S6K
p70-alpha
ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) Acetaldehyde results in increased activity of RPS6KB1 protein increases activity
protein 16962100
D000079 6198 RPS6KB1
PS6K
S6K
S6K-beta-1
S6K1
STK14A
p70_S6KA
p70(S6K)-alpha
p70-S6K
p70-alpha
ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) Sirolimus inhibits the reaction [Acetaldehyde results in increased activity of RPS6KB1 protein] decreases reaction
/ increases activity
protein 16962100
D000079 65117 RSRC2
arginine/serine-rich coiled-coil 2 Acetaldehyde results in increased expression of RSRC2 mRNA increases expression
mRNA 23416264
D000079 27111 SDCBP2
SITAC
SITAC18
ST-2
syndecan binding protein (syntenin) 2 Acetaldehyde results in increased expression of SDCBP2 mRNA increases expression
mRNA 23416264
D000079 6403 SELP
CD62
CD62P
GMP140
GRMP
LECAM3
PADGEM
PSEL
selectin P (granule membrane protein 140kDa, antigen CD62) Acetaldehyde results in increased expression of SELP protein increases expression
protein 19036374
D000079 54093 SETD4
C21orf18
C21orf27
SET domain containing 4 Acetaldehyde results in increased expression of SETD4 mRNA increases expression
mRNA 23416264
D000079 84826 SFT2D3
SFT2 domain containing 3 Acetaldehyde results in decreased expression of SFT2D3 mRNA decreases expression
mRNA 23416264
D000079 387640 SKIDA1
C10orf140
DLN-1
SKI/DACH domain containing 1 Acetaldehyde results in decreased expression of SKIDA1 mRNA decreases expression
mRNA 23416264
D000079 6498 SKIL
SNO
SnoA
SnoI
SnoN
SKI-like oncogene Acetaldehyde results in increased expression of SKIL mRNA increases expression
mRNA 23416264
D000079 6566 SLC16A1
HHF7
MCT
MCT1
solute carrier family 16 (monocarboxylate transporter), member 1 Acetaldehyde inhibits the reaction [SLC16A1 protein results in increased uptake of Butyrates] decreases reaction
/ increases uptake
protein 19023563
D000079 4088 SMAD3
HSPC193
HsT17436
JV15-2
LDS1C
LDS3
MADH3
SMAD family member 3 Acetaldehyde results in increased phosphorylation of SMAD3 protein increases phosphorylation
protein 16025520
D000079 4088 SMAD3
HSPC193
HsT17436
JV15-2
LDS1C
LDS3
MADH3
SMAD family member 3 SMAD3 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] increases expression
/ increases reaction
protein 16025520
D000079 4089 SMAD4
DPC4
JIP
MADH4
MYHRS
SMAD family member 4 SMAD4 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] increases expression
/ increases reaction
protein 16025520
D000079 6667 SP1
Sp1 transcription factor SP1 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] increases expression
/ increases reaction
protein 16025520
D000079 6696 SPP1
BNSP
BSPI
ETA-1
OPN
secreted phosphoprotein 1 Acetaldehyde results in increased expression of SPP1 mRNA increases expression
mRNA 18703563
D000079 6696 SPP1
BNSP
BSPI
ETA-1
OPN
secreted phosphoprotein 1 Acetaldehyde results in increased expression of SPP1 protein increases expression
protein 18703563
D000079 6720 SREBF1
SREBP-1c
SREBP1
bHLHd1
sterol regulatory element binding transcription factor 1 Acetaldehyde results in increased expression of SREBF1 protein increases expression
protein 12612910
D000079 56977 STOX2
storkhead box 2 Acetaldehyde results in decreased expression of STOX2 mRNA decreases expression
mRNA 23416264
D000079 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 Acetaldehyde results in increased expression of TGFB1 mRNA increases expression
mRNA 16025520
D000079 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 Acetaldehyde results in increased expression of TGFB1 protein increases expression
protein 16025520
D000079 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 TGFB1 protein inhibits the reaction [Acetaldehyde results in decreased expression of COL4A1 protein] decreases expression
/ decreases reaction
protein 8135774
D000079 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 TGFB1 protein promotes the reaction [Acetaldehyde results in increased expression of FN1 protein] increases expression
/ increases reaction
protein 8135774
D000079 7082 TJP1
ZO-1
tight junction protein 1 Acetaldehyde affects the localization of TJP1 protein affects localization
protein 17991733
22563376
D000079 7082 TJP1
ZO-1
tight junction protein 1 chelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]] affects localization
/ decreases reaction
protein 17991733
D000079 7082 TJP1
ZO-1
tight junction protein 1 EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein] affects localization
/ decreases reaction
protein 17991733
D000079 7082 TJP1
ZO-1
tight junction protein 1 PLCG1 protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]] affects localization
/ affects reaction
/ decreases reaction
protein 17991733
D000079 7082 TJP1
ZO-1
tight junction protein 1 Ro 32-0432 inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]] affects localization
/ decreases reaction
protein 17991733
D000079 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Acetaldehyde results in increased expression of TNF mRNA increases expression
mRNA 11344824
17050345
19036374
D000079 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Acetaldehyde results in increased expression of TNF protein increases expression
protein 19036374
D000079 22888 UBOX5
RNF37
UBCE7IP5
UIP5
U-box domain containing 5 Acetaldehyde results in increased expression of UBOX5 mRNA increases expression
mRNA 23416264
D000079 7498 XDH
XO
XOR
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) Acetaldehyde results in increased expression of XDH mRNA increases expression
mRNA 18845238
D000079 7498 XDH
XO
XOR
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) Acetaldehyde results in increased expression of XDH protein increases expression
protein 18845238
D000079 7498 XDH
XO
XOR
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) [MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein affects binding
/ affects cotreatment
/ affects metabolic processing
protein 23009681
D000079 7498 XDH
XO
XOR
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) [MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine] affects binding
/ affects cotreatment
/ increases reaction
protein 23009681
D000079 10138 YAF2
YY1 associated factor 2 Acetaldehyde results in increased expression of YAF2 mRNA increases expression
mRNA 23416264
D000079 56829 ZC3HAV1
ARTD13
FLB6421
PARP13
ZAP
ZC3H2
ZC3HDC2
zinc finger CCCH-type, antiviral 1 Acetaldehyde results in decreased expression of ZC3HAV1 mRNA decreases expression
mRNA 23416264
D000079 7539 ZFP37
ZNF906
zfp-37
ZFP37 zinc finger protein Acetaldehyde results in increased expression of ZFP37 mRNA increases expression
mRNA 23416264
D000079 7769 ZNF226
zinc finger protein 226 Acetaldehyde results in decreased expression of ZNF226 mRNA decreases expression
mRNA 23416264
D000079 7310 Acetaldehyde results in increased expression of ZRSR1 mRNA increases expression
mRNA 23416264

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#137800 Glioma susceptibility 1; glm1 P37231
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#601665 Obesity P37231

KEGG DISEASE (5)

KEGG disease name UniProt
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)

Diseases related to CTD interactions

15 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001249 D000079 Asthma marker/mechanism
9600491
D002277 D000079 Carcinoma marker/mechanism
12562630
D002310 D000079 Cardiomyopathy, Alcoholic marker/mechanism
10525098
D005235 D000079 Fatty Liver, Alcoholic marker/mechanism
20118189
D006331 D000079 Heart Diseases marker/mechanism
6645200
D007022 D000079 Hypotension marker/mechanism
7460472
D007414 D000079 Intestinal Neoplasms marker/mechanism
12562630
D008175 D000079 Lung Neoplasms marker/mechanism
12562630
17372256
D015674 D000079 Mammary Neoplasms, Animal marker/mechanism
12562630
D009336 D000079 Necrosis marker/mechanism
6645200
D009421 D000079 Nervous System Malformations marker/mechanism
22634333
D011041 D000079 Poisoning marker/mechanism
22634333
D012220 D000079 Rhinitis marker/mechanism
17050345
D013274 D000079 Stomach Neoplasms marker/mechanism
12562630
D013610 D000079 Tachycardia marker/mechanism
7460472