PCIDB

KNApSAcK Metabolite C00002147

Metabolite

KNApSAcK Entry

id C00002147
Name Cinchonidine
CAS RN 485-71-2
Standard InChI InChI=1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/t13-,14-,18-,19+/m0/s1
Standard InChI (Main Layer) InChI=1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2

Cluster

Phytochemical cluster No. 7
KCF-S cluster No. 1378

Link

ChEMBL

By standard InChI CHEMBL533841
By standard InChI Main Layer CHEMBL15134 CHEMBL461234 CHEMBL518804 CHEMBL533841 CHEMBL588619 CHEMBL611480 CHEMBL1414315 CHEMBL1477170 CHEMBL1590546 CHEMBL2079612 CHEMBL2357353

KEGG

By LinkDB C11379

CTD

By CAS RN C041622

Human Protein / Gene in interaction

13 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL461234 CHEMBL588619 CHEMBL1414315 CHEMBL1477170 CHEMBL1590546 CHEMBL2079612 CHEMBL729201 (1) CHEMBL729202 (1)
CHEMBL729203 (2) CHEMBL729204 (2)
CHEMBL729205 (2) CHEMBL729206 (1)
CHEMBL729208 (1) CHEMBL758056 (2)
CHEMBL828928 (1) CHEMBL827154 (1)
CHEMBL1614110 (5) CHEMBL1741321 (3)
1 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1477170 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1414315 CHEMBL1590546 CHEMBL1741325 (3)
0 / 1
O75496 Geminin Unclassified protein CHEMBL588619 CHEMBL2114780 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL15134 CHEMBL2114788 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL533841 CHEMBL1794401 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1414315 CHEMBL1590546 CHEMBL1741322 (3)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL461234 CHEMBL1414315 CHEMBL1590546 CHEMBL1613777 (2) CHEMBL1741323 (3)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL15134 CHEMBL1414315 CHEMBL1590546 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (3)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL533841 CHEMBL1794483 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL15134 CHEMBL1614250 (1) CHEMBL1614421 (1)
CHEMBL1614502 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL588619 CHEMBL1738184 (1)
0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL15134 CHEMBL2354287 (1)
1 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (8)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)