KCF-S cluster No. 1378 (7 metabolites)

Corresponding Phytochemical cluster No. 7

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (7)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	19

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Cumulative family count

class name	count
Rubiaceae	16
Oleaceae	2
Apocynaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Quinoline alkaloids	3

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metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Quinoline alkaloids	C11379	C00002147
Quinoline alkaloids	C10696	C00002173
Quinoline alkaloids	C06527	C00031117

Metabolite list (7)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002147	Cinchonidine	CHEMBL15134 CHEMBL461234 CHEMBL518804 CHEMBL533841 CHEMBL588619 CHEMBL611480 CHEMBL1414315 CHEMBL1477170 CHEMBL1590546 CHEMBL2079612 CHEMBL2357353	C041622	13 / 10 / 8
C00002173	Hydroquinidine	CHEMBL531471 CHEMBL531472 CHEMBL588934 CHEMBL602767 CHEMBL1436416 CHEMBL1531111 CHEMBL1617471 CHEMBL1740727 CHEMBL1906890 CHEMBL2079611 CHEMBL2092739 CHEMBL2305514 CHEMBL2355802	C014486	9 / 12 / 15	0 / 4
C00002193	Quinine	CHEMBL97 CHEMBL15088 CHEMBL21578 CHEMBL1294 CHEMBL170 CHEMBL387326 CHEMBL407725 CHEMBL512340 CHEMBL522505 CHEMBL460606 CHEMBL601807 CHEMBL576997 CHEMBL1358565 CHEMBL1364159 CHEMBL1616938 CHEMBL1741006 CHEMBL1878119 CHEMBL2355467	D011803	48 / 55 / 40	18 / 83
C00026411	Cupreine / Ultraquinine / Desmethylquinine / O-Demethylquinine / O6'-Demethylquinine		C029819
C00026417	Hydrocupreine / Dihydrocupreine / 10,11-Dihydrocupreine / O6'-Demethylhydroquinine / 6'-Hydroxydihydrocinchonidine	CHEMBL532678 CHEMBL587165	C029820
C00026466	N-Methyldihydroquinicinol
C00031117	Quinidine / (+)-Quinidine	CHEMBL97 CHEMBL15088 CHEMBL21578 CHEMBL1294 CHEMBL170 CHEMBL387326 CHEMBL407725 CHEMBL512340 CHEMBL522505 CHEMBL460606 CHEMBL601807 CHEMBL576997 CHEMBL1358565 CHEMBL1364159 CHEMBL1616938 CHEMBL1741006 CHEMBL1878119 CHEMBL2355467	D011802	48 / 55 / 40	28 / 83

Human Protein / Gene in interactions

51 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002147 C00002173 C00002193 C00031117	1 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00002147 C00002173 C00002193 C00031117	3 / 2
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002147 C00002173 C00002193 C00031117	0 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002173 C00002193 C00031117	3 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002147 C00002193 C00031117	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00002147 C00002193 C00031117	0 / 0
O00255	Menin	Unclassified protein	C00002173 C00002193 C00031117	2 / 5
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002147 C00002193 C00031117	1 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002173 C00002193 C00031117	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002147 C00002193 C00031117	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002173 C00002193 C00031117	1 / 2
P83916	Chromobox protein homolog 1	Unclassified protein	C00002147 C00002193 C00031117	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002147 C00002193 C00031117	0 / 0
O75496	Geminin	Unclassified protein	C00002147 C00002193 C00031117	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002147 C00002193 C00031117	0 / 1
P00352	Retinal dehydrogenase 1	Enzyme	C00002173 C00002193 C00031117	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00002193 C00031117	0 / 0
P08183	Multidrug resistance protein 1	drug	C00002193 C00031117	1 / 0
Q8TCC7	Solute carrier family 22 member 8	Antiporter	C00002193 C00031117	0 / 0
P46721	Solute carrier organic anion transporter family member 1A2	Unclassified protein	C00002193 C00031117	0 / 0
P02768	Serum albumin	Secreted protein	C00002193 C00031117	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00002193 C00031117	3 / 1
Q9NPD5	Solute carrier organic anion transporter family member 1B3	Electrochemical transporter	C00002193 C00031117	1 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00002193 C00031117	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00002193 C00031117	5 / 3
Q9NY46	Sodium channel protein type 3 subunit alpha	SCN alpha, NaV1.x	C00002193 C00031117	0 / 0
P37840	Alpha-synuclein	Unclassified protein	C00002193 C00031117	4 / 2
O15245	Solute carrier family 22 member 1	Drug uniporter	C00002193 C00031117	0 / 0
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00002193 C00031117	1 / 1
P35498	Sodium channel protein type 1 subunit alpha	SCN alpha, NaV1.x	C00002193 C00031117	3 / 2
Q86VL8	Multidrug and toxin extrusion protein 2	Cation antiporter	C00002193 C00031117	0 / 0
Q14524	Sodium channel protein type 5 subunit alpha	SCN alpha, NaV1.x	C00002193 C00031117	9 / 7
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00002193 C00031117	2 / 2
O95342	Bile salt export pump	drug	C00002193 C00031117	2 / 1
Q99700	Ataxin-2	Unclassified protein	C00002193 C00031117	1 / 1
Q99250	Sodium channel protein type 2 subunit alpha	SCN alpha, NaV1.x	C00002193 C00031117	2 / 2
Q96FL8	Multidrug and toxin extrusion protein 1	Cation antiporter	C00002193 C00031117	0 / 0
P22460	Potassium voltage-gated channel subfamily A member 5	KCNA, Kv1.x (Shaker)	C00002193 C00031117	1 / 1
P04156	Major prion protein	Surface antigen	C00002193 C00031117	6 / 2
Q9UBT6	DNA polymerase kappa	Enzyme	C00002193 C00031117	0 / 0
O94956	Solute carrier organic anion transporter family member 2B1	Unclassified protein	C00002193 C00031117	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002193 C00031117	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002193 C00031117	1 / 1
O15244	Solute carrier family 22 member 2	Drug uniporter	C00002193 C00031117	0 / 0
Q9Y6L6	Solute carrier organic anion transporter family member 1B1	Electrochemical transporter	C00002193 C00031117	1 / 0
Q9H015	Solute carrier family 22 member 4	Unclassified protein	C00002193 C00031117	1 / 1
O76082	Solute carrier family 22 member 5	Unclassified protein	C00002193 C00031117	1 / 2
P06276	Cholinesterase	Hydrolase	C00002193 C00031117	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00002147	4 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002173	2 / 2
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00002147	1 / 1

34 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00002193 C00031117
6581	SLC22A3, EMT, EMTH, OCT3	solute carrier family 22 (organic cation transporter), member 3	C00002193 C00031117
6582	SLC22A2, OCT2	solute carrier family 22 (organic cation transporter), member 2	C00002193 C00031117
6580	SLC22A1, HOCT1, OCT1, oct1_cds	solute carrier family 22 (organic cation transporter), member 1	C00002193 C00031117
338567	KCNK18, K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK	potassium channel, subfamily K, member 18	C00002193 C00031117
3757	KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1	potassium voltage-gated channel, subfamily H (eag-related), member 2	C00002193 C00031117
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00002193 C00031117
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002193 C00031117
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00002193 C00031117
1557	CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19	cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00002193 C00031117
2944	GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	C00002193 C00031117
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00002193 C00031117
3756	KCNH1, EAG, EAG1, Kv10.1, h-eag	potassium voltage-gated channel, subfamily H (eag-related), member 1	C00031117
1565	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1	cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)	C00031117
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00031117
3479	IGF1, IGF-I, IGF1A, IGFI	insulin-like growth factor 1 (somatomedin C)	C00031117
83729	INHBE	inhibin, beta E	C00031117
2168	FABP1, FABPL, L-FABP	fatty acid binding protein 1, liver	C00031117
11067	C10orf10, DEPP, FIG	chromosome 10 open reading frame 10	C00031117
440	ASNS, TS11	asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4)	C00031117
26471	NUPR1, COM1, P8	nuclear protein, transcriptional regulator, 1	C00031117
146	ADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2	adrenoceptor alpha 1D	C00031117
147	ADRA1B, ADRA1, ALPHA1BAR	adrenoceptor alpha 1B	C00031117
148	ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR	adrenoceptor alpha 1A	C00031117
6515	SLC2A3, GLUT3	solute carrier family 2 (facilitated glucose transporter), member 3	C00031117
55244	SLC47A1, MATE1	solute carrier family 47 (multidrug and toxin extrusion), member 1	C00031117
6876	TAGLN, SM22, SMCC, TAGLN1, WS3-10	transgelin	C00031117
943	TNFRSF8, CD30, D1S166E, Ki-1	tumor necrosis factor receptor superfamily, member 8	C00031117
351	APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2	amyloid beta (A4) precursor protein	C00002193
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00002193
3552	IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1	interleukin 1, alpha	C00002193
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00002193
84679	SLC9A7, NHE-7, NHE7, SLC9A6	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	C00002193
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002193

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions