PCIDB

KNApSAcK Metabolite C00049006

Metabolite

KNApSAcK Entry

id C00049006
Name n-Hexane
CAS RN 110-54-3
Standard InChI InChI=1S/C6H14/c1-3-5-6-4-2/h3-6H2,1-2H3
Standard InChI (Main Layer) InChI=1S/C6H14/c1-3-5-6-4-2/h3-6H2,1-2H3

Cluster

Phytochemical cluster
KCF-S cluster No. 5177

Link

ChEMBL

By standard InChI CHEMBL15939
By standard InChI Main Layer CHEMBL15939

KEGG

By LinkDB C11271

CTD

By CAS RN C026385

Species

Summary

Plant class

class name count
asterids 1

Family

family name count
Oleaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Olea europaea 4146 Oleaceae asterids Viridiplantae

Human Protein / Gene in interaction

CTD interaction (22)

compound gene gene name gene description interaction interaction type form reference
pmid
C026385 231 AKR1B1
ADR
ALDR1
ALR2
AR
aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) n-hexane results in increased expression of AKR1B1 mRNA increases expression
mRNA 20566472
C026385 57016 AKR1B10
AKR1B11
AKR1B12
ALDRLn
ARL-1
ARL1
HIS
HSI
aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2) n-hexane results in increased expression of AKR1B10 mRNA increases expression
mRNA 20566472
C026385 1645 AKR1C1
2-ALPHA-HSD
20-ALPHA-HSD
C9
DD1
DD1/DD2
DDH
DDH1
H-37
HAKRC
HBAB
MBAB
aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) n-hexane results in increased expression of AKR1C1 mRNA increases expression
mRNA 20566472
C026385 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) n-hexane results in increased expression of AKR1C3 mRNA increases expression
mRNA 20566472
C026385 24300 CYP2B1 protein results in increased hydroxylation of n-hexane increases hydroxylation
protein 16484137
C026385 1555 CYP2B6
CPB6
CYP2B
CYP2B7
CYP2B7P
CYPIIB6
EFVM
IIB1
P450
cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) CYP2B6 protein results in increased hydroxylation of n-hexane increases hydroxylation
protein 16484137
C026385 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) CYP2E1 gene polymorphism affects the susceptibility to n-hexane affects response to substance
gene 16484137
C026385 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) CYP2E1 protein results in increased hydroxylation of n-hexane increases hydroxylation
protein 16484137
C026385 2235 FECH
EPP
FCE
ferrochelatase (EC:4.99.1.1) n-hexane results in increased expression of FECH mRNA increases expression
mRNA 20566472
C026385 2512 FTL
NBIA3
ferritin, light polypeptide n-hexane results in increased expression of FTL mRNA increases expression
mRNA 20566472
C026385 2539 G6PD
G6PD1
glucose-6-phosphate dehydrogenase (EC:1.1.1.49) n-hexane results in increased expression of G6PD mRNA increases expression
mRNA 20566472
C026385 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) n-hexane results in increased expression of GCLC mRNA increases expression
mRNA 20566472
C026385 2730 GCLM
GLCLR
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) n-hexane results in increased expression of GCLM mRNA increases expression
mRNA 20566472
C026385 2936 GSR
glutathione reductase (EC:1.8.1.7) n-hexane results in increased expression of GSR mRNA increases expression
mRNA 20566472
C026385 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) n-hexane results in increased expression of HMOX1 mRNA increases expression
mRNA 20566472
C026385 4097 MAFG
hMAF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G n-hexane results in increased expression of MAFG mRNA increases expression
mRNA 20566472
C026385 4199 ME1
HUMNDME
MES
malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) n-hexane results in increased expression of ME1 mRNA increases expression
mRNA 20566472
C026385 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) n-hexane results in increased expression of NQO1 mRNA increases expression
mRNA 20566472
C026385 5226 PGD
6PGD
phosphogluconate dehydrogenase (EC:1.1.1.44) n-hexane results in increased expression of PGD mRNA increases expression
mRNA 20566472
C026385 22949 PTGR1
LTB4DH
PGR1
ZADH3
prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74) n-hexane results in increased expression of PTGR1 mRNA increases expression
mRNA 20566472
C026385 140809 SRXN1
C20orf139
Npn3
SRX
SRX1
sulfiredoxin 1 (EC:1.8.98.2) n-hexane results in increased expression of SRXN1 mRNA increases expression
mRNA 20566472
C026385 7296 TXNRD1
GRIM-12
TR
TR1
TRXR1
TXNR
thioredoxin reductase 1 (EC:1.8.1.9) n-hexane results in increased expression of TXNRD1 mRNA increases expression
mRNA 20566472

Related Disease

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D010523 C026385 Peripheral Nervous System Diseases marker/mechanism
16484137