Fraxinus americana

• Index
• Plant Species
• Metabolite list (14)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Fraxinus americana
Genus	Fraxinus
Family	Oleaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Fraxinus americana
Linked NCBI taxonomy ID	38872
Linked level	species

Family

Family in NCBI taxonomy	Oleaceae
ID	4144

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (14)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00002783	Kusaginin / Acteoside / Verbascoside	CHEMBL231853 CHEMBL444478 CHEMBL1364101	C058956	12 / 1 / 1	34 / 3	No. 33
C00036871	Campneoside I					No. 33
C00037161	Fraxamoside / (-)-Fraxamoside					No. 243
C00037421	Ligstroside / (-)-Ligstroside	CHEMBL1086877		1 / 1 / 0		No. 243
C00037025	Demethylligstroside / (-)-Demethylligstroside					No. 243
C00003093	Oleuropein	CHEMBL1911053	C002769		8 / 5	No. 243
C00036342	(2''R)-2''-Hydroxyoleuropein					No. 243
C00036343	(2''S)-2''-Hydroxyoleuropein					No. 243
C00037160	Frameroside					No. 389
C00033258	Nucenide / Nuezhenide	CHEMBL1076818	C083178	2 / 1 / 0		No. 545
C00033266	Oleoside dimethyl ester / (-)-Oleoside dimethyl ester	CHEMBL1087778		2 / 1 / 0		No. 924
C00037580	Oleoside 11-methyl ester / (-)-Oleoside 11-methyl ester	CHEMBL1086878		1 / 1 / 0		No. 924
C00029515	p-Tyrosol / 4-(2-Hydroxyethyl)phenol / p-Hydroxyphenethyl alcohol / 2-(4-Hydroxyphenyl)ethanol	CHEMBL53566	C011867	6 / 3 / 5		No. 936	No. 6
C00032635	3-Hydroxytyrosol / 3,4-Dihydroxyphenethyl alcohol	CHEMBL1950045	C005975		26 / 4	No. 1114	No. 6

Human Protein / Gene in interactions

19 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P14672	Solute carrier family 2, facilitated glucose transporter member 4	Unclassified protein	C00033258 C00033266 C00037421 C00037580	1 / 0
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00033258 C00033266	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002783 C00029515	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00002783	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00002783	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00029515	1 / 2
P39748	Flap endonuclease 1	Enzyme	C00002783	0 / 0
O75496	Geminin	Unclassified protein	C00002783	0 / 0
P00915	Carbonic anhydrase 1	Lyase	C00029515	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00029515	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00002783	0 / 0
P08581	Hepatocyte growth factor receptor	TK tyrosine-protein kinase MET subfamily	C00029515	2 / 3
Q9UNA4	DNA polymerase iota	Enzyme	C00002783	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00002783	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00029515	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00002783	1 / 1
Q9UBT6	DNA polymerase kappa	Enzyme	C00002783	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002783	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002783	0 / 0

53 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00002783 C00003093 C00032635
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00002783 C00003093 C00032635
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002783 C00003093 C00032635
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002783 C00003093 C00032635
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002783 C00003093 C00032635
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00003093 C00032635
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00003093 C00032635
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00002783 C00032635
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00002783 C00032635
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00002783 C00032635
7019	TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3	transcription factor A, mitochondrial	C00032635
993	CDC25A, CDC25A2	cell division cycle 25A (EC:3.1.3.48)	C00032635
37618			C00032635
1958	EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225	early growth response 1	C00032635
10922	FASTK, FAST	Fas-activated serine/threonine kinase (EC:2.7.11.8)	C00032635
1647	GADD45A, DDIT1, GADD45	growth arrest and DNA-damage-inducible, alpha	C00032635
2936	GSR	glutathione reductase (EC:1.8.1.7)	C00032635
3567	IL5, EDF, IL-5, TRF	interleukin 5 (colony-stimulating factor, eosinophil)	C00032635
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00032635
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00032635
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00032635
1588	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00003093
4779	NFE2L1, LCR-F1, NRF1, TCF11	nuclear factor, erythroid 2-like 1	C00032635
5862	RAB2A, LHX, RAB2	RAB2A, member RAS oncogene family	C00032635
6119	RPA3, REPA3	replication protein A3, 14kDa	C00032635
6773	STAT2, ISGF-3, P113, STAT113	signal transducer and activator of transcription 2, 113kDa	C00032635
6352	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP	chemokine (C-C motif) ligand 5	C00032635
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00002783
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00002783
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00002783
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00002783
894	CCND2, KIAK0002	cyclin D2	C00002783
896	CCND3	cyclin D3	C00002783
898	CCNE1, CCNE	cyclin E1	C00002783
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00002783
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00002783
1021	CDK6, PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	C00002783
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00002783
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00002783
3627	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1	chemokine (C-X-C motif) ligand 10	C00002783
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002783
1869	E2F1, E2F-1, RBAP1, RBBP3, RBP3	E2F transcription factor 1	C00002783
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00002783
3458	IFNG, IFG, IFI	interferon, gamma	C00002783
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002783
3689	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	C00002783
27035	NOX1, GP91-2, MOX1, NOH-1, NOH1	NADPH oxidase 1	C00002783
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00002783
4087	SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2	SMAD family member 2	C00002783
4088	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3	SMAD family member 3	C00002783
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00002783
7039	TGFA, TFGA	transforming growth factor, alpha	C00002783
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00002783

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions