KCF-S cluster No. 936 (10 metabolites)

Corresponding Phytochemical cluster No. 6

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (10)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	31
eudicotyledons	23
Liliopsida	9
asterids	5
Magnoliophyta	1
Spermatophyta	1

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Cumulative family count (Top 20)

class name	count
Fabaceae	27
Cactaceae	18
Poaceae	5
Brassicaceae	2
Amaryllidaceae	2
Orchidaceae	2
Enterobacteriaceae	2
Solanaceae	2
Crassulaceae	2
Viscaceae	1
Montiaceae	1
Plantaginaceae	1
Streptomycetaceae	1
Annonaceae	1
Juglandaceae	1
Aspergillaceae	1
Berberidaceae	1
Gloeophyllaceae	1
Oleaceae	1
Podocarpaceae	1

KEGG BRITE br08003

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Categories (2)

br08003 Category	# of metabolite
Others	1
Tyramine derivatives	3

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metabolites link (4)

br08003 Category	KEGG ID	KNApSAcK ID
Others	C16930	C00000621
Tyramine derivatives	C06199	C00001417
Tyramine derivatives	C00483	C00001435
Tyramine derivatives	C02442	C00027432

Metabolite list (10)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000621	Chavicol / p-Hydroxyallylbenzene	CHEMBL108862
C00000776	p-Hydroxybenzyl alcohol		C011276
C00001417	Cactine / Anhalin / Anhaline / Hordenine	CHEMBL505789	C007964	1 / 0 / 0
C00001435	Tyramine	CHEMBL11608	D014439	23 / 11 / 6	6 / 9
C00018213	p-Hydroxyphenylacetaldoxime		C020363
C00027432	N-Methyltyramine		C036244
C00029515	p-Tyrosol / 4-(2-Hydroxyethyl)phenol / p-Hydroxyphenethyl alcohol / 2-(4-Hydroxyphenyl)ethanol	CHEMBL53566	C011867	6 / 3 / 5
C00029528	4-Ethylphenol	CHEMBL108475	C042291	3 / 0 / 0	3 / 0
C00029532	4-Hydroxybenzyl cyanide / p-Hydroxyphenylacetonitrile / 4-Hydroxy-benzeneacetonitrile		C026914
C00029533	Gastrodigenin / 4-Methylolphenol / p-Hydroxybenzyl alcohol / 4-Hydroxybenzyl alcohol	CHEMBL202132	C018966	6 / 3 / 4	0 / 2

Human Protein / Gene in interactions

37 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00001417 C00001435 C00029515	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00001435	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00001435	0 / 0
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00001435	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00029515	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00029515	0 / 0
O15245	Solute carrier family 22 member 1	Drug uniporter	C00001435	0 / 0
P00519	Tyrosine-protein kinase ABL1	Abl	C00029533	1 / 2
P51649	Succinate-semialdehyde dehydrogenase, mitochondrial	Oxidoreductase	C00029533	1 / 1
P00918	Carbonic anhydrase 2	Lyase	C00029515	1 / 2
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00001435	1 / 1
P06241	Tyrosine-protein kinase Fyn	Src	C00029533	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001435	0 / 1
P14416	D(2) dopamine receptor	Dopamine receptor	C00001435	2 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00001435	0 / 0
O75496	Geminin	Unclassified protein	C00001435	0 / 0
P50225	Sulfotransferase 1A1	Enzyme	C00029528	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00029528	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00001435	2 / 0
P46098	5-hydroxytryptamine receptor 3A	NS	C00001435	0 / 0
P00915	Carbonic anhydrase 1	Lyase	C00029515	0 / 0
P46108	Adapter molecule crk	Unclassified protein	C00029533	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00001435	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00001435	4 / 2
P80404	4-aminobutyrate aminotransferase, mitochondrial	Transferase	C00029533	1 / 1
P08581	Hepatocyte growth factor receptor	TK tyrosine-protein kinase MET subfamily	C00029515	2 / 3
P62993	Growth factor receptor-bound protein 2	Other cytosolic protein	C00029533	0 / 0
P56817	Beta-secretase 1	A1A	C00001435	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001435	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001435	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001435	0 / 1
Q96RJ0	Trace amine-associated receptor 1	Trace amine receptor	C00001435	0 / 0
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00029528	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001435	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001435	0 / 0
O75751	Solute carrier family 22 member 3	Unclassified protein	C00001435	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001435	1 / 0

9 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00029528
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00029528
9970	NR1I3, CAR, CAR1, MB67	nuclear receptor subfamily 1, group I, member 3	C00029528
4128	MAOA, MAO-A	monoamine oxidase A (EC:1.4.3.4)	C00001435
6530	SLC6A2, NAT1, NET, NET1, SLC6A5	solute carrier family 6 (neurotransmitter transporter), member 2	C00001435
6531	SLC6A3, DAT, DAT1, PKDYS	solute carrier family 6 (neurotransmitter transporter), member 3	C00001435
6532	SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT	solute carrier family 6 (neurotransmitter transporter), member 4	C00001435
6818	SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1)	C00001435
134864	TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1	trace amine associated receptor 1	C00001435

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions