PCIDB

KNApSAcK Metabolite C00001435

Metabolite

KNApSAcK Entry

id C00001435
Name Tyramine
CAS RN 51-67-2
Standard InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
Standard InChI (Main Layer) InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2

Cluster

Phytochemical cluster No. 6
KCF-S cluster No. 936

Link

ChEMBL

By standard InChI CHEMBL11608
By standard InChI Main Layer CHEMBL11608

KEGG

By LinkDB C00483

CTD

By CAS RN D014439

Species

Summary

Plant class

class name count
rosids 18
eudicotyledons 8
asterids 2
Liliopsida 2

Family

family name count
Fabaceae 17
Cactaceae 6
Poaceae 2
Viscaceae 1
Plantaginaceae 1
Montiaceae 1
Solanaceae 1
Brassicaceae 1

List (33)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acacia angustissima 468212 Fabaceae rosids Viridiplantae
Acacia greggii 247878 Fabaceae rosids Viridiplantae
Acacia rigidula Benth. 205076 Fabaceae rosids Viridiplantae
Acacia roemeriana 199151 Fabaceae rosids Viridiplantae
Adenocarpus hispanicus 176334 Fabaceae rosids Viridiplantae
Antirrhinum majus 4151 Plantaginaceae asterids Viridiplantae
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Cytisus scoparius 3835 Fabaceae rosids Viridiplantae
Dendrolobium triangulare 185704 Fabaceae rosids Viridiplantae
Desmodium elegans 149687 Fabaceae rosids Viridiplantae
Desmodium triflorum 670328 Fabaceae rosids Viridiplantae
Espostoa huanucensis 432453 Cactaceae eudicotyledons Viridiplantae
Gleditsia triacanthos 54874 Fabaceae rosids Viridiplantae
Hordeum vulgare 4513 Poaceae Liliopsida Viridiplantae
Liparia parva 155120 Fabaceae rosids Viridiplantae
Liparia splendens 70407 Fabaceae rosids Viridiplantae
Lobivia bachenbergii
Lobivia binghamiana
Lobivia pentlandii 153873 Cactaceae eudicotyledons Viridiplantae
Lolium multiflorum 4521 Poaceae Liliopsida Viridiplantae
Lophophora williamsii 130138 Cactaceae eudicotyledons Viridiplantae
Lyallia kerguelensis 442941 Montiaceae eudicotyledons Viridiplantae
Pisum sativum 3888 Fabaceae rosids Viridiplantae
Prosopis alba 207710 Fabaceae rosids Viridiplantae
Prosopis glandulosa 102697 Fabaceae rosids Viridiplantae
Prosopis nigra 207716 Fabaceae rosids Viridiplantae
Pseudolobivia kermesina
Senna alata 53923 Fabaceae rosids Viridiplantae
Solanum lycopersicum L. 4081 Solanaceae asterids Viridiplantae
Trichocereus candicans 176271 Cactaceae eudicotyledons Viridiplantae
Trichocereus pachanoi 153898 Cactaceae eudicotyledons Viridiplantae
Trichocereus spachianus 153898 Cactaceae eudicotyledons Viridiplantae
Viscum album 3972 Viscaceae eudicotyledons Viridiplantae

Human Protein / Gene in interaction

23 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL11608 CHEMBL1741321 (1)
1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL11608 CHEMBL1794499 (2)
2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL11608 CHEMBL671027 (1) CHEMBL671029 (1)
CHEMBL674898 (1) CHEMBL2114744 (1)
0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase CHEMBL11608 CHEMBL1936781 (2)
0 / 0
O15245 Solute carrier family 22 member 1 Drug uniporter CHEMBL11608 CHEMBL2076204 (1)
0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL11608 CHEMBL1936780 (2)
1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL11608 CHEMBL1741325 (1)
0 / 1
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL11608 CHEMBL670395 (1) CHEMBL672210 (1)
CHEMBL848512 (1)
2 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL11608 CHEMBL1614458 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL11608 CHEMBL2114843 (1)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL11608 CHEMBL671251 (1) CHEMBL848512 (1)
0 / 0
P46098 5-hydroxytryptamine receptor 3A NS CHEMBL11608 CHEMBL926982 (1) CHEMBL923632 (1)
0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL11608 CHEMBL1614280 (1)
0 / 0
P14679 Tyrosinase Oxidoreductase CHEMBL11608 CHEMBL870666 (1)
4 / 2
P56817 Beta-secretase 1 A1A CHEMBL11608 CHEMBL947944 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL11608 CHEMBL1741322 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL11608 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL11608 CHEMBL1741324 (1)
0 / 1
Q96RJ0 Trace amine-associated receptor 1 Trace amine receptor CHEMBL11608 CHEMBL989986 (1) CHEMBL989987 (1)
CHEMBL1629167 (1) CHEMBL2354269 (1)
CHEMBL2354289 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL11608 CHEMBL1613914 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL11608 CHEMBL1738442 (1)
0 / 0
O75751 Solute carrier family 22 member 3 Unclassified protein CHEMBL11608 CHEMBL2077213 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL11608 CHEMBL2114738 (2)
0 / 0

CTD interaction (20)

compound gene gene name gene description interaction interaction type form reference
pmid
D014439 4128 MAOA
MAO-A
monoamine oxidase A (EC:1.4.3.4) MAOA protein results in increased metabolism of Tyramine increases metabolic processing
protein 10647887
D014439 6530 SLC6A2
NAT1
NET
NET1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 2 Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D014439 6530 SLC6A2
NAT1
NET
NET1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 2 indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D014439 6530 SLC6A2
NAT1
NET
NET1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 2 SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D014439 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D014439 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D014439 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D014439 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D014439 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D014439 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D014439 6818 SULT1A3
HAST
HAST3
M-PST
ST1A3/ST1A4
ST1A5
STM
TL-PST
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) SULT1A3 protein results in increased sulfation of Tyramine increases sulfation
protein 11181495
D014439 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D014439 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D014439 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D014439 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D014439 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D014439 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
D014439 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D014439 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D014439 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P14416
#300615 Brunner syndrome P21397
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#159900 Myoclonic dystonia P14416
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679

KEGG DISEASE (6)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00548 Brunner syndrome P21397 (related)
H01171 Poor drug metabolism (PM) P33261 (related)

Diseases related to CTD interactions

9 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D009202 D014439 Cardiomyopathies marker/mechanism
3578343
D002543 D014439 Cerebral Hemorrhage marker/mechanism
8492837
D002637 D014439 Chest Pain marker/mechanism
3578343
D006973 D014439 Hypertension marker/mechanism
3578343
4000229
5608715
8151003
D007022 D014439 Hypotension marker/mechanism
6117801
D008881 D014439 Migraine Disorders marker/mechanism
10792367
D015878 D014439 Mydriasis marker/mechanism
3038706
3920700
7074302
D011041 D014439 Poisoning marker/mechanism
3994754
D013610 D014439 Tachycardia marker/mechanism
6256527