PCIDB

Desmodium triflorum

Species

KNApSAcK Entry

Organism name Desmodium triflorum
Genus Desmodium
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Desmodium triflorum
Linked NCBI taxonomy ID 670328
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001059 External link 512 Isovitexin
/ Saponaretin
/ Homovitexin
/ 6-C-beta-D-Glucopyranosylapigenin
/ 6-beta-D-Glucopyranosyl-4',5,7-trihydroxyflavone
/ 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL465360
CHEMBL1601394
C049772
28 / 20 / 19 No. 22 No. 15
C00001110 External link 512 Vitexin
/ Apigenin 8-C-glucoside
/ 8-D-Glucosyl-4',5,7-trihydroxyflavone
/ 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL487417
CHEMBL1332209
CHEMBL1357921
16 / 4 / 8 No. 22 No. 15
C00001435 External link 512 Tyramine
CHEMBL11608
D014439
23 / 11 / 6 6 / 9 No. 936 No. 6
C00002074 External link 512 Stachydrine
CHEMBL394450
CHEMBL1456892
CHEMBL1986864
10 / 8 / 12 No. 2627 No. 1
C00001555 External link 512 Trigonelline
CHEMBL350675
C009560
3 / 1 / 0 No. 3681 No. 1

Human Protein / Gene in interactions

53 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001110 C00001435 C00002074 1 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001059 C00001110 C00001435 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001059 C00001110 C00001435 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001110 C00001435 C00002074 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001110 C00001435 C00002074 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001110 C00001435 C00002074 0 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001110 C00001435 C00002074 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001059 C00001110 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001059 C00001435 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001059 C00001110 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001059 C00001110 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001059 C00001110 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001059 C00001555 1 / 0
O00255 Menin Unclassified protein C00001059 C00002074 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001059 C00002074 1 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00001059 C00001435 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001059 C00001110 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001059 C00001110 1 / 4
Q9Y253 DNA polymerase eta Enzyme C00001059 C00001110 1 / 1
O75496 Geminin Unclassified protein C00001110 C00001435 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001555 0 / 0
P46098 5-hydroxytryptamine receptor 3A NS C00001435 0 / 0
P15121 Aldose reductase Enzyme C00001110 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001059 7 / 3
Q92830 Histone acetyltransferase KAT2A Enzyme C00002074 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001059 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00001435 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002074 0 / 0
P14679 Tyrosinase Oxidoreductase C00001435 4 / 2
P56817 Beta-secretase 1 A1A C00001435 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001059 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001059 0 / 0
P30989 Neurotensin receptor type 1 Neurotensin receptor C00001059 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00001435 2 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001059 1 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00001435 1 / 1
Q96RJ0 Trace amine-associated receptor 1 Trace amine receptor C00001435 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001059 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00002074 3 / 2
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001059 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00001555 0 / 0
O15245 Solute carrier family 22 member 1 Drug uniporter C00001435 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001059 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001435 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001059 1 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase C00001059 1 / 1
P06746 DNA polymerase beta Enzyme C00001059 0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00001435 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001435 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001435 2 / 0
O75751 Solute carrier family 22 member 3 Unclassified protein C00001435 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001059 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001059 2 / 1

6 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4128 MAOA, MAO-A monoamine oxidase A (EC:1.4.3.4) C00001435
6530 SLC6A2, NAT1, NET, NET1, SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 2 C00001435
6531 SLC6A3, DAT, DAT1, PKDYS solute carrier family 6 (neurotransmitter transporter), member 3 C00001435
6532 SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT solute carrier family 6 (neurotransmitter transporter), member 4 C00001435
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00001435
134864 TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1 trace amine associated receptor 1 C00001435

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (34)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P14416
#300615 Brunner syndrome P21397
#114500 Colorectal cancer; crc Q14191
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (27)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

9 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009202 Cardiomyopathies C00001435
D002543 Cerebral Hemorrhage C00001435
D002637 Chest Pain C00001435
D006973 Hypertension C00001435
D007022 Hypotension C00001435
D008881 Migraine Disorders C00001435
D015878 Mydriasis C00001435
D011041 Poisoning C00001435
D013610 Tachycardia C00001435