KCF-S cluster No. 22 (122 metabolites)

Corresponding Phytochemical cluster No. 15

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (122)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	319
asterids	95
Liliopsida	53
eudicotyledons	42
Euphyllophyta	10
Magnoliophyta	6
Spermatophyta	5
Embryophyta	3

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Cumulative family count (Top 20)

class name	count
Fabaceae	246
Gentianaceae	29
Lamiaceae	21
Asteraceae	19
Caryophyllaceae	19
Poaceae	16
Iridaceae	11
Ranunculaceae	10
Passifloraceae	10
Acanthaceae	10
Arecaceae	9
Polygonaceae	8
Ulmaceae	6
Hypericaceae	6
Rosaceae	6
Polygalaceae	6
Caprifoliaceae	6
Commelinaceae	5
Geraniaceae	5
Euphorbiaceae	5

KEGG BRITE br08003

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Categories (3)

br08003 Category	# of metabolite
Flavones	6
Xanthenes	3
Isoflavones	1

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metabolites link (10)

br08003 Category	KEGG ID	KNApSAcK ID
Flavones	C01821	C00001055
Flavones	C05990	C00001058
Flavones	C01714	C00001059
Flavones	C10114	C00001078
Flavones	C10187	C00001102
Flavones	C01460	C00001110
Xanthenes	C10067	C00002955
Xanthenes	C10075	C00002960
Xanthenes	C10077	C00002962
Isoflavones	C10420	C00006118

Metabolite list (122)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001039	8-C-Glucosylfisetin / Fisetin 8-C-glucoside
C00001055	Isoorientin / Homoorientin / Lespecapitioside / Luteolin 6-C-beta-D-glucopyranoside / 2-(3,4-Dihydroxyphenyl)-6-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one	CHEMBL239559 CHEMBL1302308	C057912	23 / 14 / 17	0 / 1
C00001058	Isoscoparin / Isoorientin 3'-methyl ether
C00001059	Isovitexin / Saponaretin / Homovitexin / 6-C-beta-D-Glucopyranosylapigenin / 6-beta-D-Glucopyranosyl-4',5,7-trihydroxyflavone / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one	CHEMBL465360 CHEMBL1601394	C049772	28 / 20 / 19
C00001078	Lutexin / Orientin / Luteolin 8-C-beta-D-glucopyranoside / 8-beta-D-Glucopyranosyl-3',4',5,7-tetrahydroxyflavone	CHEMBL520866 CHEMBL1468796	C065886	20 / 15 / 14
C00001102	Leucanthoside / Swertiajaponin / 6-beta-D-glucopyranosyl-3',4',5-trihydroxy-7-methoxyflavone
C00001110	Vitexin / Apigenin 8-C-glucoside / 8-D-Glucosyl-4',5,7-trihydroxyflavone / 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one	CHEMBL487417 CHEMBL1332209 CHEMBL1357921		16 / 4 / 8
C00002955	Irisxanthone
C00002960	Lancerin
C00002962	Aphloiol / Mangiferin / 2-beta-D-Glucopyranosyl-1,3,6,7-tetrahydroxy xanthone	CHEMBL1329826	C013592	27 / 17 / 17	39 / 41
C00006078	Cerarvensin / 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-beta-D-xylopyranosyl-4H-1-benzopyran-4-one
C00006079	Isomollupentin / 6-C-Arabinosylapigenin / 6-alpha-L-Arabinopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
C00006080	Mollupentin / Apigenin-8-C-alpha-L-arabinopyranoside / 8-alpha-L-Arabinopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
C00006081	6-C-Xylosylluteolin / 6-C-beta-D-Xylopyranosylluteolin / 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-beta-D-xylopyranosyl-4H-1-benzopyran-4-one
C00006082	8-C-alpha-L-Arabinosylluteolin
C00006083	Bayin / 8-beta-D-Glucopyranosyl-4',7-dihydroxyflavone
C00006084	Orientin 7-O-sulfate
C00006085	3'-Deoxyderhamnosylmaysin
C00006086	Isoorientin 7-O-sulfate
C00006087	Vitexin 7-O-sulfate
C00006088	Isovitexin 7-O-sulfate
C00006090	6-C-Glucopyranosylkaempferol / 6-beta-D-Glucopyranosyl-3,5,7,4'-tetrahydroxyflavone / 6-beta-D-Glucopyranosyl-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one	CHEMBL552215
C00006093	8-C-Glucosylorobol
C00006094	Puerarin / Kakonein	CHEMBL486386 CHEMBL1319403 CHEMBL1334785	C033607	8 / 7 / 7	56 / 12
C00006097	8-C-beta-D-Galactopyranosylapigenin	CHEMBL487417 CHEMBL1332209 CHEMBL1357921		16 / 4 / 8
C00006098	Isofurcatain / 6-C-alpha-L-Rhamnosylapigenin / 6-(6-Deoxy-alpha-L-mannopyranosyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
C00006099	6-C-beta-D-Galactosylapigenin	CHEMBL465360 CHEMBL1601394		28 / 20 / 19
C00006100	Torosaflavone A
C00006101	Isomolludistin / 6-alpha-L-Arabinopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
C00006102	Molludistin / 8-alpha-L-Arabinopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
C00006103	6-C-Galactosylisoscutellarein / 6-beta-D-Galactopyranosyl-5,7,8-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one		C035194
C00006104	6-C-Galactosylluteolin / 2-(3,4-Dihydroxyphenyl)-6-beta-D-galactopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one	CHEMBL239559 CHEMBL1302308		23 / 14 / 17
C00006105	6-C-Chinovopyranosylluteolin
C00006106	6-C-Fucopyranosylluteolin
C00006107	Isoaffinetin / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
C00006108	5,7,3',4',5'-Pentahydroxyflavone 8-C-glucopyranoside
C00006109	8-C-Glucosyl-5-deoxykaempferol / 8-beta-D-Glucopyranosyl-3,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
C00006111	6-C-Glucosylquercetin / 6-beta-D-Glucopyranosyl-3,5,7,3',4'-pentahydroxyflavone / 2-(3,4-dihydroxyphenyl)-6-beta-D-Glucopyranosyl-3,5,7-trihydroxy-4H-1-benzopyran-4-one	CHEMBL561741
C00006118	Genistein 8-C-glucoside	CHEMBL1945734 CHEMBL1975213
C00006119	6-C-Glucosylorobol
C00006121	8-C-beta-D-Glucopyranosyldiosmetin / 8-beta-D-Glucopyranosyl-5,7,3'-trihydroxy-4'-methoxyflavone / 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
C00006122	Isoswertiajaponin / 2-(3,4-Dihydroxyphenyl)-8-beta-D-glucopyranosyl-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one
C00006123	6-C-beta-D-Glucopyranosyldiosmetin / 6-beta-D-Glucopyranosyl-5,7,3'-trihydroxy-4'-methoxyflavone / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
C00006125	Swertisin / Flavocommelitin / 7-O-Methylapigenin 6-C-beta-D-glucopyranoside / 6-beta-D-Glucopyranosyl-4',5-dihydroxy-7-methoxyflavone / 6-beta-D-Glucopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one	CHEMBL174243 CHEMBL486415
C00006127	Isocytisoside / Acacetin-6-C-glucoside / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-4'-methoxyflavone / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one		C111464
C00006128	(-)-Isoscoparin
C00006129	Isoswertisin / 7-O-Methylvitexin / Isoflavocommelitin / 8-beta-D-Glucopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
C00006130	Trematin / Cytisoside / 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
C00006131	Keyakinin / 6-beta-D-Glucopyranosyl-3,4',5-trihydroxy-7-methoxyflavone / 6-beta-D-Glucopyranosyl-3,5-dihydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one	CHEMBL520545
C00006132	Dalpanitin
C00006133	8-C-Rhamnosylgenkwanin
C00006134	7,4'-Di-O-Methylisomollupentin
C00006135	Alternanthin / 6-(2,6-Dideoxy-beta-L-xylo-hexopyranosyl)-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one
C00006136	Torosaflavone B / 6-(2,6-Dideoxy-beta-D-lyxo-hexopyranosyl)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one	CHEMBL462245
C00006137	Keyakinin B
C00006138	8-C-Rhamnosyleuropetin / 8-(6-Deoxy-alpha-L-mannopyranosyl)-3,5-dihydroxy-7-methoxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
C00006139	Prunetin 8-C-glucoside
C00006140	Orientin 2''-acetate
C00006141	Orientin 7,3'-dimethyl ether
C00006142	7,3'-Di-O-methylisoorientin / Isoorientin 7,3'-dimethyl ether / 6-beta-D-Glucopyranosyl-5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
C00006143	Isoorientin 2''-acetate / 2''-O-Acetylisoorientin
C00006144	6-C-Glucopyranosylpilloin / Pilloin 6-C-beta-D-glucoside / 6-beta-D-Glucopyranosyl-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
C00006145	Orobol 8-C-(6''-acetylglucoside)
C00006146	Puerarin 6''-acetate
C00006147	7-Hydroxy-5,4'-dimethoxyflavone 8-C-rhamnoside / 8-(6-Deoxy-alpha-L-mannopyranosyl)-7-hydroxy-5-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
C00006148	Isoembigenin / 8-beta-D-Glucopyranosyl-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
C00006149	Precatorin I / Swertisin 8-methyl ether / 6-beta-D-Glucopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7,8-dimethoxy-4H-1-benzopyran-4-one
C00006150	Abrusin / 8-C-Glucosyl-6,7-di-O-methyl-scutellarein / 8-beta-D-Glucopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one
C00006151	Isopyrenin / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-1-benzopyran-4-one
C00006152	5,7,3'-Trihydroxy-3,4'-dimethoxyflavone 8-C-rhamnopyranoside
C00006155	Volubilinin
C00006156	Apigenin 8-C-(6''-acetylgalactoside)
C00006157	Orobol 6-C-(6''-acetylglucoside)
C00006158	Orientin 6''-acetate / 6''-O-Acetylorientin
C00006159	3',4',7-Tri-O-methylisoorientin / Isoorientin 7,3',4'-trimethyl ether / 2-(3,4-Dimethoxyphenyl)-6-beta-D-glucopyranosyl-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one
C00006160	Isoswertisin 2''-acetate
C00006161	Scoparin 6''-acetate
C00006162	Orientin 2'',6''-diacetate
C00006163	Isoorientin 2'',6''-diacetate / 2'',6''-Di-O-acetylisoorientin
C00006164	Puerarin 4',6''-diacetate
C00006165	Dalpaniculin
C00006344	8-C-Rhamnopyranosylluteolin
C00006354	Derhamnosylmaysin
C00006355	8-C-Galactosylluteolin / 2-(3,4-Dihydroxyphenyl)-8-beta-D-galactopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one	CHEMBL520866 CHEMBL1468796		20 / 15 / 14
C00006360	Pueraria glycoside 1		C075169
C00006361	Neovitexin	CHEMBL487417 CHEMBL1332209 CHEMBL1357921		16 / 4 / 8
C00006363	Puerarin 4'-methyl ether		C073003
C00006364	Scoparin / Scoparoside / Chrysoeriol 8-C-glucoside / 8-C-beta-D-Glucopyranosylchrysoeriol / 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one
C00006365	3'-O-Methylderhamnosylmaysin
C00006366	Episcoparin
C00006367	Pueraria glycoside 3
C00006369	Vitexin 2''-acetate
C00006370	Embigenin / 6-beta-D-Glucopyranosyl-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one	CHEMBL486416
C00006371	5,7-Dihydroxy-8,3',4',5'-tetramethoxyflavone 6-C-glucoside
C00006415	Aciculatin	CHEMBL2011649	C074400
C00006416	Hoslunddiol
C00014011	Chrysin 8-C-glucopyranoside / Chrysin 8-C-beta-D-glucopyranoside / 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one
C00014012	Chrysin 6-C-glucopyranoside / Chrysin 6-C-beta-D-glucopyranoside / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one
C00014013	Kaplanin / 8-beta-D-Glucopyranosyl-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one
C00014016	6-C-alpha-L-Arabinosylluteolin / Luteolin 6-C-alpha-L-arabinopyranoside / 6-alpha-L-Arabinopyranosyl-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
C00014017	Parkinsonin A / 8-D-Glucopyranosyl-7,3',4'-trihydroxy-5-methoxyflavone / 2-(3,4-Dihydroxyphenyl)-8-beta-D-glucopyranosyl-7-hydroxy-5-methoxy-4H-1-benzopyran-4-one
C00014018	Parkinsonin B / 2-(3,4-dihydroxyphenyl)-8-alpha-D-Glucopyranosyl-5,7-dimethoxy-4H-1-benzopyran-4-one
C00014019	6-C-beta-D-Glucopyranosyl-5,7,2',4',5'-pentahydroxyflavone / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(2,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
C00014020	Telephioidin / 6-C-beta-D-glucopyranosyl-5,7,2',3',5',6'-hexahydroxyflavone
C00014021	8-C-beta-D-Glucopyranosylkaempferol / 8-beta-D-Glucopyranosyl-3,5,7,4'-tetrahydroxyflavone / 8-beta-D-Glucopyranosyl-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
C00014079	2'',6''-Di-O-Acetyl isovitexin
C00014085	Isovitexin 6''-O-acetyl
C00014087	Vitexin 2''-O-(2'''-methylbutyryl)
C00014089	Vitexin 3''-O-acetate
C00014090	Psilosin / Vitexin 6''-O-acetate
C00014093	8-C-beta-D-Glucofuranosylapigenin 2''-O-acetate
C00014094	Isoswertisin 2''-O-(2'''-methylbutyrate)
C00014095	Isoswertisin 3''-O-(2'''-methylbutyrate)
C00014099	Isoorientin 6''-O-acetate
C00014105	Orientin 2''-O-(2'''-methylbutyrate)
C00019301	4'-O-Methylgenistein 8-C-glucoside / 5,7-Dihydroxy-4'-methoxyisoflavone 8-C-glucoside
C00019385	Puerarin 6''-O-malonate / 7,4'-Dihydroxyisoflavone 7-C-(6''-malonylglucoside)
C00019386	Genistein 8-C-glucoside 6''-O-malonate / 5,7,4'-Trihydroxyisoflavone 8-C-(6''-malonylglucoside)
C00019447	5,7,2',4'-Tetrahydroxyisoflavone 8-C-glucoside
C00032065	Neolancerin
C00041015	Isomangiferin		C061492
C00042175	7-O-Methylmangiferin

Human Protein / Gene in interactions

53 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q9UNA4	DNA polymerase iota	Enzyme	C00001055 C00001059 C00001078 C00001110 C00002962 C00006094 C00006097 C00006099 C00006104 C00006355 C00006361	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001055 C00001059 C00001078 C00001110 C00002962 C00006097 C00006099 C00006104 C00006355 C00006361	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00001055 C00001059 C00001078 C00001110 C00002962 C00006097 C00006099 C00006104 C00006355 C00006361	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00001055 C00001059 C00001078 C00001110 C00002962 C00006097 C00006099 C00006104 C00006355 C00006361	1 / 1
Q9UBT6	DNA polymerase kappa	Enzyme	C00001055 C00001059 C00001078 C00001110 C00002962 C00006097 C00006099 C00006104 C00006355 C00006361	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00001055 C00001059 C00001078 C00001110 C00002962 C00006097 C00006099 C00006104 C00006355 C00006361	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00001055 C00001059 C00001110 C00002962 C00006097 C00006099 C00006104 C00006361	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00001055 C00001059 C00001110 C00002962 C00006097 C00006099 C00006104 C00006361	1 / 4
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001055 C00001059 C00001078 C00002962 C00006094 C00006099 C00006104 C00006355	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00001055 C00001059 C00001110 C00002962 C00006097 C00006099 C00006104 C00006361	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00001055 C00001059 C00001078 C00006094 C00006099 C00006104 C00006355	1 / 1
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00001055 C00001059 C00001078 C00002962 C00006099 C00006104 C00006355	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00001055 C00001059 C00001078 C00002962 C00006099 C00006104 C00006355	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00001059 C00001078 C00002962 C00006094 C00006099 C00006355	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001055 C00001059 C00001078 C00006099 C00006104 C00006355	1 / 2
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00001055 C00001059 C00001078 C00006099 C00006104 C00006355	1 / 1
P06746	DNA polymerase beta	Enzyme	C00001055 C00001059 C00001078 C00006099 C00006104 C00006355	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00001055 C00001059 C00001078 C00006099 C00006104 C00006355	1 / 0
O00255	Menin	Unclassified protein	C00001055 C00001059 C00001078 C00006099 C00006104 C00006355	2 / 5
O75496	Geminin	Unclassified protein	C00001110 C00002962 C00006094 C00006097 C00006361	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00001055 C00001059 C00006099 C00006104	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001055 C00001059 C00006099 C00006104	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00001055 C00001078 C00006104 C00006355	4 / 3
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00001055 C00001059 C00006099 C00006104	2 / 1
P15121	Aldose reductase	Enzyme	C00001110 C00006097 C00006361	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001078 C00002962 C00006355	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001110 C00006097 C00006361	1 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001110 C00006097 C00006361	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001110 C00006097 C00006361	0 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001110 C00006097 C00006361	0 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001110 C00006097 C00006361	1 / 0
P30989	Neurotensin receptor type 1	Neurotensin receptor	C00001059 C00006099	0 / 0
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00001055 C00006104	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00001078 C00006355	1 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002962 C00006094	3 / 3
P10828	Thyroid hormone receptor beta	NR1A2	C00001078 C00006355	3 / 1
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00001059 C00006099	2 / 2
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00001059 C00006099	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00001059 C00006099	1 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00001059 C00006099	7 / 3
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00001059 C00006099	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002962 C00006094	2 / 2
P09923	Intestinal-type alkaline phosphatase	Enzyme	C00002962	0 / 0
P05186	Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	C00002962	3 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00002962	0 / 0
P10696	Alkaline phosphatase, placental-like	Enzyme	C00002962	0 / 1
Q9Y5X4	Photoreceptor-specific nuclear receptor	NR2E3	C00002962	2 / 2
P29466	Caspase-1	C14	C00002962	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00002962	5 / 3
Q9Y618	Nuclear receptor corepressor 2	Unclassified protein	C00002962	0 / 0
P03372	Estrogen receptor	NR3A1	C00006094	1 / 1
P55210	Caspase-7	C14	C00002962	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002962	0 / 0

86 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00002962 C00006094
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00002962 C00006094
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00002962 C00006094
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002962 C00006094
7015	TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT	telomerase reverse transcriptase (EC:2.7.7.49)	C00002962 C00006094
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00002962 C00006094
6716	SRD5A2	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22)	C00002962 C00006094
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002962 C00006094
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00002962 C00006094
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00006094
7852	CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM	chemokine (C-X-C motif) receptor 4	C00002962
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002962
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00002962
1548	CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB	cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1)	C00002962
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00002962
1565	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1	cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)	C00002962
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00002962
355	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6	Fas cell surface death receptor	C00002962
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00002962
3551	IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)	C00002962
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00002962
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002962
4023	LPL, HDLCQ11, LIPD	lipoprotein lipase (EC:3.1.1.34)	C00002962
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00002962
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00002962
4793	NFKBIB, IKBB, TRIP9	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	C00002962
4803	NGF, Beta-NGF, HSAN5, NGFB	nerve growth factor (beta polypeptide)	C00002962
5320	PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2	phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4)	C00002962
5465	PPARA, NR1C1, PPAR, PPARalpha, hPPAR	peroxisome proliferator-activated receptor alpha	C00002962
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002962
891	CCNB1, CCNB	cyclin B1	C00002962
847	CAT	catalase (EC:1.11.1.6)	C00002962
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00002962
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00002962
213	ALB, PRO0883, PRO0903, PRO1341	albumin	C00002962
25	ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl	c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2)	C00002962
7364	UGT2B7, UDPGT_2B9, UDPGT2B7, UDPGTH2, UGT2B9	UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17)	C00002962
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00002962
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00002962
47	ACLY, ACL, ATPCL, CLATP	ATP citrate lyase (EC:2.3.3.8)	C00006094
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00006094
358	AQP1, AQP-CHIP, CHIP28, CO	aquaporin 1	C00006094
360	AQP3, AQP-3, GIL	aquaporin 3 (Gill blood group)	C00006094
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00006094
581	BAX, BCL2L4	BCL2-associated X protein	C00006094
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00006094
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00006094
999	CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO	cadherin 1, type 1, E-cadherin (epithelial)	C00006094
4512	COX1, COI, MTCO1, MT-CO1	cytochrome c oxidase subunit I	C00006094
114757	CYGB, HGB, STAP	cytoglobin	C00006094
1830	DSG3, CDHF6, PVA	desmoglein 3	C00006094
1950	EGF, HOMG4, URG	epidermal growth factor	C00006094
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00006094
356	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6	Fas ligand (TNF superfamily, member 6)	C00006094
2200	FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2	fibrillin 1	C00006094
2201	FBN2, CCA, DA9	fibrillin 2	C00006094
2246	FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1	fibroblast growth factor 1 (acidic)	C00006094
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00006094
3036	HAS1, HAS	hyaluronan synthase 1 (EC:2.4.1.212)	C00006094
3315	HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27	heat shock 27kDa protein 1	C00006094
3479	IGF1, IGF-I, IGF1A, IGFI	insulin-like growth factor 1 (somatomedin C)	C00006094
3552	IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1	interleukin 1, alpha	C00006094
9365	KL	klotho (EC:3.2.1.31)	C00006094
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00006094
1147	CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16	conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)	C00002962
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00006094
5601	MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK	mitogen-activated protein kinase 9 (EC:2.7.11.24)	C00006094
4157	MC1R, CMM5, MSH-R, SHEP2	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	C00006094
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00006094
4843	NOS2, HEP-NOS, INOS, NOS, NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	C00006094
4846	NOS3, ECNOS, eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	C00006094
5241	PGR, NR3C3, PR	progesterone receptor	C00006094
8985	PLOD3, LH3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4)	C00006094
5371	PML, MYL, PP8675, RNF71, TRIM19	promyelocytic leukemia	C00006094
5468	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma	peroxisome proliferator-activated receptor gamma	C00006094
5731	PTGER1, EP1	prostaglandin E receptor 1 (subtype EP1), 42kDa	C00006094
5914	RARA, NR1B1, RAR	retinoic acid receptor, alpha	C00006094
6649	SOD3, EC-SOD	superoxide dismutase 3, extracellular (EC:1.15.1.1)	C00006094
7178	TPT1, HRF, TCTP, p02, p23	tumor protein, translationally-controlled 1	C00006094
7295	TXN, TRDX, TRX, TRX1	thioredoxin	C00006094
7306	TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN	tyrosinase-related protein 1 (EC:1.14.18.-)	C00006094
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00006094
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00006094
54578	UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F	UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17)	C00006094
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00006094
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00006094

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Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions