PCIDB

KNApSAcK Metabolite C00001078

Metabolite

KNApSAcK Entry

id C00001078
Name Lutexin / Orientin / Luteolin 8-C-beta-D-glucopyranoside / 8-beta-D-Glucopyranosyl-3',4',5,7-tetrahydroxyflavone
CAS RN 28608-75-5
Standard InChI InChI=1S/C21H20O11/c22-6-14-17(28)18(29)19(30)21(32-14)16-11(26)4-10(25)15-12(27)5-13(31-20(15)16)7-1-2-8(23)9(24)3-7/h1-5,14,17-19,21-26,28-30H,6H2/t14?,17-,18+,19?,21+/m1/s1
Standard InChI (Main Layer) InChI=1S/C21H20O11/c22-6-14-17(28)18(29)19(30)21(32-14)16-11(26)4-10(25)15-12(27)5-13(31-20(15)16)7-1-2-8(23)9(24)3-7/h1-5,14,17-19,21-26,28-30H,6H2

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 22

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL520866 CHEMBL1468796

KEGG

By LinkDB C10114

CTD

By CAS RN C065886

Species

Summary

Plant class

class name count
rosids 7
asterids 7
Liliopsida 4
eudicotyledons 4
Magnoliophyta 1
Spermatophyta 1
Euphyllophyta 1

Family (Top 10)

family name count
Lamiaceae 3
Fabaceae 3
Asteraceae 3
Poaceae 2
Caryophyllaceae 2
Commelinaceae 1
Euphorbiaceae 1
Geraniaceae 1
Ranunculaceae 1
Acanthaceae 1

List (25)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Ascarina lucida 130721 Chloranthaceae Magnoliophyta Viridiplantae
Centaurea gigantea 41503 Asteraceae asterids Viridiplantae
Centaurea melitensis L. 41503 Asteraceae asterids Viridiplantae
Centaurea solstitialis 347529 Asteraceae asterids Viridiplantae
Clinacanthus nutans 714457 Acanthaceae asterids Viridiplantae
Commelina communis L 4743 Commelinaceae Liliopsida Viridiplantae
Cucumis sativus 3659 Cucurbitaceae rosids Viridiplantae
Cyathea spp. 13470 Cyatheaceae Euphyllophyta Viridiplantae
Cyperus alopecuroides 1234173 Cyperaceae Liliopsida Viridiplantae
Euphorbia supina Rafin 3977 Euphorbiaceae rosids Viridiplantae
Gleditsia sinensis Lam. 66096 Fabaceae rosids Viridiplantae
Hordeum vulgare 4513 Poaceae Liliopsida Viridiplantae
Isodon rubescens var. lushanensis 204130 Lamiaceae asterids Viridiplantae
Lespedeza hedysaroides 53892 Fabaceae rosids Viridiplantae
Lychnis flos-cuculi L. 42036 Caryophyllaceae eudicotyledons Viridiplantae
Passiflora serratodigitata 231192 Passifloraceae rosids Viridiplantae
Pelargonium reniforme 59871 Geraniaceae rosids Viridiplantae
Pennisetum americanum 4543 Poaceae Liliopsida Viridiplantae
Podocarpus fasciculus 120615 Podocarpaceae Spermatophyta Viridiplantae
Polygonum orientale 467334 Polygonaceae eudicotyledons Viridiplantae
Retama raetam 49837 Fabaceae rosids Viridiplantae
Silene spp. 3573 Caryophyllaceae eudicotyledons Viridiplantae
Trollius ledebouri 46346 Ranunculaceae eudicotyledons Viridiplantae
Vitex cannabifolia Sieb.et.Zucc. 54476 Lamiaceae asterids Viridiplantae
Vitex polygama 54476 Lamiaceae asterids Viridiplantae

Human Protein / Gene in interaction

20 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL1468796 CHEMBL1738312 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL1468796 CHEMBL2114784 (1)
1 / 1
P06746 DNA polymerase beta Enzyme CHEMBL1468796 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL1468796 CHEMBL1614076 (1) CHEMBL1614103 (1)
CHEMBL1614031 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL1468796 CHEMBL1794585 (1)
0 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL1468796 CHEMBL1613776 (1)
3 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL1468796 CHEMBL1614166 (1)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL1468796 CHEMBL1614458 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL1468796 CHEMBL1794569 (1)
1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL1468796 CHEMBL1614280 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1468796 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL1468796 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1468796 CHEMBL1614466 (1) CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1468796 CHEMBL1614421 (1)
4 / 3
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1468796 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1468796 CHEMBL1613914 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1468796 CHEMBL1738442 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL1468796 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL1468796 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1468796 CHEMBL1614257 (1)
1 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (15)

OMIM preferred title UniProt
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (14)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)