PCIDB

Silene spp.

Family in NCBI taxonomy	Caryophyllaceae
ID	3568

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class	eudicotyledons
ID	71240

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	KCF-S cluster	phytochemical cluster
C00006392	Flavosativaside / Vitexin 2''-O-glucoside				No. 1	No. 15
C00006376	Vitexin 2''-O-xyloside				No. 1	No. 15
C00006173	Isovitexin 7-O-xyloside				No. 1	No. 15
C00006221	Isovitexin 2''-O-rhamnoside				No. 1	No. 15
C00001078	Lutexin / Orientin / Luteolin 8-C-beta-D-glucopyranoside / 8-beta-D-Glucopyranosyl-3',4',5,7-tetrahydroxyflavone	CHEMBL520866 CHEMBL1468796	C065886	20 / 15 / 14	No. 22	No. 15
C00001058	Isoscoparin / Isoorientin 3'-methyl ether				No. 22	No. 15

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00001078	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00001078	1 / 1
P06746	DNA polymerase beta	Enzyme	C00001078	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00001078	1 / 1
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00001078	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00001078	3 / 1
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00001078	1 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00001078	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00001078	1 / 1
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00001078	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00001078	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00001078	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001078	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00001078	4 / 3
Q9UBT6	DNA polymerase kappa	Enzyme	C00001078	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001078	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001078	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00001078	1 / 1
O00255	Menin	Unclassified protein	C00001078	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001078	1 / 2

OMIM	preferred title	UniProt
#600274	Frontotemporal dementia; ftd	P10636
#232300	Glycogen storage disease ii	P10253
#605130	Hairy elbows, short stature, facial dysmorphism, and developmental delay	Q03164
#145000	Hyperparathyroidism 1; hrpt1	O00255
#131100	Multiple endocrine neoplasia, type i; men1	O00255
#160900	Myotonic dystrophy 1; dm1	Q9NR56
#260540	Parkinson-dementia syndrome	P10636
#172700	Pick disease of brain	P10636
#183090	Spinocerebellar ataxia 2; sca2	Q99700
#607250	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1	Q9NUW8
#601104	Supranuclear palsy, progressive, 1; psnp1	P10636
#188570	Thyroid hormone resistance, generalized, autosomal dominant; grth	P10828
#274300	Thyroid hormone resistance, generalized, autosomal recessive; grth	P10828
#145650	Thyroid hormone resistance, selective pituitary; prth	P10828
#278750	Xeroderma pigmentosum, variant type; xpv	Q9Y253

KEGG	name	UniProt
H00033	Adrenal carcinoma	O00255 (related)
H00034	Carcinoid	O00255 (related)
H00045	Malignant islet cell carcinoma	O00255 (related)
H00246	Primary hyperparathyroidism	O00255 (related)
H01102	Pituitary adenomas	O00255 (related)
H00069	Glycogen storage diseases (GSD)	P10253 (related)
H00058	Amyotrophic lateral sclerosis (ALS)	P10636 (related)
H00077	Progressive supranuclear palsy (PSP)	P10636 (related)
H00078	Frontotemporal lobar degeneration (FTLD)	P10636 (related)
H00249	Thyroid hormone resistance syndrome	P10828 (related)
H00001	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	Q03164 (related) Q03164 (marker)
H00002	Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)	Q03164 (related)
H00063	Spinocerebellar ataxia (SCA)	Q99700 (related) Q9NUW8 (related)
H00403	Disorders of nucleotide excision repair	Q9Y253 (related)