Vitex cannabifolia Sieb.et.Zucc.
Species
KNApSAcK Entry
| Organism name | Vitex cannabifolia Sieb.et.Zucc. |
|---|---|
| Genus | Vitex |
| Family | Labiatae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Vitex |
|---|---|
| Linked NCBI taxonomy ID | 54476 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Lamiaceae |
|---|---|
| ID | 4136 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (10)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001078
|
Lutexin
/ Orientin / Luteolin 8-C-beta-D-glucopyranoside / 8-beta-D-Glucopyranosyl-3',4',5,7-tetrahydroxyflavone |
CHEMBL520866
CHEMBL1468796 |
C065886
|
20 / 15 / 14 | No. 22 | No. 15 |
|
|
|
C00001055
|
Isoorientin
/ Homoorientin / Lespecapitioside / Luteolin 6-C-beta-D-glucopyranoside / 2-(3,4-Dihydroxyphenyl)-6-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one |
CHEMBL239559
CHEMBL1302308 |
C057912
|
23 / 14 / 17 | 0 / 1 | No. 22 | No. 15 |
|
|
C00000320
|
Geniposide
|
CHEMBL462894
CHEMBL1417490 CHEMBL1718933 |
C007835
|
3 / 2 / 3 | 3 / 0 | No. 100 | No. 36 |
|
|
C00032499
|
Vitecannaside B
|
No. 174 | No. 22 |
|
||||
|
C00032498
|
Vitecannaside A
|
No. 174 | No. 22 |
|
||||
|
C00030122
|
Detetrahydroconidendrin
|
CHEMBL486411
|
No. 561 |
|
||||
|
C00032502
|
Vitrofolal F
|
CHEMBL486413
|
No. 561 |
|
||||
|
C00032501
|
Vitrofolal E
|
CHEMBL486412
|
No. 561 |
|
||||
|
C00003068
|
Agnuside
/ Buddlejoside A |
CHEMBL391454
CHEMBL483223 |
1 / 0 / 0 | No. 1380 | No. 36 |
|
||
|
C00029374
|
10-O-vanillate
/ (-)-Pedunculariside / 10-o-Vanilloyl aucubin |
No. 1380 | No. 36 |
|
Human Protein / Gene in interactions
30 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00001055 C00001078 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001055 C00001078 | 1 / 2 |
| O00255 | Menin | Unclassified protein | C00001055 C00001078 | 2 / 5 |
| P06746 | DNA polymerase beta | Enzyme | C00001055 C00001078 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00001055 C00001078 | 1 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001055 C00001078 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001055 C00001078 | 1 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001055 C00001078 | 1 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001055 C00001078 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001055 C00001078 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001055 C00001078 | 4 / 3 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001055 C00001078 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001055 C00001078 | 1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001055 C00001078 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000320 C00001055 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001055 C00001078 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001055 C00001078 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000320 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001055 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001078 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000320 | 2 / 3 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001078 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001078 | 3 / 1 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00003068 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001078 | 1 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001055 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001055 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001055 | 0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00001055 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00001055 | 2 / 1 |
3 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00000320
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000320
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000320
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (20)
| OMIM | preferred title | UniProt |
|---|---|---|
| #114500 | Colorectal cancer; crc |
Q14191
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (21)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|