PCIDB

KNApSAcK Metabolite C00000320

Metabolite

KNApSAcK Entry

id C00000320
Name Geniposide
CAS RN 24512-63-8
Standard InChI InChI=1S/C17H24O10/c1-24-15(23)9-6-25-16(11-7(4-18)2-3-8(9)11)27-17-14(22)13(21)12(20)10(5-19)26-17/h2,6,8,10-14,16-22H,3-5H2,1H3/t8?,10?,11?,12-,13+,14?,16?,17+/m1/s1
Standard InChI (Main Layer) InChI=1S/C17H24O10/c1-24-15(23)9-6-25-16(11-7(4-18)2-3-8(9)11)27-17-14(22)13(21)12(20)10(5-19)26-17/h2,6,8,10-14,16-22H,3-5H2,1H3

Cluster

Phytochemical cluster No. 36
KCF-S cluster No. 100

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL462894 CHEMBL1417490 CHEMBL1718933

KEGG

By LinkDB C09781

CTD

By CAS RN C007835

Human Protein / Gene in interaction

3 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P11473 Vitamin D3 receptor NR1I1 CHEMBL1718933 CHEMBL1794311 (1)
2 / 3
O75496 Geminin Unclassified protein CHEMBL1718933 CHEMBL2114780 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1718933 CHEMBL1738588 (1)
0 / 0

CTD interaction (6)

compound gene gene name gene description interaction interaction type form reference
pmid
C007835 581 BAX
BCL2L4
BCL2-associated X protein geniposide metabolite results in increased expression of BAX mRNA increases expression
mRNA 22245672
C007835 581 BAX
BCL2L4
BCL2-associated X protein geniposide metabolite results in increased expression of BAX protein increases expression
protein 22245672
C007835 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 geniposide metabolite results in decreased expression of BCL2 mRNA decreases expression
mRNA 22245672
C007835 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 geniposide metabolite results in decreased expression of BCL2 protein decreases expression
protein 22245672
C007835 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) geniposide metabolite results in increased activity of CASP3 protein increases activity
protein 22245672
C007835 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) geniposide metabolite results in increased expression of CASP3 protein increases expression
protein 22245672

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (3)

KEGG disease name UniProt
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)