Species

KNApSAcK Entry

Organism name Lippia alba
Genus Lippia
Family Verbenaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Lippia alba
Linked NCBI taxonomy ID 320345
Linked level species

Family

Family in NCBI taxonomy Verbenaceae
ID 21910

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (33)

Species Activity
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Analgesic
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Antemetic
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Antimutagenic
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Antioxidant
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Antiradicular
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Antiseptic
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Antispasmodic
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Antiulcer
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Antiviral
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Astringent
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Bactericide
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Candidicide
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Carminative
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Cicatrizant
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Cytotoxic
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Decongestant
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Digestive
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Emmenagogue
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Expectorant
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Febrifuge
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Fungicide
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Hypotensive
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Insecticide
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Myorelaxant
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Nervine
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Oxytocic
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Pectoral
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Sedative
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Sialagogue
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Stomachic
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Sudorific
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Tranquilizer
Lippia alba (Mill.) N.E. Br. Ex Britton & P. Wilson Vulnerary

Metabolite list (18)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00035270 External link 512 Clerodendrin
C060994
No. 1 No. 15
C00004268 External link 512 Luteolin 7-glucuronide
/ Luteolin 7-O-glucuronide
/ Luteolin 7-O-beta-D-glucuronide
CHEMBL464224
C075406
No. 2 No. 15
C00004144 External link 512 Apigenin 7-glucuronide
/ Apigenin 7-O-beta-D-glucuronide
/ (-)-Apigenin 7-O-beta-D-glucuronide
CHEMBL254213
CHEMBL1980748
No. 2 No. 15
C00033687 External link 512 Calceolarioside E
No. 33
C00002783 External link 512 Kusaginin
/ Acteoside
/ Verbascoside
CHEMBL231853
CHEMBL444478
CHEMBL1364101
C058956
12 / 1 / 1 34 / 3 No. 33
C00033958 External link 512 Isonuomioside A
No. 33
C00030516 External link 512 Isoacteoside
/ Isoverbascoside
CHEMBL504873
C064683
6 / 5 / 4 No. 33
C00030317 External link 512 Forsythoside B
CHEMBL393292
1 / 0 / 3 No. 33
C00010687 External link 512 Shanzhiside methyl ester
CHEMBL1081414
1 / 1 / 1 No. 56 No. 36
C00010595 External link 512 Caryoptoside
No. 56 No. 36
C00010630 External link 512 Mussaenoside
CHEMBL2355776
1 / 1 / 1 No. 56 No. 36
C00010719 External link 512 Theveside
No. 100 No. 36
C00000320 External link 512 Geniposide
CHEMBL462894
CHEMBL1417490
CHEMBL1718933
C007835
3 / 2 / 3 3 / 0 No. 100 No. 36
C00010564 External link 512 Geniposidic acid
CHEMBL460031
C058966
No. 100 No. 36
C00030098 External link 512 Verbasoside
/ (-)-Verbasoside
/ Decaffeoylverbascoside
/ (-)-Decaffeoylverbascoside
CHEMBL1779146
No. 128 No. 72
C00010947 External link 512 (1S,4R)-(+)-Isodihydrocarvone
No. 2206 No. 35
C00003054 External link 512 (+)-Piperitone
No. 4185 No. 35
C00035259 External link 512 Cistanoside F
No. 6662

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00000320 C00002783 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002783 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00030317 0 / 3
P17252 Protein kinase C alpha type Alpha C00002783 0 / 0
P39900 Macrophage metalloelastase M10A C00030516 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00030516 2 / 2
P60033 CD81 antigen Unclassified protein C00010687 1 / 1
P11473 Vitamin D3 receptor NR1I1 C00000320 2 / 3
P39748 Flap endonuclease 1 Enzyme C00002783 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002783 0 / 0
P03956 Interstitial collagenase M10A C00030516 0 / 1
Q99700 Ataxin-2 Unclassified protein C00002783 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00002783 0 / 0
P45452 Collagenase 3 M10A C00030516 1 / 1
P08253 72 kDa type IV collagenase M10A C00030516 1 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000320 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002783 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002783 0 / 0
P08254 Stromelysin-1 M10A C00030516 1 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002783 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002783 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002783 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00010630 1 / 1

37 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00000320
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000320
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000320
196 AHR, bHLHe76 aryl hydrocarbon receptor C00002783
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00002783
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002783
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002783
894 CCND2, KIAK0002 cyclin D2 C00002783
896 CCND3 cyclin D3 C00002783
898 CCNE1, CCNE cyclin E1 C00002783
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00002783
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00002783
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00002783
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002783
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00002783
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00002783
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002783
1869 E2F1, E2F-1, RBAP1, RBBP3, RBP3 E2F transcription factor 1 C00002783
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00002783
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00002783
3458 IFNG, IFG, IFI interferon, gamma C00002783
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00002783
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002783
3689 ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) C00002783
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002783
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002783
27035 NOX1, GP91-2, MOX1, NOH-1, NOH1 NADPH oxidase 1 C00002783
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002783
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00002783
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002783
4087 SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 SMAD family member 2 C00002783
4088 SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 SMAD family member 3 C00002783
6648 SOD2, IPOB, MNSOD, MVCD6 superoxide dismutase 2, mitochondrial (EC:1.15.1.1) C00002783
7039 TGFA, TFGA transforming growth factor, alpha C00002783
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00002783
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00002783
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00002783

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#613496 Immunodeficiency, common variable, 6; cvid6 P60033
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (12)

KEGG name UniProt
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00017 Esophageal cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00088 Common variable immunodeficiency (CVID) P60033 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

3 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D007249 Inflammation C00002783
D007938 Leukemia C00002783
D014947 Wounds and Injuries C00002783