PCIDB

Vitex polygama

Species

KNApSAcK Entry

Organism name Vitex polygama
Genus Vitex
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Vitex
Linked NCBI taxonomy ID 54476
Linked level genus

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00005374 External link 512 Quercetin
CHEMBL82242
CHEMBL479232
CHEMBL1437696
C012526
14 / 2 / 2 2 / 1 No. 2 No. 15
C00004632 External link 512 Quercetin 3-methyl ether
/ Quercetin 3-O-methyl ether
CHEMBL163316
32 / 21 / 21 No. 3 No. 15
C00001078 External link 512 Lutexin
/ Orientin
/ Luteolin 8-C-beta-D-glucopyranoside
/ 8-beta-D-Glucopyranosyl-3',4',5,7-tetrahydroxyflavone
CHEMBL520866
CHEMBL1468796
C065886
20 / 15 / 14 No. 22 No. 15
C00001059 External link 512 Isovitexin
/ Saponaretin
/ Homovitexin
/ 6-C-beta-D-Glucopyranosylapigenin
/ 6-beta-D-Glucopyranosyl-4',5,7-trihydroxyflavone
/ 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL465360
CHEMBL1601394
C049772
28 / 20 / 19 No. 22 No. 15
C00001055 External link 512 Isoorientin
/ Homoorientin
/ Lespecapitioside
/ Luteolin 6-C-beta-D-glucopyranoside
/ 2-(3,4-Dihydroxyphenyl)-6-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one
CHEMBL239559
CHEMBL1302308
C057912
23 / 14 / 17 0 / 1 No. 22 No. 15
C00001110 External link 512 Vitexin
/ Apigenin 8-C-glucoside
/ 8-D-Glucosyl-4',5,7-trihydroxyflavone
/ 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL487417
CHEMBL1332209
CHEMBL1357921
16 / 4 / 8 No. 22 No. 15
C00014103 External link 512 Orientin 2''-O-caffeate
No. 30 No. 15
C00000856 External link 512 4-Hydroxybenzoic acid
/ p-Hydroxybenzoic acid
CHEMBL441343
C038193
21 / 7 / 16 2 / 1 No. 817 No. 81

Human Protein / Gene in interactions

73 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UBT6 DNA polymerase kappa Enzyme C00001055 C00001059 C00001078 C00001110 C00004632 C00005374 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00001055 C00001059 C00001078 C00001110 C00004632 C00005374 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001055 C00001059 C00001078 C00001110 C00004632 C00005374 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001055 C00001059 C00001078 C00001110 C00004632 C00005374 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001055 C00001059 C00001078 C00001110 C00005374 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001055 C00001059 C00001078 C00004632 C00005374 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001055 C00001059 C00001110 C00004632 C00005374 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001055 C00001059 C00001078 C00004632 C00005374 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00001055 C00001059 C00001078 C00004632 1 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001055 C00001059 C00001078 C00004632 1 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001055 C00001059 C00001078 C00001110 0 / 0
O00255 Menin Unclassified protein C00001055 C00001059 C00001078 C00004632 2 / 5
P06746 DNA polymerase beta Enzyme C00001055 C00001059 C00001078 C00004632 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001055 C00001059 C00001078 C00004632 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001055 C00001059 C00001078 C00004632 1 / 0
P39748 Flap endonuclease 1 Enzyme C00001055 C00001059 C00004632 C00005374 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001055 C00001059 C00004632 2 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00001055 C00001078 C00004632 4 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00001059 C00001078 C00005374 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001055 C00001059 C00001078 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00001055 C00001059 C00001110 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001055 C00001059 C00001110 1 / 4
P15121 Aldose reductase Enzyme C00001110 C00004632 C00005374 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001055 C00001059 C00004632 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00001055 C00004632 0 / 0
Q99700 Ataxin-2 Unclassified protein C00001078 C00004632 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001059 C00004632 0 / 0
O75496 Geminin Unclassified protein C00001110 C00004632 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001059 C00004632 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001059 7 / 3
P42858 Huntingtin Unclassified protein C00004632 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00004632 2 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001059 2 / 2
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000856 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000856 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00000856 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000856 1 / 2
P23280 Carbonic anhydrase 6 Lyase C00000856 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000856 1 / 8
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00004632 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00004632 0 / 0
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00000856 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001110 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000856 0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00004632 3 / 3
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme C00000856 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000856 0 / 0
P51580 Thiopurine S-methyltransferase Enzyme C00000856 1 / 1
P30989 Neurotensin receptor type 1 Neurotensin receptor C00001059 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001110 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001110 0 / 1
P54132 Bloom syndrome protein Enzyme C00004632 1 / 2
P04792 Heat shock protein beta-1 Unclassified protein C00004632 2 / 1
P07237 Protein disulfide-isomerase Enzyme C00005374 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001110 0 / 1
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00000856 0 / 0
Q9UQ49 Sialidase-3 Enzyme C00000856 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00000856 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000856 1 / 1
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00004632 0 / 1
P00918 Carbonic anhydrase 2 Lyase C00000856 1 / 2
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00000856 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001078 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00001078 3 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001059 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00004632 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005374 1 / 1
P43166 Carbonic anhydrase 7 Lyase C00000856 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000856 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000856 0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000856 0 / 0
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00005374 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001110 1 / 0

4 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00005374
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00005374
3952 LEP, LEPD, OB, OBS leptin C00000856
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000856

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (46)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#210900 Bloom syndrome; blm P54132
#606595 Charcot-marie-tooth disease, axonal, type 2f; cmt2f P04792
#114500 Colorectal cancer; crc P84022
Q14191
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#613163 Gaba-transaminase deficiency P80404
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#143100 Huntington disease; hd P42858
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P00533
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#608634 Neuronopathy, distal hereditary motor, type iib; hmn2b P04792
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#600852 Retinitis pigmentosa 17; rp17 P22748
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#610460 Thiopurine s-methyltransferase deficiency P51580
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (50)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00856 Distal hereditary motor neuropathies (dHMN) P04792 (related)
H00079 Asthma P07550 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00192 Xanthinuria P47989 (related)
H00964 Thiopurine S-methyltransferase deficiency (TPMT deficiency) P51580 (related)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H01257 GABA-transaminase deficiency P80404 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

3 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D010146 Pain C00005374
D012220 Rhinitis C00000856
D008104 Liver Cirrhosis, Alcoholic C00001055