PCIDB

KNApSAcK Metabolite C00000856

Metabolite

KNApSAcK Entry

id C00000856
Name 4-Hydroxybenzoic acid / p-Hydroxybenzoic acid
CAS RN 99-96-7
Standard InChI InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)
Standard InChI (Main Layer) InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)

Cluster

Phytochemical cluster No. 81
KCF-S cluster No. 817

Link

ChEMBL

By standard InChI CHEMBL441343
By standard InChI Main Layer CHEMBL441343

KEGG

By LinkDB C00156

CTD

By CAS RN C038193

Species

Summary

Plant class

class name count
rosids 21
asterids 17
eudicotyledons 8
Liliopsida 5
Magnoliophyta 4
Spermatophyta 3
Embryophyta 1
Viridiplantae 1
Euphyllophyta 1

Family (Top 10)

family name count
Asteraceae 5
Bignoniaceae 3
Lamiaceae 3
Rutaceae 3
Rosaceae 2
Fabaceae 2
Pinaceae 2
Viscaceae 2
Celastraceae 2
Aristolochiaceae 2

List (70)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Aeschynanthus bracteatus 175969 Gesneriaceae asterids Viridiplantae
Anisomeles indica 516069 Lamiaceae asterids Viridiplantae
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Aristolochia elegans 143780 Aristolochiaceae Magnoliophyta Viridiplantae
Aristolochia manshuriensis 158555 Aristolochiaceae Magnoliophyta Viridiplantae
Artemisia minor 1227633 Asteraceae asterids Viridiplantae
Begonia nantoensis 78253 Begoniaceae rosids Viridiplantae
Cinnamomum subavenium MIQ. 977953 Lauraceae Magnoliophyta Viridiplantae
Colubrina faralaotra subsp.trichocarpa. 106663 Rhamnaceae rosids Viridiplantae
Conyza canadensis 72917 Asteraceae asterids Viridiplantae
Cowania mexicana 3745 Rosaceae rosids Viridiplantae
Cyperus rotundus L. 512623 Cyperaceae Liliopsida Viridiplantae
Dianthus superbus var.longicalycinus (MAXIM.) WILL 3569 Caryophyllaceae eudicotyledons Viridiplantae
Drymaria diandra 191453 Caryophyllaceae eudicotyledons Viridiplantae
Equsetum arvense
Escherichia coli 562 Enterobacteriaceae Bacteria
Euterpe precatoria 154480 Arecaceae Liliopsida Viridiplantae
Fagara macrophylla 23513 Rutaceae rosids Viridiplantae
Falcaria vulgaris 52469 Apiaceae asterids Viridiplantae
Gomphrena celosioides 217251 Amaranthaceae eudicotyledons Viridiplantae
Gymnadenia conopsea R.BR. 59323 Orchidaceae Liliopsida Viridiplantae
Hibiscus taiwanensis 47605 Malvaceae rosids Viridiplantae
Hydrangea chinensis 498914 Hydrangeaceae asterids Viridiplantae
Lithospermum erythrorhizon 34254 Boraginaceae asterids Viridiplantae
Malva silvestris 96479 Malvaceae rosids Viridiplantae
Maytenus loevis 123430 Celastraceae rosids Viridiplantae
Melilotus messanensis 1279044 Fabaceae rosids Viridiplantae
Microtropis fokienensis 1089417 Celastraceae rosids Viridiplantae
Monascus pilosus BCRC38072 147546 Elaphomycetaceae Fungi
Opunitia dillenii HAW.
Paeonia peregrina 40717 Paeoniaceae eudicotyledons Viridiplantae
Pandanus odorus 4725 Pandanaceae Liliopsida Viridiplantae
Paratecoma peroba 24079 Bignoniaceae asterids Viridiplantae
Phellodendron amurense 68554 Rutaceae rosids Viridiplantae
Phellodendron japonicum MAXIM 68553 Rutaceae rosids Viridiplantae
Picea ajanensis 3328 Pinaceae Spermatophyta Viridiplantae
Picea obovata 331118 Pinaceae Spermatophyta Viridiplantae
Plantago lanceolata 39414 Plantaginaceae asterids Viridiplantae
Plantago media 101992 Plantaginaceae asterids Viridiplantae
Polyalthia longifolia var.pendula 105756 Annonaceae Magnoliophyta Viridiplantae
Polygala caudata 4275 Polygalaceae rosids Viridiplantae
Polytrichum commune 3213 Polytrichaceae Embryophyta Viridiplantae
Populus pseudosimonii 3689 Salicaceae rosids Viridiplantae
Posidonia oceanica 55489 Posidoniaceae Liliopsida Viridiplantae
Protea obtusifolia 273577 Proteaceae eudicotyledons Viridiplantae
Pseudomonas putida 303 Pseudomonadaceae Bacteria
Pterocarpus santalinus 1071199 Fabaceae rosids Viridiplantae
Ranunculus baudotii 568534 Ranunculaceae eudicotyledons Viridiplantae
Reseda muricata C.Presl. 26963 Resedaceae rosids Viridiplantae
Rhaponticum carthamoides 362630 Asteraceae asterids Viridiplantae
Salvia officinalis 38868 Lamiaceae asterids Viridiplantae
Sarcolaeana multiflora
Saussurea muliensis 254917 Asteraceae asterids Viridiplantae
Soymida febrifuga 43707 Meliaceae rosids Viridiplantae
Spiraea formosana 409510 Rosaceae rosids Viridiplantae
Tabebuia avellanedae 39256 Bignoniaceae asterids Viridiplantae
Tabebuia impetiginosa 429701 Bignoniaceae asterids Viridiplantae
Taraxacum formosanum 170733 Asteraceae asterids Viridiplantae
Taxus baccata 25629 Taxaceae Spermatophyta Viridiplantae
Thelephora aurantiotincta 654496 Thelephoraceae Fungi
Tribulus terrestris 210369 Zygophyllaceae rosids Viridiplantae
Ulva lactuca 63410 Ulvaceae Viridiplantae Viridiplantae
Viscum articulactum 3971 Viscaceae eudicotyledons Viridiplantae
Viscum coloratum 3971 Viscaceae eudicotyledons Viridiplantae
Vitex polygama 54476 Lamiaceae asterids Viridiplantae
Vitis vinifera 29760 Vitaceae rosids Viridiplantae
Vittaria anguste-elongata 38724 Pteridaceae Euphyllophyta Viridiplantae
Xanthophylum rubescens
Xylocarpus granatum 241841 Meliaceae rosids Viridiplantae
Zyzzya fuliginosa 1346156 Metazoa

Human Protein / Gene in interaction

21 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL441343 CHEMBL1908087 (2)
0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL441343 CHEMBL992755 (1) CHEMBL1074270 (1)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL441343 CHEMBL992754 (1) CHEMBL1074269 (1)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL441343 CHEMBL992757 (1) CHEMBL1074272 (1)
0 / 0
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase CHEMBL441343 CHEMBL867028 (1)
1 / 1
P00918 Carbonic anhydrase 2 Lyase CHEMBL441343 CHEMBL933690 (1) CHEMBL991856 (1)
CHEMBL1074266 (1)
1 / 2
Q9UQ49 Sialidase-3 Enzyme CHEMBL441343 CHEMBL751097 (1)
0 / 0
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme CHEMBL441343 CHEMBL1908084 (1)
0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL441343 CHEMBL674646 (1) CHEMBL676065 (1)
CHEMBL941404 (1)
1 / 11
P23280 Carbonic anhydrase 6 Lyase CHEMBL441343 CHEMBL992756 (1) CHEMBL1074271 (1)
0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL441343 CHEMBL981174 (1) CHEMBL1074276 (1)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL441343 CHEMBL992759 (1) CHEMBL1074274 (1)
1 / 2
O60656 UDP-glucuronosyltransferase 1-9 Enzyme CHEMBL441343 CHEMBL1908086 (2)
0 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL441343 CHEMBL933689 (1) CHEMBL991855 (1)
CHEMBL1074265 (1)
0 / 0
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase CHEMBL441343 CHEMBL867027 (1)
1 / 1
Q16790 Carbonic anhydrase 9 Lyase CHEMBL441343 CHEMBL992758 (1) CHEMBL1074273 (1)
0 / 1
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme CHEMBL441343 CHEMBL1908085 (1)
0 / 0
P51580 Thiopurine S-methyltransferase Enzyme CHEMBL441343 CHEMBL814140 (1)
1 / 1
P19224 UDP-glucuronosyltransferase 1-6 Enzyme CHEMBL441343 CHEMBL1908083 (2)
0 / 0
P07451 Carbonic anhydrase 3 Lyase CHEMBL441343 CHEMBL991857 (1) CHEMBL1074267 (1)
0 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL441343 CHEMBL991858 (1) CHEMBL1074268 (1)
1 / 1

CTD interaction (2)

compound gene gene name gene description interaction interaction type form reference
pmid
C038193 3952 LEP
LEPD
OB
OBS
leptin 4-hydroxybenzoic acid results in decreased expression of LEP mRNA decreases expression
mRNA 22956630
C038193 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) 4-hydroxybenzoic acid results in increased activity of SULT1A1 protein increases activity
protein 16308312

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#613163 Gaba-transaminase deficiency P80404
#143860 Hyperchlorhidrosis, isolated O43570
#211980 Lung cancer P00533
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#600852 Retinitis pigmentosa 17; rp17 P22748
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#610460 Thiopurine s-methyltransferase deficiency P51580

KEGG DISEASE (16)

KEGG disease name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00964 Thiopurine S-methyltransferase deficiency (TPMT deficiency) P51580 (related)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H01257 GABA-transaminase deficiency P80404 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D012220 C038193 Rhinitis marker/mechanism
14763933