Maytenus loevis
Species
KNApSAcK Entry
| Organism name | Maytenus loevis |
|---|---|
| Genus | Maytenus |
| Family | Celastraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Maytenus |
|---|---|
| Linked NCBI taxonomy ID | 123430 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Celastraceae |
|---|---|
| ID | 4305 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (17)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00004762
|
Mearnsetin
|
CHEMBL484633
|
No. 3 | No. 15 |
|
|||
|
C00041212
|
Triptocallic acid A
/ (+)-Triptocallic acid A |
CHEMBL461696
CHEMBL485459 |
No. 13 | No. 51 |
|
|||
|
C00043188
|
3-Epiabruslactone A
|
CHEMBL468457
CHEMBL484855 CHEMBL484424 |
No. 13 | No. 51 |
|
|||
|
C00036675
|
Abruslactone A
|
CHEMBL468457
CHEMBL484855 CHEMBL484424 |
C052981
|
No. 13 | No. 51 |
|
||
|
C00043184
|
3beta,22beta-Dihydroxyolean-12-en-29-oic acid
|
CHEMBL513961
CHEMBL458310 CHEMBL482783 CHEMBL520845 CHEMBL482586 |
C064305
|
No. 13 | No. 51 |
|
||
|
C00037489
|
Maytenfolic acid
|
CHEMBL513961
CHEMBL458310 CHEMBL482783 CHEMBL520845 CHEMBL482586 |
No. 13 | No. 51 |
|
|||
|
C00037953
|
Triptocallic acid D
|
CHEMBL513961
CHEMBL458310 CHEMBL482783 CHEMBL520845 CHEMBL482586 |
No. 13 | No. 51 |
|
|||
|
C00009061
|
Ourateaproanthocyanidin A
|
CHEMBL503797
|
C013221
|
2 / 0 / 3 | 3 / 6 | No. 16 | No. 19 |
|
|
C00030516
|
Isoacteoside
/ Isoverbascoside |
CHEMBL504873
|
C064683
|
6 / 5 / 4 | No. 33 |
|
||
|
C00043474
|
Ebenifoline E-III
|
CHEMBL503222
|
No. 43 |
|
||||
|
C00013158
|
Mayteine
/ [8R-(8R*,9R*,10R*,11S*,12S*,13R*,14R*,15S*,18S*,19S*,20S*,21S*,22R*)]-10,14,21,22-Tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-13-(benzoyloxy)-7,8,9,10,12,13,14,15,18,19-decahydro-20-hydroxy-8,18,19,20-tetramethyl-8,11-epoxy-9,12-ethano-11,15-methano-11H-[1,8]dioxacycloheptadecino[4,3-b]pyridine-5,17-dione |
CHEMBL526919
CHEMBL1813072 |
C096143
|
No. 43 |
|
|||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00010600
|
Ajugol
/ Leonuride |
CHEMBL595516
|
No. 64 | No. 36 |
|
|||
|
C00029900
|
Canophyllol
|
CHEMBL483012
|
No. 101 | No. 52 |
|
|||
|
C00043883
|
Salaspermic acid
|
CHEMBL483649
|
C074717
|
No. 101 | No. 52 |
|
||
|
C00030622
|
Lambertic acid
/ (+)-Lambertic acid |
CHEMBL519807
CHEMBL523920 |
1 / 1 / 1 | No. 323 | No. 41 |
|
||
|
C00000856
|
4-Hydroxybenzoic acid
/ p-Hydroxybenzoic acid |
CHEMBL441343
|
C038193
|
21 / 7 / 16 | 2 / 1 | No. 817 | No. 81 |
|
Human Protein / Gene in interactions
47 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003672 | 1 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 | 0 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00000856 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00009061 | 0 / 3 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000856 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000856 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00000856 | 0 / 0 |
| P39900 | Macrophage metalloelastase | M10A | C00030516 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00030516 | 2 / 2 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 | 3 / 2 |
| P51649 | Succinate-semialdehyde dehydrogenase, mitochondrial | Oxidoreductase | C00000856 | 1 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000856 | 1 / 2 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| Q9UQ49 | Sialidase-3 | Enzyme | C00000856 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 | 0 / 1 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | C00000856 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000856 | 1 / 8 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00009061 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00000856 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000856 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00000856 | 1 / 2 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00000856 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00000856 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| Q12791 | Calcium-activated potassium channel subunit alpha-1 | KCNM, KCa1.x | C00030622 | 1 / 1 |
| P03956 | Interstitial collagenase | M10A | C00030516 | 0 / 1 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P80404 | 4-aminobutyrate aminotransferase, mitochondrial | Transferase | C00000856 | 1 / 1 |
| P45452 | Collagenase 3 | M10A | C00030516 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000856 | 0 / 1 |
| P08253 | 72 kDa type IV collagenase | M10A | C00030516 | 1 / 3 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00000856 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003672 | 1 / 1 |
| P51580 | Thiopurine S-methyltransferase | Enzyme | C00000856 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003672 | 0 / 1 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00000856 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00000856 | 0 / 0 |
| P08254 | Stromelysin-1 | M10A | C00030516 | 1 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00000856 | 1 / 1 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 | 1 / 1 |
5 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 729230 | CCR2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R | chemokine (C-C motif) receptor 2 |
C00009061
|
| 1232 | CCR3, CC-CKR-3, CD193, CKR3, CMKBR3 | chemokine (C-C motif) receptor 3 |
C00009061
|
| 1234 | CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22 | chemokine (C-C motif) receptor 5 (gene/pseudogene) |
C00009061
|
| 3952 | LEP, LEPD, OB, OBS | leptin |
C00000856
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00000856
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (32)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613163 | Gaba-transaminase deficiency |
P80404
|
| #609446 | Generalized epilepsy and paroxysmal dyskinesia; gepd |
Q12791
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #211980 | Lung cancer |
P00533
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #602111 | Spondyloepimetaphyseal dysplasia, missouri type |
P45452
|
| #601367 | Stroke, ischemic |
P00734
|
| #271980 | Succinic semialdehyde dehydrogenase deficiency; ssadhd |
P51649
|
| #610460 | Thiopurine s-methyltransferase deficiency |
P51580
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
KEGG DISEASE (33)
| KEGG | name | UniProt |
|---|---|---|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
|
| H00022 | Bladder cancer |
P00533
(related)
|
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P08253 (related) |
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) P35354 (related) |
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
P45452 (related) |
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00964 | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
P51580
(related)
|
| H00835 | Succinic semialdehyde dehydrogenase (SSADH) deficiency |
P51649
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H01257 | GABA-transaminase deficiency |
P80404
(related)
|
| H01258 | Generalized epilepsy and paroxysmal dyskinesia (GEPD) |
Q12791
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
7 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D011125 | Adenomatous Polyposis Coli |
C00009061
|
| D001929 | Brain Edema |
C00009061
|
| D006940 | Hyperemia |
C00009061
|
| D009410 | Nerve Degeneration |
C00009061
|
| D011537 | Pruritus |
C00009061
|
| D014839 | Vomiting |
C00009061
|
| D012220 | Rhinitis |
C00000856
|