Cowania mexicana

• Index
• Plant Species
• Metabolite list (15)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Cowania mexicana
Genus	Cowania
Family	Rosaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Rosaceae
Linked NCBI taxonomy ID	3745
Linked level	family

Family

Family in NCBI taxonomy	Rosaceae
ID	3745

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (15)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005367	Avicularin / Avicularine / Avicularoside / Quercetin 3-alpha-L-arabinofuranoside / Quercetin 3-O-alpha-L-arabinofuranoside	CHEMBL471282 CHEMBL1590676	C041388	10 / 2 / 3		No. 2	No. 15
C00002935	Procyanidin B4 / Catechin-(4alpha->8)-epicatechin	CHEMBL38714 CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914		20 / 7 / 8		No. 16	No. 19
C00000956	(-)-Epicatechin	CHEMBL80941 CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL206452 CHEMBL583912		85 / 58 / 54		No. 52	No. 14
C00009373	Stenophyllanin A					No. 142
C00031107	Pterocarinin A					No. 226	No. 81
C00002910	Casuarinin	CHEMBL79244 CHEMBL507387		11 / 2 / 2		No. 226	No. 81
C00032196	Stachyurin	CHEMBL79244 CHEMBL507387		11 / 2 / 2		No. 226	No. 81
C00029914	Casuglaunin A					No. 457
C00000856	4-Hydroxybenzoic acid / p-Hydroxybenzoic acid	CHEMBL441343	C038193	21 / 7 / 16	2 / 1	No. 817	No. 81
C00002647	Gallic acid	CHEMBL288114	D005707	42 / 53 / 68	52 / 16	No. 817	No. 81
C00002668	Protocatechuic acid / 3,4-Dihydroxybenzoic acid	CHEMBL37537	C009091	33 / 19 / 19	2 / 0	No. 817	No. 81
C00000152	p-Coumaric acid	CHEMBL66879 CHEMBL2336752	C032171	23 / 13 / 18	6 / 1	No. 904	No. 6
C00030743	Menisdaurin					No. 931	No. 74
C00030677	Lithospermoside	CHEMBL1817899 CHEMBL1967788	C070237			No. 931	No. 74
C00011153	Gallogen / Ellagic acid / Elagostasine / Alizarin yellow	CHEMBL6246	D004610	104 / 97 / 100	77 / 9	No. 2068	No. 81

Human Protein / Gene in interactions

187 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q16790	Carbonic anhydrase 9	Lyase	C00000152 C00000856 C00000956 C00002647 C00002668 C00011153	0 / 1
P00915	Carbonic anhydrase 1	Lyase	C00000152 C00000856 C00000956 C00002647 C00002668 C00011153	0 / 0
O43570	Carbonic anhydrase 12	Lyase	C00000152 C00000856 C00000956 C00002647 C00002668 C00011153	1 / 2
Q9ULX7	Carbonic anhydrase 14	Lyase	C00000152 C00000856 C00000956 C00002647 C00002668 C00011153	0 / 0
P23280	Carbonic anhydrase 6	Lyase	C00000152 C00000856 C00000956 C00002647 C00002668 C00011153	0 / 0
P43166	Carbonic anhydrase 7	Lyase	C00000152 C00000856 C00000956 C00002647 C00002668 C00011153	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00000152 C00000856 C00000956 C00002647 C00002668 C00011153	1 / 2
P22748	Carbonic anhydrase 4	Lyase	C00000152 C00000856 C00000956 C00002647 C00002668 C00011153	1 / 1
P15121	Aldose reductase	Enzyme	C00000152 C00002647 C00002668 C00005367 C00011153	0 / 0
P07451	Carbonic anhydrase 3	Lyase	C00000152 C00000856 C00000956 C00002647 C00011153	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00000152 C00000856 C00000956 C00002647 C00011153	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00000152 C00000856 C00000956 C00002647 C00011153	0 / 0
O94806	Serine/threonine-protein kinase D3	Pkd	C00000956 C00002910 C00002935 C00032196	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00000956 C00002668 C00005367 C00011153	0 / 0
Q13093	Platelet-activating factor acetylhydrolase	Enzyme	C00000152 C00000956 C00002647 C00002668	3 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000956 C00002647 C00002668 C00011153	4 / 3
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000956 C00002647 C00002935 C00011153	3 / 3
P17252	Protein kinase C alpha type	Alpha	C00000956 C00002910 C00002935 C00032196	0 / 0
Q05655	Protein kinase C delta type	Delta	C00000956 C00002910 C00002935 C00032196	0 / 0
P05129	Protein kinase C gamma type	Alpha	C00000956 C00002910 C00002935 C00032196	1 / 1
Q02156	Protein kinase C epsilon type	Eta	C00000956 C00002910 C00002935 C00032196	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002647 C00002668 C00005367 C00011153	0 / 0
Q04759	Protein kinase C theta type	Delta	C00000956 C00002910 C00002935 C00032196	0 / 1
Q05513	Protein kinase C zeta type	Iota	C00000956 C00002910 C00002935 C00032196	0 / 0
P24723	Protein kinase C eta type	Eta	C00000956 C00002910 C00002935 C00032196	1 / 0
P41743	Protein kinase C iota type	Iota	C00000956 C00002910 C00002935 C00032196	0 / 0
P05771	Protein kinase C beta type	Alpha	C00000956 C00002910 C00002935 C00032196	0 / 0
Q15139	Serine/threonine-protein kinase D1	Pkd	C00000956 C00002910 C00002935 C00032196	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00000956 C00002647 C00005367 C00011153	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000956 C00002647 C00002668 C00011153	0 / 0
P08581	Hepatocyte growth factor receptor	TK tyrosine-protein kinase MET subfamily	C00000956 C00002647 C00011153	2 / 3
P28482	Mitogen-activated protein kinase 1	Erk	C00000956 C00002647 C00011153	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000956 C00002647 C00011153	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00000956 C00002647 C00011153	1 / 1
Q9Y253	DNA polymerase eta	Enzyme	C00000956 C00005367 C00011153	1 / 1
P39748	Flap endonuclease 1	Enzyme	C00000956 C00005367 C00011153	0 / 0
O75496	Geminin	Unclassified protein	C00002668 C00005367 C00011153	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00000956 C00002668 C00011153	1 / 1
P06746	DNA polymerase beta	Enzyme	C00000956 C00002668 C00011153	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00000956 C00002647 C00011153	2 / 3
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000956 C00002647 C00011153	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000152 C00000956 C00002647	0 / 3
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000956 C00002935 C00011153	0 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000956 C00002647 C00011153	2 / 2
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000956 C00002935 C00011153	1 / 1
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00000152 C00000856 C00011153	1 / 8
P03372	Estrogen receptor	NR3A1	C00000152 C00002647 C00002668	1 / 1
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000956 C00002935 C00011153	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000956 C00002935	0 / 1
P12821	Angiotensin-converting enzyme	M2	C00002647 C00011153	4 / 2
P14151	L-selectin	Adhesion	C00002647 C00002668	0 / 0
P16109	P-selectin	Adhesion	C00002647 C00002668	1 / 0
P54132	Bloom syndrome protein	Enzyme	C00000956 C00011153	1 / 2
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00000956 C00002647	5 / 1
P02768	Serum albumin	Secreted protein	C00000956 C00002668	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00000956 C00002647	4 / 1
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00000956 C00011153	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000956 C00002935	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000956 C00011153	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00002647 C00011153	7 / 37
P00352	Retinal dehydrogenase 1	Enzyme	C00000956 C00002647	0 / 0
P16581	E-selectin	Adhesion	C00002647 C00002668	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00002647 C00011153	11 / 10
O00255	Menin	Unclassified protein	C00000956 C00011153	2 / 5
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000956 C00011153	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000956 C00011153	1 / 2
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00002668 C00005367	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00002668 C00011153	0 / 1
Q8N1Q1	Carbonic anhydrase 13	Lyase	C00000956 C00011153	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002647 C00011153	0 / 0
P07711	Cathepsin L1	C1A	C00000956 C00002668	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000956 C00011153	2 / 0
Q01196	Runt-related transcription factor 1	Unclassified protein	C00002668 C00011153	1 / 4
P04406	Glyceraldehyde-3-phosphate dehydrogenase	Enzyme	C00002647 C00011153	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000956 C00002935	1 / 0
Q4U2R8	Solute carrier family 22 member 6	Antiporter	C00011153	0 / 0
P10145	Interleukin-8	Secreted protein	C00002647	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00000856	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00011153	0 / 0
P07998	Ribonuclease pancreatic	Enzyme	C00000956	0 / 0
Q05397	Focal adhesion kinase 1	Fak	C00011153	0 / 0
P09211	Glutathione S-transferase P	Enzyme	C00011153	0 / 1
Q02763	Angiopoietin-1 receptor	Tie	C00011153	1 / 1
P03956	Interstitial collagenase	M10A	C00002668	0 / 1
P15056	Serine/threonine-protein kinase B-raf	Raf	C00011153	6 / 3
P08107	Heat shock 70 kDa protein 1A/1B	Unclassified protein	C00011153	0 / 0
P54760	Ephrin type-B receptor 4	Eph	C00011153	0 / 0
P09923	Intestinal-type alkaline phosphatase	Enzyme	C00000956	0 / 0
O60285	NUAK family SNF1-like kinase 1	CAMK serine/threonine protein kinase NUAK subfamily	C00011153	0 / 0
P05186	Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	C00000956	3 / 1
Q8TDS4	Hydroxycarboxylic acid receptor 2	Hydroxycarboxylic acid receptor	C00000152	0 / 0
P11308	Transcriptional regulator ERG	Unclassified protein	C00005367	1 / 2
P42330	Aldo-keto reductase family 1 member C3	Enzyme	C00000152	0 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00000956	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00011153	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00011153	0 / 0
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00011153	1 / 1
P00734	Prothrombin	S1A	C00000956	4 / 2
P04150	Glucocorticoid receptor	NR3C1	C00002647	0 / 1
P06213	Insulin receptor	TK tyrosine-protein kinase INSR subfamily	C00011153	5 / 4
P14679	Tyrosinase	Oxidoreductase	C00000152	4 / 2
P80404	4-aminobutyrate aminotransferase, mitochondrial	Transferase	C00000856	1 / 1
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00011153	5 / 9
P09619	Platelet-derived growth factor receptor beta	Pdgfr	C00011153	5 / 1
P12931	Proto-oncogene tyrosine-protein kinase Src	Src	C00011153	0 / 0
P04745	Alpha-amylase 1	Enzyme	C00000956	0 / 0
Q96GD4	Aurora kinase B	Aur	C00011153	0 / 0
P35968	Vascular endothelial growth factor receptor 2	Vegfr	C00011153	1 / 0
P18433	Receptor-type tyrosine-protein phosphatase alpha	Receptor tyrosine-protein phosphatase	C00002935	0 / 0
P68871	Hemoglobin subunit beta	Secreted protein	C00011153	4 / 4
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00011153	0 / 0
P35916	Vascular endothelial growth factor receptor 3	Vegfr	C00011153	2 / 1
P10696	Alkaline phosphatase, placental-like	Enzyme	C00000956	0 / 1
P56817	Beta-secretase 1	A1A	C00000956	0 / 0
Q9Y3R4	Sialidase-2	Enzyme	C00000956	0 / 0
P00390	Glutathione reductase, mitochondrial	Oxidoreductase	C00011153	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00000956	0 / 0
P08253	72 kDa type IV collagenase	M10A	C00002668	1 / 3
P41279	Mitogen-activated protein kinase kinase kinase 8	Ste11	C00011153	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000956	0 / 0
Q04828	Aldo-keto reductase family 1 member C1	Enzyme	C00000152	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00000956	0 / 0
Q01453	Peripheral myelin protein 22	Unclassified protein	C00000956	5 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00005367	0 / 0
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00000856	0 / 0
P00374	Dihydrofolate reductase	Oxidoreductase	C00000956	1 / 1
Q9HAW7	UDP-glucuronosyltransferase 1-7	Enzyme	C00000856	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00011153	1 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00000956	0 / 0
P53350	Serine/threonine-protein kinase PLK1	PLK serine/threonine protein kinase subfamily	C00011153	0 / 0
P23467	Receptor-type tyrosine-protein phosphatase beta	Receptor tyrosine-protein phosphatase	C00002935	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00000956	0 / 0
Q02880	DNA topoisomerase 2-beta	Isomerase	C00011153	0 / 0
Q9HC97	G-protein coupled receptor 35	Kynurenic acid receptor	C00011153	0 / 0
P31749	RAC-alpha serine/threonine-protein kinase	Akt	C00011153	4 / 1
P51580	Thiopurine S-methyltransferase	Enzyme	C00000856	1 / 1
Q9GZT9	Egl nine homolog 1	Enzyme	C00002668	1 / 1
P24385	G1/S-specific cyclin-D1	Other cytosolic protein	C00011153	1 / 8
P11802	Cyclin-dependent kinase 4	CMGC serine/threonine protein kinase family	C00011153	1 / 3
O00444	Serine/threonine-protein kinase PLK4	PLK serine/threonine protein kinase subfamily	C00011153	0 / 0
P07949	Proto-oncogene tyrosine-protein kinase receptor Ret	Ret	C00011153	9 / 4
Q9UQ49	Sialidase-3	Enzyme	C00000856	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00000956	1 / 0
P52895	Aldo-keto reductase family 1 member C2	Enzyme	C00000152	1 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00011153	0 / 0
P49327	Fatty acid synthase	Transferase	C00000956	0 / 0
P78536	Disintegrin and metalloproteinase domain-containing protein 17	M12B	C00002647	1 / 0
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00011153	0 / 0
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00000856	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002647	0 / 0
P68400	Casein kinase II subunit alpha	Ck2	C00011153	0 / 0
P08254	Stromelysin-1	M10A	C00002668	1 / 0
Q13627	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	CMGC dual-specificity kinase DYRK1	C00011153	1 / 0
P51649	Succinate-semialdehyde dehydrogenase, mitochondrial	Oxidoreductase	C00000856	1 / 1
P10415	Apoptosis regulator Bcl-2	Other cytosolic protein	C00000956	0 / 7
P10828	Thyroid hormone receptor beta	NR1A2	C00011153	3 / 1
P11142	Heat shock cognate 71 kDa protein	Unclassified protein	C00011153	0 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00000956	1 / 1
P16473	Thyrotropin receptor	Glycohormone receptor	C00000956	3 / 2
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00011153	0 / 0
P28907	ADP-ribosyl cyclase 1	Enzyme	C00000956	0 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00011153	1 / 0
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00011153	1 / 4
O14965	Aurora kinase A	Aur	C00011153	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00011153	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00002668	2 / 2
P52209	6-phosphogluconate dehydrogenase, decarboxylating	Enzyme	C00000956	0 / 0
P22894	Neutrophil collagenase	M10A	C00002668	0 / 0
P08069	Insulin-like growth factor 1 receptor	TK tyrosine-protein kinase INSR subfamily	C00011153	1 / 3
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00002668	0 / 0
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00000152	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00011153	2 / 0
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00000856	0 / 0
P17516	Aldo-keto reductase family 1 member C4	Enzyme	C00000152	1 / 0
Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	Other cytosolic protein	C00011153	0 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00000956	0 / 0
Q9NSA0	Solute carrier family 22 member 11	Transporter	C00011153	0 / 0
P20248	Cyclin-A2	Other cytosolic protein	C00011153	0 / 0
P78396	Cyclin-A1	Other cytosolic protein	C00011153	0 / 0
P24941	Cyclin-dependent kinase 2	Cdc2	C00011153	0 / 0
P22694	cAMP-dependent protein kinase catalytic subunit beta	Pka	C00011153	0 / 0
P17612	cAMP-dependent protein kinase catalytic subunit alpha	Pka	C00011153	0 / 0
P22612	cAMP-dependent protein kinase catalytic subunit gamma	Pka	C00011153	0 / 0
Q9UM73	ALK tyrosine kinase receptor	TKL serine/threonine protein kinase STKR type 1 subfamily	C00011153	1 / 1
P06748	Nucleophosmin	Other nuclear protein	C00011153	0 / 0
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00000956	3 / 0
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00000956	0 / 0

130 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00000152 C00000856 C00002647
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00002647 C00011153
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00002647 C00011153
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002647 C00011153
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002647 C00011153
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00000152 C00002647
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00000152 C00011153
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00002647 C00011153
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00002647
55	ACPP, 5'-NT, ACP-3, ACP3, PAP	acid phosphatase, prostate (EC:3.1.3.2 3.1.3.5)	C00011153
213	ALB, PRO0883, PRO0903, PRO1341	albumin	C00011153
317	APAF1, APAF-1, CED4	apoptotic peptidase activating factor 1	C00011153
429	ASCL1, ASH1, HASH1, MASH1, bHLHa46	achaete-scute family bHLH transcription factor 1	C00011153
440	ASNS, TS11	asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4)	C00011153
467	ATF3	activating transcription factor 3	C00011153
9474	ATG5, APG5, APG5-LIKE, APG5L, ASP, hAPG5	autophagy related 5	C00011153
7299	TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3	tyrosinase (EC:1.14.18.1)	C00000152
654	BMP6, VGR, VGR1	bone morphogenetic protein 6	C00011153
2972	BRF1, BRF, BRF-1, GTF3B, TAF3B2, TAF3C, TAFIII90, TF3B90, TFIIIB90, hBRF	BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit	C00011153
811	CALR, CRT, RO, SSA, cC1qR	calreticulin	C00011153
4846	NOS3, ECNOS, eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	C00000152
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00011153
929	CD14	CD14 molecule	C00011153
1616	DAXX, BING2, DAP6, EAP1	death-domain associated protein	C00011153
1676	DFFA, DFF-45, DFF1, ICAD	DNA fragmentation factor, 45kDa, alpha polypeptide	C00011153
1877	E4F1, E4F	E4F transcription factor 1	C00011153
1960	EGR3, EGR-3, PILOT	early growth response 3	C00011153
2033	EP300, KAT3B, RSTS2, p300	E1A binding protein p300 (EC:2.3.1.48)	C00011153
2060	EPS15, AF-1P, AF1P, MLLT5	epidermal growth factor receptor pathway substrate 15	C00011153
2145	EZH1, KMT6B	enhancer of zeste homolog 1 (Drosophila) (EC:2.1.1.43)	C00011153
2161	F12, HAE3, HAEX, HAF	coagulation factor XII (Hageman factor) (EC:3.4.21.38)	C00011153
2260	FGFR1, BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1	fibroblast growth factor receptor 1 (EC:2.7.10.1)	C00011153
2316	FLNA, ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD	filamin A, alpha	C00011153
2822	GPLD1, GPIPLD, GPIPLDM, PIGPLD, PIGPLD1	glycosylphosphatidylinositol specific phospholipase D1 (EC:3.1.4.50)	C00011153
2941	GSTA4, GSTA4-4, GTA4	glutathione S-transferase alpha 4 (EC:2.5.1.18)	C00011153
2961	GTF2E2, FE, TF2E2, TFIIE-B	general transcription factor IIE, polypeptide 2, beta 34kDa	C00011153
2968	GTF2H4, P52, TFB2, TFIIH	general transcription factor IIH, polypeptide 4, 52kDa	C00011153
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00011153
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00011153
9592	IER2, ETR101	immediate early response 2	C00011153
3485	IGFBP2, IBP2, IGF-BP53	insulin-like growth factor binding protein 2, 36kDa	C00011153
3487	IGFBP4, BP-4, HT29-IGFBP, IBP4, IGFBP-4	insulin-like growth factor binding protein 4	C00011153
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00011153
3554	IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80	interleukin 1 receptor, type I	C00011153
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00000152
3635	INPP5D, SHIP, SHIP-1, SHIP1, SIP-145, hp51CN	inositol polyphosphate-5-phosphatase, 145kDa (EC:3.1.3.86)	C00011153
10788	IQGAP2	IQ motif containing GTPase activating protein 2	C00011153
10379	IRF9, IRF-9, ISGF3, ISGF3G, p48	interferon regulatory factor 9	C00011153
354	KLK3, APS, KLK2A1, PSA, hK3	kallikrein-related peptidase 3 (EC:3.4.21.77)	C00011153
9516	LITAF, PIG7, SIMPLE, TP53I7	lipopolysaccharide-induced TNF factor	C00011153
4130	MAP1A, MAP1L, MTAP1A	microtubule-associated protein 1A	C00011153
23531	MMD, MMA, MMD1, PAQR11	monocyte to macrophage differentiation-associated	C00011153
1312	COMT	catechol-O-methyltransferase (EC:2.1.1.6)	C00002668
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00011153
4791	NFKB2, H2TF1, LYT-10, LYT10, NF-kB2, p105, p52	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	C00011153
4826	NNAT, Peg5	neuronatin	C00011153
10528	NOP56, NOL5A, SCA36	NOP56 ribonucleoprotein	C00011153
4862	NPAS2, MOP4, PASD4, bHLHe9	neuronal PAS domain protein 2	C00011153
9970	NR1I3, CAR, CAR1, MB67	nuclear receptor subfamily 1, group I, member 3	C00011153
8505	PARG, PARG99	poly (ADP-ribose) glycohydrolase (EC:3.2.1.143)	C00011153
5320	PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2	phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4)	C00011153
5355	PLP2, A4, A4LSB	proteolipid protein 2 (colonic epithelium-enriched)	C00011153
5371	PML, MYL, PP8675, RNF71, TRIM19	promyelocytic leukemia	C00011153
5467	PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB	peroxisome proliferator-activated receptor delta	C00011153
5592	PRKG1, 1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK_1, cGK1, cGKI, cGKI-BETA, cGKI-alpha	protein kinase, cGMP-dependent, type I (EC:2.7.11.12)	C00011153
5764	PTN, HARP, HBGF8, HBNF, NEGF1	pleiotrophin	C00011153
5799	PTPRN2, IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2	protein tyrosine phosphatase, receptor type, N polypeptide 2 (EC:3.1.3.48)	C00011153
5901	RAN, ARA24, Gsp1, TC4	RAN, member RAS oncogene family	C00011153
8434	RECK, ST15	reversion-inducing-cysteine-rich protein with kazal motifs	C00011153
2023	ENO1, ENO1L1, MPB1, NNE, PPH	enolase 1, (alpha) (EC:4.2.1.11)	C00002668
8490	RGS5, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129	regulator of G-protein signaling 5	C00011153
6319	SCD, FADS5, MSTP008, SCD1, SCDOS	stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1)	C00011153
4735	SEPT2, DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5	septin 2	C00011153
6649	SOD3, EC-SOD	superoxide dismutase 3, extracellular (EC:1.15.1.1)	C00011153
6774	STAT3, APRF, HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	C00011153
9013	TAF1C, MGC:39976, SL1, TAFI110, TAFI95	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	C00011153
6938	TCF12, CRS3, HEB, HTF4, HsT17266, bHLHb20	transcription factor 12	C00011153
7015	TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT	telomerase reverse transcriptase (EC:2.7.7.49)	C00011153
7019	TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3	transcription factor A, mitochondrial	C00011153
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00011153
7360	UGP2, UDPG, UDPGP, UDPGP2, UGP1, UGPP1, UGPP2, pHC379	UDP-glucose pyrophosphorylase 2 (EC:2.7.7.9)	C00011153
7375	USP4, UNP, Unph	ubiquitin specific peptidase 4 (proto-oncogene) (EC:3.4.19.12)	C00011153
7453	WARS, GAMMA-2, IFI53, IFP53	tryptophanyl-tRNA synthetase (EC:6.1.1.2)	C00011153
7704	ZBTB16, PLZF, ZNF145	zinc finger and BTB domain containing 16	C00011153
7750	ZMYM2, FIM, MYM, RAMP, SCLL, ZNF198	zinc finger, MYM-type 2	C00011153
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00002647
25	ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl	c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2)	C00002647
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00002647
338	APOB, FLDB, LDLCQ4	apolipoprotein B	C00002647
472	ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1	ataxia telangiectasia mutated (EC:2.7.11.1)	C00002647
545	ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1	ataxia telangiectasia and Rad3 related (EC:2.7.11.1)	C00002647
581	BAX, BCL2L4	BCL2-associated X protein	C00002647
613	BCR, ALL, BCR1, CML, D22S11, D22S662, PHL	breakpoint cluster region (EC:2.7.11.1)	C00002647
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00002647
898	CCNE1, CCNE	cyclin E1	C00002647
998	CDC42, CDC42Hs, G25K	cell division cycle 42	C00002647
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00002647
3952	LEP, LEPD, OB, OBS	leptin	C00000856
1147	CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16	conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)	C00002647
7852	CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM	chemokine (C-X-C motif) receptor 4	C00002647
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00002647
356	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6	Fas ligand (TNF superfamily, member 6)	C00002647
2551	GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07	GA binding protein transcription factor, alpha subunit 60kDa	C00002647
2885	GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2	growth factor receptor-bound protein 2	C00002647
3551	IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)	C00002647
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00002647
3949	LDLR, FH, FHC, LDLCQ2	low density lipoprotein receptor	C00002647
5604	MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1	mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)	C00002647
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00002647
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00002647
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00002647
5601	MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK	mitogen-activated protein kinase 9 (EC:2.7.11.24)	C00002647
4255	MGMT	O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63)	C00002647
4316	MMP7, MMP-7, MPSL1, PUMP-1	matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23)	C00002647
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00002647
4793	NFKBIB, IKBB, TRIP9	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	C00002647
5578	PRKCA, AAG6, PKC-alpha, PKCA, PRKACA	protein kinase C, alpha (EC:2.7.11.13)	C00002647
5591	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350	protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1)	C00002647
5879	RAC1, Rac-1, TC-25, p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	C00002647
19412			C00002647
387	RHOA, ARH12, ARHA, RHO12, RHOH12	ras homolog family member A	C00002647
388	RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6	ras homolog family member B	C00002647
6195	RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1	ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1)	C00002647
9252	RPS6KA5, MSK1, MSPK1, RLPK	ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1)	C00002647
6622	SNCA, NACP, PARK1, PARK4, PD1	synuclein, alpha (non A4 component of amyloid precursor)	C00002647
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002647
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00002647
7224	TRPC5, TRP5	transient receptor potential cation channel, subfamily C, member 5	C00002647
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00002647
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00002647

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