KCF-S cluster No. 2068 (5 metabolites)
Corresponding Phytochemical cluster No. 81
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 27 |
| eudicotyledons | 2 |
| Spermatophyta | 1 |
Cumulative family count
| class name | count |
|---|---|
| Myrtaceae | 9 |
| Rosaceae | 3 |
| Combretaceae | 3 |
| Lythraceae | 2 |
| Casuarinaceae | 2 |
| Euphorbiaceae | 2 |
| Saxifragaceae | 1 |
| Cupressaceae | 1 |
| Geraniaceae | 1 |
| Irvingiaceae | 1 |
| Melastomataceae | 1 |
| Phyllanthaceae | 1 |
| Cunoniaceae | 1 |
| Juglandaceae | 1 |
| Polygonaceae | 1 |
KEGG BRITE br08003
Categories (2)
| br08003 Category | # of metabolite |
|---|---|
| Ellagitannins | 1 |
| Galloyl derivatives | 1 |
metabolites link (2)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Ellagitannins | C10836 | C00002678 |
| Galloyl derivatives | C10788 | C00011153 |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00002678
|
Nasutin B
/ 3,3',4'-tri-O-methylellagic acid |
CHEMBL451476
|
|
|||
|
C00011153
|
Gallogen
/ Ellagic acid / Elagostasine / Alizarin yellow |
CHEMBL6246
|
D004610
|
104 / 97 / 100 | 77 / 9 |
|
|
C00011154
|
3-O-Methylellagic acid
|
CHEMBL564351
|
|
|||
|
C00029474
|
3,3'-Dimethoxyellagic acid
/ 3,3'-di-O-Methylellagic acid |
CHEMBL487203
|
C050401
|
10 / 11 / 15 |
|
|
|
C00044433
|
3,3',4-Tri-O-methylflavellagic acid
|
CHEMBL509184
|
|
Human Protein / Gene in interactions
105 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P54132 | Bloom syndrome protein | Enzyme | C00011153 C00029474 | 1 / 2 |
| O00255 | Menin | Unclassified protein | C00011153 C00029474 | 2 / 5 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00011153 C00029474 | 1 / 1 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00011153 C00029474 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00011153 C00029474 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00011153 C00029474 | 4 / 3 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00011153 C00029474 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00011153 C00029474 | 2 / 2 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00011153 C00029474 | 1 / 2 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00011153 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00011153 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00011153 | 0 / 0 |
| Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00011153 | 0 / 0 |
| O14965 | Aurora kinase A | Aur | C00011153 | 0 / 0 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00011153 | 1 / 4 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00011153 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00011153 | 11 / 10 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00011153 | 3 / 1 |
| P68400 | Casein kinase II subunit alpha | Ck2 | C00011153 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00011153 | 1 / 2 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00011153 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00011153 | 0 / 1 |
| O00444 | Serine/threonine-protein kinase PLK4 | PLK serine/threonine protein kinase subfamily | C00011153 | 0 / 0 |
| P11802 | Cyclin-dependent kinase 4 | CMGC serine/threonine protein kinase family | C00011153 | 1 / 3 |
| P24385 | G1/S-specific cyclin-D1 | Other cytosolic protein | C00011153 | 1 / 8 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00011153 | 7 / 37 |
| Q9HC97 | G-protein coupled receptor 35 | Kynurenic acid receptor | C00011153 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00011153 | 1 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00011153 | 1 / 8 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00011153 | 2 / 3 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00011153 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00011153 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00011153 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00029474 | 0 / 0 |
| P68871 | Hemoglobin subunit beta | Secreted protein | C00011153 | 4 / 4 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00011153 | 1 / 2 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00011153 | 1 / 1 |
| P54760 | Ephrin type-B receptor 4 | Eph | C00011153 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00011153 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00011153 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00011153 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00011153 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00011153 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00011153 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00011153 | 0 / 0 |
| Q05397 | Focal adhesion kinase 1 | Fak | C00011153 | 0 / 0 |
| P09211 | Glutathione S-transferase P | Enzyme | C00011153 | 0 / 1 |
| Q02763 | Angiopoietin-1 receptor | Tie | C00011153 | 1 / 1 |
| P15056 | Serine/threonine-protein kinase B-raf | Raf | C00011153 | 6 / 3 |
| P08107 | Heat shock 70 kDa protein 1A/1B | Unclassified protein | C00011153 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00011153 | 1 / 1 |
| O60285 | NUAK family SNF1-like kinase 1 | CAMK serine/threonine protein kinase NUAK subfamily | C00011153 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00011153 | 0 / 0 |
| Q4U2R8 | Solute carrier family 22 member 6 | Antiporter | C00011153 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00011153 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00011153 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00011153 | 0 / 0 |
| P06213 | Insulin receptor | TK tyrosine-protein kinase INSR subfamily | C00011153 | 5 / 4 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00011153 | 5 / 9 |
| P09619 | Platelet-derived growth factor receptor beta | Pdgfr | C00011153 | 5 / 1 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00011153 | 0 / 0 |
| Q96GD4 | Aurora kinase B | Aur | C00011153 | 0 / 0 |
| P35968 | Vascular endothelial growth factor receptor 2 | Vegfr | C00011153 | 1 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00011153 | 2 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00011153 | 0 / 0 |
| P35916 | Vascular endothelial growth factor receptor 3 | Vegfr | C00011153 | 2 / 1 |
| P00390 | Glutathione reductase, mitochondrial | Oxidoreductase | C00011153 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00011153 | 0 / 1 |
| P41279 | Mitogen-activated protein kinase kinase kinase 8 | Ste11 | C00011153 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00011153 | 3 / 3 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00011153 | 0 / 0 |
| P12821 | Angiotensin-converting enzyme | M2 | C00011153 | 4 / 2 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | C00011153 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00011153 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00011153 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00011153 | 4 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00011153 | 1 / 1 |
| P07949 | Proto-oncogene tyrosine-protein kinase receptor Ret | Ret | C00011153 | 9 / 4 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00011153 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00011153 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00011153 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00011153 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00011153 | 0 / 0 |
| Q13627 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | CMGC dual-specificity kinase DYRK1 | C00011153 | 1 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00011153 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00011153 | 0 / 0 |
| P11142 | Heat shock cognate 71 kDa protein | Unclassified protein | C00011153 | 0 / 0 |
| P08069 | Insulin-like growth factor 1 receptor | TK tyrosine-protein kinase INSR subfamily | C00011153 | 1 / 3 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00011153 | 2 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00011153 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00011153 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00011153 | 1 / 0 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00011153 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00011153 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00011153 | 1 / 4 |
| Q9NSA0 | Solute carrier family 22 member 11 | Transporter | C00011153 | 0 / 0 |
| P20248 | Cyclin-A2 | Other cytosolic protein | C00011153 | 0 / 0 |
| P78396 | Cyclin-A1 | Other cytosolic protein | C00011153 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00011153 | 0 / 0 |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | Pka | C00011153 | 0 / 0 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | C00011153 | 0 / 0 |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | Pka | C00011153 | 0 / 0 |
| Q9UM73 | ALK tyrosine kinase receptor | TKL serine/threonine protein kinase STKR type 1 subfamily | C00011153 | 1 / 1 |
| P06748 | Nucleophosmin | Other nuclear protein | C00011153 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00011153 | 0 / 0 |
77 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 55 | ACPP, 5'-NT, ACP-3, ACP3, PAP | acid phosphatase, prostate (EC:3.1.3.2 3.1.3.5) |
C00011153
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00011153
|
| 317 | APAF1, APAF-1, CED4 | apoptotic peptidase activating factor 1 |
C00011153
|
| 429 | ASCL1, ASH1, HASH1, MASH1, bHLHa46 | achaete-scute family bHLH transcription factor 1 |
C00011153
|
| 440 | ASNS, TS11 | asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4) |
C00011153
|
| 467 | ATF3 | activating transcription factor 3 |
C00011153
|
| 9474 | ATG5, APG5, APG5-LIKE, APG5L, ASP, hAPG5 | autophagy related 5 |
C00011153
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00011153
|
| 654 | BMP6, VGR, VGR1 | bone morphogenetic protein 6 |
C00011153
|
| 2972 | BRF1, BRF, BRF-1, GTF3B, TAF3B2, TAF3C, TAFIII90, TF3B90, TFIIIB90, hBRF | BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit |
C00011153
|
| 811 | CALR, CRT, RO, SSA, cC1qR | calreticulin |
C00011153
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00011153
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00011153
|
| 929 | CD14 | CD14 molecule |
C00011153
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00011153
|
| 1616 | DAXX, BING2, DAP6, EAP1 | death-domain associated protein |
C00011153
|
| 1676 | DFFA, DFF-45, DFF1, ICAD | DNA fragmentation factor, 45kDa, alpha polypeptide |
C00011153
|
| 1877 | E4F1, E4F | E4F transcription factor 1 |
C00011153
|
| 1960 | EGR3, EGR-3, PILOT | early growth response 3 |
C00011153
|
| 2033 | EP300, KAT3B, RSTS2, p300 | E1A binding protein p300 (EC:2.3.1.48) |
C00011153
|
| 2060 | EPS15, AF-1P, AF1P, MLLT5 | epidermal growth factor receptor pathway substrate 15 |
C00011153
|
| 2145 | EZH1, KMT6B | enhancer of zeste homolog 1 (Drosophila) (EC:2.1.1.43) |
C00011153
|
| 2161 | F12, HAE3, HAEX, HAF | coagulation factor XII (Hageman factor) (EC:3.4.21.38) |
C00011153
|
| 2260 | FGFR1, BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1 | fibroblast growth factor receptor 1 (EC:2.7.10.1) |
C00011153
|
| 2316 | FLNA, ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD | filamin A, alpha |
C00011153
|
| 2822 | GPLD1, GPIPLD, GPIPLDM, PIGPLD, PIGPLD1 | glycosylphosphatidylinositol specific phospholipase D1 (EC:3.1.4.50) |
C00011153
|
| 2941 | GSTA4, GSTA4-4, GTA4 | glutathione S-transferase alpha 4 (EC:2.5.1.18) |
C00011153
|
| 2961 | GTF2E2, FE, TF2E2, TFIIE-B | general transcription factor IIE, polypeptide 2, beta 34kDa |
C00011153
|
| 2968 | GTF2H4, P52, TFB2, TFIIH | general transcription factor IIH, polypeptide 4, 52kDa |
C00011153
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00011153
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00011153
|
| 9592 | IER2, ETR101 | immediate early response 2 |
C00011153
|
| 3485 | IGFBP2, IBP2, IGF-BP53 | insulin-like growth factor binding protein 2, 36kDa |
C00011153
|
| 3487 | IGFBP4, BP-4, HT29-IGFBP, IBP4, IGFBP-4 | insulin-like growth factor binding protein 4 |
C00011153
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00011153
|
| 3554 | IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80 | interleukin 1 receptor, type I |
C00011153
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00011153
|
| 3635 | INPP5D, SHIP, SHIP-1, SHIP1, SIP-145, hp51CN | inositol polyphosphate-5-phosphatase, 145kDa (EC:3.1.3.86) |
C00011153
|
| 10788 | IQGAP2 | IQ motif containing GTPase activating protein 2 |
C00011153
|
| 10379 | IRF9, IRF-9, ISGF3, ISGF3G, p48 | interferon regulatory factor 9 |
C00011153
|
| 354 | KLK3, APS, KLK2A1, PSA, hK3 | kallikrein-related peptidase 3 (EC:3.4.21.77) |
C00011153
|
| 9516 | LITAF, PIG7, SIMPLE, TP53I7 | lipopolysaccharide-induced TNF factor |
C00011153
|
| 4130 | MAP1A, MAP1L, MTAP1A | microtubule-associated protein 1A |
C00011153
|
| 23531 | MMD, MMA, MMD1, PAQR11 | monocyte to macrophage differentiation-associated |
C00011153
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00011153
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00011153
|
| 4791 | NFKB2, H2TF1, LYT-10, LYT10, NF-kB2, p105, p52 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
C00011153
|
| 4826 | NNAT, Peg5 | neuronatin |
C00011153
|
| 10528 | NOP56, NOL5A, SCA36 | NOP56 ribonucleoprotein |
C00011153
|
| 4862 | NPAS2, MOP4, PASD4, bHLHe9 | neuronal PAS domain protein 2 |
C00011153
|
| 9970 | NR1I3, CAR, CAR1, MB67 | nuclear receptor subfamily 1, group I, member 3 |
C00011153
|
| 8505 | PARG, PARG99 | poly (ADP-ribose) glycohydrolase (EC:3.2.1.143) |
C00011153
|
| 5320 | PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2 | phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4) |
C00011153
|
| 5355 | PLP2, A4, A4LSB | proteolipid protein 2 (colonic epithelium-enriched) |
C00011153
|
| 5371 | PML, MYL, PP8675, RNF71, TRIM19 | promyelocytic leukemia |
C00011153
|
| 5467 | PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB | peroxisome proliferator-activated receptor delta |
C00011153
|
| 5592 | PRKG1, 1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK_1, cGK1, cGKI, cGKI-BETA, cGKI-alpha | protein kinase, cGMP-dependent, type I (EC:2.7.11.12) |
C00011153
|
| 5764 | PTN, HARP, HBGF8, HBNF, NEGF1 | pleiotrophin |
C00011153
|
| 5799 | PTPRN2, IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 (EC:3.1.3.48) |
C00011153
|
| 5901 | RAN, ARA24, Gsp1, TC4 | RAN, member RAS oncogene family |
C00011153
|
| 8434 | RECK, ST15 | reversion-inducing-cysteine-rich protein with kazal motifs |
C00011153
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00011153
|
| 8490 | RGS5, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129 | regulator of G-protein signaling 5 |
C00011153
|
| 6319 | SCD, FADS5, MSTP008, SCD1, SCDOS | stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) |
C00011153
|
| 4735 | SEPT2, DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5 | septin 2 |
C00011153
|
| 6649 | SOD3, EC-SOD | superoxide dismutase 3, extracellular (EC:1.15.1.1) |
C00011153
|
| 6774 | STAT3, APRF, HIES | signal transducer and activator of transcription 3 (acute-phase response factor) |
C00011153
|
| 9013 | TAF1C, MGC:39976, SL1, TAFI110, TAFI95 | TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa |
C00011153
|
| 6938 | TCF12, CRS3, HEB, HTF4, HsT17266, bHLHb20 | transcription factor 12 |
C00011153
|
| 7015 | TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT | telomerase reverse transcriptase (EC:2.7.7.49) |
C00011153
|
| 7019 | TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3 | transcription factor A, mitochondrial |
C00011153
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00011153
|
| 7360 | UGP2, UDPG, UDPGP, UDPGP2, UGP1, UGPP1, UGPP2, pHC379 | UDP-glucose pyrophosphorylase 2 (EC:2.7.7.9) |
C00011153
|
| 7375 | USP4, UNP, Unph | ubiquitin specific peptidase 4 (proto-oncogene) (EC:3.4.19.12) |
C00011153
|
| 7453 | WARS, GAMMA-2, IFI53, IFP53 | tryptophanyl-tRNA synthetase (EC:6.1.1.2) |
C00011153
|
| 7704 | ZBTB16, PLZF, ZNF145 | zinc finger and BTB domain containing 16 |
C00011153
|
| 7750 | ZMYM2, FIM, MYM, RAMP, SCLL, ZNF198 | zinc finger, MYM-type 2 |
C00011153
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (97)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #615007 | Basal ganglia calcification, idiopathic, 4; ibgc4 |
P09619
|
| #613985 | Beta-thalassemia |
P68871
|
| #603902 | Beta-thalassemia, dominant inclusion body type |
P68871
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #114480 | Breast cancer |
P31749
|
| #115150 | Cardiofaciocutaneous syndrome 1; cfc1 |
P15056
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #209880 | Central hypoventilation syndrome, congenital; cchs |
P07949
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P07949
P15056 P31749 P84022 |
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #610549 | Diabetes mellitus, insulin-resistant, with acanthosis nigricans |
P06213
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P06213
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #246200 | Donohue syndrome |
P06213
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #140700 | Heinz body anemias |
P68871
|
| #602089 | Hemangioma, capillary infantile |
P35916
P35968 |
| #614519 | Hemorrhage, intracerebral, susceptibility to; ich |
P12821
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #142623 | Hirschsprung disease, susceptibility to, 1; hscr1 |
P07949
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #609968 | Hyperinsulinemic hypoglycemia, familial, 5; hhf5 |
P06213
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #270450 | Insulin-like growth factor i, resistance to |
P08069
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
P09619
|
| #613707 | Leopard syndrome 3 |
P15056
|
| #601626 | Leukemia, acute myeloid; aml |
P09619
P36888 |
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P00533
P04626 P04637 P15056 |
| #153100 | Lymphedema, hereditary, ia |
P35916
|
| #605027 | Lymphoma, non-hodgkin, familial |
P15056
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #609048 | Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 |
P11802
|
| #614104 | Mental retardation, autosomal dominant 7; mrd7 |
Q13627
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #612624 | Microvascular complications of diabetes, susceptibility to, 3; mvcd3 |
P12821
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #171400 | Multiple endocrine neoplasia, type iia; men2a |
P07949
|
| #162300 | Multiple endocrine neoplasia, type iib; men2b |
P07949
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #254500 | Myeloma, multiple |
P24385
|
| #131440 | Myeloproliferative disorder, chronic, with eosinophilia |
P09619
|
| #228550 | Myofibromatosis, infantile, 1; imf1 |
P09619
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #613014 | Neuroblastoma, susceptibility to, 3; nblst3 |
Q9UM73
|
| #613706 | Noonan syndrome 7; ns7 |
P15056
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #171300 | Pheochromocytoma |
P07949
|
| #172700 | Pick disease of brain |
P10636
|
| #262190 | Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities |
P06213
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #176920 | Proteus syndrome |
P31749
|
| #191830 | Renal adysplasia |
P07949
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #267430 | Renal tubular dysgenesis; rtd |
P12821
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #603903 | Sickle cell anemia |
P68871
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P12821
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #155240 | Thyroid carcinoma, familial medullary; mtc |
P07949
|
| #188550 | Thyroid carcinoma, papillary |
P07949
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #600195 | Venous malformations, multiple cutaneous and mucosal; vmcm |
Q02763
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (100)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) P08581 (related) Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) P24385 (related) P24385 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P24385 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) P08581 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) P68871 (marker) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04626 (related) P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) P11802 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) P09619 (related) P11802 (related) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) P24385 (related) P24385 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00026 | Endometrial Cancer |
P04626
(related)
P04637 (related) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) P24385 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P08581 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
Q13315 (related) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
P24385 (related) |
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
P24385 (related) |
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
Q9UM73 (related) |
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
P08069 (related) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) P68871 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P07949 (related) P07949 (marker) P15056 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
|
| H00038 | Malignant melanoma |
P04637
(related)
P11802 (related) P15056 (related) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
P24385 (marker) |
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00719 | Leprechaunism |
P06213
(related)
|
| H00942 | Rabson-Mendenhall syndrome |
P06213
(related)
|
| H01228 | Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) |
P06213
(related)
|
| H01267 | Familial hyperinsulinemic hypoglycemia (HHF) |
P06213
(related)
|
| H00822 | Renal agenesis and Renal adysplasia |
P07949
(related)
|
| H00910 | Hirschsprung disease (HD) |
P07949
(related)
|
| H00916 | Congenital central hypoventilation syndrome (CCHS) |
P07949
(related)
|
| H00050 | Synovial sarcoma |
P08069
(related)
|
| H01274 | Growth delay due to insulin-like growth factor I resistance |
P08069
(related)
|
| H00024 | Prostate cancer |
P09211
(related)
P09211 (marker) |
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00083 | Allograft rejection |
P12821
(related)
|
| H00575 | Renal tubular dysgenesis |
P12821
(related)
|
| H00523 | Noonan syndrome and related disorders |
P15056
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H00559 | von Hippel-Lindau syndrome |
P24385
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00535 | Lymphedemas |
P35916
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00094 | DNA repair defects |
P54132
(related)
Q13315 (related) |
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00228 | Thalassemia |
P68871
(related)
|
| H00229 | Sickle cell anemia (SCA) |
P68871
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00531 | Venous malformations |
Q02763
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
9 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000014 | Abnormalities, Drug-Induced |
C00011153
|
| D002471 | Cell Transformation, Neoplastic |
C00011153
|
| D006965 | Hyperplasia |
C00011153
|
| D007248 | Infertility, Male |
C00011153
|
| D009203 | Myocardial Infarction |
C00011153
|
| D015427 | Reperfusion Injury |
C00011153
|
| D012878 | Skin Neoplasms |
C00011153
|
| D013471 | Sunburn |
C00011153
|
| D013733 | Testicular Diseases |
C00011153
|