PCIDB

KNApSAcK Metabolite C00002668

Metabolite

KNApSAcK Entry

id C00002668
Name Protocatechuic acid / 3,4-Dihydroxybenzoic acid
CAS RN 99-50-3
Standard InChI InChI=1S/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11)
Standard InChI (Main Layer) InChI=1S/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11)

Cluster

Phytochemical cluster No. 81
KCF-S cluster No. 817

Link

ChEMBL

By standard InChI CHEMBL37537
By standard InChI Main Layer CHEMBL37537

KEGG

By LinkDB C00230

CTD

By CAS RN C009091

Species

Summary

Plant class

class name count
rosids 13
asterids 12
Liliopsida 9
Spermatophyta 5
eudicotyledons 4
Euphyllophyta 1

Family (Top 10)

family name count
Pinaceae 4
Plantaginaceae 4
Rosaceae 3
Myrtaceae 3
Asteraceae 3
Apiaceae 2
Orchidaceae 2
Malvaceae 2
Hymenochaetaceae 2
Viscaceae 2

List (48)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Actaea racemosa 64040 Ranunculaceae eudicotyledons Viridiplantae
Amorphophallus konjac K.Koch 78372 Araceae Liliopsida Viridiplantae
Begonia nantoensis 78253 Begoniaceae rosids Viridiplantae
Bletilla formosana 466243 Orchidaceae Liliopsida Viridiplantae
Brosimopsis acutifolium 3487 Moraceae rosids Viridiplantae
Bulbophyllum vaginatum 1138424 Orchidaceae Liliopsida Viridiplantae
Centaurea bracteata Scop. 41503 Asteraceae asterids Viridiplantae
Centaurea pseudoscabiosa subsp.pseudoscabiosa Boiss.et aBuhse 41503 Asteraceae asterids Viridiplantae
Cowania mexicana 3745 Rosaceae rosids Viridiplantae
Crocus sativus 82528 Iridaceae Liliopsida Viridiplantae
Cryptotympana sp. 407120 Cicadidae Metazoa
Curculigo pilosa 1037973 Hypoxidaceae Liliopsida Viridiplantae
Cyperus rotundus L. 512623 Cyperaceae Liliopsida Viridiplantae
Erica australis 13510 Ericaceae asterids Viridiplantae
Eriocaulon buergerianum 26021 Eriocaulaceae Liliopsida Viridiplantae
Eucalyptus grandis 71139 Myrtaceae rosids Viridiplantae
Eucommia ulmoides Oliver 4391 Eucommiaceae asterids Viridiplantae
Eugenia edulis 119950 Myrtaceae rosids Viridiplantae
Falcaria vulgaris 52469 Apiaceae asterids Viridiplantae
Gossypium hirsutum L. 3635 Malvaceae rosids Viridiplantae
Inonotus obliquus 167356 Hymenochaetaceae Fungi
Lespedeza bicolor 556514 Fabaceae rosids Viridiplantae
Malus doumeri varl formosana 3749 Rosaceae rosids Viridiplantae
Myrciaria cauliflora 375264 Myrtaceae rosids Viridiplantae
Opuntia dillenii HAW. 106975 Cactaceae eudicotyledons Viridiplantae
Oryza sativa cv. Heugjinjubyeo 4527 Poaceae Liliopsida Viridiplantae
Ostericum koreanum 182415 Apiaceae asterids Viridiplantae
Phellinus igniarius 40472 Hymenochaetaceae Fungi
Phyllanthus emblica 296036 Phyllanthaceae rosids Viridiplantae
Picea ajanensis 3328 Pinaceae Spermatophyta Viridiplantae
Picea koraiensis 308680 Pinaceae Spermatophyta Viridiplantae
Picea obovata 331118 Pinaceae Spermatophyta Viridiplantae
Picrorhiza kurrosa 195119 Plantaginaceae asterids Viridiplantae
Plantago lanceolata 39414 Plantaginaceae asterids Viridiplantae
Plantago media 101992 Plantaginaceae asterids Viridiplantae
Posidonia oceanica 55489 Posidoniaceae Liliopsida Viridiplantae
Pseudolarix kaempferi Gord. 3354 Pinaceae Spermatophyta Viridiplantae
Pseudomonas putida 303 Pseudomonadaceae Bacteria
Rhamnus disperma 3609 Rhamnaceae rosids Viridiplantae
Rhaponticum carthamoides 362630 Asteraceae asterids Viridiplantae
Rosa canina 74635 Rosaceae rosids Viridiplantae
Salvia sonchifolia 21880 Lamiaceae asterids Viridiplantae
Taxus baccata 25629 Taxaceae Spermatophyta Viridiplantae
Theobroma cacao L. 3640 Malvaceae rosids Viridiplantae
Veronica peregrina L. 165341 Plantaginaceae asterids Viridiplantae
Viscum articulactum 3971 Viscaceae eudicotyledons Viridiplantae
Viscum coloratum 3971 Viscaceae eudicotyledons Viridiplantae
Vittaria anguste-elongata 38724 Pteridaceae Euphyllophyta Viridiplantae

Human Protein / Gene in interaction

33 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P09917 Arachidonate 5-lipoxygenase Oxidoreductase CHEMBL37537 CHEMBL1664429 (1)
0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme CHEMBL37537 CHEMBL1032505 (1)
3 / 0
P06746 DNA polymerase beta Enzyme CHEMBL37537 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL37537 CHEMBL1614076 (1)
1 / 1
P43166 Carbonic anhydrase 7 Lyase CHEMBL37537 CHEMBL2340802 (1)
0 / 0
P22894 Neutrophil collagenase M10A CHEMBL37537 CHEMBL1664434 (1)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL37537 CHEMBL1664435 (1)
2 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL37537 CHEMBL1670882 (1)
1 / 2
P02768 Serum albumin Secreted protein CHEMBL37537 CHEMBL1177441 (1)
0 / 0
Q9GZT9 Egl nine homolog 1 Enzyme CHEMBL37537 CHEMBL2318585 (1)
1 / 1
P23280 Carbonic anhydrase 6 Lyase CHEMBL37537 CHEMBL1804479 (1) CHEMBL2045824 (1)
0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL37537 CHEMBL2340799 (1)
0 / 0
P16581 E-selectin Adhesion CHEMBL37537 CHEMBL917094 (1)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL37537 CHEMBL1670884 (1)
1 / 2
O75496 Geminin Unclassified protein CHEMBL37537 CHEMBL2114780 (1)
0 / 0
P15121 Aldose reductase Enzyme CHEMBL37537 CHEMBL984565 (1)
0 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL37537 CHEMBL1670881 (1)
0 / 0
P07711 Cathepsin L1 C1A CHEMBL37537 CHEMBL1614088 (1)
0 / 0
P03956 Interstitial collagenase M10A CHEMBL37537 CHEMBL1664431 (1)
0 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL37537 CHEMBL1614280 (1)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL37537 CHEMBL1670883 (1)
0 / 1
P08253 72 kDa type IV collagenase M10A CHEMBL37537 CHEMBL1664432 (1)
1 / 3
P03372 Estrogen receptor NR3A1 CHEMBL37537 CHEMBL1941568 (1) CHEMBL1941569 (1)
1 / 1
P14151 L-selectin Adhesion CHEMBL37537 CHEMBL917098 (1)
0 / 0
P16109 P-selectin Adhesion CHEMBL37537 CHEMBL917096 (1)
1 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL37537 CHEMBL1794483 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL37537 CHEMBL1614421 (1)
4 / 3
P08254 Stromelysin-1 M10A CHEMBL37537 CHEMBL1664433 (1)
1 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL37537 CHEMBL2045823 (1)
1 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL37537 CHEMBL1613914 (1)
0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL37537 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL37537 CHEMBL1613933 (1)
1 / 6
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL37537 CHEMBL2114738 (1)
0 / 0

CTD interaction (2)

compound gene gene name gene description interaction interaction type form reference
pmid
C009091 1312 COMT
catechol-O-methyltransferase (EC:2.1.1.6) COMT protein results in increased methylation of protocatechuic acid increases methylation
protein 11160877
C009091 2023 ENO1
ENO1L1
MPB1
NNE
PPH
enolase 1, (alpha) (EC:4.2.1.11) protocatechuic acid results in increased expression of ENO1 mRNA increases expression
mRNA 16227210

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#600807 Asthma, susceptibility to Q13093
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#143860 Hyperchlorhidrosis, isolated O43570
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#600852 Retinitis pigmentosa 17; rp17 P22748
#601367 Stroke, ischemic P16109
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (19)

KEGG disease name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00236 Congenital polycythemia Q9GZT9 (related)