Organism name | Eucommia ulmoides Oliver |
---|---|
Genus | Eucommia |
Family | Eucommiaceae |
Kingdom | Plantae |
Linked NCBI taxonomy name | Eucommia |
---|---|
Linked NCBI taxonomy ID | 4391 |
Linked level | genus |
Family in NCBI taxonomy | Eucommiaceae |
---|---|
ID | 4390 |
Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
---|---|
ID | 33090 |
Plant class | asterids |
---|---|
ID | 71274 |
KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
---|---|---|---|---|---|---|---|---|
C00000947
![]() |
D-Catechol
/ D-Catechin / Teafuran 30A / (+)-Catechin / Dexcyanidanol / (+)-3',4',5,7-Tetrahydroxy-2,3-trans-flavan-3-ol |
CHEMBL80941
CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL206452 CHEMBL583912 |
D002392
|
85 / 58 / 54 | 91 / 13 | No. 52 | No. 14 |
![]() |
C00002724
![]() |
Heriguard
/ Chlorogenic acid / 3-O-Caffeoylquinic acid |
CHEMBL284616
CHEMBL230481 CHEMBL249450 CHEMBL1332980 CHEMBL1394423 CHEMBL1419611 CHEMBL1473644 CHEMBL1552319 |
D002726
|
30 / 19 / 22 | 37 / 9 | No. 314 | No. 6 |
![]() |
C00002668
![]() |
Protocatechuic acid
/ 3,4-Dihydroxybenzoic acid |
CHEMBL37537
|
C009091
|
33 / 19 / 19 | 2 / 0 | No. 817 | No. 81 |
![]() |
C00029547
![]() |
5-Hydroxymethylfuraldehyde
/ 5-Hydroxymethyl-2-furfural / 5-Hydroxymethyl-2-furaldehyde / 5-(Hydroxymethyl)-2-furaldehyde |
CHEMBL185885
|
C008046
|
4 / 3 / 3 | 2 / 5 | No. 6025 |
![]() |
accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
---|---|---|---|---|
B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000947 C00002668 C00002724 | 0 / 0 |
P00352 | Retinal dehydrogenase 1 | Enzyme | C00000947 C00002724 C00029547 | 0 / 0 |
P16473 | Thyrotropin receptor | Glycohormone receptor | C00000947 C00002724 C00029547 | 3 / 2 |
Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00000947 C00002668 C00002724 | 3 / 0 |
Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000947 C00002724 | 3 / 3 |
P22748 | Carbonic anhydrase 4 | Lyase | C00000947 C00002668 | 1 / 1 |
P10636 | Microtubule-associated protein tau | Unclassified protein | C00000947 C00002668 | 4 / 3 |
P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000947 C00002724 | 0 / 3 |
P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000947 C00002724 | 0 / 0 |
Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000947 C00002724 | 0 / 0 |
P06746 | DNA polymerase beta | Enzyme | C00000947 C00002668 | 0 / 0 |
P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000947 C00002668 | 1 / 1 |
Q9UNA4 | DNA polymerase iota | Enzyme | C00000947 C00002668 | 0 / 0 |
P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000947 C00002724 | 0 / 1 |
P43166 | Carbonic anhydrase 7 | Lyase | C00000947 C00002668 | 0 / 0 |
P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000947 C00002724 | 1 / 1 |
P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000947 C00002724 | 1 / 0 |
Q16790 | Carbonic anhydrase 9 | Lyase | C00000947 C00002668 | 0 / 1 |
P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000947 C00002724 | 0 / 0 |
P04150 | Glucocorticoid receptor | NR3C1 | C00002724 C00029547 | 0 / 1 |
Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000947 C00002724 | 1 / 1 |
P07711 | Cathepsin L1 | C1A | C00000947 C00002668 | 0 / 0 |
P00918 | Carbonic anhydrase 2 | Lyase | C00000947 C00002668 | 1 / 2 |
P02768 | Serum albumin | Secreted protein | C00000947 C00002668 | 0 / 0 |
P00915 | Carbonic anhydrase 1 | Lyase | C00000947 C00002668 | 0 / 0 |
P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000947 C00002724 | 0 / 1 |
P15121 | Aldose reductase | Enzyme | C00002668 C00002724 | 0 / 0 |
O75496 | Geminin | Unclassified protein | C00002668 C00002724 | 0 / 0 |
O43570 | Carbonic anhydrase 12 | Lyase | C00000947 C00002668 | 1 / 2 |
O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002668 C00002724 | 0 / 0 |
Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000947 C00002668 | 0 / 0 |
P23280 | Carbonic anhydrase 6 | Lyase | C00000947 C00002668 | 0 / 0 |
Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002724 | 0 / 0 |
Q9Y3R4 | Sialidase-2 | Enzyme | C00000947 | 0 / 0 |
P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000947 | 0 / 0 |
P11473 | Vitamin D3 receptor | NR1I1 | C00000947 | 2 / 3 |
P16581 | E-selectin | Adhesion | C00002668 | 0 / 0 |
P11388 | DNA topoisomerase 2-alpha | Isomerase | C00000947 | 0 / 0 |
P39748 | Flap endonuclease 1 | Enzyme | C00000947 | 0 / 0 |
P07998 | Ribonuclease pancreatic | Enzyme | C00000947 | 0 / 0 |
P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000947 | 2 / 0 |
P54132 | Bloom syndrome protein | Enzyme | C00000947 | 1 / 2 |
O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00002724 | 0 / 0 |
P41143 | Delta-type opioid receptor | Opioid receptor | C00000947 | 0 / 0 |
Q9GZT9 | Egl nine homolog 1 | Enzyme | C00002668 | 1 / 1 |
P10145 | Interleukin-8 | Secreted protein | C00002724 | 0 / 0 |
P49327 | Fatty acid synthase | Transferase | C00000947 | 0 / 0 |
P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000947 | 1 / 1 |
P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00002724 | 1 / 2 |
P03956 | Interstitial collagenase | M10A | C00002668 | 0 / 1 |
Q9Y253 | DNA polymerase eta | Enzyme | C00000947 | 1 / 1 |
P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00000947 | 0 / 0 |
P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00000947 | 3 / 1 |
Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00002668 | 0 / 0 |
O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000947 | 0 / 0 |
P00734 | Prothrombin | S1A | C00000947 | 4 / 2 |
P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00000947 | 0 / 1 |
P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00002724 | 0 / 0 |
P04745 | Alpha-amylase 1 | Enzyme | C00000947 | 0 / 0 |
P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00000947 | 2 / 3 |
P28482 | Mitogen-activated protein kinase 1 | Erk | C00000947 | 0 / 0 |
P10696 | Alkaline phosphatase, placental-like | Enzyme | C00000947 | 0 / 1 |
P56817 | Beta-secretase 1 | A1A | C00000947 | 0 / 0 |
Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00000947 | 0 / 0 |
P14780 | Matrix metalloproteinase-9 | M10A | C00002668 | 2 / 2 |
P08253 | 72 kDa type IV collagenase | M10A | C00002668 | 1 / 3 |
P52209 | 6-phosphogluconate dehydrogenase, decarboxylating | Enzyme | C00000947 | 0 / 0 |
P51692 | Signal transducer and activator of transcription 5B | Unclassified protein | C00002724 | 1 / 1 |
P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000947 | 2 / 2 |
Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00000947 | 5 / 2 |
P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00029547 | 0 / 0 |
P00374 | Dihydrofolate reductase | Oxidoreductase | C00000947 | 1 / 1 |
P03372 | Estrogen receptor | NR3A1 | C00002668 | 1 / 1 |
P35372 | Mu-type opioid receptor | Opioid receptor | C00000947 | 0 / 0 |
P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000947 | 0 / 0 |
P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000947 | 0 / 0 |
P14151 | L-selectin | Adhesion | C00002668 | 0 / 0 |
P16109 | P-selectin | Adhesion | C00002668 | 1 / 0 |
P22894 | Neutrophil collagenase | M10A | C00002668 | 0 / 0 |
P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000947 | 0 / 0 |
Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000947 | 0 / 0 |
Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00000947 | 1 / 0 |
O75164 | Lysine-specific demethylase 4A | Enzyme | C00002724 | 0 / 0 |
Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00002724 | 2 / 2 |
P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00000947 | 5 / 1 |
P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00002668 | 0 / 0 |
P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00002724 | 0 / 0 |
P41145 | Kappa-type opioid receptor | Opioid receptor | C00000947 | 0 / 0 |
P07451 | Carbonic anhydrase 3 | Lyase | C00000947 | 0 / 0 |
P06239 | Tyrosine-protein kinase Lck | Src | C00002724 | 0 / 1 |
P08254 | Stromelysin-1 | M10A | C00002668 | 1 / 0 |
O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00002724 | 0 / 0 |
P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00000947 | 0 / 7 |
Q9UBT6 | DNA polymerase kappa | Enzyme | C00000947 | 0 / 0 |
Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000947 | 0 / 0 |
P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000947 | 0 / 0 |
P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | C00002724 | 3 / 3 |
Q16637 | Survival motor neuron protein | Unclassified protein | C00000947 | 4 / 1 |
P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000947 | 0 / 0 |
O00255 | Menin | Unclassified protein | C00000947 | 2 / 5 |
Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000947 | 1 / 2 |
Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002668 | 0 / 1 |
Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002668 | 1 / 4 |
Q05513 | Protein kinase C zeta type | Iota | C00000947 | 0 / 0 |
Q04759 | Protein kinase C theta type | Delta | C00000947 | 0 / 1 |
Q02156 | Protein kinase C epsilon type | Eta | C00000947 | 0 / 0 |
O94806 | Serine/threonine-protein kinase D3 | Pkd | C00000947 | 0 / 0 |
P17252 | Protein kinase C alpha type | Alpha | C00000947 | 0 / 0 |
Q05655 | Protein kinase C delta type | Delta | C00000947 | 0 / 0 |
P05129 | Protein kinase C gamma type | Alpha | C00000947 | 1 / 1 |
P05771 | Protein kinase C beta type | Alpha | C00000947 | 0 / 0 |
P24723 | Protein kinase C eta type | Eta | C00000947 | 1 / 0 |
P41743 | Protein kinase C iota type | Iota | C00000947 | 0 / 0 |
Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00000947 | 0 / 0 |
P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00000947 | 3 / 0 |
Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00000947 | 0 / 0 |
gene | gene name | gene description | KNApSAcK metabolite in interactions |
---|---|---|---|
6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00000947
C00029547
|
2896 | GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN | granulin |
C00000947
C00002724
|
367 | AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM | androgen receptor |
C00002724
|
2023 | ENO1, ENO1L1, MPB1, NNE, PPH | enolase 1, (alpha) (EC:4.2.1.11) |
C00002668
|
9429 | ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 | ATP-binding cassette, sub-family G (WHITE), member 2 |
C00000947
|
207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00000947
|
302 | ANXA2, ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV | annexin A2 |
C00000947
|
393 | ARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115 | Rho GTPase activating protein 4 |
C00000947
|
468 | ATF4, CREB-2, CREB2, TAXREB67, TXREB | activating transcription factor 4 |
C00000947
|
472 | ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 | ataxia telangiectasia mutated (EC:2.7.11.1) |
C00000947
|
2683 | B4GALT1, B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (EC:2.4.1.22 2.4.1.90 2.4.1.38) |
C00000947
|
56751 | BARHL1 | BarH-like homeobox 1 |
C00000947
|
581 | BAX, BCL2L4 | BCL2-associated X protein |
C00000947
|
596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000947
|
637 | BID, FP497 | BH3 interacting domain death agonist |
C00000947
|
388962 | BOLA3, MMDS2 | bolA family member 3 |
C00000947
|
79184 | BRCC3, BRCC36, C6.1A, CXorf53 | BRCA1/BRCA2-containing complex, subunit 3 (EC:3.1.2.15) |
C00000947
|
694 | BTG1 | B-cell translocation gene 1, anti-proliferative |
C00000947
|
836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000947
|
840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00000947
|
841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00000947
|
842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00000947
|
6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00000947
|
595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00000947
|
930 | CD19, B4, CVID3 | CD19 molecule |
C00000947
|
975 | CD81, CVID6, S5.7, TAPA1, TSPAN28 | CD81 molecule |
C00000947
|
928 | CD9, BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29 | CD9 molecule |
C00000947
|
1054 | CEBPG, GPE1BP, IG/EBP-1 | CCAAT/enhancer binding protein (C/EBP), gamma |
C00000947
|
10978 | CLP1, HEAB, hClp1 | cleavage and polyadenylation factor I subunit 1 (EC:2.7.1.78) |
C00000947
|
10063 | COX17 | COX17 cytochrome c oxidase copper chaperone |
C00000947
|
3627 | CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 | chemokine (C-X-C motif) ligand 10 |
C00000947
|
54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00000947
|
1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000947
|
7913 | DEK, D6S231E | DEK oncogene |
C00000947
|
1786 | DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT | DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) |
C00000947
|
2130 | EWSR1, EWS, bK984G1.4 | EWS RNA-binding protein 1 |
C00000947
|
355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00000947
|
2323 | FLT3LG, FL, FLT3L | fms-related tyrosine kinase 3 ligand |
C00000947
|
2495 | FTH1, FHC, FTH, FTHL6, PIG15, PLIF | ferritin, heavy polypeptide 1 (EC:1.16.3.1) |
C00000947
|
6799 | SULT1A2, HAST4, P-PST, ST1A2, STP2, TSPST2 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 (EC:2.8.2.1) |
C00029547
|
3014 | H2AFX, H2A.X, H2A/X, H2AX | H2A histone family, member X |
C00000947
|
3054 | HCFC1, CFF, HCF-1, HCF1, HFC1, MRX3, VCAF | host cell factor C1 (VP16-accessory protein) |
C00000947
|
3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00000947
|
3232 | HOXD3, HOX1D, HOX4, HOX4A, Hox-4.1 | homeobox D3 |
C00000947
|
3329 | HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13 | heat shock 60kDa protein 1 (chaperonin) |
C00000947
|
3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00000947
|
3586 | IL10, CSIF, GVHDS, IL-10, IL10A, TGIF | interleukin 10 |
C00000947
|
3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00000947
|
3559 | IL2RA, CD25, IDDM10, IL2R, TCGFR | interleukin 2 receptor, alpha |
C00000947
|
9235 | IL32, IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd | interleukin 32 |
C00000947
|
3662 | IRF4, LSIRF, MUM1, NF-EM5 | interferon regulatory factor 4 |
C00000947
|
3683 | ITGAL, CD11A, LFA-1, LFA1A | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) |
C00000947
|
3689 | ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
C00000947
|
4067 | LYN, JTK8, p53Lyn, p56Lyn | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) |
C00000947
|
5604 | MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 | mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) |
C00000947
|
5605 | MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2 | mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) |
C00000947
|
5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00000947
|
5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00000947
|
4282 | MIF, GIF, GLIF, MMIF | macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) |
C00000947
|
64975 | MRPL41, BMRP, MRP-L27, MRPL27, RPML27 | mitochondrial ribosomal protein L41 |
C00000947
|
4493 | MT1E, MT1, MTD | metallothionein 1E |
C00000947
|
653361 | NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox | neutrophil cytosolic factor 1 |
C00000947
|
4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00000947
|
4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00000947
|
4851 | NOTCH1, TAN1, hN1 | notch 1 |
C00000947
|
4869 | NPM1, B23, NPM | nucleophosmin (nucleolar phosphoprotein B23, numatrin) |
C00000947
|
5175 | PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM | platelet/endothelial cell adhesion molecule 1 |
C00000947
|
5187 | PER1, PER, RIGUI, hPER | period circadian clock 1 |
C00000947
|
5327 | PLAT, T-PA, TPA | plasminogen activator, tissue (EC:3.4.21.68) |
C00000947
|
5328 | PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA | plasminogen activator, urokinase (EC:3.4.21.73) |
C00000947
|
7916 | PRRC2A, BAT2, D6S51, D6S51E, G2 | proline-rich coiled-coil 2A |
C00000947
|
5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00000947
|
5747 | PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK | protein tyrosine kinase 2 (EC:2.7.10.2) |
C00000947
|
5879 | RAC1, Rac-1, TC-25, p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
C00000947
|
5915 | RARB, HAP, NR1B2, RRB2 | retinoic acid receptor, beta |
C00000947
|
5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00000947
|
6128 | RPL6, L6, SHUJUN-2, TAXREB107, TXREB1 | ribosomal protein L6 |
C00000947
|
6285 | S100B, NEF, S100, S100-B, S100beta | S100 calcium binding protein B |
C00000947
|
6286 | S100P, MIG9 | S100 calcium binding protein P |
C00000947
|
5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
C00000947
|
7536 | SF1, BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162 | splicing factor 1 |
C00000947
|
6574 | SLC20A1, GLVR1, Glvr-1, PIT1, PiT-1 | solute carrier family 20 (phosphate transporter), member 1 |
C00000947
|
6699 | SPRR1B, CORNIFIN, GADD33, SPRR1 | small proline-rich protein 1B |
C00000947
|
6772 | STAT1, CANDF7, ISGF-3, STAT91 | signal transducer and activator of transcription 1, 91kDa |
C00000947
|
6777 | STAT5B, STAT5 | signal transducer and activator of transcription 5B |
C00000947
|
6778 | STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C | signal transducer and activator of transcription 6, interleukin-4 induced |
C00000947
|
6932 | TCF7, TCF-1 | transcription factor 7 (T-cell specific, HMG-box) |
C00000947
|
7083 | TK1, TK2 | thymidine kinase 1, soluble (EC:2.7.1.21) |
C00000947
|
7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00000947
|
943 | TNFRSF8, CD30, D1S166E, Ki-1 | tumor necrosis factor receptor superfamily, member 8 |
C00000947
|
7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00000947
|
7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00000947
|
2829 | XCR1, CCXCR1, GPR5 | chemokine (C motif) receptor 1 |
C00000947
|
51042 | ZNF593, ZT86 | zinc finger protein 593 |
C00000947
|
47 | ACLY, ACL, ATPCL, CLATP | ATP citrate lyase (EC:2.3.3.8) |
C00002724
|
358 | AQP1, AQP-CHIP, CHIP28, CO | aquaporin 1 |
C00002724
|
360 | AQP3, AQP-3, GIL | aquaporin 3 (Gill blood group) |
C00002724
|
1312 | COMT | catechol-O-methyltransferase (EC:2.1.1.6) |
C00002668
|
960 | CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 | CD44 molecule (Indian blood group) |
C00002724
|
999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00002724
|
1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00002724
|
4512 | COX1, COI, MTCO1, MT-CO1 | cytochrome c oxidase subunit I |
C00002724
|
114757 | CYGB, HGB, STAP | cytoglobin |
C00002724
|
1830 | DSG3, CDHF6, PVA | desmoglein 3 |
C00002724
|
1950 | EGF, HOMG4, URG | epidermal growth factor |
C00002724
|
2200 | FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 | fibrillin 1 |
C00002724
|
2201 | FBN2, CCA, DA9 | fibrillin 2 |
C00002724
|
2246 | FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 | fibroblast growth factor 1 (acidic) |
C00002724
|
3036 | HAS1, HAS | hyaluronan synthase 1 (EC:2.4.1.212) |
C00002724
|
3315 | HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 | heat shock 27kDa protein 1 |
C00002724
|
3552 | IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 | interleukin 1, alpha |
C00002724
|
3852 | KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A | keratin 5 |
C00002724
|
4157 | MC1R, CMM5, MSH-R, SHEP2 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
C00002724
|
4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002724
|
5241 | PGR, NR3C3, PR | progesterone receptor |
C00002724
|
8985 | PLOD3, LH3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) |
C00002724
|
5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00002724
|
5886 | RAD23A, HHR23A, HR23A | RAD23 homolog A (S. cerevisiae) |
C00002724
|
5914 | RARA, NR1B1, RAR | retinoic acid receptor, alpha |
C00002724
|
6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00002724
|
6649 | SOD3, EC-SOD | superoxide dismutase 3, extracellular (EC:1.15.1.1) |
C00002724
|
6716 | SRD5A2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) |
C00002724
|
7178 | TPT1, HRF, TCTP, p02, p23 | tumor protein, translationally-controlled 1 |
C00002724
|
7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00002724
|
7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00002724
|
7306 | TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN | tyrosinase-related protein 1 (EC:1.14.18.-) |
C00002724
|
54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002724
|
54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002724
|
54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002724
|
54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002724
|
OMIM | preferred title | UniProt |
---|---|---|
#300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
#600807 | Asthma, susceptibility to |
Q13093
|
#608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
#209950 | Atypical mycobacteriosis, familial |
P42224
|
#601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
#210900 | Bloom syndrome; blm |
P54132
|
#614162 | Candidiasis, familial, 7; candf7 |
P42224
|
#118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
#118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
#114500 | Colorectal cancer; crc |
P84022
|
#614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
#218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
#606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
#119900 | Digital clubbing, isolated congenital |
P15428
|
#609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
#608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
#609820 | Erythrocytosis, familial, 3; ecyt3 |
Q9GZT9
|
#615363 | Estrogen resistance; estrr |
P03372
|
#600274 | Frontotemporal dementia; ftd |
P10636
|
#143500 | Gilbert syndrome |
P22309
P22310 |
#232300 | Glycogen storage disease ii |
P10253
|
#245590 | Growth hormone insensitivity with immunodeficiency |
P51692
|
#139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
#605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
#114550 | Hepatocellular carcinoma |
P08581
|
#147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
#237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
#143860 | Hyperchlorhidrosis, isolated |
O43570
|
#145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
#603373 | Hyperthyroidism, familial gestational |
P16473
|
#609152 | Hyperthyroidism, nonautoimmune |
P16473
|
#145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
#259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
#146300 | Hypophosphatasia, adult |
P05186
|
#241510 | Hypophosphatasia, childhood |
P05186
|
#241500 | Hypophosphatasia, infantile |
P05186
|
#275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
#147050 | Ige responsiveness, atopic; iger |
Q13093
|
#603932 | Intervertebral disc disease; idd |
P14780
|
#613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
#613688 | Long qt syndrome 2; lqt2 |
Q12809
|
#613839 | Megaloblastic anemia due to dihydrofolate reductase deficiency |
P00374
|
#300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
#300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
#613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
#259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
#131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
#613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
#607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
#162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
#259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
#260540 | Parkinson-dementia syndrome |
P10636
|
#172700 | Pick disease of brain |
P10636
|
#601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
#614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
#614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
#613679 | Prothrombin deficiency, congenital |
P00734
|
#605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
#600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
#609620 | Short qt syndrome 1; sqt1 |
Q12809
|
#253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
#253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
#253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
#271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
#605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
#607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
#601367 | Stroke, ischemic |
P00734
P16109 P24723 |
#601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
#188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
#277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
#278300 | Xanthinuria, type i |
P47989
|
#278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG | name | UniProt |
---|---|---|
H00033 | Adrenal carcinoma |
O00255
(related)
|
H00034 | Carcinoid |
O00255
(related)
|
H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
H00246 | Primary hyperparathyroidism |
O00255
(related)
|
H01102 | Pituitary adenomas |
O00255
(related)
|
H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
H00021 | Renal cell carcinoma |
O43570
(marker)
P08581 (related) Q16790 (marker) |
H01197 | Dihydrofolate reductase (DHFR) deficiency |
P00374
(related)
|
H00223 | Inherited thrombophilia |
P00734
(related)
|
H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
H00436 | Osteopetrosis |
P00918
(related)
|
H00026 | Endometrial Cancer |
P03372
(marker)
|
H00028 | Choriocarcinoma |
P03956
(related)
P08253 (related) P10415 (related) |
H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
Q9NUW8 (related) |
H00213 | Hypophosphatasia |
P05186
(related)
|
H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
H00025 | Penile cancer |
P08253
(related)
P14780 (related) P35354 (related) |
H00472 | Torg-Winchester syndrome |
P08253
(related)
|
H00018 | Gastric cancer |
P08581
(related)
P10415 (related) |
H00046 | Cholangiocarcinoma |
P08581
(related)
P35354 (related) |
H00036 | Osteosarcoma |
P08684
(marker)
|
H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
H00005 | Chronic lymphocytic leukemia (CLL) |
P10415
(related)
P28907 (marker) |
H00013 | Small cell lung cancer |
P10415
(related)
|
H00030 | Cervical cancer |
P10415
(related)
|
H00041 | Kaposi's sarcoma |
P10415
(related)
|
H00054 | Nasopharyngeal cancer |
P10415
(related)
|
H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
H00023 | Testicular cancer |
P10696
(marker)
|
H00342 | Tuberculosis |
P11473
(related)
|
H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
H01205 | Coumarin resistance |
P11712
(related)
|
H00479 | Metaphyseal dysplasias |
P14780
(related)
|
H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
H01269 | Congenital hyperthyroidism |
P16473
(related)
|
H00208 | Hyperbilirubinemia |
P22309
(related)
|
H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
H00017 | Esophageal cancer |
P35354
(related)
|
H00016 | Oral cancer |
P40763
(related)
|
H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
H00363 | Candidiasis |
P42224
(related)
|
H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
H00192 | Xanthinuria |
P47989
(related)
|
H00931 | Growth hormone insensitivity with immunodeficiency |
P51692
(related)
|
H00094 | DNA repair defects |
P54132
(related)
|
H00296 | Defects in RecQ helicases |
P54132
(related)
|
H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
H00264 | Charcot-Marie-Tooth disease (CMT) |
Q01453
(related)
|
H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
H00408 | Type I diabetes mellitus |
Q04759
(related)
|
H00720 | Long QT syndrome |
Q12809
(related)
|
H00725 | Short QT syndrome |
Q12809
(related)
|
H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
H00236 | Congenital polycythemia |
Q9GZT9
(related)
|
H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
MESH or OMIM | name |
KNApSAcK
metabolite |
---|---|---|
D008113 | Liver Neoplasms |
C00029547
C00000947 |
D056486 | Drug-Induced Liver Injury |
C00000947
C00002724 |
D020138 | HYPERHOMOCYSTEINEMIA |
C00000947
|
D010212 | Papilloma |
C00029547
|
D012878 | Skin Neoplasms |
C00029547
|
D050197 | Atherosclerosis |
C00000947
|
D001943 | Breast Neoplasms |
C00000947
|
D002471 | Cell Transformation, Neoplastic |
C00000947
|
D003556 | Cystitis |
C00000947
|
D018248 | Adenoma, Liver Cell |
C00029547
|
D034381 | Hearing Loss |
C00000947
|
D006331 | Heart Diseases |
C00000947
|
D058739 | Aberrant Crypt Foci |
C00029547
|
D008107 | Liver Diseases |
C00000947
|
D017114 | Liver Failure, Acute |
C00000947
|
D008325 | Mammary Neoplasms, Experimental |
C00000947
|
D009362 | Neoplasm Metastasis |
C00000947
|
D000647 | Amnesia |
C00002724
|
D006937 | Hypercholesterolemia |
C00002724
|
D006951 | Hyperlipoproteinemias |
C00002724
|
D015228 | Hypertriglyceridemia |
C00002724
|
D052456 | Hypoalphalipoproteinemias |
C00002724
|
D008545 | Melanoma |
C00002724
|
D009336 | Necrosis |
C00002724
|
D015431 | Weight Loss |
C00002724
|