PCIDB

KNApSAcK Metabolite C00029547

Metabolite

KNApSAcK Entry

id C00029547
Name 5-Hydroxymethylfuraldehyde / 5-Hydroxymethyl-2-furfural / 5-Hydroxymethyl-2-furaldehyde / 5-(Hydroxymethyl)-2-furaldehyde
CAS RN 67-47-0
Standard InChI InChI=1S/C6H6O3/c7-3-5-1-2-6(4-8)9-5/h1-3,8H,4H2
Standard InChI (Main Layer) InChI=1S/C6H6O3/c7-3-5-1-2-6(4-8)9-5/h1-3,8H,4H2

Cluster

Phytochemical cluster
KCF-S cluster No. 6025

Link

ChEMBL

By standard InChI CHEMBL185885
By standard InChI Main Layer CHEMBL185885

KEGG

By LinkDB C11101

CTD

By CAS RN C008046

Human Protein / Gene in interaction

4 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL185885 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL185885 CHEMBL1614458 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL185885 CHEMBL1794456 (1)
0 / 1
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL185885 CHEMBL2114842 (1)
0 / 0

CTD interaction (6)

compound gene gene name gene description interaction interaction type form reference
pmid
C008046 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) 5-hydroxymethylfurfural affects the activity of SULT1A1 protein affects activity
protein 22563731
C008046 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) SULT1A1 protein affects the metabolism of 5-hydroxymethylfurfural affects metabolic processing
protein 22349055
C008046 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) [SULT1A1 protein co-treated with SULT1A2 protein] results in increased susceptibility to 5-hydroxymethylfurfural affects cotreatment
/ increases response to substance
protein 22006426
C008046 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) SULT1A1 protein results in increased activity of 5-hydroxymethylfurfural increases activity
protein 22006426
C008046 6799 SULT1A2
HAST4
P-PST
ST1A2
STP2
TSPST2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 (EC:2.8.2.1) [SULT1A1 protein co-treated with SULT1A2 protein] results in increased susceptibility to 5-hydroxymethylfurfural affects cotreatment
/ increases response to substance
protein 22006426
C008046 6799 SULT1A2
HAST4
P-PST
ST1A2
STP2
TSPST2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 (EC:2.8.2.1) SULT1A2 protein results in increased activity of 5-hydroxymethylfurfural increases activity
protein 22006426

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (3)

OMIM preferred title UniProt
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473

KEGG DISEASE (3)

KEGG disease name UniProt
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)

Diseases related to CTD interactions

5 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D058739 C008046 Aberrant Crypt Foci marker/mechanism
19382817
22006426
D018248 C008046 Adenoma, Liver Cell marker/mechanism
19382817
D008113 C008046 Liver Neoplasms marker/mechanism
22563731
23038016
D010212 C008046 Papilloma marker/mechanism
19382817
D012878 C008046 Skin Neoplasms marker/mechanism
19382817