Disporopsis aspera
Species
KNApSAcK Entry
| Organism name | Disporopsis aspera |
|---|---|
| Genus | Disporopsis |
| Family | Convallariaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Disporopsis aspersa |
|---|---|
| Linked NCBI taxonomy ID | 100534 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Asparagaceae |
|---|---|
| ID | 40552 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Liliopsida |
|---|---|
| ID | 4447 |
Metabolite list (6)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00035078
|
Disporopsin
|
No. 106 | No. 14 |
|
||||
|
C00035142
|
N-trans-Feruloyl tyramine
|
CHEMBL206555
CHEMBL451720 |
1 / 4 / 2 | No. 499 |
|
|||
|
C00019308
|
Doursterol
/ Daucosterin / 3-O-beta-D-Glucopyranosyl sitosterol / beta-Sitosterol 3-O-beta-D-glucopyranoside |
CHEMBL197711
CHEMBL506678 CHEMBL2304043 |
C011015
|
5 / 4 / 2 | 0 / 3 | No. 520 |
|
|
|
C00029547
|
5-Hydroxymethylfuraldehyde
/ 5-Hydroxymethyl-2-furfural / 5-Hydroxymethyl-2-furaldehyde / 5-(Hydroxymethyl)-2-furaldehyde |
CHEMBL185885
|
C008046
|
4 / 3 / 3 | 2 / 5 | No. 6025 |
|
|
|
C00001490
|
Adenine
|
CHEMBL226345
|
D000225
|
52 / 44 / 38 | 1 / 6 | No. 6151 |
|
Human Protein / Gene in interactions
71 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00001490 C00003672 C00019308 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 C00019308 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 C00019308 | 4 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 C00035142 | 4 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 C00029547 | 3 / 2 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 C00019308 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 C00019308 | 0 / 0 |
| P08238 | Heat shock protein HSP 90-beta | Other cytosolic protein | C00001490 | 0 / 0 |
| P22894 | Neutrophil collagenase | M10A | C00001490 | 0 / 0 |
| P42336 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Enzyme | C00001490 | 9 / 1 |
| P45984 | Mitogen-activated protein kinase 9 | Jnk | C00001490 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00001490 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00001490 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00001490 | 2 / 2 |
| Q15303 | Receptor tyrosine-protein kinase erbB-4 | TK tyrosine-protein kinase EGFR subfamily | C00001490 | 0 / 0 |
| O14965 | Aurora kinase A | Aur | C00001490 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001490 | 11 / 10 |
| P08069 | Insulin-like growth factor 1 receptor | TK tyrosine-protein kinase INSR subfamily | C00001490 | 1 / 3 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00001490 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00001490 | 1 / 1 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00001490 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | C00001490 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00001490 | 1 / 8 |
| P31751 | RAC-beta serine/threonine-protein kinase | Akt | C00001490 | 2 / 2 |
| O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | Other serine/threonine protein kinase | C00001490 | 0 / 0 |
| Q13464 | Rho-associated protein kinase 1 | Rock | C00001490 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00029547 | 0 / 0 |
| O43353 | Receptor-interacting serine/threonine-protein kinase 2 | Ripk | C00001490 | 0 / 0 |
| P07332 | Tyrosine-protein kinase Fes/Fps | Fer | C00001490 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| Q05397 | Focal adhesion kinase 1 | Fak | C00001490 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00001490 | 0 / 1 |
| Q99683 | Mitogen-activated protein kinase kinase kinase 5 | Ste11 | C00001490 | 0 / 0 |
| P15056 | Serine/threonine-protein kinase B-raf | Raf | C00001490 | 6 / 3 |
| Q99816 | Tumor susceptibility gene 101 protein | Unclassified protein | C00001490 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003672 | 1 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00029547 | 0 / 1 |
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | C00001490 | 1 / 1 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00001490 | 5 / 9 |
| Q96GD4 | Aurora kinase B | Aur | C00001490 | 0 / 0 |
| P49137 | MAP kinase-activated protein kinase 2 | CAMK serine/threonine protein kinase MAPKAPK | C00001490 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001490 | 0 / 0 |
| P45983 | Mitogen-activated protein kinase 8 | Jnk | C00001490 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 | 0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00001490 | 1 / 3 |
| Q13177 | Serine/threonine-protein kinase PAK 2 | STE serine/threonine protein kinase PAKA subfamily | C00001490 | 0 / 0 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00029547 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003672 | 1 / 1 |
| Q08881 | Tyrosine-protein kinase ITK/TSK | Tec | C00001490 | 1 / 1 |
| O00329 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Enzyme | C00001490 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00001490 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00001490 | 4 / 1 |
| Q15118 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial | Pdhk | C00001490 | 0 / 0 |
| O00141 | Serine/threonine-protein kinase Sgk1 | AGC serine/threonine protein kinase SGK subfamily | C00001490 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003672 | 0 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001490 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00001490 | 0 / 1 |
| P52333 | Tyrosine-protein kinase JAK3 | Jakb | C00001490 | 1 / 1 |
| P04049 | RAF proto-oncogene serine/threonine-protein kinase | Raf | C00001490 | 2 / 0 |
| P43405 | Tyrosine-protein kinase SYK | Syk | C00001490 | 0 / 0 |
| P08254 | Stromelysin-1 | M10A | C00001490 | 1 / 0 |
| P48736 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Enzyme | C00001490 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 | 1 / 1 |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | Pka | C00001490 | 0 / 0 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | C00001490 | 0 / 0 |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | Pka | C00001490 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00001490 | 1 / 1 |
3 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00029547
|
| 6799 | SULT1A2, HAST4, P-PST, ST1A2, STP2, TSPST2 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 (EC:2.8.2.1) |
C00029547
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001490
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (63)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #114480 | Breast cancer |
P31749
P42336 |
| #115150 | Cardiofaciocutaneous syndrome 1; cfc1 |
P15056
|
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P15056
P31749 P42336 |
| #612918 | Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi |
P42336
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #615108 | Cowden syndrome 5; cws5 |
P42336
|
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P31751
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #114550 | Hepatocellular carcinoma |
P42336
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #240900 | Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh |
P31751
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #270450 | Insulin-like growth factor i, resistance to |
P08069
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #182000 | Keratosis, seborrheic |
P42336
|
| #611554 | Leopard syndrome 2 |
P04049
|
| #613707 | Leopard syndrome 3 |
P15056
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #211980 | Lung cancer |
P00533
P04626 P15056 |
| #605027 | Lymphoma, non-hodgkin, familial |
P15056
|
| #613011 | Lymphoproliferative syndrome 1; lpfs1 |
Q08881
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #602501 | Megalencephaly-capillary malformation-polymicrogyria syndrome; mcap |
P42336
|
| #603387 | Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph |
P42336
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #611553 | Noonan syndrome 5; ns5 |
P04049
|
| #613706 | Noonan syndrome 7; ns7 |
P15056
|
| #167000 | Ovarian cancer |
P04626
P42336 |
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #176920 | Proteus syndrome |
P31749
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #600802 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative |
P52333
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #278300 | Xanthinuria, type i |
P47989
|
KEGG DISEASE (49)
| KEGG | name | UniProt |
|---|---|---|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
|
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P08253 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P31751 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
P31751 (related) P42336 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00015 | Malignant pleural mesothelioma |
P08069
(related)
|
| H00050 | Synovial sarcoma |
P08069
(related)
|
| H01274 | Growth delay due to insulin-like growth factor I resistance |
P08069
(related)
|
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) |
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
P15056 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00032 | Thyroid cancer |
P15056
(related)
|
| H00523 | Noonan syndrome and related disorders |
P15056
(related)
Q02750 (related) |
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P52333
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
Q08881
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
14 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D058739 | Aberrant Crypt Foci |
C00029547
|
| D018248 | Adenoma, Liver Cell |
C00029547
|
| D008113 | Liver Neoplasms |
C00029547
|
| D010212 | Papilloma |
C00029547
|
| D012878 | Skin Neoplasms |
C00029547
|
| D002493 | Central Nervous System Diseases |
C00019308
|
| D003072 | Cognition Disorders |
C00019308
|
| D013118 | Spinal Cord Diseases |
C00019308
|
| D000855 | Anorexia |
C00001490
|
| D002779 | Cholestasis |
C00001490
|
| D056486 | Drug-Induced Liver Injury |
C00001490
|
| D007565 | Jaundice |
C00001490
|
| D009325 | Nausea |
C00001490
|
| D051437 | Renal Insufficiency |
C00001490
|