Gonocaryum calleryanum

• Index
• Plant Species
• Metabolite list (13)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Gonocaryum calleryanum
Genus	Gonocaryum
Family	Icacinaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Gonocaryum
Linked NCBI taxonomy ID	85208
Linked level	genus

Family

Family in NCBI taxonomy	Cardiopteridaceae
ID	125017

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (13)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00013607	Apigenin 7-apiofuranosyl-(1->6)-glucoside / 5,7,4'-Trihydroxyflavone 7-apiofuranosyl-(1->6)-glucoside / 7-[(6-O-D-Apio-beta-D-furanosyl-beta-D-glucopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one					No. 1	No. 15
C00019064	Oleanolic acid / Astrantiagenin C / Virgaureagenin B / 3beta-Hydroxyolean-12-en-28-oic acid	CHEMBL56615 CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454	D009828	30 / 8 / 12	21 / 15	No. 13	No. 51
C00003737	alpha-Amyrin / alpha-Amyrine / alpha-Amyrenol					No. 23	No. 51
C00003749	Lupeol / Lupenol / (+)-Lupenol	CHEMBL289191 CHEMBL459702	C010480	3 / 0 / 0	2 / 6	No. 23	No. 51
C00048994	Gonocaryoside E / (-)-Gonocaryoside E					No. 56	No. 36
C00022654	beta-Amyrin acetate	CHEMBL489760 CHEMBL1318082		4 / 3 / 7		No. 177
C00048974	Erythrodiol-3-acetate	CHEMBL480306				No. 177
C00029633	Ursolic acid / Acetylursolic acid	CHEMBL55086 CHEMBL410525		4 / 2 / 2		No. 177
C00002657	p-Formylphenol / 4-Hydroxybenzaldehyde / p-Hydroxybenzaldehyde	CHEMBL14193	C011483	3 / 2 / 2		No. 2076
C00030771	Methylparaben / p-Methoxycarbonylphenol	CHEMBL325372	C015358	102 / 49 / 57	3 / 0	No. 2169
C00048992	Gonocaryoside A					No. 2332
C00048993	Gonocaryoside B					No. 2332
C00029547	5-Hydroxymethylfuraldehyde / 5-Hydroxymethyl-2-furfural / 5-Hydroxymethyl-2-furaldehyde / 5-(Hydroxymethyl)-2-furaldehyde	CHEMBL185885	C008046	4 / 3 / 3	2 / 5	No. 6025

Human Protein / Gene in interactions

142 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00019064 C00030771	0 / 3
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00019064 C00029633	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00019064 C00030771	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00019064 C00029633	2 / 2
P04150	Glucocorticoid receptor	NR3C1	C00029547 C00030771	0 / 1
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00019064 C00030771	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00003749 C00022654	0 / 0
P06746	DNA polymerase beta	Enzyme	C00019064 C00029633	0 / 0
P03372	Estrogen receptor	NR3A1	C00030771	1 / 1
Q16539	Mitogen-activated protein kinase 14	p38	C00030771	0 / 0
P08246	Neutrophil elastase	S1A	C00030771	2 / 1
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00030771	0 / 0
P43166	Carbonic anhydrase 7	Lyase	C00030771	0 / 0
Q06124	Tyrosine-protein phosphatase non-receptor type 11	Tyr	C00019064	4 / 2
P29466	Caspase-1	C14	C00030771	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00030771	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00030771	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00030771	2 / 2
P24666	Low molecular weight phosphotyrosine protein phosphatase	Tyr	C00019064	0 / 0
Q8TDU6	G-protein coupled bile acid receptor 1	Steroid-like ligand receptor	C00019064	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00019064	0 / 0
P08047	Transcription factor Sp1	Unclassified protein	C00003749	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00029547	3 / 2
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00030771	1 / 1
P51649	Succinate-semialdehyde dehydrogenase, mitochondrial	Oxidoreductase	C00002657	1 / 1
P00918	Carbonic anhydrase 2	Lyase	C00030771	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00030771	0 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00030771	1 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00030771	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00030771	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00030771	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00030771	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00030771	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00030771	0 / 0
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00019064	0 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00030771	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00030771	0 / 0
P10586	Receptor-type tyrosine-protein phosphatase F	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00030771	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00030771	0 / 1
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00030771	1 / 8
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00030771	2 / 2
P11388	DNA topoisomerase 2-alpha	Isomerase	C00003749	0 / 0
P14416	D(2) dopamine receptor	Dopamine receptor	C00030771	2 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00030771	1 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00030771	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00030771	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00030771	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00030771	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00030771	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00030771	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00030771	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00030771	1 / 0
Q9ULX7	Carbonic anhydrase 14	Lyase	C00030771	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00029547	0 / 0
O43570	Carbonic anhydrase 12	Lyase	C00030771	1 / 2
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00030771	0 / 0
P14902	Indoleamine 2,3-dioxygenase 1	Enzyme	C00002657	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00019064	0 / 0
O75496	Geminin	Unclassified protein	C00019064	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00030771	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00030771	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00030771	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00030771	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00030771	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00030771	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00030771	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00030771	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00030771	0 / 0
P15121	Aldose reductase	Enzyme	C00019064	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00030771	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00030771	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00030771	1 / 0
P00915	Carbonic anhydrase 1	Lyase	C00030771	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00019064	0 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00030771	0 / 0
P08311	Cathepsin G	S1A	C00030771	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00030771	1 / 0
P03956	Interstitial collagenase	M10A	C00030771	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00030771	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00019064	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00022654	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00030771	0 / 0
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00030771	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00030771	0 / 0
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00019064	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00030771	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00030771	2 / 0
P80404	4-aminobutyrate aminotransferase, mitochondrial	Transferase	C00002657	1 / 1
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00030771	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00030771	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00030771	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00030771	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00030771	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00030771	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00019064	0 / 0
P18433	Receptor-type tyrosine-protein phosphatase alpha	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00019064	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00030771	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00030771	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00030771	2 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00030771	0 / 0
Q16790	Carbonic anhydrase 9	Lyase	C00030771	0 / 1
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00029547	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00019064	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00030771	0 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00030771	0 / 0
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00030771	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00030771	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00030771	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00030771	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00030771	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00030771	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00030771	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00030771	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00030771	0 / 0
P35228	Nitric oxide synthase, inducible	Enzyme	C00019064	1 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00030771	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00030771	0 / 1
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00030771	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00030771	7 / 37
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00019064	0 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00030771	5 / 1
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00030771	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00030771	0 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00030771	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00030771	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00030771	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00030771	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00030771	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00030771	0 / 1
P17706	Tyrosine-protein phosphatase non-receptor type 2	Tyr	C00019064	0 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00030771	0 / 0
P29350	Tyrosine-protein phosphatase non-receptor type 6	Tyr	C00019064	0 / 0
P04054	Phospholipase A2	Enzyme	C00019064	0 / 0
P23469	Receptor-type tyrosine-protein phosphatase epsilon	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00029633	0 / 0
O00255	Menin	Unclassified protein	C00022654	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00022654	1 / 2
Q13951	Core-binding factor subunit beta	Unclassified protein	C00019064	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00019064	1 / 4
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00030771	0 / 0

27 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5728	PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1	phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48)	C00003749 C00019064
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00019064
1499	CTNNB1, CTNNB, MRD19, armadillo	catenin (cadherin-associated protein), beta 1, 88kDa	C00003749
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00029547
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00030771
3952	LEP, LEPD, OB, OBS	leptin	C00030771
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00030771
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00019064
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00019064
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00019064
847	CAT	catalase (EC:1.11.1.6)	C00019064
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00019064
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00019064
6799	SULT1A2, HAST4, P-PST, ST1A2, STP2, TSPST2	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 (EC:2.8.2.1)	C00029547
3065	HDAC1, GON-10, HD1, RPD3, RPD3L1	histone deacetylase 1 (EC:3.5.1.98)	C00019064
3146	HMGB1, HMG1, HMG3, SBP-1	high mobility group box 1	C00019064
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00019064
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00019064
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00019064
4233	MET, AUTS9, HGFR, RCCP2, c-Met	met proto-oncogene (EC:2.7.10.1)	C00019064
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00019064
5052	PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2	peroxiredoxin 1 (EC:1.11.1.15)	C00019064
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00019064
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00019064
7150	TOP1, TOPI	topoisomerase (DNA) I (EC:5.99.1.2)	C00019064
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00019064
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00019064

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions