Species

KNApSAcK Entry

Organism name Cryptotympana sp.
Genus Cryptotympana
Family Cicadidae
Kingdom Animalia

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cryptotympana
Linked NCBI taxonomy ID 407120
Linked level genus

Family

Family in NCBI taxonomy Cicadidae
ID 7033

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Metazoa
ID 33208

Plant class

Plant class
ID

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002668 External link 512 Protocatechuic acid
/ 3,4-Dihydroxybenzoic acid
CHEMBL37537
C009091
33 / 19 / 19 2 / 0 No. 817 No. 81
C00018099 External link 512 Catechaldehyde
/ Protocatechualdehyde
/ 3,4-Dihydroxybenzaldehyde
CHEMBL222021
C005581
7 / 0 / 0 5 / 2 No. 2076
C00033243 External link 512 N-Acetyldopamine
CHEMBL137743
C006374
15 / 23 / 23 No. 3468
C00032630 External link 512 2-Oxo-N-acetyldopamine
C078501
No. 5869

Human Protein / Gene in interactions

49 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002668 C00018099 C00033243 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002668 C00018099 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00018099 C00033243 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002668 C00033243 4 / 3
Q9UNA4 DNA polymerase iota Enzyme C00002668 C00018099 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00002668 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00002668 0 / 0
P22894 Neutrophil collagenase M10A C00002668 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002668 2 / 2
P02545 Prelamin-A/C Unclassified protein C00033243 11 / 10
P00918 Carbonic anhydrase 2 Lyase C00002668 1 / 2
P02768 Serum albumin Secreted protein C00002668 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00033243 0 / 1
Q9GZT9 Egl nine homolog 1 Enzyme C00002668 1 / 1
P54132 Bloom syndrome protein Enzyme C00033243 1 / 2
P23280 Carbonic anhydrase 6 Lyase C00002668 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00002668 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00033243 0 / 0
P16581 E-selectin Adhesion C00002668 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00002668 1 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00033243 0 / 0
O75496 Geminin Unclassified protein C00002668 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00018099 0 / 0
P15121 Aldose reductase Enzyme C00002668 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002668 1 / 1
P07711 Cathepsin L1 C1A C00002668 0 / 0
P03956 Interstitial collagenase M10A C00002668 0 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002668 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00033243 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002668 0 / 1
P08253 72 kDa type IV collagenase M10A C00002668 1 / 3
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00033243 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00033243 2 / 2
P03372 Estrogen receptor NR3A1 C00002668 1 / 1
P14151 L-selectin Adhesion C00002668 0 / 0
P16109 P-selectin Adhesion C00002668 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00033243 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00033243 0 / 1
P06746 DNA polymerase beta Enzyme C00002668 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00018099 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00002668 3 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein C00033243 0 / 0
P08254 Stromelysin-1 M10A C00002668 1 / 0
P22748 Carbonic anhydrase 4 Lyase C00002668 1 / 1
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002668 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00018099 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00002668 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002668 1 / 4
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00033243 1 / 0

7 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
177 AGER, RAGE advanced glycosylation end product-specific receptor C00018099
6285 S100B, NEF, S100, S100-B, S100beta S100 calcium binding protein B C00018099
4087 SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 SMAD family member 2 C00018099
4088 SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 SMAD family member 3 C00018099
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00018099
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00002668
2023 ENO1, ENO1L1, MPB1, NNE, PPH enolase 1, (alpha) (EC:4.2.1.11) C00002668

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (38)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#600807 Asthma, susceptibility to Q13093
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#601367 Stroke, ischemic P16109
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (39)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00236 Congenital polycythemia Q9GZT9 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002386 Cataract C00018099
D048909 Diabetes Complications C00018099