PCIDB

KNApSAcK Metabolite C00018099

Metabolite

KNApSAcK Entry

id C00018099
Name Catechaldehyde / Protocatechualdehyde / 3,4-Dihydroxybenzaldehyde
CAS RN 139-85-5
Standard InChI InChI=1S/C7H6O3/c8-4-5-1-2-6(9)7(10)3-5/h1-4,9-10H
Standard InChI (Main Layer) InChI=1S/C7H6O3/c8-4-5-1-2-6(9)7(10)3-5/h1-4,9-10H

Cluster

Phytochemical cluster
KCF-S cluster No. 2076

Link

ChEMBL

By standard InChI CHEMBL222021
By standard InChI Main Layer CHEMBL222021

KEGG

By LinkDB C16700

CTD

By CAS RN C005581

Human Protein / Gene in interaction

7 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL222021 CHEMBL1738312 (1)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL222021 CHEMBL1613838 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL222021 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL222021 CHEMBL1737991 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL222021 CHEMBL1613914 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL222021 CHEMBL1738442 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL222021 CHEMBL2114738 (1)
0 / 0

CTD interaction (16)

compound gene gene name gene description interaction interaction type form reference
pmid
C005581 177 AGER
RAGE
advanced glycosylation end product-specific receptor protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA] decreases reaction
/ increases expression
mRNA 17597607
C005581 177 AGER
RAGE
advanced glycosylation end product-specific receptor protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein] decreases reaction
/ increases expression
protein 17597607
C005581 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA] decreases reaction
/ increases expression
protein 17597607
C005581 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein] decreases reaction
/ increases expression
protein 17597607
C005581 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA] decreases reaction
/ increases expression
protein 17597607
C005581 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein] decreases reaction
/ increases expression
protein 17597607
C005581 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein] affects localization
/ decreases reaction
/ increases phosphorylation
protein 17597607
C005581 6285 S100B
NEF
S100
S100-B
S100beta
S100 calcium binding protein B protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] affects localization
/ decreases reaction
/ increases phosphorylation
protein 17597607
C005581 4087 SMAD2
JV18
JV18-1
MADH2
MADR2
hMAD-2
hSMAD2
SMAD family member 2 protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein] affects localization
/ decreases reaction
/ increases phosphorylation
protein 17597607
C005581 4087 SMAD2
JV18
JV18-1
MADH2
MADR2
hMAD-2
hSMAD2
SMAD family member 2 protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein] affects localization
/ decreases reaction
/ increases phosphorylation
protein 17597607
C005581 4088 SMAD3
HSPC193
HsT17436
JV15-2
LDS1C
LDS3
MADH3
SMAD family member 3 protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein] affects localization
/ decreases reaction
/ increases phosphorylation
protein 17597607
C005581 4088 SMAD3
HSPC193
HsT17436
JV15-2
LDS1C
LDS3
MADH3
SMAD family member 3 protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] affects localization
/ decreases reaction
/ increases phosphorylation
protein 17597607
C005581 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA] decreases reaction
/ increases expression
mRNA 17597607
C005581 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 protein] decreases reaction
/ increases expression
protein 17597607
C005581 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA] decreases reaction
/ increases expression
mRNA 17597607
C005581 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein] decreases reaction
/ increases expression
protein 17597607

Related Disease

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D002386 C005581 Cataract therapeutic
17597607
D048909 C005581 Diabetes Complications therapeutic
17597607