Hordeum vulgare
Species
KNApSAcK Entry
| Organism name | Hordeum vulgare |
|---|---|
| Genus | Hordeum |
| Family | Poaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Hordeum vulgare |
|---|---|
| Linked NCBI taxonomy ID | 4513 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Poaceae |
|---|---|
| ID | 4479 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Liliopsida |
|---|---|
| ID | 4447 |
Metabolite list (39)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00006184
|
Lucenin 5
/ Carlinoside / Luteolin 6-C-beta-D-glucopyranoside-8-C-alpha-L-arabinopyranoside |
No. 1 | No. 15 |
|
||||
|
C00006273
|
Isoscoparin 7-O-glucoside
|
No. 1 | No. 15 |
|
||||
|
C00006206
|
Lutonarin
|
CHEMBL470327
|
No. 1 | No. 15 |
|
|||
|
C00014077
|
Isovitexin 7-O-(6'''-O-E-p-coumaroyl)glucoside
|
No. 7 | No. 15 |
|
||||
|
C00014097
|
Isoorientin 7-O-(6'''-O-(E)-feruloyl)glucoside
|
No. 7 | No. 15 |
|
||||
|
C00014078
|
6'''-Feruloylsaponarin
/ Isovitexin 7-O-beta-[6'''-O-(E)-p-feruloyl]glucoside |
No. 7 | No. 15 |
|
||||
|
C00009111
|
Prodelphinidin C
|
No. 16 | No. 19 |
|
||||
|
C00009113
|
Epigallocatechin-(4beta->8)-catechin
|
No. 16 | No. 19 |
|
||||
|
C00001078
|
Lutexin
/ Orientin / Luteolin 8-C-beta-D-glucopyranoside / 8-beta-D-Glucopyranosyl-3',4',5,7-tetrahydroxyflavone |
CHEMBL520866
CHEMBL1468796 |
C065886
|
20 / 15 / 14 | No. 22 | No. 15 |
|
|
|
C00014019
|
6-C-beta-D-Glucopyranosyl-5,7,2',4',5'-pentahydroxyflavone
/ 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(2,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one |
No. 22 | No. 15 |
|
||||
|
C00009091
|
Procyanidin C2
|
CHEMBL290632
|
13 / 5 / 6 | No. 29 | No. 19 |
|
||
|
C00009119
|
Gallocatechin-(4alpha->8)-catechin-(4alpha->8)-catechin
|
No. 29 | No. 19 |
|
||||
|
C00009099
|
Catechin-(4alpha->8)-gallocatechin-(4alpha->8)-catechin
|
No. 29 | No. 19 |
|
||||
|
C00009121
|
[Gallocatechin-(4alpha->8)]2-gallocatechin
|
No. 29 | No. 19 |
|
||||
|
C00009120
|
[Gallocatechin-(4alpha->8)]2-catechin
|
No. 29 | No. 19 |
|
||||
|
C00000003
|
GA3
/ Gibberellin A3 |
CHEMBL513241
CHEMBL566653 CHEMBL1232952 CHEMBL1476967 CHEMBL1487394 |
C007842
|
10 / 18 / 17 | No. 40 | No. 41 |
|
|
|
C00000008
|
GA8
/ Gibberellin A8 |
No. 40 | No. 41 |
|
||||
|
C00000029
|
GA29
/ Gibberellin A29 |
No. 40 | No. 41 |
|
||||
|
C00000069
|
GA69
/ Gibberellin A69 |
No. 40 | No. 41 |
|
||||
|
C00000020
|
GA20
/ Gibberellin A20 |
No. 40 | No. 41 |
|
||||
|
C00008817
|
Gallocatechin
/ (+)-Gallocatechin / (+)-Gallocatechol / (2R,3S)-3,4-Dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol |
CHEMBL47386
CHEMBL125743 CHEMBL130415 CHEMBL264167 CHEMBL404845 |
26 / 17 / 29 | No. 52 | No. 14 |
|
||
|
C00000298
|
GA97
/ Gibberellin A97 |
No. 187 | No. 41 |
|
||||
|
C00000019
|
GA19
/ Gibberellin A19 |
C120175
|
No. 187 | No. 41 |
|
|||
|
C00001434
|
Tryptamine
/ beta-(3-Indolyl)ethylamine |
CHEMBL6640
|
C030820
|
20 / 5 / 7 | 6 / 2 | No. 710 | No. 4 |
|
|
C00001417
|
Cactine
/ Anhalin / Anhaline / Hordenine |
CHEMBL505789
|
C007964
|
1 / 0 / 0 | No. 936 | No. 6 |
|
|
|
C00001435
|
Tyramine
|
CHEMBL11608
|
D014439
|
23 / 11 / 6 | 6 / 9 | No. 936 | No. 6 |
|
|
C00001411
|
Gramine
|
CHEMBL254348
|
C007884
|
13 / 11 / 15 | No. 1385 | No. 4 |
|
|
|
C00000104
|
5-Hydroxyindole-3-acetic acid
|
CHEMBL395915
|
D006897
|
22 / 32 / 22 | 0 / 8 | No. 1910 | No. 4 |
|
|
C00018099
|
Catechaldehyde
/ Protocatechualdehyde / 3,4-Dihydroxybenzaldehyde |
CHEMBL222021
|
C005581
|
7 / 0 / 0 | 5 / 2 | No. 2076 |
|
|
|
C00000769
|
alpha-Oxoglutaric acid
/ alpha-Ketoglutaric acid |
CHEMBL1686
|
C029743
|
13 / 6 / 7 | 8 / 0 | No. 2414 |
|
|
|
C00001197
|
Oxalacetic acid
|
CHEMBL2075016
|
D062907
|
1 / 0 | No. 2414 |
|
||
|
C00000091
|
trans-Zeatin
|
CHEMBL525239
|
D015026
|
2 / 3 / 2 | 0 / 1 | No. 2879 |
|
|
|
C00001428
|
Putrescine
|
CHEMBL46257
|
D011700
|
9 / 5 / 4 | 3 / 4 | No. 3767 |
|
|
|
C00000112
|
Indole-3-carboxaldehyde
/ 1H-Indole-3-carboxaldehyde |
CHEMBL147741
|
C012381
|
2 / 1 / 1 | No. 4314 |
|
||
|
C00001416
|
Hordatine B
|
No. 4654 | No. 78 |
|
||||
|
C00001415
|
Hordatine A
|
CHEMBL567589
CHEMBL566278 CHEMBL585895 CHEMBL568182 |
No. 4654 | No. 78 |
|
|||
|
C00001193
|
Malonic acid
|
CHEMBL7942
|
C030290
|
6 / 1 / 5 | 1 / 2 | No. 5377 |
|
|
|
C00001400
|
Agmatine
|
CHEMBL58343
|
D000376
|
11 / 2 / 3 | 0 / 9 | No. 7327 | No. 78 |
|
|
C00002319
|
Candicine
|
CHEMBL1186075
|
No. 8319 | No. 6 |
|
Human Protein / Gene in interactions
114 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000003 C00000104 C00001400 C00001411 C00001428 C00001434 C00001435 | 1 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000003 C00000104 C00001400 C00001411 C00001428 C00001434 C00001435 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000003 C00000104 C00001400 C00001411 C00001428 C00001434 C00001435 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000003 C00000104 C00001400 C00001411 C00001428 C00001434 C00001435 | 0 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000003 C00000104 C00001400 C00001411 C00001428 C00001434 C00001435 | 0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001078 C00001411 C00001435 C00008817 C00018099 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000104 C00001078 C00001400 C00001435 C00018099 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000104 C00001078 C00001411 C00001435 C00008817 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000003 C00000104 C00001434 C00001435 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000104 C00001400 C00001428 C00001434 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000769 C00001411 C00001434 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001417 C00001435 C00018099 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00000104 C00001428 C00001435 | 2 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00001078 C00001411 C00018099 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001078 C00001434 C00018099 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000091 C00000104 C00001411 | 3 / 2 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001078 C00018099 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000091 C00008817 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000003 C00000104 | 11 / 10 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001078 C00008817 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00000003 C00000769 | 3 / 4 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001078 C00008817 | 1 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001078 C00008817 | 4 / 3 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001078 C00008817 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00001078 C00001411 | 2 / 5 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | C00001400 C00001435 | 0 / 0 |
| P02768 | Serum albumin | Secreted protein | C00000104 C00008817 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001078 C00001411 | 1 / 2 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001400 C00008817 | 0 / 0 |
| P00374 | Dihydrofolate reductase | Oxidoreductase | C00000112 C00008817 | 1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000104 C00008817 | 2 / 2 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001078 C00001434 | 1 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001411 C00008817 | 3 / 3 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000104 C00008817 | 2 / 3 |
| O75751 | Solute carrier family 22 member 3 | Unclassified protein | C00001400 C00001435 | 0 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00001435 C00008817 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000003 C00000104 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001078 C00001435 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000003 C00000104 | 2 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001434 C00001435 | 0 / 0 |
| P28221 | 5-hydroxytryptamine receptor 1D | Serotonin receptor | C00001434 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00001434 | 0 / 0 |
| Q9NWT6 | Hypoxia-inducible factor 1-alpha inhibitor | Enzyme | C00000769 | 0 / 0 |
| Q96KS0 | Egl nine homolog 2 | Enzyme | C00000769 | 0 / 0 |
| Q16798 | NADP-dependent malic enzyme, mitochondrial | Enzyme | C00001193 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00018099 | 0 / 0 |
| Q8TCC7 | Solute carrier family 22 member 8 | Antiporter | C00000769 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00001435 | 0 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00008817 | 0 / 0 |
| P46098 | 5-hydroxytryptamine receptor 3A | NS | C00001435 | 0 / 0 |
| Q9GZT4 | Serine racemase | Enzyme | C00001193 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001078 | 1 / 1 |
| P05164 | Myeloperoxidase | Enzyme | C00001434 | 1 / 2 |
| Q4U2R8 | Solute carrier family 22 member 6 | Antiporter | C00000769 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00008817 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00008817 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00001435 | 4 / 2 |
| P00338 | L-lactate dehydrogenase A chain | Enzyme | C00001193 | 1 / 5 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00001193 | 0 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00001434 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00000104 | 1 / 1 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00008817 | 2 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000769 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00008817 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00001435 | 2 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00009091 | 1 / 3 |
| P13674 | Prolyl 4-hydroxylase subunit alpha-1 | Enzyme | C00000769 | 0 / 0 |
| Q9GZT9 | Egl nine homolog 1 | Enzyme | C00000769 | 1 / 1 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00000104 | 5 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001434 | 0 / 0 |
| P14920 | D-amino-acid oxidase | Enzyme | C00001193 | 0 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00001434 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00001434 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00008817 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001078 | 1 / 1 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00001435 | 0 / 0 |
| O15244 | Solute carrier family 22 member 2 | Drug uniporter | C00001400 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00000769 | 1 / 0 |
| P28222 | 5-hydroxytryptamine receptor 1B | Serotonin receptor | C00001434 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00000104 | 1 / 0 |
| Q96RJ0 | Trace amine-associated receptor 1 | Trace amine receptor | C00001435 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00001435 | 1 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001078 | 3 / 1 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00008817 | 1 / 1 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00000104 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00008817 | 0 / 3 |
| P12268 | Inosine-5'-monophosphate dehydrogenase 2 | Oxidoreductase | C00000112 | 0 / 0 |
| P43235 | Cathepsin K | C1A | C00001434 | 1 / 2 |
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00008817 | 0 / 7 |
| Q9Y694 | Solute carrier family 22 member 7 | Unclassified protein | C00000769 | 0 / 0 |
| Q9H6Z9 | Egl nine homolog 3 | Enzyme | C00000769 | 0 / 0 |
| Q99489 | D-aspartate oxidase | Enzyme | C00001193 | 0 / 0 |
| P17707 | S-adenosylmethionine decarboxylase proenzyme | Enzyme | C00001428 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001078 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00000104 | 1 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00009091 | 2 / 2 |
| P52209 | 6-phosphogluconate dehydrogenase, decarboxylating | Enzyme | C00008817 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00008817 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00008817 | 1 / 4 |
| Q05513 | Protein kinase C zeta type | Iota | C00009091 | 0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | C00009091 | 0 / 1 |
| Q02156 | Protein kinase C epsilon type | Eta | C00009091 | 0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00009091 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00009091 | 0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | C00009091 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00009091 | 1 / 1 |
| P05771 | Protein kinase C beta type | Alpha | C00009091 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00009091 | 1 / 0 |
| P41743 | Protein kinase C iota type | Iota | C00009091 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00009091 | 0 / 0 |
| Q9H015 | Solute carrier family 22 member 4 | Unclassified protein | C00001428 | 1 / 1 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00001078 | 1 / 1 |
| O76082 | Solute carrier family 22 member 5 | Unclassified protein | C00000769 | 1 / 2 |
| P06746 | DNA polymerase beta | Enzyme | C00001078 | 0 / 0 |
25 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00001193
C00001197
|
| 134864 | TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1 | trace amine associated receptor 1 |
C00001434
C00001435
|
| 6532 | SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT | solute carrier family 6 (neurotransmitter transporter), member 4 |
C00001434
C00001435
|
| 6531 | SLC6A3, DAT, DAT1, PKDYS | solute carrier family 6 (neurotransmitter transporter), member 3 |
C00001434
C00001435
|
| 6530 | SLC6A2, NAT1, NET, NET1, SLC6A5 | solute carrier family 6 (neurotransmitter transporter), member 2 |
C00001434
C00001435
|
| 7428 | VHL, HRCA1, RCA1, VHL1, pVHL | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase |
C00000769
|
| 728294 | D2HGDH, D2HGD | D-2-hydroxyglutarate dehydrogenase (EC:1.1.99.-) |
C00000769
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00000769
|
| 8290 | HIST3H3, H3.4, H3/g, H3FT, H3t | histone cluster 3, H3 |
C00000769
|
| 55818 | KDM3A, JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA | lysine (K)-specific demethylase 3A |
C00000769
|
| 54681 | P4HTM, EGLN4, HIFPH4, P4H-TM, PH-4, PH4, PHD4 | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) |
C00000769
|
| 9356 | SLC22A6, HOAT1, OAT1, PAHT, ROAT1 | solute carrier family 22 (organic anion transporter), member 6 |
C00000769
|
| 8424 | BBOX1, BBH, BBOX, G-BBH, gamma-BBH | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 (EC:1.14.11.1) |
C00000769
|
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor |
C00018099
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00001434
|
| 3356 | HTR2A, 5-HT2A, HTR2 | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled |
C00001434
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00018099
|
| 4088 | SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 | SMAD family member 3 |
C00018099
|
| 4087 | SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 | SMAD family member 2 |
C00018099
|
| 6285 | S100B, NEF, S100, S100-B, S100beta | S100 calcium binding protein B |
C00018099
|
| 153 | ADRB1, ADRB1R, B1AR, BETA1AR, RHR | adrenoceptor beta 1 |
C00001428
|
| 154 | ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR | adrenoceptor beta 2, surface |
C00001428
|
| 26 | AOC1, ABP, ABP1, DAO, DAO1, KAO | amine oxidase, copper containing 1 (EC:1.4.3.22) |
C00001428
|
| 4128 | MAOA, MAO-A | monoamine oxidase A (EC:1.4.3.4) |
C00001435
|
| 6818 | SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) |
C00001435
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (77)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P14416
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #212140 | Carnitine deficiency, systemic primary; cdsp |
O76082
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #609820 | Erythrocytosis, familial, 3; ecyt3 |
Q9GZT9
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #612933 | Glycogen storage disease xi; gsd11 |
P00338
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613839 | Megaloblastic anemia due to dihydrofolate reductase deficiency |
P00374
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #254600 | Myeloperoxidase deficiency; mpod |
P05164
|
| #159900 | Myoclonic dystonia |
P14416
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #265800 | Pycnodysostosis |
P43235
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #180300 | Rheumatoid arthritis; ra |
Q9H015
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P24723
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (75)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00286 | Crohn's disease |
O76082
(related)
Q9H015 (related) |
| H00525 | Disorders of fatty-acid oxidation |
O76082
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P00338
(related)
P10253 (related) |
| H00010 | Multiple myeloma |
P00338
(marker)
|
| H00023 | Testicular cancer |
P00338
(marker)
|
| H00035 | Ewing's sarcoma |
P00338
(marker)
|
| H00043 | Neuroblastoma |
P00338
(marker)
|
| H01197 | Dihydrofolate reductase (DHFR) deficiency |
P00374
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
Q99700 (related) Q9NUW8 (related) |
| H00101 | Other phagocyte defects |
P05164
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P05164
(marker)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00125 | Fabry disease |
P06280
(related)
|
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) P35354 (related) |
| H00028 | Choriocarcinoma |
P08253
(related)
P10415 (related) |
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00018 | Gastric cancer |
P08581
(related)
P10415 (related) |
| H00021 | Renal cell carcinoma |
P08581
(related)
|
| H00046 | Cholangiocarcinoma |
P08581
(related)
P35354 (related) |
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P10415
(related)
|
| H00013 | Small cell lung cancer |
P10415
(related)
|
| H00030 | Cervical cancer |
P10415
(related)
|
| H00041 | Kaposi's sarcoma |
P10415
(related)
|
| H00054 | Nasopharyngeal cancer |
P10415
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00273 | Pycnodysostosis |
P43235
(related)
|
| H00425 | Lysosomal cysteine protease deficiencies |
P43235
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00236 | Congenital polycythemia |
Q9GZT9
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
31 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D006973 | Hypertension |
C00001400
C00000104 C00001428 C00001435 |
| D007022 | Hypotension |
C00001400
C00001435 |
| D013610 | Tachycardia |
C00001400
C00001435 |
| D012640 | Seizures |
C00001434
C00000104 |
| D000987 | Antisocial Personality Disorder |
C00000104
|
| D014202 | Tremor |
C00001434
|
| D001919 | Bradycardia |
C00001400
|
| D006930 | Hyperalgesia |
C00001400
|
| D020258 | Neurotoxicity Syndromes |
C00001193
|
| D001930 | Brain Injuries |
C00001193
|
| D009021 | Morphine Dependence |
C00001400
|
| D009293 | Opioid-Related Disorders |
C00001400
|
| D010146 | Pain |
C00001400
|
| D013375 | Substance Withdrawal Syndrome |
C00001400
|
| D048909 | Diabetes Complications |
C00018099
|
| D002386 | Cataract |
C00018099
|
| D001927 | Brain Diseases |
C00000104
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00000104
|
| D005391 | Firesetting Behavior |
C00000104
|
| D007174 | Impulse Control Disorders |
C00000104
|
| D013226 | Status Epilepticus |
C00000104
|
| D006332 | Cardiomegaly |
C00001428
|
| D056486 | Drug-Induced Liver Injury |
C00001428
|
| D011230 | Precancerous Conditions |
C00001428
|
| D009202 | Cardiomyopathies |
C00001435
|
| D002543 | Cerebral Hemorrhage |
C00001435
|
| D002637 | Chest Pain |
C00001435
|
| D008881 | Migraine Disorders |
C00001435
|
| D015878 | Mydriasis |
C00001435
|
| D011041 | Poisoning |
C00001435
|
| D000647 | Amnesia |
C00000091
|