PCIDB

KNApSAcK Metabolite C00000104

Metabolite

KNApSAcK Entry

id C00000104
Name 5-Hydroxyindole-3-acetic acid
CAS RN 54-16-0
Standard InChI InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)
Standard InChI (Main Layer) InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 1910

Link

ChEMBL

By standard InChI CHEMBL395915
By standard InChI Main Layer CHEMBL395915

KEGG

By LinkDB

CTD

By CAS RN D006897

Human Protein / Gene in interaction

22 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL395915 CHEMBL1741321 (1)
1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL395915 CHEMBL1794499 (1)
2 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL395915 CHEMBL1614310 (1)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL395915 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P02768 Serum albumin Secreted protein CHEMBL395915 CHEMBL894775 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL395915 CHEMBL1614027 (1) CHEMBL1741325 (1)
0 / 1
P11473 Vitamin D3 receptor NR1I1 CHEMBL395915 CHEMBL1794311 (1)
2 / 3
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL395915 CHEMBL1614458 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL395915 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL395915 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL395915 CHEMBL1738610 (1)
0 / 0
P06280 Alpha-galactosidase A Enzyme CHEMBL395915 CHEMBL1614217 (1)
1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL395915 CHEMBL1741322 (1)
0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL395915 CHEMBL1614038 (1)
2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL395915 CHEMBL1614171 (1)
5 / 2
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL395915 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL395915 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL395915 CHEMBL1741324 (1)
0 / 1
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL395915 CHEMBL1614052 (1)
1 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL395915 CHEMBL1738402 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL395915 CHEMBL1738442 (2)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL395915 CHEMBL2354311 (1)
1 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (32)

OMIM preferred title UniProt
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#301500 Fabry disease P06280
#137800 Glioma susceptibility 1; glm1 O75874
#139393 Guillain-barre syndrome, familial; gbs Q01453
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (22)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)

Diseases related to CTD interactions

8 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000987 D006897 Antisocial Personality Disorder marker/mechanism
7506515
D001927 D006897 Brain Diseases marker/mechanism
2428491
D064420 D006897 Drug-Related Side Effects and Adverse Reactions marker/mechanism
2428491
D005391 D006897 Firesetting Behavior marker/mechanism
7506515
D006973 D006897 Hypertension marker/mechanism
2452247
8724428
D007174 D006897 Impulse Control Disorders marker/mechanism
7506515
D012640 D006897 Seizures marker/mechanism
20433896
D013226 D006897 Status Epilepticus marker/mechanism
15488322
15876489
16563474