PCIDB

KNApSAcK Metabolite C00001428

Metabolite

KNApSAcK Entry

id C00001428
Name Putrescine
CAS RN 110-60-1
Standard InChI InChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2
Standard InChI (Main Layer) InChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2

Cluster

Phytochemical cluster
KCF-S cluster No. 3767

Link

ChEMBL

By standard InChI CHEMBL46257
By standard InChI Main Layer CHEMBL46257

KEGG

By LinkDB C00134

CTD

By CAS RN D011700

Human Protein / Gene in interaction

9 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL46257 CHEMBL1741321 (1)
1 / 0
P17707 S-adenosylmethionine decarboxylase proenzyme Enzyme CHEMBL46257 CHEMBL798947 (1)
0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL46257 CHEMBL1794499 (1)
2 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL46257 CHEMBL1741325 (1)
0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL46257 CHEMBL1741322 (1)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL46257 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL46257 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL46257 CHEMBL1741324 (1)
0 / 1
Q9H015 Solute carrier family 22 member 4 Unclassified protein CHEMBL46257 CHEMBL2076155 (1)
1 / 1

CTD interaction (8)

compound gene gene name gene description interaction interaction type form reference
pmid
D011700 153 ADRB1
ADRB1R
B1AR
BETA1AR
RHR
adrenoceptor beta 1 Putrescine binds to and results in increased activity of ADRB1 protein affects binding
/ increases activity
protein 20885010
D011700 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Putrescine binds to and results in increased activity of ADRB2 protein affects binding
/ increases activity
protein 20885010
D011700 26 AOC1
ABP
ABP1
DAO
DAO1
KAO
amine oxidase, copper containing 1 (EC:1.4.3.22) Amiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine] decreases reaction
/ increases degradation
protein 8144586
D011700 26 AOC1
ABP
ABP1
DAO
DAO1
KAO
amine oxidase, copper containing 1 (EC:1.4.3.22) AOC1 protein results in increased degradation of Putrescine increases degradation
protein 8144586
D011700 26 AOC1
ABP
ABP1
DAO
DAO1
KAO
amine oxidase, copper containing 1 (EC:1.4.3.22) AOC1 protein results in increased metabolism of Putrescine increases metabolic processing
protein 12072962
D011700 26 AOC1
ABP
ABP1
DAO
DAO1
KAO
amine oxidase, copper containing 1 (EC:1.4.3.22) ethylisopropylamiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine] decreases reaction
/ increases degradation
protein 8144586
D011700 26 AOC1
ABP
ABP1
DAO
DAO1
KAO
amine oxidase, copper containing 1 (EC:1.4.3.22) phenylamil inhibits the reaction [AOC1 protein results in increased degradation of Putrescine] decreases reaction
/ increases degradation
protein 8144586
D011700 26 AOC1
ABP
ABP1
DAO
DAO1
KAO
amine oxidase, copper containing 1 (EC:1.4.3.22) pimagedine inhibits the reaction [AOC1 protein results in increased degradation of Putrescine] decreases reaction
/ increases degradation
protein 8144586

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#180300 Rheumatoid arthritis; ra Q9H015
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798

KEGG DISEASE (4)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00286 Crohn's disease Q9H015 (related)

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D006332 D011700 Cardiomegaly marker/mechanism
6218830
D056486 D011700 Drug-Induced Liver Injury marker/mechanism
20832458
D006973 D011700 Hypertension marker/mechanism
6218830
D011230 D011700 Precancerous Conditions marker/mechanism
17474863