PCIDB

KCF-S cluster No. 1385 (6 metabolites)

Corresponding Phytochemical cluster No. 4

KEGG BRITE br08003 External link 512

Categories (1)

br08003 Category # of metabolite
Indole alkaloids 4

metabolites link (4)

br08003 Category KEGG ID KNApSAcK ID
Indole alkaloids C08299 C00001402
Indole alkaloids C08302 C00001407
Indole alkaloids C08304 C00001411
Indole alkaloids C08309 C00001420

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00001402 External link 512 Bufotenine
CHEMBL416526
D002027
6 / 3 / 0
C00001407 External link 512 N,N-Dimethyltryptamine
CHEMBL12420
D004130
4 / 1 / 0 1 / 2
C00001411 External link 512 Gramine
CHEMBL254348
C007884
13 / 11 / 15
C00001420 External link 512 O-Methylbufotenine
/ N,N-Dimethyl-5-methoxytryptamine
/ 5-Methoxy-N,N-dimethyltryptamine
CHEMBL7257
14 / 3 / 3
C00001427 External link 512 Psilocin
CHEMBL65547
C009105
4 / 1 / 0
C00046585 External link 512 5,6-Dibromo-N,N-dimethyltryptamine
CHEMBL256339
2 / 0 / 0

Human Protein / Gene in interactions

26 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001402 C00001407 C00001420 C00001427 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001402 C00001407 C00001420 C00001427 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00001402 C00001407 C00001420 C00001427 1 / 0
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00001407 C00001420 C00001427 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001411 C00001420 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001411 C00001420 0 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001411 C00001420 0 / 1
P28221 5-hydroxytryptamine receptor 1D Serotonin receptor C00001402 C00001420 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001411 C00001420 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001411 C00001420 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001420 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00001402 2 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00001420 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00046585 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001411 3 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00001411 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00046585 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00001420 0 / 0
P28222 5-hydroxytryptamine receptor 1B Serotonin receptor C00001420 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001411 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001411 3 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001411 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001411 0 / 0
O00255 Menin Unclassified protein C00001411 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001411 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001402 0 / 0

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3356 HTR2A, 5-HT2A, HTR2 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled C00001407

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (14)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103780 Alcohol dependence P31645
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#164230 Obsessive-compulsive disorder; ocd P31645
#614674 Periodic fever, menstrual cycle-dependent P08908

KEGG DISEASE (15)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006212 Hallucinations C00001407
D001523 Mental Disorders C00001407