PCIDB

KNApSAcK Metabolite C00001434

Metabolite

KNApSAcK Entry

id C00001434
Name Tryptamine / beta-(3-Indolyl)ethylamine
CAS RN 61-54-1
Standard InChI InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2
Standard InChI (Main Layer) InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 710

Link

ChEMBL

By standard InChI CHEMBL6640
By standard InChI Main Layer CHEMBL6640

KEGG

By LinkDB C00398

CTD

By CAS RN C030820

Human Protein / Gene in interaction

20 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL6640 CHEMBL1614110 (1) CHEMBL1741321 (1)
1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL6640 CHEMBL1738091 (1) CHEMBL2114744 (1)
0 / 0
P28222 5-hydroxytryptamine receptor 1B Serotonin receptor CHEMBL6640 CHEMBL617320 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL6640 CHEMBL1741325 (1)
0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL6640 CHEMBL1614166 (1)
1 / 0
P05164 Myeloperoxidase Enzyme CHEMBL6640 CHEMBL2352940 (1)
1 / 2
P43235 Cathepsin K C1A CHEMBL6640 CHEMBL938815 (1)
1 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL6640 CHEMBL1743275 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL6640 CHEMBL2114780 (1)
0 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL6640 CHEMBL618122 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL6640 CHEMBL1741322 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL6640 CHEMBL1738675 (1)
0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL6640 CHEMBL617104 (1)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL6640 CHEMBL616819 (1)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL6640 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL6640 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL6640 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1)
0 / 1
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL6640 CHEMBL1737991 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL6640 CHEMBL1737980 (1)
0 / 0
P28221 5-hydroxytryptamine receptor 1D Serotonin receptor CHEMBL6640 CHEMBL616731 (1) CHEMBL617573 (1)
CHEMBL617575 (1) CHEMBL617599 (1)
CHEMBL852461 (1)
0 / 0

CTD interaction (22)

compound gene gene name gene description interaction interaction type form reference
pmid
C030820 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) tryptamine results in decreased activity of CYP2A6 protein decreases activity
protein 11353760
C030820 3356 HTR2A
5-HT2A
HTR2
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled HTR2A gene SNP results in decreased susceptibility to tryptamine decreases response to substance
gene 16314884
C030820 3356 HTR2A
5-HT2A
HTR2
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled HTR2A protein affects the susceptibility to tryptamine affects response to substance
protein 16314884
C030820 3356 HTR2A
5-HT2A
HTR2
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled tryptamine binds to and results in increased activity of HTR2A protein affects binding
/ increases activity
protein 16314884
C030820 6530 SLC6A2
NAT1
NET
NET1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 2 Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
C030820 6530 SLC6A2
NAT1
NET
NET1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 2 indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
C030820 6530 SLC6A2
NAT1
NET
NET1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 2 SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
C030820 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
C030820 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
C030820 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
C030820 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
C030820 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
C030820 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
C030820 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
C030820 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
C030820 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
C030820 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
C030820 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
C030820 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 17234900
C030820 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
C030820 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
C030820 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#254600 Myeloperoxidase deficiency; mpod P05164
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#265800 Pycnodysostosis P43235

KEGG DISEASE (7)

KEGG disease name UniProt
H00101 Other phagocyte defects P05164 (related)
H00003 Acute myeloid leukemia (AML) P05164 (marker)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00273 Pycnodysostosis P43235 (related)
H00425 Lysosomal cysteine protease deficiencies P43235 (related)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D012640 C030820 Seizures marker/mechanism
1975278
2889795
4048012
9223539
D014202 C030820 Tremor marker/mechanism
2889795