Species

KNApSAcK Entry

Organism name Desmodium elegans
Genus Desmodium
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Desmodium elegans
Linked NCBI taxonomy ID 149687
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001434 External link 512 Tryptamine
/ beta-(3-Indolyl)ethylamine
CHEMBL6640
C030820
20 / 5 / 7 6 / 2 No. 710 No. 4
C00001417 External link 512 Cactine
/ Anhalin
/ Anhaline
/ Hordenine
CHEMBL505789
C007964
1 / 0 / 0 No. 936 No. 6
C00001435 External link 512 Tyramine
CHEMBL11608
D014439
23 / 11 / 6 6 / 9 No. 936 No. 6
C00001331 External link 512 L-Abrine
CHEMBL552941
CHEMBL2360657
2 / 0 / 0 No. 1432 No. 4

Human Protein / Gene in interactions

37 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001434 C00001435 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001331 C00001435 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001434 C00001435 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001434 C00001435 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001434 C00001435 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001434 C00001435 0 / 0
O75496 Geminin Unclassified protein C00001434 C00001435 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001434 C00001435 0 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001417 C00001435 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00001435 2 / 0
P05164 Myeloperoxidase Enzyme C00001434 1 / 2
P43235 Cathepsin K C1A C00001434 1 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00001435 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00001434 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001434 1 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00001435 0 / 0
P46098 5-hydroxytryptamine receptor 3A NS C00001435 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001435 0 / 0
P28222 5-hydroxytryptamine receptor 1B Serotonin receptor C00001434 0 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00001434 0 / 0
P56817 Beta-secretase 1 A1A C00001435 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00001435 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001434 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001434 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001434 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00001434 0 / 0
O15245 Solute carrier family 22 member 1 Drug uniporter C00001435 0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00001435 0 / 0
Q96RJ0 Trace amine-associated receptor 1 Trace amine receptor C00001435 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001434 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001434 0 / 0
P28221 5-hydroxytryptamine receptor 1D Serotonin receptor C00001434 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001435 2 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001435 0 / 0
O75751 Solute carrier family 22 member 3 Unclassified protein C00001435 0 / 0
Q05BR4 SLC16A10 protein Unclassified protein C00001331 0 / 0
P14679 Tyrosinase Oxidoreductase C00001435 4 / 2

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
6532 SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT solute carrier family 6 (neurotransmitter transporter), member 4 C00001434 C00001435
134864 TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1 trace amine associated receptor 1 C00001434 C00001435
6530 SLC6A2, NAT1, NET, NET1, SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 2 C00001434 C00001435
6531 SLC6A3, DAT, DAT1, PKDYS solute carrier family 6 (neurotransmitter transporter), member 3 C00001434 C00001435
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00001434
3356 HTR2A, 5-HT2A, HTR2 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled C00001434
4128 MAOA, MAO-A monoamine oxidase A (EC:1.4.3.4) C00001435
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00001435

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (14)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P14416
#300615 Brunner syndrome P21397
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#254600 Myeloperoxidase deficiency; mpod P05164
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#265800 Pycnodysostosis P43235
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679

KEGG DISEASE (10)

KEGG name UniProt
H00101 Other phagocyte defects P05164 (related)
H00003 Acute myeloid leukemia (AML) P05164 (marker)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00548 Brunner syndrome P21397 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00273 Pycnodysostosis P43235 (related)
H00425 Lysosomal cysteine protease deficiencies P43235 (related)

Diseases related to CTD interactions

11 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D012640 Seizures C00001434
D014202 Tremor C00001434
D009202 Cardiomyopathies C00001435
D002543 Cerebral Hemorrhage C00001435
D002637 Chest Pain C00001435
D006973 Hypertension C00001435
D007022 Hypotension C00001435
D008881 Migraine Disorders C00001435
D015878 Mydriasis C00001435
D011041 Poisoning C00001435
D013610 Tachycardia C00001435