KCF-S cluster No. 1432 (7 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (7)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	40
asterids	9
Spermatophyta	6
Euphyllophyta	2
eudicotyledons	2
Liliopsida	1

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Cumulative family count (Top 20)

class name	count
Fabaceae	21
Solanaceae	5
Brassicaceae	5
Pinaceae	5
Rosaceae	3
Hominidae	2
Fagaceae	2
Euphorbiaceae	2
Rutaceae	2
Poaceae	1
Anacardiaceae	1
Saccharomycetaceae	1
Vitaceae	1
Ebenaceae	1
Rhizopodaceae	1
Betulaceae	1
Cupressaceae	1
Lygodiaceae	1
Araliaceae	1
Cucurbitaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Indole alkaloids	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Indole alkaloids	C00954	C00000100

Metabolite list (7)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000100	IAA / Indole-3-acetic acid	CHEMBL82411	C030737	3 / 0 / 0	2 / 1
C00000115	Indol-3-propionic acid / 1H-Indole-3-propanoic acid	CHEMBL207225	C015292	1 / 0 / 0
C00000116	IBA / Indole-3-butyric acid / 1H-Indole-3-butanoic acid	CHEMBL582878	C014612	6 / 9 / 8
C00001331	L-Abrine	CHEMBL552941 CHEMBL2360657		2 / 0 / 0
C00001396	L-Tryptophan	CHEMBL54976 CHEMBL292303 CHEMBL484901		49 / 41 / 39
C00001740	Hypaphorine	CHEMBL503867 CHEMBL448328	C001529	3 / 1 / 1
C00007571	IPA / Indolepyruvate	CHEMBL485012		16 / 20 / 16

Human Protein / Gene in interactions

65 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q16773	Kynurenine--oxoglutarate transaminase 1	Enzyme	C00000100 C00000115 C00001396 C00007571	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001331 C00001396 C00007571	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001396 C00001740	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001396 C00007571	0 / 0
Q05BR4	SLC16A10 protein	Unclassified protein	C00001331 C00001396	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00001396 C00007571	4 / 3
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00001396 C00007571	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00001396 C00007571	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001396 C00007571	1 / 2
O75496	Geminin	Unclassified protein	C00001396 C00007571	0 / 0
O00255	Menin	Unclassified protein	C00001396 C00007571	2 / 5
P02768	Serum albumin	Secreted protein	C00000100 C00001396	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001396	0 / 1
P02545	Prelamin-A/C	Unclassified protein	C00001396	11 / 10
Q9Y263	Phospholipase A-2-activating protein	Unclassified protein	C00001396	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00001396	3 / 2
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00000116	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00001396	1 / 2
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00000116	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001396	0 / 1
P54132	Bloom syndrome protein	Enzyme	C00001396	1 / 2
Q9HAW7	UDP-glucuronosyltransferase 1-7	Enzyme	C00001396	0 / 0
P23280	Carbonic anhydrase 6	Lyase	C00001396	0 / 0
Q9ULX7	Carbonic anhydrase 14	Lyase	C00001396	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00007571	0 / 0
O43570	Carbonic anhydrase 12	Lyase	C00001396	1 / 2
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00001396	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00001396	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00001396	0 / 0
P42858	Huntingtin	Unclassified protein	C00001396	1 / 1
P43166	Carbonic anhydrase 7	Lyase	C00001396	0 / 0
P00915	Carbonic anhydrase 1	Lyase	C00001396	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00007571	7 / 3
P09923	Intestinal-type alkaline phosphatase	Enzyme	C00001396	0 / 0
P05186	Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	C00001396	3 / 1
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00001396	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00007571	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00000116	5 / 3
Q9HBH1	Peptide deformylase, mitochondrial	Enzyme	C00000100	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001396	0 / 0
Q16790	Carbonic anhydrase 9	Lyase	C00001396	0 / 1
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00001396	1 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00007571	2 / 2
Q01453	Peripheral myelin protein 22	Unclassified protein	C00001396	5 / 2
P03372	Estrogen receptor	NR3A1	C00000116	1 / 1
P48775	Tryptophan 2,3-dioxygenase	Enzyme	C00001396	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001396	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001396	1 / 1
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00007571	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00001396	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00007571	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00001740	1 / 1
P06746	DNA polymerase beta	Enzyme	C00001740	0 / 0
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00001396	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000116	0 / 0
P10275	Androgen receptor	NR3C4	C00000116	3 / 4
P07451	Carbonic anhydrase 3	Lyase	C00001396	0 / 0
P08254	Stromelysin-1	M10A	C00001396	1 / 0
P22748	Carbonic anhydrase 4	Lyase	C00001396	1 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00001396	2 / 0
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00001396	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00007571	4 / 1
Q13951	Core-binding factor subunit beta	Unclassified protein	C00001396	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00001396	1 / 4
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001396	1 / 0

2 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00000100
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00000100

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions