PCIDB

KNApSAcK Metabolite C00001396

Metabolite

KNApSAcK Entry

id C00001396
Name L-Tryptophan
CAS RN 73-22-3
Standard InChI InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1
Standard InChI (Main Layer) InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 1432

Link

ChEMBL

By standard InChI CHEMBL54976
By standard InChI Main Layer CHEMBL54976 CHEMBL292303 CHEMBL484901

KEGG

By LinkDB C00078

CTD

By CAS RN

Human Protein / Gene in interaction

49 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL54976 CHEMBL1741321 (1)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL54976 CHEMBL1738312 (1)
0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL484901 CHEMBL1908087 (1)
0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL292303 CHEMBL1794499 (1)
2 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL54976 CHEMBL292303 CHEMBL885804 (2) CHEMBL987036 (2)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL54976 CHEMBL292303 CHEMBL885803 (2) CHEMBL987035 (2)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL54976 CHEMBL292303 CHEMBL889439 (2) CHEMBL987038 (2)
0 / 0
Q16773 Kynurenine--oxoglutarate transaminase 1 Enzyme CHEMBL54976 CHEMBL1002982 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL54976 CHEMBL292303 CHEMBL1614310 (1) CHEMBL1614544 (1)
11 / 10
Q9Y263 Phospholipase A-2-activating protein Unclassified protein CHEMBL54976 CHEMBL1074487 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL54976 CHEMBL1614361 (1)
3 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL54976 CHEMBL292303 CHEMBL869780 (2) CHEMBL889437 (2)
CHEMBL887924 (2) CHEMBL932482 (2)
CHEMBL970751 (2) CHEMBL987029 (2)
CHEMBL987030 (2) CHEMBL953312 (2)
CHEMBL1017972 (2) CHEMBL1067705 (2)
CHEMBL1067709 (2) CHEMBL1106967 (2)
CHEMBL2318049 (2)
1 / 2
P02768 Serum albumin Secreted protein CHEMBL54976 CHEMBL702885 (1) CHEMBL1805606 (1)
CHEMBL1805607 (1) CHEMBL1805608 (1)
CHEMBL1805609 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL54976 CHEMBL1741325 (1)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL54976 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme CHEMBL484901 CHEMBL1908084 (1)
0 / 0
P23280 Carbonic anhydrase 6 Lyase CHEMBL54976 CHEMBL292303 CHEMBL887925 (2) CHEMBL987037 (2)
CHEMBL1067706 (2) CHEMBL1067710 (2)
0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL54976 CHEMBL292303 CHEMBL889441 (2) CHEMBL987042 (2)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL54976 CHEMBL292303 CHEMBL932484 (2) CHEMBL987040 (2)
1 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL54976 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL54976 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL292303 CHEMBL1738606 (1)
0 / 0
P42858 Huntingtin Unclassified protein CHEMBL292303 CHEMBL1613918 (1)
1 / 1
O75496 Geminin Unclassified protein CHEMBL292303 CHEMBL2114780 (1)
0 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL54976 CHEMBL292303 CHEMBL869779 (2) CHEMBL889435 (2)
CHEMBL887923 (2) CHEMBL932481 (2)
CHEMBL970750 (2) CHEMBL987028 (2)
CHEMBL965608 (2) CHEMBL1067704 (2)
CHEMBL1067708 (2) CHEMBL2318048 (2)
0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme CHEMBL54976 CHEMBL1074489 (1)
0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme CHEMBL54976 CHEMBL1074488 (1)
3 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL54976 CHEMBL1614257 (1) CHEMBL1614410 (1)
1 / 3
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL54976 CHEMBL1741322 (1)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL54976 CHEMBL292303 CHEMBL932483 (2) CHEMBL987039 (2)
0 / 1
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL54976 CHEMBL1006005 (1)
1 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL54976 CHEMBL1614171 (1)
5 / 2
P48775 Tryptophan 2,3-dioxygenase Enzyme CHEMBL54976 CHEMBL845244 (1) CHEMBL845245 (1)
CHEMBL1817449 (1) CHEMBL1816040 (2)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL484901 CHEMBL1614240 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL54976 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL54976 CHEMBL484901 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL54976 CHEMBL1794483 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL292303 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL54976 CHEMBL484901 CHEMBL1614421 (2)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL54976 CHEMBL1738402 (1)
0 / 0
P07451 Carbonic anhydrase 3 Lyase CHEMBL54976 CHEMBL292303 CHEMBL970752 (2) CHEMBL987033 (2)
CHEMBL953319 (2)
0 / 0
P08254 Stromelysin-1 M10A CHEMBL54976 CHEMBL292303 CHEMBL810391 (2)
1 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL54976 CHEMBL292303 CHEMBL970753 (2) CHEMBL1008327 (2)
CHEMBL987034 (2)
1 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL54976 CHEMBL484901 CHEMBL1613914 (2)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL54976 CHEMBL1738442 (2)
0 / 0
O00255 Menin Unclassified protein CHEMBL54976 CHEMBL1614257 (1)
2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL292303 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL292303 CHEMBL1613933 (1)
1 / 6
Q05BR4 SLC16A10 protein Unclassified protein CHEMBL54976 CHEMBL2076232 (1) CHEMBL2076248 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (41)

OMIM preferred title UniProt
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (39)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00213 Hypophosphatasia P05186 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00208 Hyperbilirubinemia Q92887 (related)