Escherichia coli K12

• Index
• Plant Species
• Metabolite list (31)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Escherichia coli K12
Genus	Escherichia
Family	Enterobacteriaceae
Kingdom

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Escherichia coli K-12
Linked NCBI taxonomy ID	83333
Linked level	no rank

Family

Family in NCBI taxonomy	Enterobacteriaceae
ID	543

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Bacteria
ID	2

Plant class

Plant class
ID

Metabolite list (31)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00001173	Sorbitol / D-Sorbitol / D-Glucitol / (-)-Sorbitol	CHEMBL16105 CHEMBL689 CHEMBL1682 CHEMBL1735282 CHEMBL1773904	D013012	101 / 49 / 42	8 / 5	No. 630
C00007391	alpha-D-Galactose 1-phosphate	CHEMBL291890 CHEMBL67622 CHEMBL1159526 CHEMBL1741538	C029973	6 / 2 / 3	1 / 1	No. 713
C00019673	cGMP / Cyclic GMP / 3',5'-Cyclic GMP / Guanosine 3',5'-cyclic monophosphate	CHEMBL68554 CHEMBL395336	D006152	9 / 3 / 2	11 / 7	No. 1201
C00007445	Adenosine 5'-phosphosulfate	CHEMBL578658 CHEMBL572546	D000250			No. 1201
C00001396	L-Tryptophan	CHEMBL54976 CHEMBL292303 CHEMBL484901		49 / 41 / 39		No. 1432	No. 4
C00019660	Xanthine	CHEMBL1424	D019820	8 / 6 / 2	4 / 2	No. 2266	No. 12
C00007287	3-Phosphoserine	CHEMBL284377 CHEMBL1418244	C046162	20 / 11 / 11		No. 2301
C00007385	O-Phospho-L-homoserine					No. 2301
C00007469	L-Aspartate 4-semialdehyde	CHEMBL404100				No. 2595
C00007396	XMP / Xanthosine 5'-monophosphate	CHEMBL1206243	C011141			No. 2692	No. 12
C00019675	2-Oxobutyric acid / 2-Ketobutyric acid / 2-Oxobutanoic acid / alpha-Ketobutyric acid	CHEMBL171246	C005087	1 / 0 / 0	1 / 0	No. 2782
C00007311	UMP / Uridine 5'-phosphate	CHEMBL214393 CHEMBL603336	D014542	4 / 3 / 1		No. 3259
C00019637	dTMP / Thymidine 5'-phosphate	CHEMBL394429	D013938	3 / 0 / 1		No. 3259
C00001386	L-Phenylalanine	CHEMBL25080 CHEMBL301523 CHEMBL379630		27 / 18 / 14		No. 3303
C00019655	AIR (nucleotide) / Aminoimidazole ribonucleotide / 5-Amino-1-beta-D-ribofuranosyl-5'-(dihydrogen phosphate)-imidazole		C024828			No. 3393
C00001366	L-Homoserine	CHEMBL11722				No. 3420
C00019688	L-Arginosuccinic acid / L-Argininosuccinic acid		D001125			No. 3841
C00001337	gamma-Aminobutyric acid	CHEMBL96	D005680	50 / 36 / 27	21 / 17	No. 3932
C00007229	Adenylosuccinate / Adenylsuccinic acid / Adenylosuccinic acid	CHEMBL1812061	C052755	1 / 0 / 0		No. 4121
C00001374	L-isoleucine	CHEMBL297800 CHEMBL56053 CHEMBL1233584 CHEMBL1720399 CHEMBL1867019 CHEMBL1869615		4 / 2 / 0		No. 4144
C00007623	2-Ketoisovalerate / alpha-Ketoisovalerate / 3-Methyl-2-oxobutanoic acid	CHEMBL146554	C001505	1 / 0 / 0		No. 5279
C00019678	2,3-Dihydroxyisovaleric acid / 2,3-Dihydroxy-isovaleric acid		C027749			No. 5300
C00007607	4-Amino-2-methyl-5-phosphomethylpyrimidine / 4-Amino-5-phosphomethyl-2-methylpyrimidine					No. 5373
C00007373	Uroporphyrinogen III					No. 5446
C00007583	Orotidine 5'-phosphate	CHEMBL610606 CHEMBL1207358				No. 6439
C00001394	L-Threonine	CHEMBL30037 CHEMBL291747 CHEMBL59238 CHEMBL319354 CHEMBL555743 CHEMBL1734340		4 / 11 / 10		No. 6720
C00007610	4-methyl-5-(2hydroxyethyl)thiazole / 4-Metyl-5-(beta-hydroxyethyl)thiazole	CHEMBL1236482	C012572			No. 7034	No. 5
C00019621	O-Succinyl-L-homoserine					No. 7675
C00019682	4-Oxobutanoic acid / Succinaldehydic acid / beta-Formylpropionic acid		C009338		2 / 0	No. 7950
C00007471	L-4-Aspartyl phosphate					No. 8177
C00019632	Prephenic acid		C005550			No. 8339

Human Protein / Gene in interactions

203 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001173 C00001337 C00001386 C00001396 C00007287 C00007391	0 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001173 C00001337 C00001386 C00001396 C00007287 C00007391	1 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001173 C00001337 C00001386 C00001396 C00007287 C00007391	1 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001173 C00001337 C00001386 C00001396 C00007287 C00007391	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00001173 C00001337 C00001374 C00001394 C00001396 C00007287	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00001337 C00001374 C00001386 C00001396 C00007287 C00007311	2 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001173 C00001337 C00001386 C00001396 C00007287 C00007391	0 / 1
P10828	Thyroid hormone receptor beta	NR1A2	C00001337 C00001386 C00007287 C00019660	3 / 1
P00918	Carbonic anhydrase 2	Lyase	C00001173 C00001386 C00001396 C00007287	1 / 2
P02545	Prelamin-A/C	Unclassified protein	C00001173 C00001337 C00001394 C00001396	11 / 10
P22748	Carbonic anhydrase 4	Lyase	C00001386 C00001396 C00007287	1 / 1
P00915	Carbonic anhydrase 1	Lyase	C00001386 C00001396 C00007287	0 / 0
Q05BR4	SLC16A10 protein	Unclassified protein	C00001337 C00001386 C00001396	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00001386 C00001396 C00007287	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00001337 C00001396 C00007287	1 / 2
O75496	Geminin	Unclassified protein	C00001173 C00001337 C00001396	0 / 0
Q16790	Carbonic anhydrase 9	Lyase	C00001386 C00001396 C00007287	0 / 1
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00001386 C00001396	0 / 0
P43166	Carbonic anhydrase 7	Lyase	C00001386 C00001396	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001386 C00001396	0 / 0
Q7Z2H8	Proton-coupled amino acid transporter 1	Unclassified protein	C00001337 C00001374	0 / 0
P03372	Estrogen receptor	NR3A1	C00001173 C00001386	1 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00001173 C00001386	0 / 0
P07451	Carbonic anhydrase 3	Lyase	C00001386 C00001396	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00001173 C00001386	0 / 1
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001337 C00001396	1 / 2
P05186	Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	C00001386 C00001396	3 / 1
P09923	Intestinal-type alkaline phosphatase	Enzyme	C00001386 C00001396	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00001374 C00001394	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001396 C00007287	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001337 C00001396	0 / 0
O15427	Monocarboxylate transporter 4	Unclassified protein	C00007623 C00019675	0 / 0
Q9Y263	Phospholipase A-2-activating protein	Unclassified protein	C00001386 C00001396	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00001337 C00001396	3 / 2
P21728	D(1A) dopamine receptor	Dopamine receptor	C00001173 C00001337	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00001173 C00001396	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00001337 C00001396	0 / 0
O43570	Carbonic anhydrase 12	Lyase	C00001386 C00001396	1 / 2
P00352	Retinal dehydrogenase 1	Enzyme	C00001394 C00007287	0 / 0
Q9ULX7	Carbonic anhydrase 14	Lyase	C00001386 C00001396	0 / 0
P23280	Carbonic anhydrase 6	Lyase	C00001386 C00001396	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00001173 C00019660	0 / 0
P10323	Acrosin	S1A	C00001173 C00007391	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00001173 C00001337	1 / 1
Q07343	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE_4B	C00019660	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00001173	0 / 0
P04183	Thymidine kinase, cytosolic	Enzyme	C00019637	0 / 1
P02768	Serum albumin	Secreted protein	C00001396	0 / 0
P25098	Beta-adrenergic receptor kinase 1	Bark	C00019673	0 / 0
P08183	Multidrug resistance protein 1	drug	C00001173	1 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00001173	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00001173	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00001173	0 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00001173	0 / 0
Q14831	Metabotropic glutamate receptor 7	Metabotropic glutamate receptor	C00007287	0 / 0
P24046	Gamma-aminobutyric acid receptor subunit rho-1	GABA-A rho	C00001337	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00001173	1 / 0
Q9HAW7	UDP-glucuronosyltransferase 1-7	Enzyme	C00001396	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00001173	1 / 8
P14416	D(2) dopamine receptor	Dopamine receptor	C00001173	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00001173	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00001173	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00001173	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00001173	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00001173	0 / 0
P25021	Histamine H2 receptor	Histamine receptor	C00001173	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00001173	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00001173	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00001173	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00001173	1 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00001173	1 / 1
P14867	Gamma-aminobutyric acid receptor subunit alpha-1	GABA-A alpha	C00001337	1 / 1
P48065	Sodium- and chloride-dependent betaine transporter	Betaine and GABA Na-symporter	C00001337	0 / 0
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00001173	0 / 1
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00001173	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00001396	0 / 0
Q15077	P2Y purinoceptor 6	Purine receptor	C00007311	0 / 0
P23415	Glycine receptor subunit alpha-1	GLR alpha	C00001337	1 / 1
P42858	Huntingtin	Unclassified protein	C00001396	1 / 1
P29973	cGMP-gated cation channel alpha-1	Unclassified protein	C00019673	1 / 1
Q16280	Cyclic nucleotide-gated olfactory channel	Unclassified protein	C00019673	0 / 0
O15439	Multidrug resistance-associated protein 4	Unclassified protein	C00019673	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00001173	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00001173	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00001173	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00001173	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00001173	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00001173	0 / 0
P46098	5-hydroxytryptamine receptor 3A	NS	C00001337	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00001173	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00001173	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00001173	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00001173	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00001173	1 / 0
Q16281	Cyclic nucleotide-gated cation channel alpha-3	Unclassified protein	C00019673	1 / 1
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00001173	0 / 0
P08311	Cathepsin G	S1A	C00001173	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00001173	1 / 0
P03956	Interstitial collagenase	M10A	C00001173	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00001173	0 / 0
O15245	Solute carrier family 22 member 1	Drug uniporter	C00001173	0 / 0
P11172	Uridine 5'-monophosphate synthase	Enzyme	C00007311	1 / 1
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00001173	0 / 0
P11308	Transcriptional regulator ERG	Unclassified protein	C00001337	1 / 2
P14780	Matrix metalloproteinase-9	M10A	C00001173	2 / 2
P83916	Chromobox protein homolog 1	Unclassified protein	C00001173	0 / 0
P23919	Thymidylate kinase	Enzyme	C00019637	0 / 0
P04818	Thymidylate synthase	Transferase	C00019637	0 / 0
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00001173	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00001173	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00001386	4 / 2
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00001173	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00001173	2 / 0
P80404	4-aminobutyrate aminotransferase, mitochondrial	Transferase	C00001337	1 / 1
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00001173	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00001173	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00001173	0 / 0
Q9UBS5	Gamma-aminobutyric acid type B receptor subunit 1	GABA-B receptor	C00001337	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00001173	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00001173	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00001173	0 / 0
P36544	Neuronal acetylcholine receptor subunit alpha-7	CHRN alpha	C00001337	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00001173	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00001173	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00001173	2 / 1
P27361	Mitogen-activated protein kinase 3	Erk	C00001173	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00001173	0 / 0
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00001396	1 / 1
Q01453	Peripheral myelin protein 22	Unclassified protein	C00001396	5 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001337	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00001173	0 / 0
P29466	Caspase-1	C14	C00001173	0 / 0
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00001173	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00001173	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00001173	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00001173	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00001173	0 / 0
Q04609	Glutamate carboxypeptidase 2	M28B	C00007287	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00001173	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00001173	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00001173	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00001173	0 / 0
Q14833	Metabotropic glutamate receptor 4	Metabotropic glutamate receptor	C00007287	0 / 0
P48775	Tryptophan 2,3-dioxygenase	Enzyme	C00001396	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001396	0 / 0
Q16773	Kynurenine--oxoglutarate transaminase 1	Enzyme	C00001396	0 / 0
Q9Y2T3	Guanine deaminase	Enzyme	C00019660	0 / 0
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00001173	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00001396	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00001337	1 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00001173	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00001396	4 / 3
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00001396	0 / 0
Q6DHV7	Adenosine deaminase-like protein	Enzyme	C00007229	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00001173	0 / 0
P30085	UMP-CMP kinase	Enzyme	C00007311	0 / 0
P00492	Hypoxanthine-guanine phosphoribosyltransferase	Enzyme	C00019660	2 / 1
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00001173	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00001173	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00001173	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00001173	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00001173	1 / 1
P33765	Adenosine receptor A3	Adenosine receptor	C00001173	0 / 0
P06239	Tyrosine-protein kinase Lck	Src	C00001173	0 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00001173	0 / 0
P08254	Stromelysin-1	M10A	C00001396	1 / 0
P08246	Neutrophil elastase	S1A	C00001173	2 / 1
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00001173	2 / 2
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00001173	0 / 3
P30531	Sodium- and chloride-dependent GABA transporter 1	GABA	C00001337	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00007287	1 / 1
O15440	Multidrug resistance-associated protein 5	Unclassified protein	C00019673	0 / 0
O00255	Menin	Unclassified protein	C00001396	2 / 5
Q13951	Core-binding factor subunit beta	Unclassified protein	C00001396	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00001396	1 / 4
Q08493	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE_4C	C00019660	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00001173	0 / 0
P27815	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE_4A	C00019660	0 / 0
Q08499	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE_4D	C00019660	1 / 0
Q9UN88	Gamma-aminobutyric acid receptor subunit theta	GABA-A theta	C00001337	0 / 0
P28472	Gamma-aminobutyric acid receptor subunit beta-3	GABA-A beta	C00001337	1 / 0
P48169	Gamma-aminobutyric acid receptor subunit alpha-4	GABA-A alpha	C00001337	0 / 0
O14764	Gamma-aminobutyric acid receptor subunit delta	GABA-A delta	C00001337	1 / 1
P31644	Gamma-aminobutyric acid receptor subunit alpha-5	GABA-A alpha	C00001337	0 / 0
Q99928	Gamma-aminobutyric acid receptor subunit gamma-3	GABA-A gamma	C00001337	0 / 0
P78334	Gamma-aminobutyric acid receptor subunit epsilon	GABA-A epsilon	C00001337	0 / 0
Q8N1C3	Gamma-aminobutyric acid receptor subunit gamma-1	GABA-A gamma	C00001337	0 / 0
P34903	Gamma-aminobutyric acid receptor subunit alpha-3	GABA-A alpha	C00001337	0 / 0
O00591	Gamma-aminobutyric acid receptor subunit pi	GABA-A pi	C00001337	0 / 0
P47870	Gamma-aminobutyric acid receptor subunit beta-2	GABA-A beta	C00001337	0 / 0
P18507	Gamma-aminobutyric acid receptor subunit gamma-2	GABA-A gamma	C00001337	4 / 2
P18505	Gamma-aminobutyric acid receptor subunit beta-1	GABA-A beta	C00001337	0 / 0
Q16445	Gamma-aminobutyric acid receptor subunit alpha-6	GABA-A alpha	C00001337	0 / 0
P47869	Gamma-aminobutyric acid receptor subunit alpha-2	GABA-A alpha	C00001337	1 / 0
A8MPY1	Gamma-aminobutyric acid receptor subunit rho-3	GABA-A rho	C00001337	0 / 0
P28476	Gamma-aminobutyric acid receptor subunit rho-2	GABA-A rho	C00001337	0 / 0
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00001173	0 / 0
Q96J66	ATP-binding cassette sub-family C member 11	Unclassified protein	C00019673	1 / 0
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00001396	0 / 0
Q13370	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	PDE_3B	C00019673	0 / 0
Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE_3A	C00019673	0 / 0
O75899	Gamma-aminobutyric acid type B receptor subunit 2	GABA-B receptor	C00001337	0 / 0
P48066	Sodium- and chloride-dependent GABA transporter 3	GABA	C00001337	0 / 0

48 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
6566	SLC16A1, HHF7, MCT, MCT1	solute carrier family 16 (monocarboxylate transporter), member 1	C00019675
10327	AKR1A1, ALDR1, ALR, ARM, DD3	aldo-keto reductase family 1, member A1 (aldehyde reductase) (EC:1.1.1.2)	C00019682
8574	AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11)	C00019682
2584	GALK1, GALK, GK1	galactokinase 1 (EC:2.7.1.6)	C00007391
18	ABAT, GABA-AT, GABAT, NPD009	4-aminobutyrate aminotransferase (EC:2.6.1.19 2.6.1.22)	C00001337
1138	CHRNA5, LNCR2	cholinergic receptor, nicotinic, alpha 5 (neuronal)	C00001337
1140	CHRNB1, ACHRB, CHRNB, CMS1D, CMS2A, SCCMS	cholinergic receptor, nicotinic, beta 1 (muscle)	C00001337
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00001337
2550	GABBR1, GABABR1, GABBR1-3, GB1, GPRC3A, dJ271M21.1.1, dJ271M21.1.2	gamma-aminobutyric acid (GABA) B receptor, 1	C00001337
9568	GABBR2, GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099	gamma-aminobutyric acid (GABA) B receptor, 2	C00001337
2554	GABRA1, ECA4, EJM, EJM5	gamma-aminobutyric acid (GABA) A receptor, alpha 1	C00001337
2555	GABRA2	gamma-aminobutyric acid (GABA) A receptor, alpha 2	C00001337
2557	GABRA4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	C00001337
2558	GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	C00001337
2559	GABRA6	gamma-aminobutyric acid (GABA) A receptor, alpha 6	C00001337
2560	GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1	C00001337
2561	GABRB2	gamma-aminobutyric acid (GABA) A receptor, beta 2	C00001337
2562	GABRB3, ECA5	gamma-aminobutyric acid (GABA) A receptor, beta 3	C00001337
2563	GABRD, EIG10, EJM7, GEFSP5	gamma-aminobutyric acid (GABA) A receptor, delta	C00001337
2564	GABRE	gamma-aminobutyric acid (GABA) A receptor, epsilon	C00001337
2566	GABRG2, CAE2, ECA2, GEFSP3	gamma-aminobutyric acid (GABA) A receptor, gamma 2	C00001337
2571	GAD1, CPSQ1, GAD, SCP	glutamate decarboxylase 1 (brain, 67kDa) (EC:4.1.1.15)	C00001337
6529	SLC6A1, GABATHG, GABATR, GAT1	solute carrier family 6 (neurotransmitter transporter), member 1	C00001337
6538	SLC6A11, GAT-3, GAT3, GAT4	solute carrier family 6 (neurotransmitter transporter), member 11	C00001337
6540	SLC6A13, GAT-2, GAT2, GAT3	solute carrier family 6 (neurotransmitter transporter), member 13	C00001337
10257	ABCC4, EST170205, MOAT-B, MOATB, MRP4	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	C00019673
217	ALDH2, ALDH-E2, ALDHI, ALDM	aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)	C00019673
5604	MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1	mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)	C00019673
5605	MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2	mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)	C00019673
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00019673
4878	NPPA, ANF, ANP, ATFB6, CDD-ANF, PND	natriuretic peptide A	C00019673
10846	PDE10A, HSPDE10A	phosphodiesterase 10A (EC:3.1.4.35 3.1.4.17)	C00019673
50940	PDE11A, PPNAD2	phosphodiesterase 11A (EC:3.1.4.35 3.1.4.17)	C00019673
8654	PDE5A, CGB-PDE, CN5A, PDE5	phosphodiesterase 5A, cGMP-specific (EC:3.1.4.35)	C00019673
5152	PDE9A, HSPDE9A2	phosphodiesterase 9A (EC:3.1.4.35)	C00019673
6794	STK11, LKB1, PJS, hLKB1	serine/threonine kinase 11 (EC:2.7.11.1)	C00019673
1977	EIF4E, AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F	eukaryotic translation initiation factor 4E	C00001173
1978	EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I	eukaryotic translation initiation factor 4E binding protein 1	C00001173
5602	MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK	mitogen-activated protein kinase 10 (EC:2.7.11.24)	C00001173
6300	MAPK12, ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3	mitogen-activated protein kinase 12 (EC:2.7.11.24)	C00001173
1432	MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	C00001173
9261	MAPKAPK2, MAPKAP-K2, MK-2, MK2	mitogen-activated protein kinase-activated protein kinase 2 (EC:2.7.11.1)	C00001173
8569	MKNK1, MNK1	MAP kinase interacting serine/threonine kinase 1 (EC:2.7.11.1)	C00001173
51035	UBXN1, 2B28, SAKS1, UBXD10	UBX domain protein 1	C00001173
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00019660
847	CAT	catalase (EC:1.11.1.6)	C00019660
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00019660
7498	XDH, XO, XOR	xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2)	C00019660

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