KCF-S cluster No. 1201 (8 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (8)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

---

Cumulative plant class count

class name	count
rosids	3
asterids	2

---

Cumulative family count

class name	count
Enterobacteriaceae	5
Brassicaceae	2
Apiaceae	1
Fabaceae	1
Solanaceae	1
Nocardiaceae	1

KEGG BRITE br08003

---

Categories (0)

br08003 Category	# of metabolite

---

metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (8)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001497	3' 5'-cyclic AMP	CHEMBL9871 CHEMBL316966 CHEMBL1365681 CHEMBL1416083 CHEMBL1741513 CHEMBL2359042	D000242	29 / 24 / 19	80 / 7
C00007445	Adenosine 5'-phosphosulfate	CHEMBL578658 CHEMBL572546	D000250
C00007446	PAPS / 3'-phosphoadenosine 5'-phosphosulfate		D010724		6 / 0
C00018618	B-Factor / 3'-(1-Butylphosphoryl)adenosine		C044533
C00019347	AMP / Adenosine 5'-phosphate	CHEMBL16720 CHEMBL752 CHEMBL603811 CHEMBL608290 CHEMBL1230732	D000249	21 / 18 / 14	4 / 0
C00019350	3'-AMP / Adenosine 3'-phosphate	CHEMBL576739		1 / 0 / 0
C00019352	Adenosine 3',5'-bisphosphate	CHEMBL416789 CHEMBL574817	C010840	1 / 1 / 1
C00019673	cGMP / Cyclic GMP / 3',5'-Cyclic GMP / Guanosine 3',5'-cyclic monophosphate	CHEMBL68554 CHEMBL395336	D006152	9 / 3 / 2	11 / 7

Human Protein / Gene in interactions

53 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00001497 C00019347	2 / 0
Q96J66	ATP-binding cassette sub-family C member 11	Unclassified protein	C00001497 C00019673	1 / 0
O15440	Multidrug resistance-associated protein 5	Unclassified protein	C00001497 C00019673	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001497 C00019347	0 / 0
P28329	Choline O-acetyltransferase	Enzyme	C00019347 C00019352	1 / 1
P30542	Adenosine receptor A1	Adenosine receptor	C00019347 C00019350	0 / 0
O15439	Multidrug resistance-associated protein 4	Unclassified protein	C00001497 C00019673	0 / 0
Q16280	Cyclic nucleotide-gated olfactory channel	Unclassified protein	C00001497 C00019673	0 / 0
P05186	Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	C00019347	3 / 1
Q9Y694	Solute carrier family 22 member 7	Unclassified protein	C00001497	0 / 0
P21589	5'-nucleotidase	Enzyme	C00019347	1 / 1
P10828	Thyroid hormone receptor beta	NR1A2	C00001497	3 / 1
P51582	P2Y purinoceptor 4	Purine receptor	C00019347	0 / 0
P25098	Beta-adrenergic receptor kinase 1	Bark	C00019673	0 / 0
P60891	Ribose-phosphate pyrophosphokinase 1	Enzyme	C00019347	4 / 4
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001497	0 / 1
P54132	Bloom syndrome protein	Enzyme	C00001497	1 / 2
Q96G91	P2Y purinoceptor 11	Purine receptor	C00019347	0 / 0
P41231	P2Y purinoceptor 2	Purine receptor	C00019347	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00001497	0 / 0
O75496	Geminin	Unclassified protein	C00001497	0 / 0
Q16281	Cyclic nucleotide-gated cation channel alpha-3	Unclassified protein	C00019673	1 / 1
Q8TCC7	Solute carrier family 22 member 8	Antiporter	C00001497	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00001497	11 / 10
P07195	L-lactate dehydrogenase B chain	Enzyme	C00019347	1 / 4
Q9Y253	DNA polymerase eta	Enzyme	C00001497	1 / 1
P29973	cGMP-gated cation channel alpha-1	Unclassified protein	C00019673	1 / 1
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001497	1 / 2
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00001497	0 / 0
P00338	L-lactate dehydrogenase A chain	Enzyme	C00019347	1 / 5
P12931	Proto-oncogene tyrosine-protein kinase Src	Src	C00019347	0 / 0
P09467	Fructose-1,6-bisphosphatase 1	Enzyme	C00019347	1 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001497	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001497	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001497	0 / 1
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00001497	1 / 0
Q6DHV7	Adenosine deaminase-like protein	Enzyme	C00019347	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00001497	0 / 0
P47900	P2Y purinoceptor 1	Purine receptor	C00019347	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00001497	0 / 0
Q8WZA2	Rap guanine nucleotide exchange factor 4	Unclassified protein	C00001497	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001497	1 / 0
Q08493	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE_4C	C00001497	0 / 0
Q07343	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE_4B	C00001497	0 / 0
P27815	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE_4A	C00001497	0 / 0
Q08499	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE_4D	C00001497	1 / 0
Q9UBF8	Phosphatidylinositol 4-kinase beta	Enzyme	C00019347	0 / 0
Q8TCG2	Phosphatidylinositol 4-kinase type 2-beta	Enzyme	C00019347	0 / 0
Q9BTU6	Phosphatidylinositol 4-kinase type 2-alpha	Enzyme	C00019347	0 / 0
P42356	Phosphatidylinositol 4-kinase alpha	Enzyme	C00019347	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00019347	4 / 1
Q13370	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	PDE_3B	C00019673	0 / 0
Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE_3A	C00019673	0 / 0

97 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
10257	ABCC4, EST170205, MOAT-B, MOATB, MRP4	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	C00001497 C00019673
5152	PDE9A, HSPDE9A2	phosphodiesterase 9A (EC:3.1.4.35)	C00001497 C00019673
50940	PDE11A, PPNAD2	phosphodiesterase 11A (EC:3.1.4.35 3.1.4.17)	C00001497 C00019673
10846	PDE10A, HSPDE10A	phosphodiesterase 10A (EC:3.1.4.35 3.1.4.17)	C00001497 C00019673
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00001497
155	ADRB3, BETA3AR	adrenoceptor beta 3	C00001497
250	ALPP, ALP, PALP, PLAP, PLAP-1	alkaline phosphatase, placental (EC:3.1.3.1)	C00001497
551	AVP, ADH, ARVP, AVP-NPII, AVRP, VP	arginine vasopressin	C00001497
554	AVPR2, ADHR, DI1, DIR, DIR3, NDI, V2R	arginine vasopressin receptor 2	C00001497
673	BRAF, B-RAF1, BRAF1, NS7, RAFB1	v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1)	C00001497
796	CALCA, CALC1, CGRP, CGRP-I, CGRP1, CT, KC	calcitonin-related polypeptide alpha	C00001497
10498	CARM1, PRMT4	coactivator-associated arginine methyltransferase 1 (EC:2.1.1.125)	C00001497
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00001497
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00001497
1080	CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	C00001497
1081	CGA, CG-ALPHA, FSHA, GPHA1, GPHa, HCG, LHA, TSHA	glycoprotein hormones, alpha polypeptide	C00001497
1082	CGB, CGB3, CGB5, CGB7, CGB8, hCGB	chorionic gonadotropin, beta polypeptide	C00001497
1268	CNR1, CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR	cannabinoid receptor 1 (brain)	C00001497
1269	CNR2, CB-2, CB2, CX5	cannabinoid receptor 2 (macrophage)	C00001497
1387	CREBBP, CBP, KAT3A, RSTS	CREB binding protein (EC:2.3.1.48)	C00001497
1392	CRH, CRF	corticotropin releasing hormone	C00001497
1394	CRHR1, CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRH-R1h, CRHR, CRHR1L, CRHR1f	corticotropin releasing hormone receptor 1	C00001497
1440	CSF3, C17orf33, CSF3OS, GCSF, G-CSF	colony stimulating factor 3 (granulocyte)	C00001497
1584	CYP11B1, CPN1, CYP11B, FHI, P450C11	cytochrome P450, family 11, subfamily B, polypeptide 1 (EC:1.14.15.4)	C00001497
1586	CYP17A1, CPT7, CYP17, P450C17, S17AH	cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30)	C00001497
27185	DISC1, C1orf136, SCZD9	disrupted in schizophrenia 1	C00001497
22943	DKK1, DKK-1, SK	dickkopf WNT signaling pathway inhibitor 1	C00001497
1812	DRD1, DADR, DRD1A	dopamine receptor D1	C00001497
1813	DRD2, D2DR, D2R	dopamine receptor D2	C00001497
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00001497
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00001497
2150	F2RL1, GPR11, PAR2	coagulation factor II (thrombin) receptor-like 1	C00001497
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00001497
2488	FSHB	follicle stimulating hormone, beta polypeptide	C00001497
2668	GDNF, ATF1, ATF2, HFB1-GDNF, HSCR3	glial cell derived neurotrophic factor	C00001497
2778	GNAS, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH	GNAS complex locus	C00001497
338442	HCAR2, GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g	hydroxycarboxylic acid receptor 2	C00001497
8843	HCAR3, GPR109B, HCA3, HM74, PUMAG, Puma-g	hydroxycarboxylic acid receptor 3	C00001497
3269	HRH1, H1-R, hisH1	histamine receptor H1	C00001497
3274	HRH2, H2R	histamine receptor H2	C00001497
3284	HSD3B2, HSD3B, HSDB, SDR11E2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1)	C00001497
3350	HTR1A, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	C00001497
3351	HTR1B, 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	C00001497
3363	HTR7, 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	C00001497
3592	IL12A, CLMF, IL-12A, NFSK, NKSF1, P35	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	C00001497
3593	IL12B, CLMF, CLMF2, IL-12B, NKSF, NKSF2	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	C00001497
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00001497
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00001497
3624	INHBA, EDF, FRP	inhibin, beta A	C00001497
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00001497
3952	LEP, LEPD, OB, OBS	leptin	C00001497
3972	LHB, CGB4, LSH-B, hLHB	luteinizing hormone beta polypeptide	C00001497
3973	LHCGR, HHG, LCGR, LGR2, LH/CG-R, LH/CGR, LHR, LHRHR, LSH-R, ULG5	luteinizing hormone/choriogonadotropin receptor	C00001497
3991	LIPE, HSL, LHS	lipase, hormone-sensitive (EC:3.1.1.79)	C00001497
4158	MC2R, ACTHR	melanocortin 2 receptor (adrenocorticotropic hormone)	C00001497
54539	NDUFB11, CI-ESSS, ESSS, NP17.3, Np15, P17.3	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa	C00001497
4988	OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM	opioid receptor, mu 1	C00001497
153	ADRB1, ADRB1R, B1AR, BETA1AR, RHR	adrenoceptor beta 1	C00001497
9370	ADIPOQ, ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28	adiponectin, C1Q and collagen domain containing	C00001497
5142	PDE4B, DPDE4, PDE4B5, PDEIVB	phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17)	C00001497
5150	PDE7A, HCP1, PDE7	phosphodiesterase 7A (EC:3.1.4.17)	C00001497
27115	PDE7B, bA472E5.1	phosphodiesterase 7B (EC:3.1.4.17)	C00001497
5151	PDE8A, HsT19550	phosphodiesterase 8A (EC:3.1.4.17)	C00001497
8622	PDE8B, ADSD, PPNAD3	phosphodiesterase 8B (EC:3.1.4.17)	C00001497
116	ADCYAP1, PACAP	adenylate cyclase activating polypeptide 1 (pituitary)	C00001497
5617	PRL	prolactin	C00001497
84432	PROK1, EGVEGF, PK1, PRK1	prokineticin 1	C00001497
5739	PTGIR, IP, PRIPR	prostaglandin I2 (prostacyclin) receptor (IP)	C00001497
5744	PTHLH, BDE2, HHM, PLP, PTHR, PTHRP	parathyroid hormone-like hormone	C00001497
5908	RAP1B, K-REV, RAL1B	RAP1B, member of RAS oncogene family	C00001497
9376	SLC22A8, OAT3	solute carrier family 22 (organic anion transporter), member 8	C00001497
6518	SLC2A5, GLUT-5, GLUT5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	C00001497
154	ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR	adrenoceptor beta 2, surface	C00001497
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00001497
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00001497
7252	TSHB, TSH-B, TSH-BETA	thyroid stimulating hormone, beta	C00001497
7253	TSHR, CHNG1, LGR3, hTSHR-I	thyroid stimulating hormone receptor	C00001497
7432	VIP, PHM27	vasoactive intestinal peptide	C00001497
7434	VIPR2, C16DUPq36.3, DUP7q36.3, PACAP-R-3, PACAP-R3, VIP-R-2, VPAC2, VPAC2R, VPCAP2R	vasoactive intestinal peptide receptor 2	C00001497
7474	WNT5A, hWNT5A	wingless-type MMTV integration site family, member 5A	C00001497
216	ALDH1A1, ALDC, ALDH-E1, ALDH1, ALDH11, PUMB1, RALDH1	aldehyde dehydrogenase 1 family, member A1 (EC:1.2.1.36)	C00019347
170685	NUDT10, APS2, DIPP3a, hDIPP3alpha	nudix (nucleoside diphosphate linked moiety X)-type motif 10 (EC:3.6.1.52 3.6.1.60)	C00019347
55190	NUDT11, APS1, ASP1, DIPP3b, DIPP3beta, hDIPP3beta	nudix (nucleoside diphosphate linked moiety X)-type motif 11 (EC:3.6.1.52 3.6.1.60)	C00019347
10891	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	C00019347
217	ALDH2, ALDH-E2, ALDHI, ALDM	aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)	C00019673
5604	MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1	mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)	C00019673
5605	MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2	mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)	C00019673
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00019673
4878	NPPA, ANF, ANP, ATFB6, CDD-ANF, PND	natriuretic peptide A	C00019673
8654	PDE5A, CGB-PDE, CN5A, PDE5	phosphodiesterase 5A, cGMP-specific (EC:3.1.4.35)	C00019673
6794	STK11, LKB1, PJS, hLKB1	serine/threonine kinase 11 (EC:2.7.11.1)	C00019673
10	NAT2, AAC2, NAT-2, PNAT	N-acetyltransferase 2 (arylamine N-acetyltransferase) (EC:2.3.1.5)	C00007446
1728	NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	C00007446
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00007446
6799	SULT1A2, HAST4, P-PST, ST1A2, STP2, TSPST2	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 (EC:2.8.2.1)	C00007446
6818	SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1)	C00007446
6822	SULT2A1, DHEA-ST, DHEAS, HST, ST2, ST2A1, ST2A3, STD, hSTa	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (EC:2.8.2.14)	C00007446

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions