PCIDB

KNApSAcK Metabolite C00001497

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00001497
Name	3' 5'-cyclic AMP
CAS RN	60-92-4
Standard InChI	InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6?,7+,10-/m1/s1
Standard InChI (Main Layer)	InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)

Cluster

Phytochemical cluster
KCF-S cluster	No. 1201

Link

ChEMBL

By standard InChI
By standard InChI Main Layer	CHEMBL9871 CHEMBL316966 CHEMBL1365681 CHEMBL1416083 CHEMBL1741513 CHEMBL2359042

KEGG

By LinkDB	C00575

CTD

By CAS RN	D000242

Species

Summary

Plant class

class name	count
asterids	2
rosids	1

Family

family name	count
Apiaceae	1
Solanaceae	1
Fabaceae	1

List (3)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Daucus carota	4039	Apiaceae	asterids	Viridiplantae
Nicotiana tabacum	4097	Solanaceae	asterids	Viridiplantae
Phaseolus vulgaris	3885	Fabaceae	rosids	Viridiplantae

Human Protein / Gene in interaction

29 ChEMBL Protein in interactions

accession	description	class description	compound	assay ID (# of activities)	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	CHEMBL1365681 CHEMBL1416083 CHEMBL1741513	CHEMBL1741321 (3)	1 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	CHEMBL316966	CHEMBL1794499 (1)	2 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	CHEMBL316966	CHEMBL1738565 (1) CHEMBL2114744 (1)	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	CHEMBL316966	CHEMBL1738600 (1)	0 / 0
P02545	Prelamin-A/C	Unclassified protein	CHEMBL316966 CHEMBL1416083	CHEMBL1614544 (2)	11 / 10
Q9Y694	Solute carrier family 22 member 7	Unclassified protein	CHEMBL316966	CHEMBL2077536 (1)	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	CHEMBL316966	CHEMBL1613776 (1)	3 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	CHEMBL1365681 CHEMBL1416083 CHEMBL1741513	CHEMBL1741325 (3)	0 / 1
P54132	Bloom syndrome protein	Enzyme	CHEMBL316966	CHEMBL1614522 (1) CHEMBL1614067 (1)	1 / 2
Q92830	Histone acetyltransferase KAT2A	Enzyme	CHEMBL316966	CHEMBL1738606 (1)	0 / 0
O75496	Geminin	Unclassified protein	CHEMBL316966	CHEMBL1613941 (1)	0 / 0
Q16280	Cyclic nucleotide-gated olfactory channel	Unclassified protein	CHEMBL316966	CHEMBL1629186 (1)	0 / 0
Q8TCC7	Solute carrier family 22 member 8	Antiporter	CHEMBL316966	CHEMBL2076228 (1)	0 / 0
O15439	Multidrug resistance-associated protein 4	Unclassified protein	CHEMBL316966	CHEMBL1743162 (1) CHEMBL2077477 (1) CHEMBL2078534 (1) CHEMBL2078625 (1) CHEMBL2077733 (1) CHEMBL2077907 (1)	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	CHEMBL316966	CHEMBL1794569 (1)	1 / 1
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	CHEMBL316966	CHEMBL1614410 (1)	1 / 3
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	CHEMBL1416083	CHEMBL1794467 (1)	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	CHEMBL1365681 CHEMBL1416083 CHEMBL1741513	CHEMBL1741322 (3)	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	CHEMBL1365681 CHEMBL1416083 CHEMBL1741513	CHEMBL1741323 (3)	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	CHEMBL1365681 CHEMBL1416083 CHEMBL1741513	CHEMBL1741324 (3)	0 / 1
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	CHEMBL316966	CHEMBL1614052 (1)	1 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	CHEMBL316966	CHEMBL1738442 (2)	0 / 0
Q8WZA2	Rap guanine nucleotide exchange factor 4	Unclassified protein	CHEMBL316966	CHEMBL2033344 (1) CHEMBL2033345 (1) CHEMBL2319315 (1)	0 / 0
O15440	Multidrug resistance-associated protein 5	Unclassified protein	CHEMBL316966	CHEMBL2075979 (1) CHEMBL2078520 (1)	0 / 0
Q08493	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE_4C	CHEMBL316966	CHEMBL821996 (1)	0 / 0
Q07343	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE_4B	CHEMBL316966	CHEMBL821996 (1)	0 / 0
P27815	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE_4A	CHEMBL316966	CHEMBL821996 (1)	0 / 0
Q08499	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE_4D	CHEMBL316966	CHEMBL821996 (1)	1 / 0
Q96J66	ATP-binding cassette sub-family C member 11	Unclassified protein	CHEMBL316966	CHEMBL2075321 (1) CHEMBL2077921 (1)	1 / 0

CTD interaction (345)

compound	gene	gene name	gene description	interaction	interaction type	form	reference pmid
D000242	10257	ABCC4 EST170205 MOAT-B MOATB MRP4	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	ABCC4 protein results in increased transport of Cyclic AMP	increases transport	protein	11856762
D000242	116	ADCYAP1 PACAP	adenylate cyclase activating polypeptide 1 (pituitary)	[ADCYAP1 protein binds to VIPR2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance	protein	7733904
D000242	9370	ADIPOQ ACDC ACRP30 ADIPQTL1 ADPN APM-1 APM1 GBP28	adiponectin, C1Q and collagen domain containing	ADIPOQ protein results in increased abundance of Cyclic AMP	increases abundance	protein	18931039
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP	affects cotreatment / increases abundance		12761341
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	ADRB1 protein affects the abundance of Cyclic AMP	affects abundance	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance	protein	19419905
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	ADRB1 protein polymorphism affects the abundance of Cyclic AMP	affects abundance	protein	14502278
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	ADRB1 protein polymorphism affects the reaction [[carvedilol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP]	affects binding / affects reaction / decreases abundance / decreases activity	protein	17200720
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	ADRB1 protein results in increased abundance of Cyclic AMP	increases abundance	protein	11562432 18787115
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Alprenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	Alprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance	protein	15060759
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Atenolol co-treated with ADRB1] results in increased abundance of Cyclic AMP	affects cotreatment / increases abundance		12761341
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	Atenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance	protein	15060759
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Bisoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	Bisoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance	protein	15060759
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Bupranolol co-treated with ADRB1] results in increased abundance of Cyclic AMP	affects cotreatment / increases abundance		12761341
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	Bupranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance	protein	15060759
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[carvedilol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417 17200720
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP	affects cotreatment / increases abundance		12761341
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	carvedilol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance	protein	15060759
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance	protein	15060759
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[CGP 12177 binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[CGP 12177 co-treated with ADRB1] results in increased abundance of Cyclic AMP	affects cotreatment / increases abundance		12761341
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	CGP 20712A inhibits the reaction [[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP]	affects cotreatment / decreases reaction / increases abundance		12761341
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	CGP 20712A inhibits the reaction [[carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP]	affects cotreatment / decreases reaction / increases abundance		12761341
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	CGP 20712A inhibits the reaction [[CGP 12177 co-treated with ADRB1] results in increased abundance of Cyclic AMP]	affects cotreatment / decreases reaction / increases abundance		12761341
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	CGP 20712A inhibits the reaction [[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP]	affects cotreatment / decreases reaction / increases abundance		12761341
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]	affects binding / affects cotreatment / increases abundance / increases reaction	protein	19419905
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Epinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Fenoterol binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[formoterol binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[ICI 118551 binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Isoproterenol binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417 17200720
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	Isoproterenol promotes the reaction [ADRB1 protein results in increased abundance of Cyclic AMP]	increases abundance / increases reaction	protein	18787115
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP	affects cotreatment / increases abundance		12761341
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Metoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	Metoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance	protein	15060759
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	Nadolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance	protein	15060759
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Norepinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417 17200720
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	Oxprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance	protein	15060759
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Pindolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	Pindolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance	protein	15060759
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Propranolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[Propranolol co-treated with ADRB1] results in increased abundance of Cyclic AMP	affects cotreatment / increases abundance		12761341
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	Propranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance	protein	15060759
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	[salmeterol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	Sotalol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance	protein	15060759
D000242	153	ADRB1 ADRB1R B1AR BETA1AR RHR	adrenoceptor beta 1	Timolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance	protein	15060759
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Acebutolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance	protein	19419905
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	ADRB2 protein affects the abundance of Cyclic AMP	affects abundance	protein	14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	ADRB2 protein polymorphism results in increased chemical synthesis of Cyclic AMP	increases chemical synthesis	protein	21868359
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	ADRB2 protein results in increased abundance of Cyclic AMP	increases abundance	protein	11562432
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	ADRB2 protein results in increased chemical synthesis of Cyclic AMP	increases chemical synthesis	protein	21868359
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	10516654 10952688 12920204 14730417 16980553
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Alprenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Atenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Atenolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	12920204
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	12920204
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	Atenolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	12920204
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	Atenolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	12920204
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Betaxolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Bisoprolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Bisoprolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[BRL 37344 binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[broxaterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[carvedilol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[carvedilol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[CGP 12177 binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[CGP 20712A binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]	affects binding / affects cotreatment / increases abundance / increases reaction	protein	19419905
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	12920204 14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417 16980553
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[formoterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	16980553
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[ICI 118551 binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[ICI 118551 binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	ICI 118551 inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	12920204
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	ICI 118551 inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	12920204
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	ICI 118551 inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	12920204
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	12920204
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	10516654 12920204 14730417 16036225 16980553
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Labetalol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Metaproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	16980553
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Metoprolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Metoprolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Nadolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Norepinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Oxprenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Pindolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Pindolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Practolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Propranolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	Propranolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	10952688 12920204
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	Propranolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	12920204
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	Propranolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	12920204
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	Propranolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	12920204
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[salmeterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	10516654 14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Sotalol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance	protein	17925438
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	10516654 12920204 14730417
D000242	154	ADRB2 ADRB2R ADRBR B2AR BAR BETA2AR	adrenoceptor beta 2, surface	[Timolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance	protein	17925438
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [[SR 59119A binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	10952688
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	ADRB3 protein affects the abundance of Cyclic AMP	affects abundance	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[Albuterol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[Alprenolol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[BRL 37344 binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[broxaterol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[CGP 12177 binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[CGP 20712A binds to and results in decreased activity of ADRB3 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[Epinephrine binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[Fenoterol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[formoterol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[ICI 118551 binds to and results in decreased activity of ADRB3 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[Isoproterenol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[Norepinephrine binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[Pindolol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[salmeterol binds to and results in decreased activity of ADRB3 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14730417
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[SR 59119A binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	10952688
D000242	155	ADRB3 BETA3AR	adrenoceptor beta 3	[Terbutaline binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14730417
D000242	250	ALPP ALP PALP PLAP PLAP-1	alkaline phosphatase, placental (EC:3.1.3.1)	[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of ALPP mRNA	increases abundance / increases expression	mRNA	16036225
D000242	551	AVP ADH ARVP AVP-NPII AVRP VP	arginine vasopressin	[AVP protein binds to and results in increased activity of AVPR2 protein mutant form] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	20683494
D000242	551	AVP ADH ARVP AVP-NPII AVRP VP	arginine vasopressin	[AVP protein binds to and results in increased activity of AVPR2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	20683494
D000242	554	AVPR2 ADHR DI1 DIR DIR3 NDI V2R	arginine vasopressin receptor 2	[AVP protein binds to and results in increased activity of AVPR2 protein mutant form] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	20683494
D000242	554	AVPR2 ADHR DI1 DIR DIR3 NDI V2R	arginine vasopressin receptor 2	[AVP protein binds to and results in increased activity of AVPR2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	20683494
D000242	673	BRAF B-RAF1 BRAF1 NS7 RAFB1	v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1)	Cyclic AMP results in increased activity of BRAF protein	increases activity	protein	21693435
D000242	796	CALCA CALC1 CGRP CGRP-I CGRP1 CT KC	calcitonin-related polypeptide alpha	CALCA protein modified form results in increased abundance of Cyclic AMP	increases abundance	protein	15297469
D000242	796	CALCA CALC1 CGRP CGRP-I CGRP1 CT KC	calcitonin-related polypeptide alpha	CALCA protein results in increased abundance of Cyclic AMP	increases abundance	protein	17295025 18463244
D000242	796	CALCA CALC1 CGRP CGRP-I CGRP1 CT KC	calcitonin-related polypeptide alpha	Isoflurane inhibits the reaction [CALCA protein modified form results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance	protein	15297469
D000242	796	CALCA CALC1 CGRP CGRP-I CGRP1 CT KC	calcitonin-related polypeptide alpha	sevoflurane inhibits the reaction [CALCA protein modified form results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance	protein	15297469
D000242	10498	CARM1 PRMT4	coactivator-associated arginine methyltransferase 1 (EC:2.1.1.125)	CARM1 protein promotes the reaction [Cyclic AMP results in increased activity of ESR1 protein]	increases activity / increases reaction	protein	20360387
D000242	10498	CARM1 PRMT4	coactivator-associated arginine methyltransferase 1 (EC:2.1.1.125)	CARM1 protein promotes the reaction [Cyclic AMP results in increased expression of TFF1 mRNA]	increases expression / increases reaction	protein	20360387
D000242	10498	CARM1 PRMT4	coactivator-associated arginine methyltransferase 1 (EC:2.1.1.125)	Cyclic AMP promotes the reaction [CARM1 protein binds to ESR1 protein]	affects binding / increases reaction	protein	20360387
D000242	10498	CARM1 PRMT4	coactivator-associated arginine methyltransferase 1 (EC:2.1.1.125)	Cyclic AMP promotes the reaction [CARM1 protein binds to TFF1 promoter]	affects binding / increases reaction	protein	20360387
D000242	10498	CARM1 PRMT4	coactivator-associated arginine methyltransferase 1 (EC:2.1.1.125)	Cyclic AMP results in increased phosphorylation of CARM1 protein	increases phosphorylation	protein	20360387
D000242	10498	CARM1 PRMT4	coactivator-associated arginine methyltransferase 1 (EC:2.1.1.125)	[Cyclic AMP results in increased phosphorylation of CARM1 protein] promotes the reaction [CARM1 protein binds to ESR1 protein]	affects binding / increases phosphorylation / increases reaction	protein	20360387
D000242	595	CCND1 BCL1 D11S287E PRAD1 U21B31	cyclin D1	[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CCND1 protein	increases abundance / increases expression	protein	21693435
D000242	1027	CDKN1B CDKN4 KIP1 MEN1B MEN4 P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein	increases abundance / increases expression	protein	21693435
D000242	1080	CFTR ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	Cyclic AMP promotes the reaction [CFTR protein results in increased transport of Bicarbonates]	increases reaction / increases transport	protein	11786964
D000242	1080	CFTR ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	Cyclic AMP promotes the reaction [CFTR protein results in increased transport of Chlorides]	increases reaction / increases transport	protein	11786964
D000242	1080	CFTR ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	Cyclic AMP results in increased activity of CFTR protein	increases activity	protein	15229107 15371258
D000242	1081	CGA CG-ALPHA FSHA GPHA1 GPHa HCG LHA TSHA	glycoprotein hormones, alpha polypeptide	CGA protein affects the secretion of Cyclic AMP	affects secretion	protein	23071612
D000242	1081	CGA CG-ALPHA FSHA GPHA1 GPHa HCG LHA TSHA	glycoprotein hormones, alpha polypeptide	[CGA protein affects the secretion of Cyclic AMP] which results in increased secretion of Progesterone	affects secretion / increases secretion	protein	23071612
D000242	1081	CGA CG-ALPHA FSHA GPHA1 GPHa HCG LHA TSHA	glycoprotein hormones, alpha polypeptide	[CGA protein co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Cyclic AMP	affects cotreatment / increases abundance	protein	23071612
D000242	1081	CGA CG-ALPHA FSHA GPHA1 GPHa HCG LHA TSHA	glycoprotein hormones, alpha polypeptide	CGA protein results in increased abundance of Cyclic AMP	increases abundance	protein	20378682 21642635
D000242	1081	CGA CG-ALPHA FSHA GPHA1 GPHa HCG LHA TSHA	glycoprotein hormones, alpha polypeptide	Colforsin promotes the reaction [CGA protein results in increased abundance of Cyclic AMP]	increases abundance / increases reaction	protein	20378682
D000242	1082	CGB CGB3 CGB5 CGB7 CGB8 hCGB	chorionic gonadotropin, beta polypeptide	Atrazine inhibits the reaction [CGB protein results in increased secretion of Cyclic AMP]	decreases reaction / increases secretion	protein	19541795
D000242	1082	CGB CGB3 CGB5 CGB7 CGB8 hCGB	chorionic gonadotropin, beta polypeptide	Atrazine promotes the reaction [CGB protein results in increased abundance of Cyclic AMP]	increases abundance / increases reaction	protein	20667998
D000242	1082	CGB CGB3 CGB5 CGB7 CGB8 hCGB	chorionic gonadotropin, beta polypeptide	CGB protein results in increased abundance of Cyclic AMP	increases abundance	protein	20667998 22461451 23347875
D000242	1082	CGB CGB3 CGB5 CGB7 CGB8 hCGB	chorionic gonadotropin, beta polypeptide	[CGB protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP	increases abundance / increases activity	protein	19766106
D000242	1082	CGB CGB3 CGB5 CGB7 CGB8 hCGB	chorionic gonadotropin, beta polypeptide	CGB protein results in increased secretion of Cyclic AMP	increases secretion	protein	19541795
D000242	1082	CGB CGB3 CGB5 CGB7 CGB8 hCGB	chorionic gonadotropin, beta polypeptide	Colforsin promotes the reaction [CGB protein results in increased abundance of Cyclic AMP]	increases abundance / increases reaction	protein	23347875
D000242	1082	CGB CGB3 CGB5 CGB7 CGB8 hCGB	chorionic gonadotropin, beta polypeptide	ESR1 protein promotes the reaction [[CGB protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP]	increases abundance / increases activity / increases reaction	protein	19766106
D000242	1082	CGB CGB3 CGB5 CGB7 CGB8 hCGB	chorionic gonadotropin, beta polypeptide	ESR2 protein promotes the reaction [[CGB protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP]	increases abundance / increases activity / increases reaction	protein	19766106
D000242	1082	CGB CGB3 CGB5 CGB7 CGB8 hCGB	chorionic gonadotropin, beta polypeptide	Estradiol inhibits the reaction [[CGB protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance / increases activity	protein	19766106
D000242	1082	CGB CGB3 CGB5 CGB7 CGB8 hCGB	chorionic gonadotropin, beta polypeptide	Flame Retardants inhibits the reaction [[CGB protein co-treated with Colforsin] results in increased abundance of Cyclic AMP]	affects cotreatment / decreases reaction / increases abundance	protein	23347875
D000242	1082	CGB CGB3 CGB5 CGB7 CGB8 hCGB	chorionic gonadotropin, beta polypeptide	Flame Retardants inhibits the reaction [Colforsin promotes the reaction [CGB protein results in increased abundance of Cyclic AMP]]	decreases reaction / increases abundance / increases reaction	protein	23347875
D000242	1082	CGB CGB3 CGB5 CGB7 CGB8 hCGB	chorionic gonadotropin, beta polypeptide	hexabromocyclododecane inhibits the reaction [Colforsin promotes the reaction [CGB protein results in increased abundance of Cyclic AMP]]	decreases reaction / increases abundance / increases reaction	protein	23347875
D000242	1082	CGB CGB3 CGB5 CGB7 CGB8 hCGB	chorionic gonadotropin, beta polypeptide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atrazine promotes the reaction [CGB protein results in increased abundance of Cyclic AMP]]	decreases reaction / increases abundance / increases reaction	protein	20667998
D000242	1268	CNR1 CANN6 CB-R CB1 CB1A CB1K5 CB1R CNR	cannabinoid receptor 1 (brain)	[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	10422789 11730719
D000242	1268	CNR1 CANN6 CB-R CB1 CB1A CB1K5 CB1R CNR	cannabinoid receptor 1 (brain)	rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	10422789
D000242	1269	CNR2 CB-2 CB2 CX5	cannabinoid receptor 2 (macrophage)	[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	17558435
D000242	1269	CNR2 CB-2 CB2 CX5	cannabinoid receptor 2 (macrophage)	Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	affects binding / decreases reaction / increases abundance / increases activity	protein	17558435
D000242	1269	CNR2 CB-2 CB2 CX5	cannabinoid receptor 2 (macrophage)	Pertussis Toxin inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	affects binding / decreases reaction / increases abundance / increases activity	protein	17558435
D000242	1269	CNR2 CB-2 CB2 CX5	cannabinoid receptor 2 (macrophage)	SR 144528 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	affects binding / decreases reaction / increases abundance / increases activity	protein	17558435
D000242	1269	CNR2 CB-2 CB2 CX5	cannabinoid receptor 2 (macrophage)	SR 144528 inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	affects binding / decreases reaction / increases abundance / increases activity	protein	17558435
D000242	1269	CNR2 CB-2 CB2 CX5	cannabinoid receptor 2 (macrophage)	[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	17558435
D000242	1387	CREBBP CBP KAT3A RSTS	CREB binding protein (EC:2.3.1.48)	CREBBP protein promotes the reaction [Cyclic AMP results in increased activity of ESR1 protein]	increases activity / increases reaction	protein	20360387
D000242	1392	CRH CRF	corticotropin releasing hormone	[CRHR1 protein binds to and results in increased activity of CRH protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	20702571
D000242	1392	CRH CRF	corticotropin releasing hormone	Progesterone promotes the reaction [[CRHR1 protein binds to and results in increased activity of CRH protein] which results in increased abundance of Cyclic AMP]	affects binding / increases abundance / increases activity / increases reaction	protein	20702571
D000242	1394	CRHR1 CRF-R CRF-R-1 CRF-R1 CRF1 CRFR-1 CRFR1 CRH-R-1 CRH-R1 CRH-R1h CRHR CRHR1L CRHR1f	corticotropin releasing hormone receptor 1	[CRHR1 protein binds to and results in increased activity of CRH protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	20702571
D000242	1394	CRHR1 CRF-R CRF-R-1 CRF-R1 CRF1 CRFR-1 CRFR1 CRH-R-1 CRH-R1 CRH-R1h CRHR CRHR1L CRHR1f	corticotropin releasing hormone receptor 1	Progesterone promotes the reaction [[CRHR1 protein binds to and results in increased activity of CRH protein] which results in increased abundance of Cyclic AMP]	affects binding / increases abundance / increases activity / increases reaction	protein	20702571
D000242	1440	CSF3 C17orf33 CSF3OS GCSF G-CSF	colony stimulating factor 3 (granulocyte)	Cyclic AMP results in increased expression of CSF3 protein	increases expression	protein	7540958
D000242	1584	CYP11B1 CPN1 CYP11B FHI P450C11	cytochrome P450, family 11, subfamily B, polypeptide 1 (EC:1.14.15.4)	Cyclic AMP results in increased expression of CYP11B1 mRNA	increases expression	mRNA	22172629
D000242	1584	CYP11B1 CPN1 CYP11B FHI P450C11	cytochrome P450, family 11, subfamily B, polypeptide 1 (EC:1.14.15.4)	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased expression of CYP11B1 mRNA]	decreases reaction / increases expression	mRNA	22172629
D000242	1586	CYP17A1 CPT7 CYP17 P450C17 S17AH	cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30)	[acetyl methyl tetramethyl tetralin co-treated with Cyclic AMP] results in decreased activity of CYP17A1 protein	affects cotreatment / decreases activity	protein	23084589
D000242	1586	CYP17A1 CPT7 CYP17 P450C17 S17AH	cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30)	[acetyl methyl tetramethyl tetralin co-treated with Cyclic AMP] results in increased activity of CYP17A1 protein	affects cotreatment / increases activity	protein	23084589
D000242	1586	CYP17A1 CPT7 CYP17 P450C17 S17AH	cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30)	[galaxolide co-treated with Cyclic AMP] results in decreased activity of CYP17A1 protein	affects cotreatment / decreases activity	protein	23084589
D000242	1586	CYP17A1 CPT7 CYP17 P450C17 S17AH	cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30)	[galaxolide co-treated with Cyclic AMP] results in increased activity of CYP17A1 protein	affects cotreatment / increases activity	protein	23084589
D000242	27185	DISC1 C1orf136 SCZD9	disrupted in schizophrenia 1	Cyclic AMP inhibits the reaction [DISC1 protein binds to PDE4B protein]	affects binding / decreases reaction	protein	16293762
D000242	22943	DKK1 DKK-1 SK	dickkopf WNT signaling pathway inhibitor 1	DKK1 protein affects the susceptibility to Cyclic AMP	affects response to substance	protein	21546446
D000242	1812	DRD1 DADR DRD1A	dopamine receptor D1	A 86929 promotes the reaction [DRD1 protein results in increased chemical synthesis of Cyclic AMP]	increases chemical synthesis / increases reaction	protein	8558425
D000242	1813	DRD2 D2DR D2R	dopamine receptor D2	epigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	affects binding / decreases reaction / increases abundance / increases activity	protein	17958328
D000242	1813	DRD2 D2DR D2R	dopamine receptor D2	[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	17958328
D000242	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	CARM1 protein promotes the reaction [Cyclic AMP results in increased activity of ESR1 protein]	increases activity / increases reaction	protein	20360387
D000242	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	CREBBP protein promotes the reaction [Cyclic AMP results in increased activity of ESR1 protein]	increases activity / increases reaction	protein	20360387
D000242	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	Cyclic AMP promotes the reaction [CARM1 protein binds to ESR1 protein]	affects binding / increases reaction	protein	20360387
D000242	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	Cyclic AMP results in increased activity of ESR1 protein	increases activity	protein	20360387
D000242	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	[Cyclic AMP results in increased phosphorylation of CARM1 protein] promotes the reaction [CARM1 protein binds to ESR1 protein]	affects binding / increases phosphorylation / increases reaction	protein	20360387
D000242	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	ESR1 protein promotes the reaction [[CGB protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP]	increases abundance / increases activity / increases reaction	protein	19766106
D000242	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased activity of ESR1 protein]	decreases reaction / increases activity	protein	20360387
D000242	2100	ESR2 ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2	estrogen receptor 2 (ER beta)	ESR2 protein promotes the reaction [[CGB protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP]	increases abundance / increases activity / increases reaction	protein	19766106
D000242	2150	F2RL1 GPR11 PAR2	coagulation factor II (thrombin) receptor-like 1	Cyclic AMP promotes the reaction [F2RL1 protein results in increased transport of Chlorides]	increases reaction / increases transport	protein	11804840
D000242	2353	FOS AP-1 C-FOS p55	FBJ murine osteosarcoma viral oncogene homolog	[Etoposide co-treated with Cyclic AMP] results in increased expression of FOS mRNA	affects cotreatment / increases expression	mRNA	10711420
D000242	2488	FSHB	follicle stimulating hormone, beta polypeptide	[FSHB protein co-treated with Testosterone] results in increased chemical synthesis of Cyclic AMP	affects cotreatment / increases chemical synthesis	protein	18535249
D000242	2668	GDNF ATF1 ATF2 HFB1-GDNF HSCR3	glial cell derived neurotrophic factor	3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium]	affects cotreatment / decreases reaction / increases response to substance	protein	19647008
D000242	2668	GDNF ATF1 ATF2 HFB1-GDNF HSCR3	glial cell derived neurotrophic factor	[GDNF protein co-treated with Cyclic AMP] results in decreased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	affects cotreatment / decreases response to substance	protein	19647008
D000242	2668	GDNF ATF1 ATF2 HFB1-GDNF HSCR3	glial cell derived neurotrophic factor	[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium	affects cotreatment / increases response to substance	protein	19647008
D000242	2668	GDNF ATF1 ATF2 HFB1-GDNF HSCR3	glial cell derived neurotrophic factor	Mazindol inhibits the reaction [[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium]	affects cotreatment / decreases reaction / increases response to substance	protein	19647008
D000242	2668	GDNF ATF1 ATF2 HFB1-GDNF HSCR3	glial cell derived neurotrophic factor	vanoxerine inhibits the reaction [[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium]	affects cotreatment / decreases reaction / increases response to substance	protein	19647008
D000242	2778	GNAS AHO C20orf45 GNAS1 GPSA GSA GSP NESP PHP1A PHP1B PHP1C POH	GNAS complex locus	GNAS protein promotes the reaction [[cicaprost results in increased activity of PTGIR protein] which results in increased abundance of Cyclic AMP]	increases abundance / increases activity / increases reaction	protein	11895442
D000242	338442	HCAR2 GPR109A HCA2 HM74a HM74b NIACR1 PUMAG Puma-g	hydroxycarboxylic acid receptor 2	[3-Hydroxybutyric Acid results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance / increases activity	protein	19223991
D000242	338442	HCAR2 GPR109A HCA2 HM74a HM74b NIACR1 PUMAG Puma-g	hydroxycarboxylic acid receptor 2	HCAR2 protein results in decreased abundance of Cyclic AMP	decreases abundance	protein	20655299
D000242	338442	HCAR2 GPR109A HCA2 HM74a HM74b NIACR1 PUMAG Puma-g	hydroxycarboxylic acid receptor 2	[Niacin results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance / increases activity	protein	19223991
D000242	338442	HCAR2 GPR109A HCA2 HM74a HM74b NIACR1 PUMAG Puma-g	hydroxycarboxylic acid receptor 2	[Nicotinic Acids binds to and results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	17124637
D000242	338442	HCAR2 GPR109A HCA2 HM74a HM74b NIACR1 PUMAG Puma-g	hydroxycarboxylic acid receptor 2	Pertussis Toxin inhibits the reaction [[Nicotinic Acids binds to and results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	affects binding / decreases reaction / increases abundance / increases activity	protein	17124637
D000242	8843	HCAR3 GPR109B HCA3 HM74 PUMAG Puma-g	hydroxycarboxylic acid receptor 3	HCAR3 protein results in decreased abundance of Cyclic AMP	decreases abundance	protein	19237584
D000242	3269	HRH1 H1-R hisH1	histamine receptor H1	1-Methyl-3-isobutylxanthine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]	decreases abundance / decreases reaction / increases reaction	protein	2419744
D000242	3269	HRH1 H1-R hisH1	histamine receptor H1	HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]	decreases abundance / increases reaction	protein	2419744
D000242	3269	HRH1 H1-R hisH1	histamine receptor H1	Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]	decreases abundance / decreases reaction / increases reaction	protein	2419744
D000242	3274	HRH2 H2R	histamine receptor H2	Burimamide inhibits the reaction [[Cyclic AMP binds to and results in decreased activity of HRH2 protein] which results in decreased abundance of Cimetidine]	affects binding / decreases abundance / decreases activity / decreases reaction	protein	9681472
D000242	3274	HRH2 H2R	histamine receptor H2	Burimamide inhibits the reaction [[Cyclic AMP binds to and results in increased activity of HRH2 protein] which results in increased abundance of Histamine]	affects binding / decreases reaction / increases abundance / increases activity	protein	9681472
D000242	3274	HRH2 H2R	histamine receptor H2	[Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	9681472
D000242	3274	HRH2 H2R	histamine receptor H2	Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein]	decreases expression / increases activity / increases reaction	protein	15843518
D000242	3274	HRH2 H2R	histamine receptor H2	Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein]	decreases expression / increases activity / increases reaction	protein	15843518
D000242	3274	HRH2 H2R	histamine receptor H2	[Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	9187264
D000242	3274	HRH2 H2R	histamine receptor H2	Dimaprit inhibits the reaction [HRH2 protein promotes the reaction [Colforsin results in increased abundance of Cyclic AMP]]	decreases reaction / increases abundance / increases reaction	protein	9187264
D000242	3274	HRH2 H2R	histamine receptor H2	Dimaprit inhibits the reaction [HRH2 protein promotes the reaction [Dinoprostone results in increased abundance of Cyclic AMP]]	decreases reaction / increases abundance / increases reaction	protein	9187264
D000242	3274	HRH2 H2R	histamine receptor H2	[Histamine binds to and results in increased activity of HRH2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	9187264 9681472
D000242	3274	HRH2 H2R	histamine receptor H2	HRH2 protein promotes the reaction [Colforsin results in increased abundance of Cyclic AMP]	increases abundance / increases reaction	protein	9187264
D000242	3274	HRH2 H2R	histamine receptor H2	HRH2 protein promotes the reaction [Dinoprostone results in increased abundance of Cyclic AMP]	increases abundance / increases reaction	protein	9187264
D000242	3274	HRH2 H2R	histamine receptor H2	HRH2 protein results in increased abundance of Cyclic AMP	increases abundance	protein	9681472
D000242	3284	HSD3B2 HSD3B HSDB SDR11E2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1)	Cyclic AMP results in increased expression of HSD3B2 mRNA	increases expression	mRNA	18490834
D000242	3350	HTR1A 5-HT-1A 5-HT1A 5HT1a ADRB2RL1 ADRBRL1 G-21 PFMCD	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	Arachidonic Acid metabolite inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	decreases reaction / increases abundance	protein	11356925
D000242	3350	HTR1A 5-HT-1A 5-HT1A 5HT1a ADRB2RL1 ADRBRL1 G-21 PFMCD	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance	protein	11356925
D000242	3350	HTR1A 5-HT-1A 5-HT1A 5HT1a ADRB2RL1 ADRBRL1 G-21 PFMCD	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	[JB-788 binds to and results in increased activity of HTR1A protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	affects binding / decreases reaction / increases abundance / increases activity	protein	20580787
D000242	3350	HTR1A 5-HT-1A 5-HT1A 5HT1a ADRB2RL1 ADRBRL1 G-21 PFMCD	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	Melitten inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	decreases reaction / increases abundance	protein	11356925
D000242	3351	HTR1B 5-HT1B 5-HT1DB HTR1D2 HTR1DB S12	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	HTR1B affects the reaction [almotriptan inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	affects reaction / decreases reaction / increases abundance		11134654
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[3,N-dimethyl-N-(1-methyl-3-(4-methylpiperidin-1-yl)propyl)benzenesulfonamide binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	14578406
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[5-carboxamidotryptamine binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14578406
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[5-Methoxytryptamine binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14578406
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[9-hydroxy-risperidone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	19509219
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[Bromocriptine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	19509219
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	14578406
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	HTR7 results in increased abundance of Cyclic AMP	increases abundance		10720076
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[Ketanserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	14578406
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[Lisuride binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	19509219
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[MDL 100907 binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	14578406
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[mesulergine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	14578406
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[Metergoline binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	14578406
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[Metergoline binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	19509219
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[Methiothepin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	19509219
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[Methiothepin binds to and results in decreased activity of HTR7 protein] which results in decreased abundance of Cyclic AMP	affects binding / decreases abundance / decreases activity	protein	14578406
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[Methoxydimethyltryptamines binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14578406
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[Mianserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	14578406
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[Risperidone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	19509219
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[Ritanserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	14578406
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[Serotonin binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance / increases activity	protein	14578406
D000242	3363	HTR7 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	[Spiperone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]	affects binding / decreases activity / decreases reaction / increases abundance	protein	14578406
D000242	3592	IL12A CLMF IL-12A NFSK NKSF1 P35	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein]	decreases expression / increases activity / increases reaction	protein	15843518
D000242	3593	IL12B CLMF CLMF2 IL-12B NKSF NKSF2	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein]	decreases expression / increases activity / increases reaction	protein	15843518
D000242	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]	increases abundance / increases reaction	protein	8904084
D000242	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]	increases abundance / increases reaction	protein	8904084
D000242	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	Ibuprofen inhibits the reaction [IL1B protein results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance	protein	17709599
D000242	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	IL1B protein results in increased abundance of Cyclic AMP	increases abundance	protein	8904084 17709599
D000242	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	KT 5720 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]]	decreases reaction / increases abundance / increases reaction	protein	8904084
D000242	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	KT 5823 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]]	decreases reaction / increases abundance / increases reaction	protein	8904084
D000242	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	Rolipram promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]	increases abundance / increases reaction	protein	8904084
D000242	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	[Terbutaline results in increased abundance of Cyclic AMP] which results in increased expression of IL8 protein	increases abundance / increases expression	protein	9258252
D000242	3624	INHBA EDF FRP	inhibin, beta A	Cyclic AMP results in increased secretion of INHBA protein	increases secretion	protein	20074812
D000242	3725	JUN AP-1 AP1 c-Jun	jun proto-oncogene	[Etoposide co-treated with Cyclic AMP] results in increased expression of JUN mRNA	affects cotreatment / increases expression	mRNA	10711420
D000242	3952	LEP LEPD OB OBS	leptin	LEP protein results in increased abundance of Cyclic AMP	increases abundance	protein	11342529
D000242	3972	LHB CGB4 LSH-B hLHB	luteinizing hormone beta polypeptide	LHB protein affects the secretion of Cyclic AMP	affects secretion	protein	23071612
D000242	3972	LHB CGB4 LSH-B hLHB	luteinizing hormone beta polypeptide	[LHB protein affects the secretion of Cyclic AMP] which results in increased secretion of Progesterone	affects secretion / increases secretion	protein	23071612
D000242	3972	LHB CGB4 LSH-B hLHB	luteinizing hormone beta polypeptide	[LHB protein co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Cyclic AMP	affects cotreatment / increases abundance	protein	23071612
D000242	3973	LHCGR HHG LCGR LGR2 LH/CG-R LH/CGR LHR LHRHR LSH-R ULG5	luteinizing hormone/choriogonadotropin receptor	[CGB protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP	increases abundance / increases activity	protein	19766106
D000242	3973	LHCGR HHG LCGR LGR2 LH/CG-R LH/CGR LHR LHRHR LSH-R ULG5	luteinizing hormone/choriogonadotropin receptor	ESR1 protein promotes the reaction [[CGB protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP]	increases abundance / increases activity / increases reaction	protein	19766106
D000242	3973	LHCGR HHG LCGR LGR2 LH/CG-R LH/CGR LHR LHRHR LSH-R ULG5	luteinizing hormone/choriogonadotropin receptor	ESR2 protein promotes the reaction [[CGB protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP]	increases abundance / increases activity / increases reaction	protein	19766106
D000242	3973	LHCGR HHG LCGR LGR2 LH/CG-R LH/CGR LHR LHRHR LSH-R ULG5	luteinizing hormone/choriogonadotropin receptor	Estradiol inhibits the reaction [[CGB protein results in increased activity of LHCGR protein] which results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance / increases activity	protein	19766106
D000242	3991	LIPE HSL LHS	lipase, hormone-sensitive (EC:3.1.1.79)	Cyclic AMP results in increased activity of LIPE protein	increases activity	protein	7155675
D000242	4158	MC2R ACTHR	melanocortin 2 receptor (adrenocorticotropic hormone)	[acetyl methyl tetramethyl tetralin co-treated with Cyclic AMP] results in decreased expression of MC2R mRNA	affects cotreatment / decreases expression	mRNA	23084589
D000242	54539	NDUFB11 CI-ESSS ESSS NP17.3 Np15 P17.3	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa	Cyclic AMP results in increased phosphorylation of NDUFB11 protein	increases phosphorylation	protein	17904600
D000242	54539	NDUFB11 CI-ESSS ESSS NP17.3 Np15 P17.3	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa	Zalcitabine inhibits the reaction [Cyclic AMP results in increased phosphorylation of NDUFB11 protein]	decreases reaction / increases phosphorylation	protein	17904600
D000242	54539	NDUFB11 CI-ESSS ESSS NP17.3 Np15 P17.3	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa	Zidovudine inhibits the reaction [Cyclic AMP results in increased phosphorylation of NDUFB11 protein]	decreases reaction / increases phosphorylation	protein	17904600
D000242	4988	OPRM1 LMOR M-OR-1 MOP MOR MOR1 OPRM	opioid receptor, mu 1	[7-benzylidenenaltrexone binds to and results in decreased activity of OPRM1 protein] which results in increased expression of Cyclic AMP	affects binding / decreases activity / increases expression	protein	11413242
D000242	4988	OPRM1 LMOR M-OR-1 MOP MOR MOR1 OPRM	opioid receptor, mu 1	[chlornaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in increased expression of Cyclic AMP	affects binding / decreases activity / increases expression	protein	11413242
D000242	4988	OPRM1 LMOR M-OR-1 MOP MOR MOR1 OPRM	opioid receptor, mu 1	[clocinnamox binds to and results in decreased activity of OPRM1 protein] which results in increased expression of Cyclic AMP	affects binding / decreases activity / increases expression	protein	11413242
D000242	4988	OPRM1 LMOR M-OR-1 MOP MOR MOR1 OPRM	opioid receptor, mu 1	[nalmefene binds to and results in decreased activity of OPRM1 protein] which results in increased expression of Cyclic AMP	affects binding / decreases activity / increases expression	protein	11413242
D000242	4988	OPRM1 LMOR M-OR-1 MOP MOR MOR1 OPRM	opioid receptor, mu 1	[[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP	affects binding / affects cotreatment / decreases activity / increases expression	protein	11413242
D000242	4988	OPRM1 LMOR M-OR-1 MOP MOR MOR1 OPRM	opioid receptor, mu 1	[[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP	affects binding / affects cotreatment / decreases activity / increases expression	protein	11413242
D000242	10846	PDE10A HSPDE10A	phosphodiesterase 10A (EC:3.1.4.35 3.1.4.17)	Cyclic AMP inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic GMP]	decreases reaction / increases hydrolysis	protein	10373451
D000242	10846	PDE10A HSPDE10A	phosphodiesterase 10A (EC:3.1.4.35 3.1.4.17)	Cyclic GMP inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic AMP]	decreases reaction / increases hydrolysis	protein	10373451
D000242	10846	PDE10A HSPDE10A	phosphodiesterase 10A (EC:3.1.4.35 3.1.4.17)	Dipyridamole inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic AMP]	decreases reaction / increases hydrolysis	protein	10373451
D000242	10846	PDE10A HSPDE10A	phosphodiesterase 10A (EC:3.1.4.35 3.1.4.17)	PDE10A protein results in increased hydrolysis of Cyclic AMP	increases hydrolysis	protein	10373451
D000242	50940	PDE11A PPNAD2	phosphodiesterase 11A (EC:3.1.4.35 3.1.4.17)	PDE11A protein results in increased hydrolysis of Cyclic AMP	increases hydrolysis	protein	10725373
D000242	5142	PDE4B DPDE4 PDE4B5 PDEIVB	phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17)	[Bresol results in decreased activity of PDE4B protein] which results in increased abundance of Cyclic AMP	decreases activity / increases abundance	protein	21854221
D000242	5142	PDE4B DPDE4 PDE4B5 PDEIVB	phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17)	Cyclic AMP inhibits the reaction [DISC1 protein binds to PDE4B protein]	affects binding / decreases reaction	protein	16293762
D000242	5150	PDE7A HCP1 PDE7	phosphodiesterase 7A (EC:3.1.4.17)	1-Methyl-3-isobutylxanthine inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP]	decreases reaction / increases hydrolysis	protein	10618442
D000242	5150	PDE7A HCP1 PDE7	phosphodiesterase 7A (EC:3.1.4.17)	Dipyridamole inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP]	decreases reaction / increases hydrolysis	protein	10618442
D000242	5150	PDE7A HCP1 PDE7	phosphodiesterase 7A (EC:3.1.4.17)	Papaverine inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP]	decreases reaction / increases hydrolysis	protein	10618442
D000242	5150	PDE7A HCP1 PDE7	phosphodiesterase 7A (EC:3.1.4.17)	PDE7A protein results in increased hydrolysis of Cyclic AMP	increases hydrolysis	protein	10618442 10814504
D000242	5150	PDE7A HCP1 PDE7	phosphodiesterase 7A (EC:3.1.4.17)	SCH 51866 inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP]	decreases reaction / increases hydrolysis	protein	10618442
D000242	27115	PDE7B bA472E5.1	phosphodiesterase 7B (EC:3.1.4.17)	1-Methyl-3-isobutylxanthine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]	decreases reaction / increases hydrolysis	protein	10814504 10872825
D000242	27115	PDE7B bA472E5.1	phosphodiesterase 7B (EC:3.1.4.17)	Dipyridamole inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]	decreases reaction / increases hydrolysis	protein	10814504 10872825
D000242	27115	PDE7B bA472E5.1	phosphodiesterase 7B (EC:3.1.4.17)	E 4021 inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]	decreases reaction / increases hydrolysis	protein	10814504
D000242	27115	PDE7B bA472E5.1	phosphodiesterase 7B (EC:3.1.4.17)	PDE7B protein results in increased hydrolysis of Cyclic AMP	increases hydrolysis	protein	10814504 10872825
D000242	27115	PDE7B bA472E5.1	phosphodiesterase 7B (EC:3.1.4.17)	SCH 51866 inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]	decreases reaction / increases hydrolysis	protein	10814504
D000242	27115	PDE7B bA472E5.1	phosphodiesterase 7B (EC:3.1.4.17)	vinpocetine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]	decreases reaction / increases hydrolysis	protein	10814504
D000242	5151	PDE8A HsT19550	phosphodiesterase 8A (EC:3.1.4.17)	Dipyridamole inhibits the reaction [PDE8A protein results in increased metabolism of Cyclic AMP]	decreases reaction / increases metabolic processing	protein	12681444
D000242	5151	PDE8A HsT19550	phosphodiesterase 8A (EC:3.1.4.17)	E 4021 inhibits the reaction [PDE8A protein results in increased metabolism of Cyclic AMP]	decreases reaction / increases metabolic processing	protein	12681444
D000242	5151	PDE8A HsT19550	phosphodiesterase 8A (EC:3.1.4.17)	PDE8A protein results in increased metabolism of Cyclic AMP	increases metabolic processing	protein	12681444
D000242	8622	PDE8B ADSD PPNAD3	phosphodiesterase 8B (EC:3.1.4.17)	9-(2-hydroxy-3-nonyl)adenine inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP]	decreases reaction / increases metabolic processing	protein	12681444
D000242	8622	PDE8B ADSD PPNAD3	phosphodiesterase 8B (EC:3.1.4.17)	Dipyridamole inhibits the reaction [PDE8B protein results in increased hydrolysis of Cyclic AMP]	decreases reaction / increases hydrolysis	protein	9784418
D000242	8622	PDE8B ADSD PPNAD3	phosphodiesterase 8B (EC:3.1.4.17)	Dipyridamole inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP]	decreases reaction / increases metabolic processing	protein	12681444
D000242	8622	PDE8B ADSD PPNAD3	phosphodiesterase 8B (EC:3.1.4.17)	E 4021 inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP]	decreases reaction / increases metabolic processing	protein	12681444
D000242	8622	PDE8B ADSD PPNAD3	phosphodiesterase 8B (EC:3.1.4.17)	PDE8B protein results in increased hydrolysis of Cyclic AMP	increases hydrolysis	protein	9784418
D000242	8622	PDE8B ADSD PPNAD3	phosphodiesterase 8B (EC:3.1.4.17)	PDE8B protein results in increased metabolism of Cyclic AMP	increases metabolic processing	protein	12681444
D000242	8622	PDE8B ADSD PPNAD3	phosphodiesterase 8B (EC:3.1.4.17)	sildenafil inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP]	decreases reaction / increases metabolic processing	protein	12681444
D000242	5152	PDE9A HSPDE9A2	phosphodiesterase 9A (EC:3.1.4.35)	PDE9A protein results in increased hydrolysis of Cyclic AMP	increases hydrolysis	protein	9624146
D000242	5617	PRL	prolactin	Cyclic AMP results in increased secretion of PRL protein	increases secretion	protein	20074812
D000242	84432	PROK1 EGVEGF PK1 PRK1	prokineticin 1	PROK1 protein affects the susceptibility to Cyclic AMP	affects response to substance	protein	21546446
D000242	5739	PTGIR IP PRIPR	prostaglandin I2 (prostacyclin) receptor (IP)	[cicaprost results in increased activity of PTGIR protein] which results in increased abundance of Cyclic AMP	increases abundance / increases activity	protein	11895442
D000242	5739	PTGIR IP PRIPR	prostaglandin I2 (prostacyclin) receptor (IP)	GNAS protein promotes the reaction [[cicaprost results in increased activity of PTGIR protein] which results in increased abundance of Cyclic AMP]	increases abundance / increases activity / increases reaction	protein	11895442
D000242	5744	PTHLH BDE2 HHM PLP PTHR PTHRP	parathyroid hormone-like hormone	PTHLH protein results in increased abundance of Cyclic AMP	increases abundance	protein	10600786
D000242	5908	RAP1B K-REV RAL1B	RAP1B, member of RAS oncogene family	[Pentoxifylline results in increased abundance of Cyclic AMP] results in increased abundance of [RAP1B protein binds to Guanosine Triphosphate]	affects binding / increases abundance	protein	21693435
D000242	9376	SLC22A8 OAT3	solute carrier family 22 (organic anion transporter), member 8	SLC22A8 protein affects the transport of Cyclic AMP	affects transport	protein	11306713
D000242	6518	SLC2A5 GLUT-5 GLUT5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	Cyclic AMP affects the expression of SLC2A5 mRNA	affects expression	mRNA	8554516
D000242	6518	SLC2A5 GLUT-5 GLUT5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	[Fructose results in increased abundance of Cyclic AMP] which results in increased stability of SLC2A5 mRNA	increases abundance / increases stability	mRNA	12820898
D000242	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	WNT5A protein affects the reaction [[Medroxyprogesterone Acetate results in increased abundance of Cyclic AMP] which results in increased expression of SOD2 mRNA]	affects reaction / increases abundance / increases expression	mRNA	20685861
D000242	7031	TFF1 BCEI D21S21 HP1.A HPS2 pNR-2 pS2	trefoil factor 1	CARM1 protein promotes the reaction [Cyclic AMP results in increased expression of TFF1 mRNA]	increases expression / increases reaction	mRNA	20360387
D000242	7031	TFF1 BCEI D21S21 HP1.A HPS2 pNR-2 pS2	trefoil factor 1	Cyclic AMP promotes the reaction [CARM1 protein binds to TFF1 promoter]	affects binding / increases reaction	promoter	20360387
D000242	7031	TFF1 BCEI D21S21 HP1.A HPS2 pNR-2 pS2	trefoil factor 1	Cyclic AMP results in increased expression of TFF1 mRNA	increases expression	mRNA	20360387
D000242	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Cyclic AMP results in decreased expression of TNF protein	decreases expression	protein	8550079
D000242	7252	TSHB TSH-B TSH-BETA	thyroid stimulating hormone, beta	bisphenol A inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance / increases activity	protein	19766106
D000242	7252	TSHB TSH-B TSH-BETA	thyroid stimulating hormone, beta	Diethylstilbestrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance / increases activity	protein	19766106
D000242	7252	TSHB TSH-B TSH-BETA	thyroid stimulating hormone, beta	Estradiol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance / increases activity	protein	19766106
D000242	7252	TSHB TSH-B TSH-BETA	thyroid stimulating hormone, beta	resveratrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance / increases activity	protein	19766106
D000242	7252	TSHB TSH-B TSH-BETA	thyroid stimulating hormone, beta	TSHB protein inhibits the reaction [NCGC 00229600 inhibits the reaction [TSHR protein results in increased abundance of Cyclic AMP]]	decreases reaction / increases abundance	protein	21123444
D000242	7252	TSHB TSH-B TSH-BETA	thyroid stimulating hormone, beta	[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP	increases abundance / increases activity	protein	19766106
D000242	7253	TSHR CHNG1 LGR3 hTSHR-I	thyroid stimulating hormone receptor	bisphenol A inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance / increases activity	protein	19766106
D000242	7253	TSHR CHNG1 LGR3 hTSHR-I	thyroid stimulating hormone receptor	Diethylstilbestrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance / increases activity	protein	19766106
D000242	7253	TSHR CHNG1 LGR3 hTSHR-I	thyroid stimulating hormone receptor	Estradiol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance / increases activity	protein	19766106
D000242	7253	TSHR CHNG1 LGR3 hTSHR-I	thyroid stimulating hormone receptor	NCGC 00229600 inhibits the reaction [TSHR protein results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance	protein	21123444
D000242	7253	TSHR CHNG1 LGR3 hTSHR-I	thyroid stimulating hormone receptor	resveratrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	decreases reaction / increases abundance / increases activity	protein	19766106
D000242	7253	TSHR CHNG1 LGR3 hTSHR-I	thyroid stimulating hormone receptor	TSHB protein inhibits the reaction [NCGC 00229600 inhibits the reaction [TSHR protein results in increased abundance of Cyclic AMP]]	decreases reaction / increases abundance	protein	21123444
D000242	7253	TSHR CHNG1 LGR3 hTSHR-I	thyroid stimulating hormone receptor	[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP	increases abundance / increases activity	protein	19766106
D000242	7253	TSHR CHNG1 LGR3 hTSHR-I	thyroid stimulating hormone receptor	TSHR protein results in increased abundance of Cyclic AMP	increases abundance	protein	21123444
D000242	7432	VIP PHM27	vasoactive intestinal peptide	[VIP protein binds to VIPR2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance	protein	7733904
D000242	7434	VIPR2 C16DUPq36.3 DUP7q36.3 PACAP-R-3 PACAP-R3 VIP-R-2 VPAC2 VPAC2R VPCAP2R	vasoactive intestinal peptide receptor 2	[ADCYAP1 protein binds to VIPR2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance	protein	7733904
D000242	7434	VIPR2 C16DUPq36.3 DUP7q36.3 PACAP-R-3 PACAP-R3 VIP-R-2 VPAC2 VPAC2R VPCAP2R	vasoactive intestinal peptide receptor 2	[VIP protein binds to VIPR2 protein] which results in increased abundance of Cyclic AMP	affects binding / increases abundance	protein	7733904
D000242	7474	WNT5A hWNT5A	wingless-type MMTV integration site family, member 5A	WNT5A protein affects the reaction [Medroxyprogesterone Acetate results in increased abundance of Cyclic AMP]	affects reaction / increases abundance	protein	20685861
D000242	7474	WNT5A hWNT5A	wingless-type MMTV integration site family, member 5A	WNT5A protein affects the reaction [[Medroxyprogesterone Acetate results in increased abundance of Cyclic AMP] which results in increased expression of SOD2 mRNA]	affects reaction / increases abundance / increases expression	protein	20685861

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM	preferred title	UniProt
#614613	Acrodysostosis 2, with or without hormone resistance; acrdys2	Q08499
#117800	Apocrine gland secretion, variation in	Q96J66
#608584	Asthma-related traits, susceptibility to, 2	Q6W5P4
#210900	Bloom syndrome; blm	P54132
#115200	Cardiomyopathy, dilated, 1a; cmd1a	P02545
#212112	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	P02545
#605588	Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1	P02545
#609535	Drug metabolism, poor, cyp2c19-related	P33261
#608902	Drug metabolism, poor, cyp2d6-related	P10635
#181350	Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2	P02545
#605130	Hairy elbows, short stature, facial dysmorphism, and developmental delay	Q03164
#610140	Heart-hand syndrome, slovenian type	P02545
#176670	Hutchinson-gilford progeria syndrome; hgps	P02545
#151660	Lipodystrophy, familial partial, type 2; fpld2	P02545
#248370	Mandibuloacral dysplasia with type a lipodystrophy; mada	P02545
#613205	Muscular dystrophy, congenital, lmna-related	P02545
#159001	Muscular dystrophy, limb-girdle, type 1b; lgmd1b	P02545
#275210	Restrictive dermopathy, lethal	P02545
#604906	Schizophrenia 9; sczd9	P49798
#181500	Schizophrenia; sczd	P49798
#188570	Thyroid hormone resistance, generalized, autosomal dominant; grth	P10828
#274300	Thyroid hormone resistance, generalized, autosomal recessive; grth	P10828
#145650	Thyroid hormone resistance, selective pituitary; prth	P10828
#278750	Xeroderma pigmentosum, variant type; xpv	Q9Y253

KEGG DISEASE (19)

KEGG	disease name	UniProt
H00264	Charcot-Marie-Tooth disease (CMT)	P02545 (related)
H00294	Dilated cardiomyopathy (DCM)	P02545 (related)
H00420	Familial partial lipodystrophy (FPL)	P02545 (related)
H00563	Emery-Dreifuss muscular dystrophy	P02545 (related)
H00590	Congenital muscular dystrophies (CMD/MDC)	P02545 (related)
H00593	Limb-girdle muscular dystrophy (LGMD)	P02545 (related)
H00601	Hutchinson-Gilford progeria syndrome	P02545 (related)
H00663	Restrictive dermopathy	P02545 (related)
H00665	Mandibuloacral dysplasia	P02545 (related)
H01216	Left ventricular noncompaction (LVNC)	P02545 (related)
H00036	Osteosarcoma	P08684 (marker)
H00249	Thyroid hormone resistance syndrome	P10828 (related)
H01205	Coumarin resistance	P11712 (related)
H01171	Poor drug metabolism (PM)	P33261 (related)
H00094	DNA repair defects	P54132 (related)
H00296	Defects in RecQ helicases	P54132 (related)
H00001	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	Q03164 (related) Q03164 (marker)
H00002	Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)	Q03164 (related)
H00403	Disorders of nucleotide excision repair	Q9Y253 (related)

Diseases related to CTD interactions

7 disease from interactions of metabolites

MeSH disease	compound	disease name	evidence type	reference pmid
D001249	D000242	Asthma	therapeutic	6327346
D004409	D000242	Dyskinesia, Drug-Induced	marker/mechanism	189712
D006930	D000242	Hyperalgesia	marker/mechanism	10401557
D006973	D000242	Hypertension	marker/mechanism	20713914
D020326	D000242	Migraine without Aura	marker/mechanism	11304026
D013375	D000242	Substance Withdrawal Syndrome	marker/mechanism	15196791 15542745 15829634
D014202	D000242	Tremor	marker/mechanism	6291971 6327346

KNApSAcK Metabolite C00001497

Index Metabolite Species Human Protein / Gene in interactions Related Diseases

Metabolite

KNApSAcK Entry

Cluster

Link

ChEMBL

KEGG

CTD

Species

Summary

Plant class

Family

List (3)

* NCBI

Human Protein / Gene in interaction

29 ChEMBL Protein in interactions

CTD interaction (345)

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (24)

KEGG DISEASE (19)

Diseases related to CTD interactions

7 disease from interactions of metabolites

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases