PCIDB

KCF-S cluster No. 3303 (3 metabolites)

KEGG BRITE br08003 External link 512

Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00001386 External link 512 L-Phenylalanine
CHEMBL25080
CHEMBL301523
CHEMBL379630
27 / 18 / 14
C00001397 External link 512 L-Tyrosine
CHEMBL925
CHEMBL108615
CHEMBL1076637
17 / 9 / 14
C00037792 External link 512 S-Benzyl-L-cysteine sulfoxide

Human Protein / Gene in interactions

31 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q05BR4 SLC16A10 protein Unclassified protein C00001386 C00001397 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001386 C00001397 2 / 0
P22748 Carbonic anhydrase 4 Lyase C00001386 C00001397 1 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00001386 C00001397 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00001386 C00001397 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00001386 C00001397 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00001386 C00001397 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00001386 C00001397 0 / 1
P00918 Carbonic anhydrase 2 Lyase C00001386 C00001397 1 / 2
P00915 Carbonic anhydrase 1 Lyase C00001386 C00001397 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00001386 C00001397 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00001386 C00001397 1 / 2
Q9ULX7 Carbonic anhydrase 14 Lyase C00001386 C00001397 0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme C00001386 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001386 0 / 1
P05164 Myeloperoxidase Enzyme C00001397 1 / 2
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00001386 3 / 1
P04150 Glucocorticoid receptor NR3C1 C00001386 0 / 1
P14679 Tyrosinase Oxidoreductase C00001386 4 / 2
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001386 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00001386 3 / 1
P03372 Estrogen receptor NR3A1 C00001386 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001386 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001386 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001386 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001386 0 / 0
Q9Y263 Phospholipase A-2-activating protein Unclassified protein C00001386 0 / 0
P41240 Tyrosine-protein kinase CSK Csk C00001397 0 / 0
O00255 Menin Unclassified protein C00001397 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001397 1 / 2
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001386 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (22)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#254600 Myeloperoxidase deficiency; mpod P05164
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (23)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00101 Other phagocyte defects P05164 (related)
H00003 Acute myeloid leukemia (AML) P05164 (marker)
H00213 Hypophosphatasia P05186 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)