PCIDB

KNApSAcK Metabolite C00001386

Metabolite

KNApSAcK Entry

id C00001386
Name L-Phenylalanine
CAS RN 63-91-2
Standard InChI InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
Standard InChI (Main Layer) InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)

Cluster

Phytochemical cluster
KCF-S cluster No. 3303

Link

ChEMBL

By standard InChI CHEMBL301523
By standard InChI Main Layer CHEMBL25080 CHEMBL301523 CHEMBL379630

KEGG

By LinkDB C00079

CTD

By CAS RN

Human Protein / Gene in interaction

27 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL301523 CHEMBL1741321 (1)
1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL379630 CHEMBL1794499 (1)
2 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL301523 CHEMBL379630 CHEMBL885804 (2)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL301523 CHEMBL379630 CHEMBL885803 (2)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL301523 CHEMBL379630 CHEMBL889438 (2) CHEMBL889439 (2)
0 / 0
Q9Y263 Phospholipase A-2-activating protein Unclassified protein CHEMBL301523 CHEMBL1074487 (1)
0 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL301523 CHEMBL1794399 (1)
3 / 1
P00918 Carbonic anhydrase 2 Lyase CHEMBL301523 CHEMBL379630 CHEMBL653174 (1) CHEMBL869780 (2)
CHEMBL889436 (2) CHEMBL889437 (2)
CHEMBL887921 (2) CHEMBL887924 (2)
CHEMBL932482 (2) CHEMBL932486 (2)
CHEMBL970751 (2) CHEMBL953312 (2)
CHEMBL1017972 (2) CHEMBL1067709 (2)
CHEMBL1106967 (2) CHEMBL2156558 (2)
CHEMBL2156561 (2) CHEMBL2318049 (2)
1 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL301523 CHEMBL1741325 (1)
0 / 1
P23280 Carbonic anhydrase 6 Lyase CHEMBL301523 CHEMBL379630 CHEMBL887922 (2) CHEMBL887925 (2)
CHEMBL1067710 (2)
0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL301523 CHEMBL379630 CHEMBL889440 (2) CHEMBL889441 (2)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL301523 CHEMBL379630 CHEMBL932484 (2) CHEMBL932488 (2)
1 / 2
P00915 Carbonic anhydrase 1 Lyase CHEMBL301523 CHEMBL379630 CHEMBL662713 (1) CHEMBL869779 (2)
CHEMBL889434 (2) CHEMBL889435 (2)
CHEMBL887920 (2) CHEMBL887923 (2)
CHEMBL932481 (2) CHEMBL932485 (2)
CHEMBL970750 (2) CHEMBL965608 (2)
CHEMBL1067708 (2) CHEMBL2156557 (2)
CHEMBL2156560 (2) CHEMBL2318048 (2)
0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme CHEMBL301523 CHEMBL1074489 (1)
0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme CHEMBL301523 CHEMBL1074488 (1)
3 / 1
P04150 Glucocorticoid receptor NR3C1 CHEMBL301523 CHEMBL1794456 (1)
0 / 1
P14679 Tyrosinase Oxidoreductase CHEMBL301523 CHEMBL813552 (1)
4 / 2
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL301523 CHEMBL1741322 (1)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL301523 CHEMBL379630 CHEMBL932483 (2) CHEMBL932487 (2)
0 / 1
P03372 Estrogen receptor NR3A1 CHEMBL301523 CHEMBL1794364 (1)
1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL301523 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL301523 CHEMBL1741324 (1)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL379630 CHEMBL1614211 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL301523 CHEMBL2114890 (1)
0 / 0
P07451 Carbonic anhydrase 3 Lyase CHEMBL301523 CHEMBL379630 CHEMBL970752 (2) CHEMBL953319 (2)
0 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL301523 CHEMBL379630 CHEMBL863243 (1) CHEMBL970753 (2)
CHEMBL1008327 (2)
1 / 1
Q05BR4 SLC16A10 protein Unclassified protein CHEMBL301523 CHEMBL379630 CHEMBL2076232 (2) CHEMBL2076248 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#143860 Hyperchlorhidrosis, isolated O43570
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (14)

KEGG disease name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00213 Hypophosphatasia P05186 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)