KNApSAcK Metabolite C00019660
Metabolite
KNApSAcK Entry
| id | C00019660 |
|---|---|
| Name | Xanthine |
| CAS RN | 69-89-6 |
| Standard InChI | InChI=1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11) |
| Standard InChI (Main Layer) | InChI=1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11) |
Cluster
| Phytochemical cluster | No. 12 |
|---|---|
| KCF-S cluster | No. 2266 |
Link
ChEMBL
| By standard InChI | CHEMBL1424 |
|---|---|
| By standard InChI Main Layer | CHEMBL1424 |
KEGG
| By LinkDB | C00385 |
|---|
CTD
| By CAS RN | D019820 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Enterobacteriaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Escherichia coli K12 | 83333 | Enterobacteriaceae | Bacteria |
Human Protein / Gene in interaction
8 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P00492 | Hypoxanthine-guanine phosphoribosyltransferase | Enzyme | CHEMBL1424 |
CHEMBL909307
(1)
CHEMBL853907
(1)
|
2 / 1 |
| Q9Y2T3 | Guanine deaminase | Enzyme | CHEMBL1424 |
CHEMBL1225632
(1)
CHEMBL1225633
(1)
|
0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | CHEMBL1424 |
CHEMBL1794561
(1)
|
3 / 1 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | CHEMBL1424 |
CHEMBL680424
(1)
|
0 / 0 |
| Q08493 | cAMP-specific 3',5'-cyclic phosphodiesterase 4C | PDE_4C | CHEMBL1424 |
CHEMBL821509
(1)
|
0 / 0 |
| Q07343 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | PDE_4B | CHEMBL1424 |
CHEMBL821509
(1)
|
0 / 0 |
| P27815 | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | PDE_4A | CHEMBL1424 |
CHEMBL821509
(1)
|
0 / 0 |
| Q08499 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | PDE_4D | CHEMBL1424 |
CHEMBL821509
(1)
|
1 / 0 |
CTD interaction (7)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D019820 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | [Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein |
affects cotreatment
/ increases activity |
protein |
19268487
|
| D019820 | 847 |
CAT
|
catalase (EC:1.11.1.6) | CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein] |
affects cotreatment
/ decreases reaction / increases abundance / increases secretion |
protein |
19268487
|
| D019820 | 7040 |
TGFB1
CED DPD1 LAP TGFB TGFbeta |
transforming growth factor, beta 1 | CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein] |
affects cotreatment
/ decreases reaction / increases abundance / increases secretion |
protein |
19268487
|
| D019820 | 7040 |
TGFB1
CED DPD1 LAP TGFB TGFbeta |
transforming growth factor, beta 1 | [[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein |
affects cotreatment
/ increases abundance / increases secretion |
protein |
19268487
|
| D019820 | 7498 |
XDH
XO XOR |
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) | CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein] |
affects cotreatment
/ decreases reaction / increases abundance / increases secretion |
protein |
19268487
|
| D019820 | 7498 |
XDH
XO XOR |
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) | [[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein |
affects cotreatment
/ increases abundance / increases secretion |
protein |
19268487
|
| D019820 | 7498 |
XDH
XO XOR |
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) | [Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein |
affects cotreatment
/ increases activity |
protein |
19268487
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (6)
| OMIM | preferred title | UniProt |
|---|---|---|
| #614613 | Acrodysostosis 2, with or without hormone resistance; acrdys2 |
Q08499
|
| #300323 | Kelley-seegmiller syndrome |
P00492
|
| #300322 | Lesch-nyhan syndrome; lns |
P00492
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|