PCIDB

Trifolium pratense L.

Species

KNApSAcK Entry

Organism name Trifolium pratense L.
Genus Trifolium
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Trifolium pratense
Linked NCBI taxonomy ID 57577
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (24)

Species Activity
Trifolium pratense L. Alterative
Trifolium pratense L. Antiangiogenic
Trifolium pratense L. Anticancer
Trifolium pratense L. Anticarcinogenic
Trifolium pratense L. Antiinflammatory
Trifolium pratense L. Antiosteoporotic
Trifolium pratense L. Antirheumatic
Trifolium pratense L. Antiseptic
Trifolium pratense L. Antispasmodic
Trifolium pratense L. Aperitif
Trifolium pratense L. Astringent
Trifolium pratense L. Bitter
Trifolium pratense L. Cholagogue
Trifolium pratense L. Decongestant
Trifolium pratense L. Depurative
Trifolium pratense L. Diuretic
Trifolium pratense L. Emmenagogue
Trifolium pratense L. Estrogenic
Trifolium pratense L. Expectorant
Trifolium pratense L. Mastogenic
Trifolium pratense L. Progesterogenic
Trifolium pratense L. Sedative
Trifolium pratense L. Tonic
Trifolium pratense L. Vulnerary

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00002546 External link 512 Inermin
/ Maackiain
/ (-)-Maackiain
/ Demethylpterocarpin
/ 3-Hydroxy-8,9-methylenedioxypterocarpan
CHEMBL334918
CHEMBL239047
CHEMBL445279
3 / 2 / 3 No. 66 No. 15
C00002724 External link 512 Heriguard
/ Chlorogenic acid
/ 3-O-Caffeoylquinic acid
CHEMBL284616
CHEMBL230481
CHEMBL249450
CHEMBL1332980
CHEMBL1394423
CHEMBL1419611
CHEMBL1473644
CHEMBL1552319
D002726
30 / 19 / 22 37 / 9 No. 314 No. 6
C00000152 External link 512 p-Coumaric acid
CHEMBL66879
CHEMBL2336752
C032171
23 / 13 / 18 6 / 1 No. 904 No. 6
C00001396 External link 512 L-Tryptophan
CHEMBL54976
CHEMBL292303
CHEMBL484901
49 / 41 / 39 No. 1432 No. 4
C00001378 External link 512 L-Lysine
CHEMBL8085
CHEMBL28328
CHEMBL319497
5 / 12 / 11 No. 1538
C00003401 External link 512 Alectrol
/ Orobanchyl acetate
/ (+)-Orobanchyl acetate
No. 1816 No. 38
C00001351 External link 512 L-Cysteine
CHEMBL863
CHEMBL54943
CHEMBL171281
D003545
11 / 22 / 17 13 / 7 No. 2426
C00001358 External link 512 L-Glutamic acid
CHEMBL76232
CHEMBL575060
37 / 11 / 11 No. 2641
C00001341 External link 512 L-Asparagine
CHEMBL58832
CHEMBL1232369
1 / 2 / 0 No. 3843
C00001363 External link 512 L-Histidine
CHEMBL17962
CHEMBL104875
25 / 9 / 16 No. 7202

Human Protein / Gene in interactions

117 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001358 C00001363 C00001396 C00002546 C00002724 0 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001351 C00001358 C00001363 C00001396 C00002724 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001358 C00001363 C00001396 C00002724 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001358 C00001363 C00001396 C00002724 1 / 1
Q05BR4 SLC16A10 protein Unclassified protein C00001358 C00001363 C00001378 C00001396 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001358 C00001363 C00001396 C00002724 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001358 C00001363 C00001396 C00002724 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00000152 C00001363 C00001396 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00000152 C00001363 C00001396 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000152 C00001363 C00001396 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00000152 C00001363 C00001396 1 / 2
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001341 C00001358 C00001396 2 / 0
O43570 Carbonic anhydrase 12 Lyase C00000152 C00001363 C00001396 1 / 2
P02545 Prelamin-A/C Unclassified protein C00001351 C00001378 C00001396 11 / 10
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000152 C00001363 C00001396 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000152 C00001363 C00001396 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00000152 C00001363 C00001396 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001358 C00001396 C00002724 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000152 C00001363 C00001396 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000152 C00001363 C00001396 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000152 C00001363 C00001396 0 / 1
P00390 Glutathione reductase, mitochondrial Oxidoreductase C00001358 C00001378 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000152 C00002724 3 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001351 C00001396 4 / 3
P16473 Thyrotropin receptor Glycohormone receptor C00001396 C00002724 3 / 2
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000152 C00002724 0 / 3
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001363 C00001396 1 / 2
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00000152 C00002724 0 / 0
P15121 Aldose reductase Enzyme C00000152 C00002724 0 / 0
O75496 Geminin Unclassified protein C00001396 C00002724 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001363 C00001396 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001363 C00001396 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001396 C00002724 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001358 C00002724 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001363 C00002724 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001351 C00002724 1 / 1
O00255 Menin Unclassified protein C00001363 C00001396 2 / 5
Q9UNA4 DNA polymerase iota Enzyme C00001396 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00001351 2 / 3
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme C00001396 0 / 0
P54132 Bloom syndrome protein Enzyme C00001396 1 / 2
Q14831 Metabotropic glutamate receptor 7 Metabotropic glutamate receptor C00001358 0 / 0
P43005 Excitatory amino acid transporter 3 Aspartate, glutamate and cysteine Na-symporter C00001358 1 / 1
Q13002 Glutamate receptor ionotropic, kainate 2 NS C00001358 1 / 1
P39086 Glutamate receptor ionotropic, kainate 1 NS C00001358 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001396 0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000152 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000152 0 / 0
Q16478 Glutamate receptor ionotropic, kainate 5 NS C00001358 0 / 0
P78536 Disintegrin and metalloproteinase domain-containing protein 17 M12B C00001351 1 / 0
P42858 Huntingtin Unclassified protein C00001396 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001351 2 / 0
P42357 Histidine ammonia-lyase Enzyme C00001363 1 / 1
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00002724 0 / 0
P42261 Glutamate receptor 1 NS C00001358 0 / 0
P10145 Interleukin-8 Secreted protein C00002724 0 / 0
P02768 Serum albumin Secreted protein C00001396 0 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00002724 1 / 2
Q14416 Metabotropic glutamate receptor 2 Metabotropic glutamate receptor C00001358 0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme C00001396 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00001396 3 / 1
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00001358 0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001358 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00002724 0 / 1
P14679 Tyrosinase Oxidoreductase C00000152 4 / 2
P42263 Glutamate receptor 3 NS C00001358 1 / 1
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00002724 0 / 0
O15303 Metabotropic glutamate receptor 6 Metabotropic glutamate receptor C00001358 1 / 1
Q9Y263 Phospholipase A-2-activating protein Unclassified protein C00001396 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001358 0 / 0
P43004 Excitatory amino acid transporter 2 Aspartate and glutamate Na-symporter C00001358 0 / 0
Q9Y2Q3 Glutathione S-transferase kappa 1 Enzyme C00001351 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002724 3 / 3
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00001396 1 / 1
P51692 Signal transducer and activator of transcription 5B Unclassified protein C00002724 1 / 1
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000152 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00001396 5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001363 0 / 0
P03372 Estrogen receptor NR3A1 C00000152 1 / 1
Q04609 Glutamate carboxypeptidase 2 M28B C00001358 0 / 0
Q14833 Metabotropic glutamate receptor 4 Metabotropic glutamate receptor C00001358 0 / 0
Q13255 Metabotropic glutamate receptor 1 Metabotropic glutamate receptor C00001358 1 / 0
P48775 Tryptophan 2,3-dioxygenase Enzyme C00001396 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001396 0 / 0
Q16773 Kynurenine--oxoglutarate transaminase 1 Enzyme C00001396 0 / 0
O00222 Metabotropic glutamate receptor 8 Metabotropic glutamate receptor C00001358 0 / 0
P52732 Kinesin-like protein KIF11 Other cytosolic protein C00001351 1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000152 1 / 8
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000152 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002724 0 / 0
Q13003 Glutamate receptor ionotropic, kainate 3 NS C00001358 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00001358 0 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein C00001396 0 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00002724 0 / 0
Q7Z2H8 Proton-coupled amino acid transporter 1 Unclassified protein C00001351 0 / 0
Q9UPY5 Cystine/glutamate transporter Unclassified protein C00001351 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002724 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002724 2 / 2
P06239 Tyrosine-protein kinase Lck Src C00002724 0 / 1
Q14832 Metabotropic glutamate receptor 3 Metabotropic glutamate receptor C00001358 0 / 0
P08254 Stromelysin-1 M10A C00001396 1 / 0
P42262 Glutamate receptor 2 NS C00001358 0 / 0
P41594 Metabotropic glutamate receptor 5 Metabotropic glutamate receptor C00001358 0 / 0
P43003 Excitatory amino acid transporter 1 Aspartate and glutamate Na-symporter C00001358 1 / 1
P14618 Pyruvate kinase PKM Enzyme C00001358 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001378 0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00001396 0 / 0
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein C00002724 3 / 3
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001396 0 / 0
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000152 1 / 0
P31639 Sodium/glucose cotransporter 2 Glucose C00002546 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00001396 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001396 1 / 4
Q9H015 Solute carrier family 22 member 4 Unclassified protein C00001378 1 / 1
P13866 Sodium/glucose cotransporter 1 Glucose C00002546 1 / 1
P48058 Glutamate receptor 4 NS C00001358 0 / 0
Q9C0B1 Alpha-ketoglutarate-dependent dioxygenase FTO Unclassified protein C00001358 1 / 2

54 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00000152 C00002724
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00000152 C00002724
8985 PLOD3, LH3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) C00002724
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000152
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000152
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000152
47 ACLY, ACL, ATPCL, CLATP ATP citrate lyase (EC:2.3.3.8) C00002724
358 AQP1, AQP-CHIP, CHIP28, CO aquaporin 1 C00002724
360 AQP3, AQP-3, GIL aquaporin 3 (Gill blood group) C00002724
367 AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM androgen receptor C00002724
960 CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 CD44 molecule (Indian blood group) C00002724
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00002724
1277 COL1A1, OI4 collagen, type I, alpha 1 C00002724
4512 COX1, COI, MTCO1, MT-CO1 cytochrome c oxidase subunit I C00002724
114757 CYGB, HGB, STAP cytoglobin C00002724
1830 DSG3, CDHF6, PVA desmoglein 3 C00002724
1950 EGF, HOMG4, URG epidermal growth factor C00002724
2200 FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 fibrillin 1 C00002724
2201 FBN2, CCA, DA9 fibrillin 2 C00002724
2246 FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 fibroblast growth factor 1 (acidic) C00002724
2896 GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN granulin C00002724
3036 HAS1, HAS hyaluronan synthase 1 (EC:2.4.1.212) C00002724
3315 HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 heat shock 27kDa protein 1 C00002724
3552 IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 interleukin 1, alpha C00002724
3852 KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A keratin 5 C00002724
4157 MC1R, CMM5, MSH-R, SHEP2 melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) C00002724
5241 PGR, NR3C3, PR progesterone receptor C00002724
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000152
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00002724
5886 RAD23A, HHR23A, HR23A RAD23 homolog A (S. cerevisiae) C00002724
5914 RARA, NR1B1, RAR retinoic acid receptor, alpha C00002724
6256 RXRA, NR2B1 retinoid X receptor, alpha C00002724
6649 SOD3, EC-SOD superoxide dismutase 3, extracellular (EC:1.15.1.1) C00002724
6716 SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) C00002724
7178 TPT1, HRF, TCTP, p02, p23 tumor protein, translationally-controlled 1 C00002724
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00002724
7306 TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN tyrosinase-related protein 1 (EC:1.14.18.-) C00002724
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002724
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002724
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002724
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002724
1244 ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP ATP-binding cassette, sub-family C (CFTR/MRP), member 2 C00001351
875 CBS, HIP4 cystathionine-beta-synthase (EC:4.2.1.22) C00001351
883 CCBL1, GTK, KAT1, KATI cysteine conjugate-beta lyase, cytoplasmic (EC:2.6.1.64 2.6.1.7 4.4.1.13) C00001351
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00001351
942 CD86, B7-2, B7.2, B70, CD28LG2, LAB72 CD86 molecule C00001351
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00001351
1491 CTH cystathionase (cystathionine gamma-lyase) (EC:4.4.1.1) C00001351
3347 HTN3, HIS2, HTN2, HTN5 histatin 3 C00001351
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00001351
4793 NFKBIB, IKBB, TRIP9 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta C00001351
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00001351
5979 RET, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51 ret proto-oncogene (EC:2.7.10.1) C00001351
6519 SLC3A1, ATR1, CSNU1, D2H, NBAT, RBAT solute carrier family 3 (amino acid transporter heavy chain), member 1 C00001351

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (79)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#600807 Asthma, susceptibility to Q13093
#209950 Atypical mycobacteriosis, familial P42224
#210900 Bloom syndrome; blm P54132
#614162 Candidiasis, familial, 7; candf7 P42224
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#612656 Episodic ataxia, type 6; ea6 P43003
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#606824 Glucose/galactose malabsorption; ggm P13866
#245590 Growth hormone insensitivity with immunodeficiency P51692
#612938 Growth retardation, developmental delay, coarse facies, and early death; gdfd Q9C0B1
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#235800 Histidinemia P42357
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#614328 Inflammatory skin and bowel disease, neonatal; nisbd P78536
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#611092 Mental retardation, autosomal recessive 6; mrt6 Q13002
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#300699 Mental retardation, x-linked, syndromic, wu type; mrxsw P42263
#152950 Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation; mclmr P52732
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#257270 Night blindness, congenital stationary, type 1b; csnb1b O15303
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#233100 Renal glucosuria; glys1 P31639
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#180300 Rheumatoid arthritis; ra Q9H015
#615232 Schizophrenia 18; sczd18 P43005
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#614831 Spinocerebellar ataxia, autosomal recessive 13; scar13 Q13255
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (80)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00787 Congenital stationary night blindness (CSNB) O15303 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P40763 (related)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00213 Hypophosphatasia P05186 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H01261 Congenital glucose-galactose malabsorption (GGM) P13866 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01126 Familial renal glucosuria (FRG) P31639 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00577 Syndromic X-linked mental retardation with epilepsy or seizures P42263 (related)
H00171 Histidinemia P42357 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00749 Episodic ataxias P43003 (related)
H00911 Dicarboxylic aminoaciduria P43005 (related)
H00931 Growth hormone insensitivity with immunodeficiency P51692 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00768 Nonsyndromic autosomal recessive mental retardation (NS-ARMR) Q13002 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00409 Type II diabetes mellitus Q9C0B1 (related)
H00926 Growth retardation, developmental delay, coarse facies, and early death Q9C0B1 (related)
H00286 Crohn's disease Q9H015 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

16 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D008545 Melanoma C00000152
C00002724
D015431 Weight Loss C00002724
D056486 Drug-Induced Liver Injury C00002724
D006937 Hypercholesterolemia C00002724
D006951 Hyperlipoproteinemias C00002724
D015228 Hypertriglyceridemia C00002724
D052456 Hypoalphalipoproteinemias C00002724
D009336 Necrosis C00002724
D000647 Amnesia C00002724
D001321 Autistic Disorder C00001351
D064420 Drug-Related Side Effects and Adverse Reactions C00001351
D006461 Hemolysis C00001351
D007683 Kidney Tubular Necrosis, Acute C00001351
D008106 Liver Cirrhosis, Experimental C00001351
D017114 Liver Failure, Acute C00001351
D020258 Neurotoxicity Syndromes C00001351