PCIDB

KNApSAcK Metabolite C00001363

Metabolite

KNApSAcK Entry

id C00001363
Name L-Histidine
CAS RN 71-00-1
Standard InChI InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
Standard InChI (Main Layer) InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)

Cluster

Phytochemical cluster
KCF-S cluster No. 7202

Link

ChEMBL

By standard InChI CHEMBL17962
By standard InChI Main Layer CHEMBL17962 CHEMBL104875

KEGG

By LinkDB C00768

CTD

By CAS RN

Human Protein / Gene in interaction

25 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL17962 CHEMBL1741321 (1)
1 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL17962 CHEMBL104875 CHEMBL885804 (2)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL17962 CHEMBL104875 CHEMBL885803 (2)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL17962 CHEMBL104875 CHEMBL889439 (2)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL17962 CHEMBL104875 CHEMBL657923 (1) CHEMBL658038 (1)
CHEMBL869780 (2) CHEMBL856914 (1)
CHEMBL889437 (2) CHEMBL887924 (3)
CHEMBL932482 (2) CHEMBL1010572 (1)
CHEMBL967910 (2) CHEMBL970751 (2)
CHEMBL953312 (2) CHEMBL1017972 (2)
CHEMBL1067709 (2) CHEMBL1106967 (2)
CHEMBL2156561 (2) CHEMBL2318049 (2)
1 / 2
P42357 Histidine ammonia-lyase Enzyme CHEMBL17962 CHEMBL858416 (1) CHEMBL686687 (1)
CHEMBL879478 (1) CHEMBL689514 (1)
CHEMBL689515 (1) CHEMBL689516 (1)
CHEMBL857349 (1) CHEMBL795908 (1)
1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL17962 CHEMBL1741325 (1)
0 / 1
P23280 Carbonic anhydrase 6 Lyase CHEMBL17962 CHEMBL104875 CHEMBL887925 (3) CHEMBL1067710 (2)
0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL17962 CHEMBL104875 CHEMBL889441 (2)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL104875 CHEMBL1614458 (1)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL17962 CHEMBL104875 CHEMBL932484 (2)
1 / 2
P39748 Flap endonuclease 1 Enzyme CHEMBL17962 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL17962 CHEMBL1738606 (1)
0 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL17962 CHEMBL104875 CHEMBL662718 (1) CHEMBL662719 (1)
CHEMBL869779 (2) CHEMBL856915 (1)
CHEMBL889435 (2) CHEMBL887923 (3)
CHEMBL932481 (2) CHEMBL1010571 (1)
CHEMBL967909 (2) CHEMBL970750 (2)
CHEMBL965608 (2) CHEMBL1067708 (2)
CHEMBL2156560 (2) CHEMBL2318048 (2)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL17962 CHEMBL1741322 (1)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL17962 CHEMBL104875 CHEMBL932483 (2) CHEMBL1010573 (1)
0 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL17962 CHEMBL1738675 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL17962 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL17962 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1)
0 / 1
P07451 Carbonic anhydrase 3 Lyase CHEMBL17962 CHEMBL104875 CHEMBL967911 (2) CHEMBL970752 (2)
CHEMBL953319 (2)
0 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL17962 CHEMBL104875 CHEMBL863243 (1) CHEMBL970749 (2)
CHEMBL970753 (2) CHEMBL1008325 (2)
CHEMBL1008327 (2)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL17962 CHEMBL1738442 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL104875 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL104875 CHEMBL1614531 (1)
1 / 3
Q05BR4 SLC16A10 protein Unclassified protein CHEMBL17962 CHEMBL2076232 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#235800 Histidinemia P42357
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#600852 Retinitis pigmentosa 17; rp17 P22748

KEGG DISEASE (16)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00171 Histidinemia P42357 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)