Trifolium repens L.
Species
KNApSAcK Entry
| Organism name | Trifolium repens L. |
|---|---|
| Genus | Trifolium |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Trifolium repens |
|---|---|
| Linked NCBI taxonomy ID | 3899 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (20)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00005372
|
Hyperin
/ Hyperoside / Quercetin 3-O-galactoside / Quercetin 3-O-beta-D-galactoside / Quercetin 3-beta-galactopyranoside / Quercetin 3-O-beta-D-galactopyranoside |
CHEMBL33027
CHEMBL309323 CHEMBL250450 CHEMBL251254 CHEMBL457304 CHEMBL1098724 CHEMBL2337335 CHEMBL2337336 |
C021304
|
38 / 43 / 34 | 4 / 0 | No. 2 | No. 15 |
|
|
C00005137
|
Trifolin
/ Kaempferol 3-O-beta-D-galactopyranoside |
CHEMBL233930
CHEMBL453290 CHEMBL1572115 |
C066407
|
10 / 6 / 7 | 1 / 1 | No. 2 | No. 15 |
|
|
C00002923
|
Prodelphinidin B4
/ Gallocatechin-(4alpha->8)-epigallocatechin |
CHEMBL349509
CHEMBL161013 |
No. 16 | No. 19 |
|
|||
|
C00000805
|
alpha-Pinene
|
CHEMBL442565
|
C005451
|
3 / 3 / 2 | 0 / 1 | No. 476 | No. 35 |
|
|
C00000816
|
beta-Pinene
|
CHEMBL501351
|
C010789
|
No. 476 | No. 35 |
|
||
|
C00003110
|
Caryophyllene
/ (E)-Caryophyllene / beta-Caryophyllene / (-)-(E)-Caryophyllene / (E)-beta-Caryophyllene |
CHEMBL445740
CHEMBL448700 |
2 / 3 / 7 | No. 478 | No. 38 |
|
||
|
C00034818
|
cis-Linalool oxide
|
CHEMBL29660
CHEMBL282731 CHEMBL63592 CHEMBL397730 |
14 / 17 / 50 | No. 518 | No. 6 |
|
||
|
C00000823
|
Limonene
|
CHEMBL15799
CHEMBL449062 |
C008281
|
7 / 21 / 48 | 6 / 6 | No. 848 | No. 35 |
|
|
C00003047
|
Linalool
/ (R)-linalool / (R)-(-)-3,7-Dimethyl-1,6-octadien-3-ol |
CHEMBL25306
CHEMBL235672 |
C018584
|
6 / 8 / 2 | 35 / 4 | No. 958 | No. 34 |
|
|
C00029674
|
alpha-Terpineol
|
CHEMBL447597
CHEMBL449810 |
C016775
|
3 / 16 / 11 | No. 983 | No. 35 |
|
|
|
C00001396
|
L-Tryptophan
|
CHEMBL54976
CHEMBL292303 CHEMBL484901 |
49 / 41 / 39 | No. 1432 | No. 4 |
|
||
|
C00003040
|
p-Cymene
|
CHEMBL442915
|
C007210
|
No. 2172 | No. 35 |
|
||
|
C00007630
|
beta-Sesquiphellandrene
|
CHEMBL469718
|
No. 2380 | No. 38 |
|
|||
|
C00001351
|
L-Cysteine
|
CHEMBL863
CHEMBL54943 CHEMBL171281 |
D003545
|
11 / 22 / 17 | 13 / 7 | No. 2426 |
|
|
|
C00003029
|
Camphene
|
CHEMBL506889
CHEMBL510535 |
C019286
|
No. 2460 | No. 35 |
|
||
|
C00003060
|
alpha-Terpinene
|
No. 2468 | No. 35 |
|
||||
|
C00001358
|
L-Glutamic acid
|
CHEMBL76232
CHEMBL575060 |
37 / 11 / 11 | No. 2641 |
|
|||
|
C00001341
|
L-Asparagine
|
CHEMBL58832
CHEMBL1232369 |
1 / 2 / 0 | No. 3843 |
|
|||
|
C00001363
|
L-Histidine
|
CHEMBL17962
CHEMBL104875 |
25 / 9 / 16 | No. 7202 |
|
|||
|
C00035043
|
alpha-Terpinyl acetate
|
No. 7305 | No. 35 |
|
Human Protein / Gene in interactions
131 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P02545 | Prelamin-A/C | Unclassified protein | C00000823 C00001351 C00001396 C00005372 C00029674 | 11 / 10 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001358 C00001396 C00005137 C00005372 C00034818 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001351 C00001358 C00001363 C00001396 C00005372 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001358 C00001363 C00001396 | 1 / 0 |
| Q05BR4 | SLC16A10 protein | Unclassified protein | C00001358 C00001363 C00001396 | 0 / 0 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001396 C00005372 C00034818 | 1 / 4 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001363 C00001396 C00005372 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001396 C00005372 C00034818 | 0 / 1 |
| O00255 | Menin | Unclassified protein | C00001363 C00001396 C00003110 | 2 / 5 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001341 C00001358 C00001396 | 2 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001358 C00001363 C00001396 | 0 / 1 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001363 C00001396 C00003110 | 1 / 2 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001358 C00001363 C00001396 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001396 C00003047 C00034818 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001358 C00001363 C00001396 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001358 C00001363 C00001396 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001396 C00005137 C00005372 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001351 C00001396 C00005372 | 4 / 3 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000805 C00001396 | 3 / 2 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00001363 C00001396 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00003047 C00029674 | 5 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001358 C00005372 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00001363 C00001396 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00001363 C00001396 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001358 C00005137 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000823 C00034818 | 7 / 37 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00001363 C00001396 | 1 / 1 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00001363 C00001396 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001396 C00005372 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000823 C00003047 | 3 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001363 C00005137 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001363 C00001396 | 1 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00000805 C00034818 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00001363 C00001396 | 0 / 1 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00003047 C00029674 | 3 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000805 C00005372 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00005137 C00005372 | 4 / 2 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000823 C00005372 | 0 / 3 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00001396 C00005372 | 3 / 1 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00001396 C00005372 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001351 C00034818 | 1 / 1 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00005137 C00005372 | 1 / 1 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00005137 C00005372 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00001363 C00001396 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00005137 C00005372 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001396 C00005372 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001363 C00001396 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00001396 C00005372 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00001363 C00001396 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00001363 C00001396 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00001363 C00001396 | 1 / 2 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00034818 | 1 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001363 | 0 / 0 |
| P39086 | Glutamate receptor ionotropic, kainate 1 | NS | C00001358 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00005372 | 1 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001396 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00005372 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00001351 | 2 / 3 |
| P42858 | Huntingtin | Unclassified protein | C00001396 | 1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001351 | 2 / 0 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | C00001396 | 0 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00005372 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00005372 | 1 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00034818 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00001396 | 1 / 2 |
| P43005 | Excitatory amino acid transporter 3 | Aspartate, glutamate and cysteine Na-symporter | C00001358 | 1 / 1 |
| Q14416 | Metabotropic glutamate receptor 2 | Metabotropic glutamate receptor | C00001358 | 0 / 0 |
| Q14831 | Metabotropic glutamate receptor 7 | Metabotropic glutamate receptor | C00001358 | 0 / 0 |
| Q13002 | Glutamate receptor ionotropic, kainate 2 | NS | C00001358 | 1 / 1 |
| Q16478 | Glutamate receptor ionotropic, kainate 5 | NS | C00001358 | 0 / 0 |
| P78536 | Disintegrin and metalloproteinase domain-containing protein 17 | M12B | C00001351 | 1 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00003047 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001358 | 0 / 0 |
| P42357 | Histidine ammonia-lyase | Enzyme | C00001363 | 1 / 1 |
| P42263 | Glutamate receptor 3 | NS | C00001358 | 1 / 1 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00034818 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00005372 | 1 / 1 |
| O15303 | Metabotropic glutamate receptor 6 | Metabotropic glutamate receptor | C00001358 | 1 / 1 |
| P42261 | Glutamate receptor 1 | NS | C00001358 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00005372 | 0 / 1 |
| P02768 | Serum albumin | Secreted protein | C00001396 | 0 / 0 |
| P00390 | Glutathione reductase, mitochondrial | Oxidoreductase | C00001358 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00005372 | 0 / 0 |
| Q9Y2Q3 | Glutathione S-transferase kappa 1 | Enzyme | C00001351 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00034818 | 3 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00005372 | 2 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00001396 | 1 / 1 |
| P51692 | Signal transducer and activator of transcription 5B | Unclassified protein | C00034818 | 1 / 1 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00001396 | 5 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00001358 | 0 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00000823 | 0 / 0 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00003047 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00005372 | 0 / 0 |
| Q04609 | Glutamate carboxypeptidase 2 | M28B | C00001358 | 0 / 0 |
| Q14833 | Metabotropic glutamate receptor 4 | Metabotropic glutamate receptor | C00001358 | 0 / 0 |
| Q13255 | Metabotropic glutamate receptor 1 | Metabotropic glutamate receptor | C00001358 | 1 / 0 |
| P48775 | Tryptophan 2,3-dioxygenase | Enzyme | C00001396 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00005372 | 1 / 1 |
| Q9Y263 | Phospholipase A-2-activating protein | Unclassified protein | C00001396 | 0 / 0 |
| P43004 | Excitatory amino acid transporter 2 | Aspartate and glutamate Na-symporter | C00001358 | 0 / 0 |
| P52732 | Kinesin-like protein KIF11 | Other cytosolic protein | C00001351 | 1 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000823 | 0 / 0 |
| Q16773 | Kynurenine--oxoglutarate transaminase 1 | Enzyme | C00001396 | 0 / 0 |
| O00222 | Metabotropic glutamate receptor 8 | Metabotropic glutamate receptor | C00001358 | 0 / 0 |
| Q13003 | Glutamate receptor ionotropic, kainate 3 | NS | C00001358 | 0 / 0 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00001396 | 0 / 0 |
| Q7Z2H8 | Proton-coupled amino acid transporter 1 | Unclassified protein | C00001351 | 0 / 0 |
| Q9UPY5 | Cystine/glutamate transporter | Unclassified protein | C00001351 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000823 | 0 / 0 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00005372 | 1 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00005372 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00034818 | 0 / 1 |
| Q14832 | Metabotropic glutamate receptor 3 | Metabotropic glutamate receptor | C00001358 | 0 / 0 |
| P08254 | Stromelysin-1 | M10A | C00001396 | 1 / 0 |
| P42262 | Glutamate receptor 2 | NS | C00001358 | 0 / 0 |
| P41594 | Metabotropic glutamate receptor 5 | Metabotropic glutamate receptor | C00001358 | 0 / 0 |
| P43003 | Excitatory amino acid transporter 1 | Aspartate and glutamate Na-symporter | C00001358 | 1 / 1 |
| P34949 | Mannose-6-phosphate isomerase | Enzyme | C00005372 | 1 / 1 |
| P04062 | Glucosylceramidase | Enzyme | C00005372 | 6 / 4 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00005372 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00005372 | 0 / 0 |
| P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | C00034818 | 3 / 3 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00001358 | 0 / 0 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00001358 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00005137 | 1 / 1 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00001396 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00005372 | 4 / 1 |
| Q9NPH5 | NADPH oxidase 4 | Enzyme | C00005372 | 0 / 0 |
| P48058 | Glutamate receptor 4 | NS | C00001358 | 0 / 0 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00005137 | 0 / 3 |
| Q9C0B1 | Alpha-ketoglutarate-dependent dioxygenase FTO | Unclassified protein | C00001358 | 1 / 2 |
55 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000823
C00003047
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00001351
C00003047
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00000823
C00003047
|
| 4852 | NPY, PYY4 | neuropeptide Y |
C00000823
C00003047
|
| 3398 | ID2, GIG8, ID2A, ID2H, bHLHb26 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
C00003047
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00000823
|
| 1646 | AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 | aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) |
C00003047
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003047
|
| 1386 | ATF2, CRE-BP1, CREB2, HB16, TREB7 | activating transcription factor 2 (EC:2.3.1.48) |
C00003047
|
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00003047
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00003047
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00003047
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000823
|
| 1028 | CDKN1C, BWCR, BWS, KIP2, WBS, p57, p57Kip2 | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
C00003047
|
| 1030 | CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
C00003047
|
| 1447 | CSN2, CASB | casein beta |
C00003047
|
| 1509 | CTSD, CLN10, CPSD | cathepsin D (EC:3.4.23.5) |
C00003047
|
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00003047
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00003047
|
| 2335 | FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF | fibronectin 1 |
C00003047
|
| 1647 | GADD45A, DDIT1, GADD45 | growth arrest and DNA-damage-inducible, alpha |
C00003047
|
| 2729 | GCLC, GCL, GCS, GLCL, GLCLC | glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) |
C00003047
|
| 3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00003047
|
| 3297 | HSF1, HSTF1 | heat shock transcription factor 1 |
C00003047
|
| 3320 | HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2 | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
C00003047
|
| 3308 | HSPA4, APG-2, HS24/P52, HSPH2, RY, hsp70, hsp70RY | heat shock 70kDa protein 4 |
C00003047
|
| 3316 | HSPB2, HSP27, Hs.78846, LOH11CR1K, MKBP | heat shock 27kDa protein 2 |
C00003047
|
| 3265 | HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 | Harvey rat sarcoma viral oncogene homolog |
C00000823
|
| 3638 | INSIG1, CL-6, CL6 | insulin induced gene 1 |
C00003047
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00003047
|
| 8850 | KAT2B, CAF, P, P/CAF, PCAF | K(lysine) acetyltransferase 2B (EC:2.3.1.48) |
C00003047
|
| 4193 | MDM2, ACTFS, HDMX, hdm2 | MDM2 oncogene, E3 ubiquitin protein ligase |
C00003047
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00003047
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00003047
|
| 100124292 |
C00003047
|
||
| 7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00003047
|
| 7471 | WNT1, BMND16, INT1, OI15 | wingless-type MMTV integration site family, member 1 |
C00003047
|
| 26118 | WSB1, SWIP1, WSB-1 | WD repeat and SOCS box containing 1 |
C00003047
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00005372
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00005372
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00005372
|
| 23411 | SIRT1, SIR2L1 | sirtuin 1 |
C00005372
|
| 5320 | PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2 | phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4) |
C00005137
|
| 1244 | ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
C00001351
|
| 875 | CBS, HIP4 | cystathionine-beta-synthase (EC:4.2.1.22) |
C00001351
|
| 883 | CCBL1, GTK, KAT1, KATI | cysteine conjugate-beta lyase, cytoplasmic (EC:2.6.1.64 2.6.1.7 4.4.1.13) |
C00001351
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00001351
|
| 942 | CD86, B7-2, B7.2, B70, CD28LG2, LAB72 | CD86 molecule |
C00001351
|
| 1491 | CTH | cystathionase (cystathionine gamma-lyase) (EC:4.4.1.1) |
C00001351
|
| 3347 | HTN3, HIS2, HTN2, HTN5 | histatin 3 |
C00001351
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00001351
|
| 4793 | NFKBIB, IKBB, TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
C00001351
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00001351
|
| 5979 | RET, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51 | ret proto-oncogene (EC:2.7.10.1) |
C00001351
|
| 6519 | SLC3A1, ATR1, CSNU1, D2H, NBAT, RBAT | solute carrier family 3 (amino acid transporter heavy chain), member 1 |
C00001351
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (104)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #209950 | Atypical mycobacteriosis, familial |
P42224
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #614162 | Candidiasis, familial, 7; candf7 |
P42224
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #602579 | Congenital disorder of glycosylation, type ib; cdg1b |
P34949
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #612656 | Episodic ataxia, type 6; ea6 |
P43003
|
| #133239 | Esophageal cancer |
P04637
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #245590 | Growth hormone insensitivity with immunodeficiency |
P51692
|
| #612938 | Growth retardation, developmental delay, coarse facies, and early death; gdfd |
Q9C0B1
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #235800 | Histidinemia |
P42357
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #614328 | Inflammatory skin and bowel disease, neonatal; nisbd |
P78536
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #611092 | Mental retardation, autosomal recessive 6; mrt6 |
Q13002
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #300699 | Mental retardation, x-linked, syndromic, wu type; mrxsw |
P42263
|
| #152950 | Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation; mclmr |
P52732
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #257270 | Night blindness, congenital stationary, type 1b; csnb1b |
O15303
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #615232 | Schizophrenia 18; sczd18 |
P43005
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #614831 | Spinocerebellar ataxia, autosomal recessive 13; scar13 |
Q13255
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (109)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00787 | Congenital stationary night blindness (CSNB) |
O15303
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
P16473 (related) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) P40763 (related) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
Q92887 (related) |
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00118 | Congenital disorders of glycosylation (CDG) type I |
P34949
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
| H00363 | Candidiasis |
P42224
(related)
|
| H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
| H00577 | Syndromic X-linked mental retardation with epilepsy or seizures |
P42263
(related)
|
| H00171 | Histidinemia |
P42357
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00749 | Episodic ataxias |
P43003
(related)
|
| H00911 | Dicarboxylic aminoaciduria |
P43005
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00931 | Growth hormone insensitivity with immunodeficiency |
P51692
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00768 | Nonsyndromic autosomal recessive mental retardation (NS-ARMR) |
Q13002
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00409 | Type II diabetes mellitus |
Q9C0B1
(related)
|
| H00926 | Growth retardation, developmental delay, coarse facies, and early death |
Q9C0B1
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
18 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D003877 | Dermatitis, Contact |
C00000805
C00000823 |
| D009369 | Neoplasms |
C00003047
|
| D008107 | Liver Diseases |
C00000823
|
| D008114 | Liver Neoplasms, Experimental |
C00000823
|
| D008569 | Memory Disorders |
C00000823
|
| D013276 | Stomach Ulcer |
C00000823
|
| D017453 | Dermatitis, Irritant |
C00003047
|
| D006937 | Hypercholesterolemia |
C00003047
|
| D007938 | Leukemia |
C00003047
|
| D007674 | Kidney Diseases |
C00000823
|
| D004487 | Edema |
C00005137
|
| D001321 | Autistic Disorder |
C00001351
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00001351
|
| D006461 | Hemolysis |
C00001351
|
| D007683 | Kidney Tubular Necrosis, Acute |
C00001351
|
| D008106 | Liver Cirrhosis, Experimental |
C00001351
|
| D017114 | Liver Failure, Acute |
C00001351
|
| D020258 | Neurotoxicity Syndromes |
C00001351
|