PCIDB

KNApSAcK Metabolite C00001358

Metabolite

KNApSAcK Entry

id C00001358
Name L-Glutamic acid
CAS RN 56-86-0
Standard InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
Standard InChI (Main Layer) InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)

Cluster

Phytochemical cluster
KCF-S cluster No. 2641

Link

ChEMBL

By standard InChI CHEMBL575060
By standard InChI Main Layer CHEMBL76232 CHEMBL575060

KEGG

By LinkDB C00025

CTD

By CAS RN

Human Protein / Gene in interaction

37 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL76232 CHEMBL575060 CHEMBL1614110 (1) CHEMBL1741321 (3)
1 / 0
P48058 Glutamate receptor 4 NS CHEMBL76232 CHEMBL575060 CHEMBL878454 (1) CHEMBL696661 (1)
CHEMBL696662 (1) CHEMBL895668 (2)
0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL575060 CHEMBL1794499 (2)
2 / 0
P14618 Pyruvate kinase PKM Enzyme CHEMBL76232 CHEMBL1614177 (1) CHEMBL1614265 (1)
0 / 0
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL575060 CHEMBL881969 (1)
0 / 0
Q13003 Glutamate receptor ionotropic, kainate 3 NS CHEMBL76232 CHEMBL575060 CHEMBL701553 (1) CHEMBL701554 (1)
0 / 0
O00222 Metabotropic glutamate receptor 8 Metabotropic glutamate receptor CHEMBL575060 CHEMBL712473 (1) CHEMBL828593 (1)
0 / 0
P43004 Excitatory amino acid transporter 2 Aspartate and glutamate Na-symporter CHEMBL575060 CHEMBL859748 (2) CHEMBL907706 (2)
CHEMBL1016591 (2)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL575060 CHEMBL1738600 (1)
0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL575060 CHEMBL1613894 (1)
0 / 1
P42261 Glutamate receptor 1 NS CHEMBL76232 CHEMBL575060 CHEMBL878883 (1) CHEMBL701240 (1)
CHEMBL701241 (1) CHEMBL895662 (2)
CHEMBL1105503 (1) CHEMBL1117247 (1)
0 / 0
Q16478 Glutamate receptor ionotropic, kainate 5 NS CHEMBL76232 CHEMBL575060 CHEMBL874133 (1) CHEMBL698076 (1)
CHEMBL701557 (1)
0 / 0
Q13002 Glutamate receptor ionotropic, kainate 2 NS CHEMBL76232 CHEMBL575060 CHEMBL683696 (1) CHEMBL685948 (1)
CHEMBL884244 (1) CHEMBL699990 (1)
CHEMBL701169 (1) CHEMBL701332 (1)
1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL76232 CHEMBL575060 CHEMBL1741325 (3)
0 / 1
Q14831 Metabotropic glutamate receptor 7 Metabotropic glutamate receptor CHEMBL76232 CHEMBL575060 CHEMBL712391 (1) CHEMBL712460 (1)
CHEMBL712461 (1) CHEMBL863304 (1)
CHEMBL892221 (1)
0 / 0
P43005 Excitatory amino acid transporter 3 Aspartate, glutamate and cysteine Na-symporter CHEMBL575060 CHEMBL859749 (2) CHEMBL907707 (2)
CHEMBL1013069 (2)
1 / 1
P39086 Glutamate receptor ionotropic, kainate 1 NS CHEMBL76232 CHEMBL575060 CHEMBL683542 (1) CHEMBL683695 (1)
CHEMBL697422 (1) CHEMBL697426 (1)
CHEMBL698072 (1) CHEMBL698073 (1)
CHEMBL865002 (1)
0 / 0
Q14416 Metabotropic glutamate receptor 2 Metabotropic glutamate receptor CHEMBL76232 CHEMBL575060 CHEMBL877752 (1) CHEMBL717757 (1)
CHEMBL718221 (1) CHEMBL718222 (1)
CHEMBL713617 (2) CHEMBL713618 (1)
CHEMBL820339 (1) CHEMBL852485 (1)
CHEMBL863297 (1) CHEMBL892218 (1)
CHEMBL895145 (1) CHEMBL1018993 (1)
CHEMBL1671545 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL76232 CHEMBL1794467 (1)
0 / 0
P42263 Glutamate receptor 3 NS CHEMBL575060 CHEMBL895666 (2) CHEMBL1105505 (1)
CHEMBL1117249 (1)
1 / 1
O15303 Metabotropic glutamate receptor 6 Metabotropic glutamate receptor CHEMBL76232 CHEMBL575060 CHEMBL718128 (1) CHEMBL718130 (1)
CHEMBL712215 (1) CHEMBL712387 (1)
CHEMBL712388 (1) CHEMBL1052814 (1)
1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL76232 CHEMBL575060 CHEMBL1741322 (3)
0 / 0
P00390 Glutathione reductase, mitochondrial Oxidoreductase CHEMBL575060 CHEMBL1825434 (1) CHEMBL1825435 (1)
0 / 0
Q04609 Glutamate carboxypeptidase 2 M28B CHEMBL575060 CHEMBL888570 (1)
0 / 0
Q14833 Metabotropic glutamate receptor 4 Metabotropic glutamate receptor CHEMBL76232 CHEMBL575060 CHEMBL714803 (1) CHEMBL884506 (1)
CHEMBL716502 (1) CHEMBL714668 (1)
CHEMBL714003 (1) CHEMBL714009 (2)
CHEMBL852486 (1) CHEMBL895143 (1)
CHEMBL1018994 (1)
0 / 0
Q13255 Metabotropic glutamate receptor 1 Metabotropic glutamate receptor CHEMBL76232 CHEMBL575060 CHEMBL709770 (1) CHEMBL709773 (1)
CHEMBL719076 (1) CHEMBL717333 (2)
CHEMBL717334 (1) CHEMBL717930 (1)
CHEMBL851587 (1) CHEMBL895144 (1)
CHEMBL1018991 (1)
1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL76232 CHEMBL575060 CHEMBL1741323 (3)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL76232 CHEMBL575060 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (3)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL76232 CHEMBL1614211 (1)
0 / 0
Q14832 Metabotropic glutamate receptor 3 Metabotropic glutamate receptor CHEMBL76232 CHEMBL575060 CHEMBL714446 (1) CHEMBL717238 (1)
CHEMBL818777 (1)
0 / 0
P42262 Glutamate receptor 2 NS CHEMBL76232 CHEMBL575060 CHEMBL696974 (1) CHEMBL696975 (1)
CHEMBL696976 (1) CHEMBL895664 (2)
CHEMBL1105504 (1) CHEMBL1117248 (1)
CHEMBL1104014 (2) CHEMBL1226126 (1)
0 / 0
P41594 Metabotropic glutamate receptor 5 Metabotropic glutamate receptor CHEMBL76232 CHEMBL575060 CHEMBL711712 (1) CHEMBL709916 (1)
CHEMBL715721 (1) CHEMBL715723 (1)
CHEMBL895146 (1) CHEMBL1018992 (1)
CHEMBL1052813 (1)
0 / 0
P43003 Excitatory amino acid transporter 1 Aspartate and glutamate Na-symporter CHEMBL575060 CHEMBL859747 (2) CHEMBL907705 (2)
CHEMBL1016590 (2)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL575060 CHEMBL1738442 (1)
0 / 0
Q05BR4 SLC16A10 protein Unclassified protein CHEMBL76232 CHEMBL2076232 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL575060 CHEMBL2114738 (1)
0 / 0
Q9C0B1 Alpha-ketoglutarate-dependent dioxygenase FTO Unclassified protein CHEMBL76232 CHEMBL575060 CHEMBL2344107 (2)
1 / 2

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#612656 Episodic ataxia, type 6; ea6 P43003
#612938 Growth retardation, developmental delay, coarse facies, and early death; gdfd Q9C0B1
#611092 Mental retardation, autosomal recessive 6; mrt6 Q13002
#300699 Mental retardation, x-linked, syndromic, wu type; mrxsw P42263
#257270 Night blindness, congenital stationary, type 1b; csnb1b O15303
#615232 Schizophrenia 18; sczd18 P43005
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#614831 Spinocerebellar ataxia, autosomal recessive 13; scar13 Q13255

KEGG DISEASE (11)

KEGG disease name UniProt
H00787 Congenital stationary night blindness (CSNB) O15303 (related)
H00079 Asthma P07550 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00577 Syndromic X-linked mental retardation with epilepsy or seizures P42263 (related)
H00749 Episodic ataxias P43003 (related)
H00911 Dicarboxylic aminoaciduria P43005 (related)
H00768 Nonsyndromic autosomal recessive mental retardation (NS-ARMR) Q13002 (related)
H00409 Type II diabetes mellitus Q9C0B1 (related)
H00926 Growth retardation, developmental delay, coarse facies, and early death Q9C0B1 (related)