KCF-S cluster No. 2641 (4 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 6 |
Cumulative family count
| class name | count |
|---|---|
| Brassicaceae | 3 |
| Fabaceae | 3 |
| Enterobacteriaceae | 1 |
KEGG BRITE br08003
Categories (0)
| br08003 Category | # of metabolite |
|---|
metabolites link (0)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00001342
|
L-Aspartic acid
|
CHEMBL274323
CHEMBL29757 |
19 / 24 / 28 |
|
||
|
C00001358
|
L-Glutamic acid
|
CHEMBL76232
CHEMBL575060 |
37 / 11 / 11 |
|
||
|
C00007393
|
L-2-Aminoadipate
/ alpha-Aminoadipic acid |
CHEMBL433238
CHEMBL88804 CHEMBL1169505 |
D015074
|
16 / 9 / 12 |
|
|
|
C00019577
|
D-Glutamate
/ D-Glutamic acid / D-Glutaminic acid / D-2-Aminoglutaric acid |
CHEMBL76232
CHEMBL575060 |
37 / 11 / 11 |
|
Human Protein / Gene in interactions
49 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001342 C00001358 C00007393 C00019577 | 1 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001342 C00001358 C00007393 C00019577 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001342 C00001358 C00007393 C00019577 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001342 C00001358 C00007393 C00019577 | 1 / 1 |
| Q13255 | Metabotropic glutamate receptor 1 | Metabotropic glutamate receptor | C00001342 C00001358 C00007393 C00019577 | 1 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001342 C00001358 C00007393 C00019577 | 0 / 0 |
| O15303 | Metabotropic glutamate receptor 6 | Metabotropic glutamate receptor | C00001342 C00001358 C00007393 C00019577 | 1 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001342 C00001358 C00007393 C00019577 | 0 / 1 |
| Q14416 | Metabotropic glutamate receptor 2 | Metabotropic glutamate receptor | C00001342 C00001358 C00007393 C00019577 | 0 / 0 |
| P41594 | Metabotropic glutamate receptor 5 | Metabotropic glutamate receptor | C00001358 C00007393 C00019577 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001342 C00001358 C00019577 | 0 / 0 |
| Q14833 | Metabotropic glutamate receptor 4 | Metabotropic glutamate receptor | C00001358 C00007393 C00019577 | 0 / 0 |
| P48058 | Glutamate receptor 4 | NS | C00001358 C00019577 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00001358 C00019577 | 0 / 1 |
| P42261 | Glutamate receptor 1 | NS | C00001358 C00019577 | 0 / 0 |
| Q16478 | Glutamate receptor ionotropic, kainate 5 | NS | C00001358 C00019577 | 0 / 0 |
| Q13002 | Glutamate receptor ionotropic, kainate 2 | NS | C00001358 C00019577 | 1 / 1 |
| P43004 | Excitatory amino acid transporter 2 | Aspartate and glutamate Na-symporter | C00001358 C00019577 | 0 / 0 |
| Q14831 | Metabotropic glutamate receptor 7 | Metabotropic glutamate receptor | C00001358 C00019577 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00001342 C00007393 | 1 / 2 |
| Q05BR4 | SLC16A10 protein | Unclassified protein | C00001358 C00019577 | 0 / 0 |
| P43005 | Excitatory amino acid transporter 3 | Aspartate, glutamate and cysteine Na-symporter | C00001358 C00019577 | 1 / 1 |
| P39086 | Glutamate receptor ionotropic, kainate 1 | NS | C00001358 C00019577 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001358 C00019577 | 0 / 0 |
| O00222 | Metabotropic glutamate receptor 8 | Metabotropic glutamate receptor | C00001358 C00019577 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001358 C00019577 | 0 / 0 |
| P42263 | Glutamate receptor 3 | NS | C00001358 C00019577 | 1 / 1 |
| Q13003 | Glutamate receptor ionotropic, kainate 3 | NS | C00001358 C00019577 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00001358 C00019577 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001358 C00019577 | 0 / 0 |
| Q04609 | Glutamate carboxypeptidase 2 | M28B | C00001358 C00019577 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001342 C00007393 | 3 / 2 |
| P43003 | Excitatory amino acid transporter 1 | Aspartate and glutamate Na-symporter | C00001358 C00019577 | 1 / 1 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00001358 C00019577 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001358 C00019577 | 2 / 0 |
| Q9C0B1 | Alpha-ketoglutarate-dependent dioxygenase FTO | Unclassified protein | C00001358 C00019577 | 1 / 2 |
| Q14832 | Metabotropic glutamate receptor 3 | Metabotropic glutamate receptor | C00001358 C00019577 | 0 / 0 |
| P42262 | Glutamate receptor 2 | NS | C00001358 C00019577 | 0 / 0 |
| P00390 | Glutathione reductase, mitochondrial | Oxidoreductase | C00001358 C00019577 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00007393 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00001342 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001342 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00001342 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001342 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00007393 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00007393 | 1 / 4 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001342 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001342 | 1 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001342 | 11 / 10 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (32)
| OMIM | preferred title | UniProt |
|---|---|---|
| #210900 | Bloom syndrome; blm |
P54132
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #612656 | Episodic ataxia, type 6; ea6 |
P43003
|
| #612938 | Growth retardation, developmental delay, coarse facies, and early death; gdfd |
Q9C0B1
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #611092 | Mental retardation, autosomal recessive 6; mrt6 |
Q13002
|
| #300699 | Mental retardation, x-linked, syndromic, wu type; mrxsw |
P42263
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #257270 | Night blindness, congenital stationary, type 1b; csnb1b |
O15303
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #615232 | Schizophrenia 18; sczd18 |
P43005
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #614831 | Spinocerebellar ataxia, autosomal recessive 13; scar13 |
Q13255
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
KEGG DISEASE (38)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00787 | Congenital stationary night blindness (CSNB) |
O15303
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00577 | Syndromic X-linked mental retardation with epilepsy or seizures |
P42263
(related)
|
| H00749 | Episodic ataxias |
P43003
(related)
|
| H00911 | Dicarboxylic aminoaciduria |
P43005
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00768 | Nonsyndromic autosomal recessive mental retardation (NS-ARMR) |
Q13002
(related)
|
| H00409 | Type II diabetes mellitus |
Q9C0B1
(related)
|
| H00926 | Growth retardation, developmental delay, coarse facies, and early death |
Q9C0B1
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|