PCIDB

KNApSAcK Metabolite C00007393

Metabolite

KNApSAcK Entry

id C00007393
Name L-2-Aminoadipate / alpha-Aminoadipic acid
CAS RN 542-32-5
Standard InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
Standard InChI (Main Layer) InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)

Cluster

Phytochemical cluster
KCF-S cluster No. 2641

Link

ChEMBL

By standard InChI CHEMBL88804
By standard InChI Main Layer CHEMBL433238 CHEMBL88804 CHEMBL1169505

KEGG

By LinkDB C00956

CTD

By CAS RN D015074

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Brassicaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae

Human Protein / Gene in interaction

16 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1169505 CHEMBL1741321 (1)
1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL88804 CHEMBL2114744 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1169505 CHEMBL1614361 (1)
3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1169505 CHEMBL1741325 (1)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL88804 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
Q14416 Metabotropic glutamate receptor 2 Metabotropic glutamate receptor CHEMBL88804 CHEMBL1169505 CHEMBL718215 (1) CHEMBL713617 (2)
0 / 0
O15303 Metabotropic glutamate receptor 6 Metabotropic glutamate receptor CHEMBL88804 CHEMBL1169505 CHEMBL718130 (1) CHEMBL712215 (2)
1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1169505 CHEMBL1741322 (1)
0 / 0
Q14833 Metabotropic glutamate receptor 4 Metabotropic glutamate receptor CHEMBL88804 CHEMBL716502 (1) CHEMBL714009 (1)
0 / 0
Q13255 Metabotropic glutamate receptor 1 Metabotropic glutamate receptor CHEMBL88804 CHEMBL1169505 CHEMBL719076 (1) CHEMBL717333 (2)
1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1169505 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1169505 CHEMBL1741324 (1)
0 / 1
P41594 Metabotropic glutamate receptor 5 Metabotropic glutamate receptor CHEMBL88804 CHEMBL711712 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL88804 CHEMBL1738442 (2)
0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL88804 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL88804 CHEMBL1613933 (1)
1 / 6

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#210900 Bloom syndrome; blm P54132
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#257270 Night blindness, congenital stationary, type 1b; csnb1b O15303
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614831 Spinocerebellar ataxia, autosomal recessive 13; scar13 Q13255

KEGG DISEASE (12)

KEGG disease name UniProt
H00787 Congenital stationary night blindness (CSNB) O15303 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)