KCF-S cluster No. 2426 (5 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 6 |
| eudicotyledons | 1 |
Cumulative family count
| class name | count |
|---|---|
| Brassicaceae | 4 |
| Enterobacteriaceae | 3 |
| Fabaceae | 2 |
| Amaranthaceae | 1 |
KEGG BRITE br08003
Categories (0)
| br08003 Category | # of metabolite |
|---|
metabolites link (0)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00001332
|
L-Alanine
|
CHEMBL12198
CHEMBL279597 CHEMBL66693 |
11 / 6 / 6 |
|
||
|
C00001351
|
L-Cysteine
|
CHEMBL863
CHEMBL54943 CHEMBL171281 |
D003545
|
11 / 22 / 17 | 13 / 7 |
|
|
C00001365
|
L-Homocysteine
|
CHEMBL310604
CHEMBL469662 |
1 / 0 / 0 |
|
||
|
C00007323
|
D-Cysteine
|
CHEMBL863
CHEMBL54943 CHEMBL171281 |
11 / 22 / 17 |
|
||
|
C00019654
|
D-Alanine
/ D-2-Aminopropionic acid |
CHEMBL12198
CHEMBL279597 CHEMBL66693 |
11 / 6 / 6 |
|
Human Protein / Gene in interactions
21 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001332 C00001351 C00007323 C00019654 | 1 / 1 |
| Q7Z2H8 | Proton-coupled amino acid transporter 1 | Unclassified protein | C00001332 C00001351 C00007323 C00019654 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001332 C00019654 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001332 C00019654 | 1 / 2 |
| P78536 | Disintegrin and metalloproteinase domain-containing protein 17 | M12B | C00001351 C00007323 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001332 C00019654 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001332 C00019654 | 1 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00001351 C00007323 | 2 / 3 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001351 C00007323 | 2 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00001332 C00019654 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001351 C00007323 | 11 / 10 |
| Q9Y2Q3 | Glutathione S-transferase kappa 1 | Enzyme | C00001351 C00007323 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001351 C00007323 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001332 C00019654 | 0 / 1 |
| P52732 | Kinesin-like protein KIF11 | Other cytosolic protein | C00001351 C00007323 | 1 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001332 C00019654 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001351 C00007323 | 4 / 3 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001332 C00019654 | 2 / 0 |
| Q9UPY5 | Cystine/glutamate transporter | Unclassified protein | C00001351 C00007323 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001332 C00019654 | 1 / 1 |
| O94760 | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | Enzyme | C00001365 | 0 / 0 |
13 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1244 | ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
C00001351
|
| 875 | CBS, HIP4 | cystathionine-beta-synthase (EC:4.2.1.22) |
C00001351
|
| 883 | CCBL1, GTK, KAT1, KATI | cysteine conjugate-beta lyase, cytoplasmic (EC:2.6.1.64 2.6.1.7 4.4.1.13) |
C00001351
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00001351
|
| 942 | CD86, B7-2, B7.2, B70, CD28LG2, LAB72 | CD86 molecule |
C00001351
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00001351
|
| 1491 | CTH | cystathionase (cystathionine gamma-lyase) (EC:4.4.1.1) |
C00001351
|
| 3347 | HTN3, HIS2, HTN2, HTN5 | histatin 3 |
C00001351
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00001351
|
| 4793 | NFKBIB, IKBB, TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
C00001351
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00001351
|
| 5979 | RET, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51 | ret proto-oncogene (EC:2.7.10.1) |
C00001351
|
| 6519 | SLC3A1, ATR1, CSNU1, D2H, NBAT, RBAT | solute carrier family 3 (amino acid transporter heavy chain), member 1 |
C00001351
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (27)
| OMIM | preferred title | UniProt |
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #614328 | Inflammatory skin and bowel disease, neonatal; nisbd |
P78536
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #152950 | Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation; mclmr |
P52732
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (22)
| KEGG | name | UniProt |
|---|---|---|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
7 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001321 | Autistic Disorder |
C00001351
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00001351
|
| D006461 | Hemolysis |
C00001351
|
| D007683 | Kidney Tubular Necrosis, Acute |
C00001351
|
| D008106 | Liver Cirrhosis, Experimental |
C00001351
|
| D017114 | Liver Failure, Acute |
C00001351
|
| D020258 | Neurotoxicity Syndromes |
C00001351
|